Effects of gut microbiota on in vivo metabolism and tissue accumulation of cytochrome P450 3A metabolized drug: Midazolam

Mapping human microbiome drug metabolism by gut bacteria and their genes

(2019) Michael Zimmermann et al.   NATURE

The gut microbiome: an orchestrator of xenobiotic metabolism

(2019) Stephanie L. Collins et al.   Acta Pharmaceutica Sinica B

Reduction in hepatic secondary bile acids caused by short-term antibiotic-induced dysbiosis decreases mouse serum glucose and triglyceride levels

(2018) Takuya Kuno et al.   Scientific Reports

Role of the gut microbiota in nutrition and health

(2018) Ana M Valdes et al.   BMJ-British Medical Journal

Role of the gut microbiota in nutrition and health

(2018) Ana M Valdes et al.   BMJ-British Medical Journal

Effect of Intestinal Flora on Protein Expression of Drug-Metabolizing Enzymes and Transporters in the Liver and Kidney of Germ-Free and Antibiotics-Treated Mice

(2016) Takuya Kuno et al.   MOLECULAR PHARMACEUTICS

The Human Intestinal Microbiome in Health and Disease

(2016) Susan V. Lynch et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evaluation of hypothermia on thein vitrometabolism and binding andin vivodisposition of midazolam in rats

(2015) Hirotaka Miyamoto et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Developmental Regulation of Drug-Processing Genes in Livers of Germ-Free Mice

(2015) Felcy Pavithra Selwyn et al.   TOXICOLOGICAL SCIENCES

Generation of Ugt1-Deficient Murine Liver Cell Lines Using TALEN Technology

(2014) Fabiola Porro et al.   PLoS One

Different Diets Cause Alterations in the Enteric Environment and Trigger Changes in the Expression of Hepatic Cytochrome P450 3A, a Drug-Metabolizing Enzyme

(2013) Masataka Tajima et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

CYP3A-dependent drug metabolism is reduced in bacterial inflammation in mice

(2012) AS Gandhi et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Impact of the Gut Microbiota on Human Health: An Integrative View

(2012) Jose C. Clemente et al.   CELL

Intestinal flora induces the expression of Cyp3a in the mouse liver

(2009) T. Toda et al.   XENOBIOTICA

Contribution of the N-Glucuronidation Pathway to the Overall in Vitro Metabolic Clearance of Midazolam in Humans

(2008) S. Klieber et al.   DRUG METABOLISM AND DISPOSITION

Effects of dietary salt on the expression of drug transporters, cytochrome P4503a, and nuclear receptors in rats

(2008) H. J. Kang et al.   XENOBIOTICA