Role of immune responses in the development of NAFLD-associated liver cancer and prospects for therapeutic modulation

Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches

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CXCR2 inhibition enables NASH-HCC immunotherapy

(2022) Jack Leslie et al.   GUT

Replication stress triggered by nucleotide pool imbalance drives DNA damage and cGAS-STING pathway activation in NAFLD

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Regular Aspirin Use Is Associated with a Reduced Risk of Hepatocellular Carcinoma (HCC) in Chronic Liver Disease: a Systematic Review and Meta-analysis

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Atezolizumab plus bevacizumab versus lenvatinib or sorafenib in non-viral unresectable hepatocellular carcinoma: an international propensity score matching analysis

(2022) M. Rimini et al.   ESMO Open

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(2021) Josep M. Llovet et al.   Nature Reviews Disease Primers

TREM2 sustains macrophage-hepatocyte metabolic coordination in nonalcoholic fatty liver disease and sepsis

(2021) Jinchao Hou et al.   JOURNAL OF CLINICAL INVESTIGATION

Once-Weekly Semaglutide in Adults with Overweight or Obesity

(2021) John P.H. Wilding et al.   NEW ENGLAND JOURNAL OF MEDICINE

Revisiting the Role of Natural Killer Cells in Non-Alcoholic Fatty Liver Disease

(2021) María Luz Martínez-Chantar et al.   Frontiers in Immunology

Mechanisms and disease consequences of nonalcoholic fatty liver disease

(2021) Rohit Loomba et al.   CELL

Molecular characterization of hepatocellular carcinoma in patients with non-alcoholic steatohepatitis

(2021) Roser Pinyol et al.   JOURNAL OF HEPATOLOGY

NASH limits anti-tumour surveillance in immunotherapy-treated HCC

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Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH

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XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis

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The aetiology and molecular landscape of insulin resistance

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CD8+ tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells

(2021) Yuzo Koda et al.   Nature Communications

Updated efficacy and safety data from IMbrave150: Atezolizumab plus bevacizumab vs. sorafenib for unresectable hepatocellular carcinoma

(2021) Ann-Lii Cheng et al.   JOURNAL OF HEPATOLOGY

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(2021) Josep M. Llovet et al.   Nature Reviews Clinical Oncology

The Scavenger Function of Liver Sinusoidal Endothelial Cells in Health and Disease

(2021) Sabin Bhandari et al.   Frontiers in Physiology

Hepatocytes Are Resistant to Cell Death From Canonical and Non-Canonical Inflammasome-Activated Pyroptosis

(2021) Ping Sun et al.   Cellular and Molecular Gastroenterology and Hepatology

Mechanisms of Fibrosis Development in NASH

(2020) Robert F. Schwabe et al.   GASTROENTEROLOGY

Update on NAFLD genetics: from new variants to the clinic

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Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease

(2020) Ze Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

DANGER SIGNALS IN LIVER INJURY AND RESTORATION OF HOMEOSTASIS

(2020) Hui Han et al.   JOURNAL OF HEPATOLOGY

Regulatory myeloid cells paralyze T cells through cell–cell transfer of the metabolite methylglyoxal

(2020) Tobias Baumann et al.   NATURE IMMUNOLOGY

Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders

(2020) Judith Aron-Wisnewsky et al.   Nature Reviews Gastroenterology & Hepatology

Association of Aspirin with Hepatocellular Carcinoma and Liver-Related Mortality

(2020) Tracey G. Simon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma

(2020) Richard S. Finn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immune-based therapies for hepatocellular carcinoma

(2020) David J. Pinato et al.   ONCOGENE

Role of c-Jun N-terminal Kinase (JNK) in Obesity and Type 2 Diabetes

(2020) Justin Hou Ming Yung et al.   Cells

Immunological distinctions between nonalcoholic steatohepatitis and hepatocellular carcinoma

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The NLRP3 Inflammasome in Alcoholic and Nonalcoholic Steatohepatitis

(2020) Jana Knorr et al.   SEMINARS IN LIVER DISEASE

The role of neutrophils in innate immunity-driven nonalcoholic steatohepatitis: lessons learned and future promise

(2020) Lihong Wu et al.   Hepatology International

The Intersection between Tumor Angiogenesis and Immune Suppression

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Daily aspirin use associated with reduced risk for fibrosis progression in patients with nonalcoholic fatty liver disease

(2019) Tracey G. Simon et al.   Clinical Gastroenterology and Hepatology

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer

(2019) Mohsen Malehmir et al.   NATURE MEDICINE

From NASH to HCC: current concepts and future challenges

(2019) Quentin M. Anstee et al.   Nature Reviews Gastroenterology & Hepatology

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(2019) Jordi Bruix et al.   Nature Reviews Gastroenterology & Hepatology

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Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche

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Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223

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CD8+T CELLS REGULATE LIVER INJURY IN OBESITY-RELATED NONALCOHOLIC FATTY LIVER DISEASE

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Genetic contributions to NAFLD: leveraging shared genetics to uncover systems biology

(2019) Mohammed Eslam et al.   Nature Reviews Gastroenterology & Hepatology

Immunotherapy for hepatocellular carcinoma

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Nutrition and Nonalcoholic Fatty Liver Disease

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Intestinal microbiome and NAFLD: molecular insights and therapeutic perspectives

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CC chemokine receptor 2 promotes recruitment of myeloid cells associated with insulin resistance in nonalcoholic fatty liver disease

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Immune Responses in the Liver

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Lipotoxicity and the gut-liver axis in NASH pathogenesis

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Liver sinusoidal endothelial cells — gatekeepers of hepatic immunity

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Cabozantinib in Patients with Advanced and Progressing Hepatocellular Carcinoma

(2018) Ghassan K. Abou-Alfa et al.   NEW ENGLAND JOURNAL OF MEDICINE

Key Inflammatory Processes in Human NASH Are Reflected in Ldlr−/−.Leiden Mice: A Translational Gene Profiling Study

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Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR

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ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P

(2018) Ju Youn Kim et al.   CELL

Mechanisms of Insulin Action and Insulin Resistance

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Mucosal-Associated Invariant T Cells Improve Nonalcoholic Fatty Liver Disease Through Regulating Macrophage Polarization

(2018) Yanmei Li et al.   Frontiers in Immunology

DAMPs and sterile inflammation in drug hepatotoxicity

(2018) Runkuan Yang et al.   Hepatology International

Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics

(2018) Stergios A. Polyzos et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis

(2018) M. Welz et al.   Nature Communications

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

(2017) Auvro R. Mridha et al.   JOURNAL OF HEPATOLOGY

NCCN Guidelines Insights: Hepatobiliary Cancers, Version 1.2017

(2017) Al B. Benson et al.   Journal of the National Comprehensive Cancer Network

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(2017) Gökhan S. Hotamisligil   NATURE

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Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

(2017) Zobair Younossi et al.   Nature Reviews Gastroenterology & Hepatology

Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans

(2017) Kasper W. ter Horst et al.   Cell Reports

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Metabolic Inflammation-Associated IL-17A Causes Non-alcoholic Steatohepatitis and Hepatocellular Carcinoma

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Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease

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Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis

(2016) Xiaobo Wang et al.   Cell Metabolism

Interleukin-15-mediated inflammation promotes non-alcoholic fatty liver disease

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Adipose tissue plasticity: how fat depots respond differently to pathophysiological cues

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Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease

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Innate Immunity and Inflammation in NAFLD/NASH

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p38  and p38  reprogram liver metabolism by modulating neutrophil infiltration

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Histological severity and clinical outcomes of nonalcoholic fatty liver disease in nonobese patients

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Bile acids and nonalcoholic fatty liver disease: Molecular insights and therapeutic perspectives

(2016) Juan P. Arab et al.   HEPATOLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Liver-Resident Memory CD8 + T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection

(2016) Daniel Fernandez-Ruiz et al.   IMMUNITY

Tissue-Resident Macrophage Ontogeny and Homeostasis

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Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance

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Adipose tissue regulates insulin sensitivity: role of adipogenesis,de novolipogenesis and novel lipids

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Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment

(2016) Meric Erikci Ertunc et al.   JOURNAL OF LIPID RESEARCH

NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis

(2016) Chi Ma et al.   NATURE

Immunology in the liver — from homeostasis to disease

(2016) Felix Heymann et al.   Nature Reviews Gastroenterology & Hepatology

The role of the gut microbiota in NAFLD

(2016) Christopher Leung et al.   Nature Reviews Gastroenterology & Hepatology

The Human Intestinal Microbiome in Health and Disease

(2016) Susan V. Lynch et al.   NEW ENGLAND JOURNAL OF MEDICINE

EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease

(2016)   Obesity Facts

Obesity is an independent risk factor for non-alcoholic fatty liver disease: evidence from a meta-analysis of 21 cohort studies

(2016) L. Li et al.   Obesity Reviews

Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

(2016) Charlotte L. Scott et al.   Nature Communications

Farnesoid X Receptor Signaling Shapes the Gut Microbiota and Controls Hepatic Lipid Metabolism

(2016) Limin Zhang et al.   mSystems

Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy

(2015) Suzanne L. Topalian et al.   CANCER CELL

Efficacy of rifaximin on circulating endotoxins and cytokines in patients with nonalcoholic fatty liver disease

(2015) Venkatanarayana Gangarapu et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Systematic review on intervention with prebiotics/probiotics in patients with obesity-related nonalcoholic fatty liver disease

(2015) Giovanni Tarantino et al.   Future Microbiology

Liver inflammation abrogates immunological tolerance induced by Kupffer cells

(2015) Felix Heymann et al.   HEPATOLOGY

Liver sinusoidal endothelial cells in hepatic fibrosis

(2015) Laurie D. DeLeve   HEPATOLOGY

Progression from Nonalcoholic Fatty Liver to Nonalcoholic Steatohepatitis Is Marked by a Higher Frequency of Th17 Cells in the Liver and an Increased Th17/Resting Regulatory T Cell Ratio in Peripheral Blood and in the Liver

(2015) Monika Rau et al.   JOURNAL OF IMMUNOLOGY

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

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European Guidelines for Obesity Management in Adults

(2015) Volkan Yumuk et al.   Obesity Facts

A gut-vascular barrier controls the systemic dissemination of bacteria

(2015) Ilaria Spadoni et al.   SCIENCE

Synbiotic supplementation in nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled pilot study

(2014) Tannaz Eslamparast et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development

(2014) Hayato Nakagawa et al.   CANCER CELL

Metabolic Activation of Intrahepatic CD8+ T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes

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Cell Death and Cell Death Responses in Liver Disease: Mechanisms and Clinical Relevance

(2014) Tom Luedde et al.   GASTROENTEROLOGY

PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells

(2014) Carlo Pirazzi et al.   HUMAN MOLECULAR GENETICS

The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis

(2014) Peter Huebener et al.   JOURNAL OF CLINICAL INVESTIGATION

Carriage of the PNPLA3 rs738409 C >G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma

(2014) Y.-L. Liu et al.   JOURNAL OF HEPATOLOGY

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

(2014) Rachel J. Perry et al.   NATURE

Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease

(2014) Julia Kozlitina et al.   NATURE GENETICS

GPBAR1/TGR5 Mediates Bile Acid-Induced Cytokine Expression in Murine Kupffer Cells

(2014) Guiyu Lou et al.   PLoS One

The Liver May Act as a Firewall Mediating Mutualism Between the Host and Its Gut Commensal Microbiota

(2014) M. L. Balmer et al.   Science Translational Medicine

The Role of Dietary Sugars and De novo Lipogenesis in Non-Alcoholic Fatty Liver Disease

(2014) J. Moore et al.   Nutrients

IL-6 trans-Signaling-Dependent Rapid Development of Cytotoxic CD8+ T Cell Function

(2014) Jan P. Böttcher et al.   Cell Reports

Adherence to the Mediterranean diet is associated with the severity of non-alcoholic fatty liver disease

(2013) Meropi D. Kontogianni et al.   CLINICAL NUTRITION

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(2013) Gaetano Serviddio et al.   FREE RADICAL BIOLOGY AND MEDICINE

Efficacy and Safety of the Farnesoid X Receptor Agonist Obeticholic Acid in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease

(2013) Sunder Mudaliar et al.   GASTROENTEROLOGY

Increased De Novo Lipogenesis Is a Distinct Characteristic of Individuals With Nonalcoholic Fatty Liver Disease

(2013) Jennifer E. Lambert et al.   GASTROENTEROLOGY

Cross-talk between Notch and Hedgehog regulates hepatic stellate cell fate in mice

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Primary Prevention of Cardiovascular Disease with a Mediterranean Diet

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Liver-Primed Memory T Cells Generated under Noninflammatory Conditions Provide Anti-infectious Immunity

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Monocyte/macrophage-elicited natural killer cell dysfunction in hepatocellular carcinoma is mediated by CD48/2B4 interactions

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Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B

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(2011) N. Kumashiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

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(2010) Zhao-Xia Yang et al.   Hepatology International

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(2010) Ahmed Abu-Shanab et al.   Nature Reviews Gastroenterology & Hepatology

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5

(2010) M. Vijay-Kumar et al.   SCIENCE

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(2009) Ian Nicholas Crispe   Annual Review of Immunology

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(2009) Luca Miele et al.   HEPATOLOGY

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Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis

(2009) Kittichai Promrat et al.   HEPATOLOGY

The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver

(2009) Nicola L. Beer et al.   HUMAN MOLECULAR GENETICS

A Sequence Variation (I148M) in PNPLA3 Associated with Nonalcoholic Fatty Liver Disease Disrupts Triglyceride Hydrolysis

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Endoplasmic Reticulum Stress Is Reduced in Tissues of Obese Subjects After Weight Loss

(2008) M. F. Gregor et al.   DIABETES

A New Population of Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Induces CD4+CD25+Foxp3+ T Cells

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B7-H1 on Hepatocytes Facilitates Priming of Specific CD8 T Cells But Limits the Specific Recall of Primed Responses

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(2008) Stefano Romeo et al.   NATURE GENETICS

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS

Molecular Mechanisms of Lipotoxicity in Nonalcoholic Fatty Liver Disease

(2008) Harmeet Malhi et al.   SEMINARS IN LIVER DISEASE

It's Not How Fat You Are, It's What You Do with It That Counts

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Blood oxidative stress markers in non-alcoholic steatohepatitis and how it correlates with diet

(2007) Maiana Verdelho Machado et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY