Immunological distinctions between nonalcoholic steatohepatitis and hepatocellular carcinoma

Challenges of combination therapy with immune checkpoint inhibitors for hepatocellular carcinoma

(2020) Ann-Lii Cheng et al.   JOURNAL OF HEPATOLOGY

Combination therapy for non-alcoholic steatohepatitis: rationale, opportunities and challenges

(2020) Jean-François Dufour et al.   GUT

Individualized Precision Treatment：Targeting TAM in HCC

(2019) Zhixuan Li et al.   CANCER LETTERS

Retained NK Cell Phenotype and Functionality in Non-alcoholic Fatty Liver Disease

(2019) Natalie Stiglund et al.   Frontiers in Immunology

Dual CCR5/CCR2 targeting: opportunities for the cure of complex disorders

(2019) Laura Fantuzzi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

REGENERATE: Design of a pivotal, randomised, phase 3 study evaluating the safety and efficacy of obeticholic acid in patients with fibrosis due to nonalcoholic steatohepatitis

(2019) Vlad Ratziu et al.   Contemporary Clinical Trials

Emerging agents and regimens for hepatocellular carcinoma

(2019) Xiao-Dong Zhu et al.   Journal of Hematology & Oncology

Emerging metabolic risk factors in hepatocellular carcinoma and their influence on the liver microenvironment

(2018) Pasquale Agosti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Non-alcoholic steatohepatitis pathogenesis: sublethal hepatocyte injury as a driver of liver inflammation

(2018) Samar H Ibrahim et al.   GUT

B lymphocytes limit senescence-driven fibrosis resolution and favor hepatocarcinogenesis in mouse liver injury

(2018) Francesca Faggioli et al.   HEPATOLOGY

Neutrophil extracellular traps promote inflammation and development of hepatocellular carcinoma in nonalcoholic steatohepatitis

(2018) Dirk J. van der Windt et al.   HEPATOLOGY

Hypoxia-inducible factor-1α/interleukin-1β signaling enhances hepatoma epithelial-mesenchymal transition through macrophages in a hypoxic-inflammatory microenvironment

(2018) Jingying Zhang et al.   HEPATOLOGY

Macrophages: Their role, activation and polarization in pulmonary diseases

(2018) Shweta Arora et al.   IMMUNOBIOLOGY

Pharmacotherapy for NASH: Current and emerging

(2018) Monica A. Konerman et al.   JOURNAL OF HEPATOLOGY

The immunology of hepatocellular carcinoma

(2018) Marc Ringelhan et al.   NATURE IMMUNOLOGY

M2-polarized tumor-associated macrophages facilitated migration and epithelial-mesenchymal transition of HCC cells via the TLR4/STAT3 signaling pathway

(2018) Rong-Rong Yao et al.   World Journal of Surgical Oncology

Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?

(2018) Carlos Rosales   Frontiers in Physiology

NKT cells in liver diseases

(2018) Shasha Zhu et al.   Frontiers of Medicine

An optical nanoreporter of endolysosomal lipid accumulation reveals enduring effects of diet on hepatic macrophages in vivo

(2018) Thomas V. Galassi et al.   Science Translational Medicine

Tumor Microenvironment, a Paradigm in Hepatocellular Carcinoma Progression and Therapy

(2017) Maryam Tahmasebi Birgani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Importance of Dendritic Cells in Maintaining Immune Tolerance

(2017) Cindy Audiger et al.   JOURNAL OF IMMUNOLOGY

Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity

(2017) Shabnam Shalapour et al.   NATURE

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

(2017) Zobair Younossi et al.   Nature Reviews Gastroenterology & Hepatology

Mitochondrial Adaptation in Nonalcoholic Fatty Liver Disease: Novel Mechanisms and Treatment Strategies

(2017) Nishanth E. Sunny et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Tumor-infiltrating B cells producing antitumor active immunoglobulins in resected HCC prolong patient survival

(2017) Stefan M. Brunner et al.   Oncotarget

Neutrophil count is associated with myeloid derived suppressor cell level and presents prognostic value for hepatocellular carcinoma patients

(2017) Xing Li et al.   Oncotarget

The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy

(2017) Sourav Paul et al.   Frontiers in Immunology

Interleukin-15-mediated inflammation promotes non-alcoholic fatty liver disease

(2016) Yuneivy Cepero-Donates et al.   CYTOKINE

Tumor-Associated Neutrophils Recruit Macrophages and T-Regulatory Cells to Promote Progression of Hepatocellular Carcinoma and Resistance to Sorafenib

(2016) Shao-Lai Zhou et al.   GASTROENTEROLOGY

A new HIF-1α/RANTES-driven pathway to hepatocellular carcinoma mediated by germline haploinsufficiency of SART1/HAF in mice

(2016) Mei Yee Koh et al.   HEPATOLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Type II NKT cells: a distinct CD1d-restricted immune regulatory NKT cell subset

(2016) Suryasarathi Dasgupta et al.   IMMUNOGENETICS

International trends in liver cancer incidence, overall and by histologic subtype, 1978-2007

(2016) Jessica L. Petrick et al.   INTERNATIONAL JOURNAL OF CANCER

NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis

(2016) Chi Ma et al.   NATURE

Impact of myeloid-derived suppressor cell on Kupffer cells from mouse livers with hepatocellular carcinoma

(2016) Stéphanie Lacotte et al.   OncoImmunology

The Immune Landscape in Nonalcoholic Steatohepatitis

(2016) Sowmya Narayanan et al.   Immune Network

Neutrophils Play a Crucial Role in the Early Stage of Nonalcoholic Steatohepatitis via Neutrophil Elastase in Mice

(2015) Shufei Zang et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

TGF-β Regulates Hepatocellular Carcinoma Progression by Inducing Treg Cell Polarization

(2015) Yinan Shen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

B Cells, Antibodies, and More

(2015) W. Hoffman et al.   Clinical Journal of the American Society of Nephrology

Hepatocellular Carcinoma in the Setting of Non-cirrhotic Nonalcoholic Fatty Liver Disease and the Metabolic Syndrome: US Experience

(2015) Ryan B. Perumpail et al.   DIGESTIVE DISEASES AND SCIENCES

Interaction between tumour-infiltrating B cells and T cells controls the progression of hepatocellular carcinoma

(2015) Marta Garnelo et al.   GUT

Progression from Nonalcoholic Fatty Liver to Nonalcoholic Steatohepatitis Is Marked by a Higher Frequency of Th17 Cells in the Liver and an Increased Th17/Resting Regulatory T Cell Ratio in Peripheral Blood and in the Liver

(2015) Monika Rau et al.   JOURNAL OF IMMUNOLOGY

Metabolic Activation of Intrahepatic CD8+ T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes

(2014) Monika Julia Wolf et al.   CANCER CELL

Tumor-associated macrophages promote cancer stem cell-like properties via transforming growth factor-beta1-induced epithelial–mesenchymal transition in hepatocellular carcinoma

(2014) Qing-Min Fan et al.   CANCER LETTERS

Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

(2014) L. Rahib et al.   CANCER RESEARCH

Tumor-Associated Macrophages Produce Interleukin 6 and Signal via STAT3 to Promote Expansion of Human Hepatocellular Carcinoma Stem Cells

(2014) Shanshan Wan et al.   GASTROENTEROLOGY

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

3, 3′-diindolylmethane alleviates steatosis and the progression of NASH partly through shifting the imbalance of Treg/Th17 cells to Treg dominance

(2014) Yun Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Serum immunoglobulin levels predict fibrosis in patients with non-alcoholic fatty liver disease

(2014) Stuart McPherson et al.   JOURNAL OF HEPATOLOGY

From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation

(2014) Paola Italiani et al.   Frontiers in Immunology

Hepatic B cells are readily activated by Toll-like receptor-4 ligation and secrete less interleukin-10 than lymphoid tissue B cells

(2013) H. Zhang et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Role of the Microenvironment in the Pathogenesis and Treatment of Hepatocellular Carcinoma

(2013) Virginia Hernandez–Gea et al.   GASTROENTEROLOGY

Dendritic cells limit fibroinflammatory injury in nonalcoholic steatohepatitis in mice

(2013) Justin R. Henning et al.   HEPATOLOGY

Adaptive immune responses triggered by oxidative stress contribute to hepatic inflammation in NASH

(2013) Salvatore Sutti et al.   HEPATOLOGY

Immunodominance and functional alterations of tumor-associated antigen-specific CD8+T-cell responses in hepatocellular carcinoma

(2013) Tobias Flecken et al.   HEPATOLOGY

Nonalcoholic steatohepatitis is the most rapidly growing indication for liver transplantation in patients with hepatocellular carcinoma in the U.S.

(2013) Robert J. Wong et al.   HEPATOLOGY

The Functions of Type I and Type II Natural Killer T Cells in Inflammatory Bowel Diseases

(2013) Chia-Min Liao et al.   INFLAMMATORY BOWEL DISEASES

Hepatocellular cancer: The impact of obesity, type 2 diabetes and a multidisciplinary team

(2013) Jessica Dyson et al.   JOURNAL OF HEPATOLOGY

Chemokine Receptor CXCR6-Dependent Hepatic NK T Cell Accumulation Promotes Inflammation and Liver Fibrosis

(2013) A. Wehr et al.   JOURNAL OF IMMUNOLOGY

IL-17A Plays a Critical Role in the Pathogenesis of Liver Fibrosis through Hepatic Stellate Cell Activation

(2013) Z. Tan et al.   JOURNAL OF IMMUNOLOGY

Role of immunodeficient animal models in the development of fructose induced NAFLD

(2013) Jashdeep Bhattacharjee et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Trapping of oxidized LDL in lysosomes of Kupffer cells is a trigger for hepatic inflammation

(2013) Veerle Bieghs et al.   LIVER INTERNATIONAL

Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis

(2013) Quentin M. Anstee et al.   Nature Reviews Gastroenterology & Hepatology

The global NAFLD epidemic

(2013) Rohit Loomba et al.   Nature Reviews Gastroenterology & Hepatology

NAFLD, NASH and liver cancer

(2013) Gregory A. Michelotti et al.   Nature Reviews Gastroenterology & Hepatology

The innate immune response during liver inflammation and metabolic disease

(2013) Veerle Bieghs et al.   TRENDS IN IMMUNOLOGY

CXCR6 Upregulation Contributes to a Proinflammatory Tumor Microenvironment That Drives Metastasis and Poor Patient Outcomes in Hepatocellular Carcinoma

(2012) Q. Gao et al.   CANCER RESEARCH

The Proinflammatory Myeloid Cell Receptor TREM-1 Controls Kupffer Cell Activation and Development of Hepatocellular Carcinoma

(2012) Juan Wu et al.   CANCER RESEARCH

NF-κB1 deficiency stimulates the progression of non-alcoholic steatohepatitis (NASH) in mice by promoting NKT-cell-mediated responses

(2012) Irene Locatelli et al.   CLINICAL SCIENCE

Toll-like receptor-4 mediates obesity-induced non-alcoholic steatohepatitis through activation of X-box binding protein-1 in mice

(2012) Dewei Ye et al.   GUT

Adaptive immunity suppresses formation and progression of diethylnitrosamine-induced liver cancer

(2012) Carlo Schneider et al.   GUT

Chronic inflammation, immune escape, and oncogenesis in the liver: A unique neighborhood for novel intersections

(2012) Jimmy K. Stauffer et al.   HEPATOLOGY

Inhibition of natural killer cells protects the liver against acute injury in the absence of glycine N-methyltransferase

(2012) Laura Gomez-Santos et al.   HEPATOLOGY

Monocyte/macrophage-elicited natural killer cell dysfunction in hepatocellular carcinoma is mediated by CD48/2B4 interactions

(2012) Yan Wu et al.   HEPATOLOGY

B cell-activating factor is associated with the histological severity of nonalcoholic fatty liver disease

(2012) Teruki Miyake et al.   Hepatology International

Kuppfer Cells Trigger Nonalcoholic Steatohepatitis Development in Diet-induced Mouse Model through Tumor Necrosis Factor-α Production

(2012) Annie-Carole Tosello-Trampont et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of Innate Cells Is Coupled to a Th1-Polarized Immune Response in Pediatric Nonalcoholic Steatohepatitis

(2012) Nazarena E. Ferreyra Solari et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Oncogenic β-catenin triggers an inflammatory response that determines the aggressiveness of hepatocellular carcinoma in mice

(2012) Marie Anson et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophil-Derived Myeloperoxidase Aggravates Non-Alcoholic Steatohepatitis in Low-Density Lipoprotein Receptor-Deficient Mice

(2012) Sander S. Rensen et al.   PLoS One

Regulation of innate CD8+ T-cell activation mediated by cytokines

(2012) B. E. Freeman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Inflammatory Microenvironment in Hepatocellular Carcinoma: A Pivotal Role for Tumor-Associated Macrophages

(2012) Daria Capece et al.   Biomed Research International

Large-Scale Long-Term Follow-Up Study of Japanese Patients With Non-Alcoholic Fatty Liver Disease for the Onset of Hepatocellular Carcinoma

(2011) Yusuke Kawamura et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Kupffer Cells Influence Parenchymal Invasion and Phenotypic Orientation, but Not the Proliferation, of Liver Progenitor Cells in a Murine Model of Liver Injury

(2011) Noémi Van Hul et al.   AMERICAN JOURNAL OF PATHOLOGY

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Interleukin-17 exacerbates hepatic steatosis and inflammation in non-alcoholic fatty liver disease

(2011) Y. Tang et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Metabolic syndrome increases the risk of primary liver cancer in the United States: A study in the SEER-medicare database

(2011) Tania M. Welzel et al.   HEPATOLOGY

Metabolic risk factors and primary liver cancer in a prospective study of 578,700 adults

(2011) Wegene Borena et al.   INTERNATIONAL JOURNAL OF CANCER

Altered Phenotype and Functionality of Circulating Immune Cells Characterize Adult Patients with Nonalcoholic Steatohepatitis

(2011) María Eugenia Inzaugarat et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Neutrophil to lymphocyte ratio: a new marker for predicting steatohepatitis and fibrosis in patients with nonalcoholic fatty liver disease

(2011) Naim Alkhouri et al.   LIVER INTERNATIONAL

Th1/Th2/Th17 and Regulatory T-Cell Paradigm in Pregnancy

(2010) Shigeru Saito et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Population-based risk factors and resource utilization for HCC: US perspective

(2010) A. Sanyal et al.   CURRENT MEDICAL RESEARCH AND OPINION

Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease

(2010) Wing-Kin Syn et al.   HEPATOLOGY

T-helper 17 cell: A distinctive cell in liver diseases

(2010) Chao Ye et al.   HEPATOLOGY RESEARCH

Peritumoral neutrophils link inflammatory response to disease progression by fostering angiogenesis in hepatocellular carcinoma

(2010) Dong-Ming Kuang et al.   JOURNAL OF HEPATOLOGY

B cell activation factor (BAFF) is a novel adipokine that links obesity and inflammation

(2009) Yu-Hee Kim et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Major histocompatibility complex class I-related chains A and B (MIC A/B): A novel role in nonalcoholic steatohepatitis

(2009) Alisan Kahraman et al.   HEPATOLOGY

Myeloid derived suppressor cells inhibit natural killer cells in patients with hepatocellular carcinoma via the NKp30 receptor

(2009) Bastian Hoechst et al.   HEPATOLOGY

Activated monocytes in peritumoral stroma of hepatocellular carcinoma promote expansion of memory T helper 17 cells

(2009) Dong-Ming Kuang et al.   HEPATOLOGY

Role of macrophages in tumour progression

(2009) K.S. Siveen et al.   IMMUNOLOGY LETTERS

Increased intratumoral regulatory T cells are related to intratumoral macrophages and poor prognosis in hepatocellular carcinoma patients

(2009) Jia Zhou et al.   INTERNATIONAL JOURNAL OF CANCER

Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1

(2009) Dong-Ming Kuang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Enrichment of Human CD4+ V 24/V 11 Invariant NKT Cells in Intrahepatic Malignant Tumors

(2009) G. Bricard et al.   JOURNAL OF IMMUNOLOGY

Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases

(2009) B. Gao et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The expression profile of glypican-3 and its relation to macrophage population in human hepatocellular carcinoma

(2009) Hirotake Takai et al.   LIVER INTERNATIONAL

Functional impairment in circulating and intrahepatic NK cells and relative mechanism in hepatocellular carcinoma patients

(2008) Lun Cai et al.   CLINICAL IMMUNOLOGY

Mechanism of T cell tolerance induction by murine hepatic Kupffer cells

(2008) Qiang You et al.   HEPATOLOGY

High Expression of Macrophage Colony-Stimulating Factor in Peritumoral Liver Tissue Is Associated With Poor Survival After Curative Resection of Hepatocellular Carcinoma

(2008) Xiao-Dong Zhu et al.   JOURNAL OF CLINICAL ONCOLOGY

Enhanced serum concentrations of transforming growth factor-beta1 in simple fatty liver: is it really benign?

(2008) Giovanni Tarantino et al.   Journal of Translational Medicine

Functions of natural killer cells

(2008) Eric Vivier et al.   NATURE IMMUNOLOGY