CXCR2 inhibition enables NASH-HCC immunotherapy

Neutrophils as potential therapeutic targets in hepatocellular carcinoma

(2022) Daniel Geh et al.   Nature Reviews Gastroenterology & Hepatology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Molecular characterization of hepatocellular carcinoma in patients with non-alcoholic steatohepatitis

(2021) Roser Pinyol et al.   JOURNAL OF HEPATOLOGY

Targeting CXCR2 inhibits the progression of lung cancer and promotes therapeutic effect of cisplatin

(2021) Yuan Cheng et al.   Molecular Cancer

NASH limits anti-tumour surveillance in immunotherapy-treated HCC

(2021) Dominik Pfister et al.   NATURE

The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments

(2021) Ricardo Grieshaber-Bouyer et al.   Nature Communications

Evidence-Based Management of Hepatocellular Carcinoma: Systematic Review and Meta-analysis of Randomized Controlled Trials (2002–2020)

(2021) Philipp K. Haber et al.   GASTROENTEROLOGY

XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis

(2021) Aleksandra Deczkowska et al.   NATURE MEDICINE

The Evolving Challenge of Infections in Cirrhosis

(2021) Jasmohan S. Bajaj et al.   NEW ENGLAND JOURNAL OF MEDICINE

Combined Inhibition of SHP2 and CXCR1/2 Promotes Anti-Tumor T Cell Response in NSCLC

(2021) Kwan Ho Tang et al.   Cancer Discovery

Key features of the environment promoting liver cancer in the absence of cirrhosis

(2021) Marco Youssef William Zaki et al.   Scientific Reports

Nivolumab versus sorafenib in advanced hepatocellular carcinoma (CheckMate 459): a randomised, multicentre, open-label, phase 3 trial

(2021) Thomas Yau et al.   LANCET ONCOLOGY

Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma

(2020) Richard S. Finn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dendritic Cells and Their Role in Immunotherapy

(2020) Alycia Gardner et al.   Frontiers in Immunology

Granzyme B is correlated with clinical outcome after PD-1 blockade in patients with stage IV non-small-cell lung cancer

(2020) Daan P. Hurkmans et al.   Journal for ImmunoTherapy of Cancer

Lactoferrin’s Anti-Cancer Properties: Safety, Selectivity, and Wide Range of Action

(2020) Antimo Cutone et al.   Biomolecules

Association of inflammatory biomarkers with clinical outcomes in nivolumab-treated patients with advanced hepatocellular carcinoma

(2020) Bruno Sangro et al.   JOURNAL OF HEPATOLOGY

Association between body mass index and survival outcomes for cancer patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis

(2020) Yue An et al.   Journal of Translational Medicine

Cabozantinib enhances the efficacy and immune modulatory activity of anti-PD1 therapy in a syngeneic mouse model of hepatocellular carcinoma

(2020) Roger Esteban-Fabró et al.   JOURNAL OF HEPATOLOGY

Chemokines in Non-alcoholic Fatty Liver Disease: A Systematic Review and Network Meta-Analysis

(2020) Xiongfeng Pan et al.   Frontiers in Immunology

Efficacy and Safety of Nivolumab Plus Ipilimumab in Patients With Advanced Hepatocellular Carcinoma Previously Treated With Sorafenib

(2020) Thomas Yau et al.   JAMA Oncology

Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis

(2020) Olivier Govaere et al.   Science Translational Medicine

Obesity diminishes response to PD-1-based immunotherapies in renal cancer

(2020) Shannon K Boi et al.   Journal for ImmunoTherapy of Cancer

Chemokine Receptor Redundancy and Specificity Are Context Dependent

(2019) Douglas P. Dyer et al.   IMMUNITY

From NASH to HCC: current concepts and future challenges

(2019) Quentin M. Anstee et al.   Nature Reviews Gastroenterology & Hepatology

Tumour-associated neutrophils in patients with cancer

(2019) Merav E. Shaul et al.   Nature Reviews Clinical Oncology

Pembrolizumab As Second-Line Therapy in Patients With Advanced Hepatocellular Carcinoma in KEYNOTE-240: A Randomized, Double-Blind, Phase III Trial

(2019) Richard S. Finn et al.   JOURNAL OF CLINICAL ONCOLOGY

Targeting cellular heterogeneity with CXCR2 blockade for the treatment of therapy-resistant prostate cancer

(2019) Yanjing Li et al.   Science Translational Medicine

Non-alcoholic Steatohepatitis is the Fastest Growing Cause of Hepatocellular Carcinoma in Liver Transplant Candidates

(2018) Zobair Younossi et al.   Clinical Gastroenterology and Hepatology

Landscape of immune microenvironment in hepatocellular carcinoma and its additional impact on histological and molecular classification

(2018) Yutaka Kurebayashi et al.   HEPATOLOGY

Neutrophils and PMN-MDSC: Their biological role and interaction with stromal cells

(2018) Jie Zhou et al.   SEMINARS IN IMMUNOLOGY

Identification of an Early Unipotent Neutrophil Progenitor with Pro-tumoral Activity in Mouse and Human Bone Marrow

(2018) Yanfang Peipei Zhu et al.   Cell Reports

Identification of an Immune-specific Class of Hepatocellular Carcinoma, Based on Molecular Features

(2017) Daniela Sia et al.   GASTROENTEROLOGY

IFN-γ–related mRNA profile predicts clinical response to PD-1 blockade

(2017) Mark Ayers et al.   JOURNAL OF CLINICAL INVESTIGATION

CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma

(2016) Colin W. Steele et al.   CANCER CELL

Lipocalin-2 mediates non-alcoholic steatohepatitis by promoting neutrophil-macrophage crosstalk via the induction of CXCR2

(2016) Dewei Ye et al.   JOURNAL OF HEPATOLOGY

Survival of residual neutrophils and accelerated myelopoiesis limit the efficacy of antibody-mediated depletion of Ly-6G+ cells in tumor-bearing mice

(2016) K. Moses et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Prognostic Role of Mitotic Index in Hepatocellular Carcinoma Patients after Curative Hepatectomy

(2016) Sang Yun Ha et al.   Cancer Research and Treatment

Tumor-associated neutrophils display a distinct N1 profile following TGFβ modulation: A transcriptomics analysis of pro- vs. antitumor TANs

(2016) Merav E. Shaul et al.   OncoImmunology

DNA methylation-based prognosis and epidrivers in hepatocellular carcinoma

(2015) Augusto Villanueva et al.   HEPATOLOGY

The Multifaceted Functions of Neutrophils

(2013) Tanya N. Mayadas et al.   Annual Review of Pathology-Mechanisms of Disease

CXCR2-Expressing Myeloid-Derived Suppressor Cells Are Essential to Promote Colitis-Associated Tumorigenesis

(2013) Hiroshi Katoh et al.   CANCER CELL

Recombinant human lactoferrin induces human and mouse dendritic cell maturation via Toll-like receptors 2 and 4

(2013) Michela Spadaro et al.   FASEB JOURNAL

Hepatocellular cancer: The impact of obesity, type 2 diabetes and a multidisciplinary team

(2013) Jessica Dyson et al.   JOURNAL OF HEPATOLOGY

Neutrophil Function: From Mechanisms to Disease

(2012) Borko Amulic et al.   Annual Review of Immunology

Tumor-associated neutrophils: friend or foe?

(2012) Z. G. Fridlender et al.   CARCINOGENESIS

Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis

(2012) Thomas Jamieson et al.   JOURNAL OF CLINICAL INVESTIGATION

CXCR2 Promotes Ovarian Cancer Growth through Dysregulated Cell Cycle, Diminished Apoptosis, and Enhanced Angiogenesis

(2010) G. Yang et al.   CLINICAL CANCER RESEARCH

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

Lactoferrin as a Natural Immune Modulator

(2009) Jeffrey Actor et al.   CURRENT PHARMACEUTICAL DESIGN