Liver sinusoidal endothelial cells — gatekeepers of hepatic immunity

IL-33 exacerbates liver sterile inflammation by amplifying neutrophil extracellular trap formation

(2018) Hamza O. Yazdani et al.   JOURNAL OF HEPATOLOGY

GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis

(2017) Cyrill Géraud et al.   JOURNAL OF CLINICAL INVESTIGATION

Novel roles of DC-SIGNR in colon cancer cell adhesion, migration, invasion, and liver metastasis

(2017) Heya Na et al.   Journal of Hematology & Oncology

Liver sinusoidal endothelial cells: Physiology and role in liver diseases

(2017) Johanne Poisson et al.   JOURNAL OF HEPATOLOGY

Mechanisms of hepatic stellate cell activation

(2017) Takuma Tsuchida et al.   Nature Reviews Gastroenterology & Hepatology

Vascular heterogeneity and specialization in development and disease

(2017) Michael Potente et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Visualizing the function and fate of neutrophils in sterile injury and repair

(2017) Jing Wang et al.   SCIENCE

Mouse Liver Sinusoidal Endothelium Eliminates HIV-Like Particles from Blood at a Rate of 100 Million per Minute by a Second-Order Kinetic Process

(2017) Jessica M. Mates et al.   Frontiers in Immunology

Dietary macronutrients and the aging liver sinusoidal endothelial cell

(2016) Victoria Carroll Cogger et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

A Reservoir of Mature Cavity Macrophages that Can Rapidly Invade Visceral Organs to Affect Tissue Repair

(2016) Jing Wang et al.   CELL

Pharmacokinetics, Safety, and CCR2/CCR5 Antagonist Activity of Cenicriviroc in Participants With Mild or Moderate Hepatic Impairment

(2016) E Lefebvre et al.   CTS-Clinical and Translational Science

Leukocyte Trafficking to the Small Intestine and Colon

(2016) Aida Habtezion et al.   GASTROENTEROLOGY

Human liver sinusoidal endothelial cells promote intracellular crawling of lymphocytes during recruitment: A new step in migration

(2016) Daniel A. Patten et al.   HEPATOLOGY

Interleukin-1 and inflammasomes in alcoholic liver disease/acute alcoholic hepatitis and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

(2016) Herbert Tilg et al.   HEPATOLOGY

Transendothelial migration: unifying principles from the endothelial perspective

(2016) William A. Muller   IMMUNOLOGICAL REVIEWS

Characterization of the Inflammasome in Human Kupffer Cells in Response to Synthetic Agonists and Pathogens

(2016) Claudia Zannetti et al.   JOURNAL OF IMMUNOLOGY

Deconvoluting hepatic processing of carbon nanotubes

(2016) Simone Alidori et al.   Nature Communications

Designing a fibrotic microenvironment to investigate changes in human liver sinusoidal endothelial cell function

(2015) Andrew J. Ford et al.   Acta Biomaterialia

Higher proliferation of peritumoral endothelial cells to IL-6/sIL-6R than tumoral endothelial cells in hepatocellular carcinoma

(2015) Peng-Yuan Zhuang et al.   BMC CANCER

Selectins: initiators of leucocyte adhesion and signalling at the vascular wall

(2015) Rodger P. McEver   CARDIOVASCULAR RESEARCH

Immunosurveillance of the Liver by Intravascular Effector CD8 + T Cells

(2015) Luca G. Guidotti et al.   CELL

Hepatitis C Virus Infection Induces Autocrine Interferon Signaling by Human Liver Endothelial Cells and Release of Exosomes, Which Inhibits Viral Replication

(2015) Silvia Giugliano et al.   GASTROENTEROLOGY

Bidirectional transendothelial migration of monocytes across hepatic sinusoidal endothelium shapes monocyte differentiation and regulates the balance between immunity and tolerance in liver

(2015) Henning W. Zimmermann et al.   HEPATOLOGY

Liver sinusoidal endothelial cells in hepatic fibrosis

(2015) Laurie D. DeLeve   HEPATOLOGY

Human spleen microanatomy: why mice do not suffice

(2015) Birte S. Steiniger   IMMUNOLOGY

A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+monocytes at a site of sterile injury

(2015) Daniela Dal-Secco et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice

(2015) Antonella Carambia et al.   JOURNAL OF HEPATOLOGY

CMV infection of human sinusoidal endothelium regulates hepatic T cell recruitment and activation

(2015) Tony Bruns et al.   JOURNAL OF HEPATOLOGY

The yin and yang of evasion and immune activation in HCC

(2015) Oxana V. Makarova-Rusher et al.   JOURNAL OF HEPATOLOGY

Pivotal role of liver sinusoidal endothelial cells in NAFLD/NASH progression

(2015) Masashi Miyao et al.   LABORATORY INVESTIGATION

Multimodal super-resolution optical microscopy visualizes the close connection between membrane and the cytoskeleton in liver sinusoidal endothelial cell fenestrations

(2015) Viola Mönkemöller et al.   Scientific Reports

Liver Sinusoidal Endothelial Cells Escape Senescence by Loss of p19ARF

(2015) Petra Koudelkova et al.   PLoS One

Hepatic Immune Regulation and Its Involvement in Viral Hepatitis Infection

(2014) Percy A. Knolle et al.   GASTROENTEROLOGY

Leukocyte Migration into Inflamed Tissues

(2014) Sussan Nourshargh et al.   IMMUNITY

Vascular adhesion protein-1 promotes liver inflammation and drives hepatic fibrosis

(2014) Chris J. Weston et al.   JOURNAL OF CLINICAL INVESTIGATION

TGF-β-dependent induction of CD4+CD25+Foxp3+ Tregs by liver sinusoidal endothelial cells

(2014) Antonella Carambia et al.   JOURNAL OF HEPATOLOGY

Macrophage heterogeneity in liver injury and fibrosis

(2014) Frank Tacke et al.   JOURNAL OF HEPATOLOGY

IL-6 trans-Signaling-Dependent Rapid Development of Cytotoxic CD8+ T Cell Function

(2014) Jan P. Böttcher et al.   Cell Reports

Paracrine signals from liver sinusoidal endothelium regulate hepatitis C virus replication

(2013) Ian A. Rowe et al.   HEPATOLOGY

Hepatic ischemia and reperfusion injury: Effects on the liver sinusoidal milieu

(2013) Carmen Peralta et al.   JOURNAL OF HEPATOLOGY

A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse

(2013) Anna Moles et al.   JOURNAL OF HEPATOLOGY

Primary sclerosing cholangitis

(2013) Gideon M Hirschfield et al.   LANCET

Endothelial transdifferentiation in hepatocellular carcinoma: loss of Stabilin-2 expression in peri-tumourous liver correlates with increased survival

(2013) Cyrill Géraud et al.   LIVER INTERNATIONAL

Characterization of Cells Expressing Lymphatic Marker LYVE-1 in Macaque Large Intestine during Simian Immunodeficiency Virus Infection Identifies A Large Population of Nonvascular LYVE-1+/DC-SIGN+ Cells

(2013) Yang-Kyu Choi et al.   Lymphatic Research and Biology

Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis

(2013) Bi-Sen Ding et al.   NATURE

Abnormal Plasma Microparticles Impair Vasoconstrictor Responses in Patients With Cirrhosis

(2012) Pierre–Emmanuel Rautou et al.   GASTROENTEROLOGY

Novel roles of liver sinusoidal endothelial cell lectin in colon carcinoma cell adhesion, migration and in-vivo metastasis to the liver

(2012) Yunfei Zuo et al.   GUT

Hedgehog signalling regulates liver sinusoidal endothelial cell capillarisation

(2012) Guanhua Xie et al.   GUT

Liver sinusoidal endothelial cells contribute to CD8 T cell tolerance toward circulating carcinoembryonic antigen in mice

(2012) Bastian Höchst et al.   HEPATOLOGY

Recruitment mechanisms of primary and malignant B cells to the human liver

(2012) Shishir Shetty et al.   HEPATOLOGY

Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics

(2012) Evaggelia Liaskou et al.   HEPATOLOGY

CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver

(2012) Ye Htun Oo et al.   JOURNAL OF HEPATOLOGY

Inhibition of inflammatory CD4 T cell activity by murine liver sinusoidal endothelial cells

(2012) Antonella Carambia et al.   JOURNAL OF HEPATOLOGY

Unique Cell Type-Specific Junctional Complexes in Vascular Endothelium of Human and Rat Liver Sinusoids

(2012) Cyrill Géraud et al.   PLoS One

The Relationship between Fenestrations, Sieve Plates and Rafts in Liver Sinusoidal Endothelial Cells

(2012) Dmitri Svistounov et al.   PLoS One

TNF-Induced Target Cell Killing by CTL Activated through Cross-Presentation

(2012) Dirk Wohlleber et al.   Cell Reports

Role of Differentiation of Liver Sinusoidal Endothelial Cells in Progression and Regression of Hepatic Fibrosis in Rats

(2011) Guanhua Xie et al.   GASTROENTEROLOGY

Common Lymphatic Endothelial and Vascular Endothelial Receptor-1 Mediates the Transmigration of Regulatory T Cells across Human Hepatic Sinusoidal Endothelium

(2011) Shishir Shetty et al.   JOURNAL OF IMMUNOLOGY

Rapid and Efficient Clearance of Blood-borne Virus by Liver Sinusoidal Endothelium

(2011) Latha P. Ganesan et al.   PLoS Pathogens

Role of liver sinusoidal endothelial cells and stabilins in elimination of oxidized low-density lipoproteins

(2010) Ruomei Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Lymphatic marker podoplanin/D2-40 in human advanced cirrhotic liver- Re-evaluations of microlymphatic abnormalities

(2010) Hiroaki Yokomori et al.   BMC GASTROENTEROLOGY

CX3CR1 and vascular adhesion protein-1-dependent recruitment of CD16+ monocytes across human liver sinusoidal endothelium

(2010) Alexander I. Aspinall et al.   HEPATOLOGY

Regulation of mucosal addressin cell adhesion molecule 1 expression in human and mice by vascular adhesion protein 1 amine oxidase activity

(2010) Evaggelia Liaskou et al.   HEPATOLOGY

Distinct Roles for CCR4 and CXCR3 in the Recruitment and Positioning of Regulatory T Cells in the Inflamed Human Liver

(2010) Y. H. Oo et al.   JOURNAL OF IMMUNOLOGY

In Hepatic Fibrosis, Liver Sinusoidal Endothelial Cells Acquire Enhanced Immunogenicity

(2010) M. K. Connolly et al.   JOURNAL OF IMMUNOLOGY

Dynamic Regulation of CD8 T Cell Tolerance Induction by Liver Sinusoidal Endothelial Cells

(2010) A. Schurich et al.   JOURNAL OF IMMUNOLOGY

The effect of feeding and fasting on fenestrations in the liver sinusoidal endothelial cell

(2010) Jennifer N. O’Reilly et al.   PATHOLOGY

Chemokine patterning by glycosaminoglycans and interceptors

(2009) Antal Rot   Frontiers in Bioscience-Landmark

Liver Sinusoidal Endothelial Cell Lectin, LSECtin, Negatively Regulates Hepatic T-Cell Immune Response

(2009) Li Tang et al.   GASTROENTEROLOGY

Distinct kinetics and dynamics of cross-presentation in liver sinusoidal endothelial cells compared to dendritic cells

(2009) Anna Schurich et al.   HEPATOLOGY

Toll-like receptor-induced innate immune responses in non-parenchymal liver cells are cell type-specific

(2009) Jun Wu et al.   IMMUNOLOGY

Angiogenesis in liver disease

(2009) Mercedes Fernández et al.   JOURNAL OF HEPATOLOGY

Three-dimensional organization of fenestrae labyrinths in liver sinusoidal endothelial cells

(2009) Filip Braet et al.   LIVER INTERNATIONAL

C-type lectin LSECtin interacts with DC-SIGNR and is involved in hepatitis C virus binding

(2009) Yi Li et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

CCL25 and CCL28 promote α4β7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow

(2008) Alice Miles et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Liver Myofibroblasts Regulate Infiltration and Positioning of Lymphocytes in Human Liver

(2008) Andrew P. Holt et al.   GASTROENTEROLOGY

Liver sinusoidal endothelial cells depend on mannose receptor-mediated recruitment of lysosomal enzymes for normal degradation capacity

(2008) Kjetil Elvevold et al.   HEPATOLOGY

Enhanced T cell transmigration across the murine liver sinusoidal endothelium is mediated by transcytosis and surface presentation of chemokines

(2008) Arnhild Schrage et al.   HEPATOLOGY

Chemokines in the immunopathogenesis of hepatitis C infection

(2008) Mathis Heydtmann et al.   HEPATOLOGY

Endothelial adhesion receptors are recruited to adherent leukocytes by inclusion in preformed tetraspanin nanoplatforms

(2008) Olga Barreiro et al.   JOURNAL OF CELL BIOLOGY

Interaction of CD44 and hyaluronan is the dominant mechanism for neutrophil sequestration in inflamed liver sinusoids

(2008) Braedon McDonald et al.   JOURNAL OF EXPERIMENTAL MEDICINE