- Home
- Publications
- Publication Search
- Publication Details
Title
From NASH to HCC: current concepts and future challenges
Authors
Keywords
-
Journal
Nature Reviews Gastroenterology & Hepatology
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2019-04-26
DOI
10.1038/s41575-019-0145-7
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Genetic variants in PNPLA3 and TM6SF2 predispose to the development of hepatocellular carcinoma in individuals with alcohol-related cirrhosis
- (2018) Felix Stickel et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Farnesoid X receptor: A “homeostat” for hepatic nutrient metabolism
- (2018) Vittoria Massafra et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Systemic therapy for intermediate and advanced hepatocellular carcinoma: Sorafenib and beyond
- (2018) Jean-Luc Raoul et al. CANCER TREATMENT REVIEWS
- Fibrosis Severity as a Determinant of Cause-Specific Mortality in Patients With Advanced Nonalcoholic Fatty Liver Disease
- (2018) Eduardo Vilar-Gomez et al. GASTROENTEROLOGY
- Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis
- (2018) Oliver Krenkel et al. HEPATOLOGY
- The bidirectional impacts of alcohol consumption and the metabolic syndrome: Cofactors for progressive fatty liver disease
- (2018) Marie Boyle et al. JOURNAL OF HEPATOLOGY
- Association between non-alcoholic fatty liver disease and cancer incidence rate
- (2018) Gi-Ae Kim et al. JOURNAL OF HEPATOLOGY
- Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016–2030
- (2018) Chris Estes et al. JOURNAL OF HEPATOLOGY
- Fructose and sugar: A major mediator of non-alcoholic fatty liver disease
- (2018) Thomas Jensen et al. JOURNAL OF HEPATOLOGY
- A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer
- (2018) Takuma Tsuchida et al. JOURNAL OF HEPATOLOGY
- The immunology of hepatocellular carcinoma
- (2018) Marc Ringelhan et al. NATURE IMMUNOLOGY
- Cabozantinib in Patients with Advanced and Progressing Hepatocellular Carcinoma
- (2018) Ghassan K. Abou-Alfa et al. NEW ENGLAND JOURNAL OF MEDICINE
- Role of Oxidative Stress in Pathophysiology of Nonalcoholic Fatty Liver Disease
- (2018) Mario Masarone et al. Oxidative Medicine and Cellular Longevity
- Supervised learning reveals circulating biomarker levels diagnostic of hepatocellular carcinoma in a clinically relevant model of non-alcoholic steatohepatitis; An OAD to NASH
- (2018) Anne Hwang et al. PLoS One
- High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism
- (2018) Miguel A. Lanaspa et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Single cell polarity in liquid phase facilitates tumour metastasis
- (2018) Anna Lorentzen et al. Nature Communications
- mTOR at the Transmitting and Receiving Ends in Tumor Immunity
- (2018) Yakir Guri et al. Frontiers in Immunology
- The role of the microbiome in NAFLD and NASH
- (2018) Aleksandra A Kolodziejczyk et al. EMBO Molecular Medicine
- Risk of Hepatocellular Cancer in Patients With Non-Alcoholic Fatty Liver Disease
- (2018) Fasiha Kanwal et al. GASTROENTEROLOGY
- Lipid Metabolic Reprogramming in Hepatocellular Carcinoma
- (2018) Hayato Nakagawa et al. Cancers
- Associations between dietary factors and markers of NAFLD in a general Dutch adult population
- (2017) A Rietman et al. EUROPEAN JOURNAL OF CLINICAL NUTRITION
- Bile Acid Control of Metabolism and Inflammation in Obesity, Type 2 Diabetes, Dyslipidemia, and Nonalcoholic Fatty Liver Disease
- (2017) Oscar Chávez-Talavera et al. GASTROENTEROLOGY
- Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases
- (2017) Leon A Adams et al. GUT
- Modeling the benefits and harms of surveillance for hepatocellular carcinoma: Information to support informed choices
- (2017) Eleanor J. Taylor et al. HEPATOLOGY
- The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation
- (2017) Soumik BasuRay et al. HEPATOLOGY
- Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease
- (2017) Chris Estes et al. HEPATOLOGY
- Serum extracellular vesicles contain protein biomarkers for primary sclerosing cholangitis and cholangiocarcinoma
- (2017) Ander Arbelaiz et al. HEPATOLOGY
- Increased risk of mortality by fibrosis stage in nonalcoholic fatty liver disease: Systematic review and meta-analysis
- (2017) Parambir S. Dulai et al. HEPATOLOGY
- AASLD guidelines for the treatment of hepatocellular carcinoma
- (2017) Julie K. Heimbach et al. HEPATOLOGY
- Hepatic Tm6sf2 overexpression affects cellular ApoB-trafficking, plasma lipid levels, hepatic steatosis and atherosclerosis
- (2017) Nicole Ehrhardt et al. HUMAN MOLECULAR GENETICS
- Hepatocellular carcinoma in a mouse model fed a choline-deficient, L-amino acid-defined, high-fat diet
- (2017) Ayae Ikawa-Yoshida et al. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
- Patterns and challenges of treatment sequencing in patients with hepatocellular carcinoma: Experience from a German referral center
- (2017) Martha M Kirstein et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Prognostic factors and predictors of sorafenib benefit in patients with hepatocellular carcinoma: Analysis of two phase III studies
- (2017) Jordi Bruix et al. JOURNAL OF HEPATOLOGY
- Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trial
- (2017) Jordi Bruix et al. LANCET
- Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial
- (2017) Anthony B El-Khoueiry et al. LANCET
- Efficacy and safety of selective internal radiotherapy with yttrium-90 resin microspheres compared with sorafenib in locally advanced and inoperable hepatocellular carcinoma (SARAH): an open-label randomised controlled phase 3 trial
- (2017) Valérie Vilgrain et al. LANCET ONCOLOGY
- Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity
- (2017) Shabnam Shalapour et al. NATURE
- Circulating tumour DNA methylation markers for diagnosis and prognosis of hepatocellular carcinoma
- (2017) Rui-hua Xu et al. NATURE MATERIALS
- Circulating tumour cells and cell-free DNA in gastrointestinal cancer
- (2017) Klaus Pantel et al. Nature Reviews Gastroenterology & Hepatology
- Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention
- (2017) Zobair Younossi et al. Nature Reviews Gastroenterology & Hepatology
- An RNA-based signature enables high specificity detection of circulating tumor cells in hepatocellular carcinoma
- (2017) Mark Kalinich et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mitochondrial Adaptation in Nonalcoholic Fatty Liver Disease: Novel Mechanisms and Treatment Strategies
- (2017) Nishanth E. Sunny et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Lenvatinib in Advanced Hepatocellular Carcinoma
- (2017) Masatoshi Kudo Liver Cancer
- A systems biology approach to investigating the influence of exercise and fitness on the composition of leukocytes in peripheral blood
- (2017) Michael P. Gustafson et al. Journal for ImmunoTherapy of Cancer
- Obesity is Independently Associated With Increased Risk of Hepatocellular Cancer–related Mortality
- (2017) Arjun Gupta et al. AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
- MBOAT7 rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals
- (2017) Benedetta Donati et al. Scientific Reports
- Nonalcoholic Fatty Liver Disease: Pathogenesis and Disease Spectrum
- (2016) Timothy Hardy et al. Annual Review of Pathology-Mechanisms of Disease
- p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells
- (2016) Atsushi Umemura et al. CANCER CELL
- Metabolic Inflammation-Associated IL-17A Causes Non-alcoholic Steatohepatitis and Hepatocellular Carcinoma
- (2016) Ana L. Gomes et al. CANCER CELL
- Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies
- (2016) Cynthia Ju et al. Cellular & Molecular Immunology
- Role of the GALAD and BALAD-2 Serologic Models in Diagnosis of Hepatocellular Carcinoma and Prediction of Survival in Patients
- (2016) Sarah Berhane et al. Clinical Gastroenterology and Hepatology
- EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease
- (2016) et al. DIABETOLOGIA
- Hepatocellular Carcinoma in Obesity, Type 2 Diabetes, and NAFLD
- (2016) Helen L. Reeves et al. DIGESTIVE DISEASES AND SCIENCES
- Innate Immunity and Inflammation in NAFLD/NASH
- (2016) Marco Arrese et al. DIGESTIVE DISEASES AND SCIENCES
- DNA-PKcs: A promising therapeutic target in human hepatocellular carcinoma?
- (2016) Rosa M. Pascale et al. DNA REPAIR
- p62/SQSTM1-Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer
- (2016) Koji Taniguchi et al. FEBS LETTERS
- Genetic Factors That Affect Risk of Alcoholic and Nonalcoholic Fatty Liver Disease
- (2016) Quentin M. Anstee et al. GASTROENTEROLOGY
- Comparison of Gene Expression Patterns Between Mouse Models of Nonalcoholic Fatty Liver Disease and Liver Tissues From Patients
- (2016) Andreas Teufel et al. GASTROENTEROLOGY
- Microbiota-induced obesity requires farnesoid X receptor
- (2016) Ava Parséus et al. GUT
- Extracellular vesicles in liver pathobiology: Small particles with big impact
- (2016) Petra Hirsova et al. HEPATOLOGY
- Rubicon inhibits autophagy and accelerates hepatocyte apoptosis and lipid accumulation in nonalcoholic fatty liver disease in mice
- (2016) Satoshi Tanaka et al. HEPATOLOGY
- Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes
- (2016) Zobair M. Younossi et al. HEPATOLOGY
- Clinical patterns of hepatocellular carcinoma in nonalcoholic fatty liver disease: A multicenter prospective study
- (2016) Fabio Piscaglia et al. HEPATOLOGY
- Development of hepatocellular carcinoma in Japanese patients with biopsy-proven non-alcoholic fatty liver disease: Association between PNPLA3 genotype and hepatocarcinogenesis/fibrosis progression
- (2016) Yuya Seko et al. HEPATOLOGY RESEARCH
- International trends in liver cancer incidence, overall and by histologic subtype, 1978-2007
- (2016) Jessica L. Petrick et al. INTERNATIONAL JOURNAL OF CANCER
- Unique features associated with hepatic oxidative DNA damage and DNA methylation in non-alcoholic fatty liver disease
- (2016) Naoshi Nishida et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Laminin-332 sustains chemoresistance and quiescence as part of the human hepatic cancer stem cell niche
- (2016) Olivier Govaere et al. JOURNAL OF HEPATOLOGY
- Imagestream detection and characterisation of circulating tumour cells – A liquid biopsy for hepatocellular carcinoma?
- (2016) Laura F. Ogle et al. JOURNAL OF HEPATOLOGY
- A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer
- (2016) Amon Asgharpour et al. JOURNAL OF HEPATOLOGY
- Induction of farnesoid X receptor signaling in germ-free mice colonized with a human microbiota
- (2016) Annika Wahlström et al. JOURNAL OF LIPID RESEARCH
- Assessment of the Hong Kong Liver Cancer Staging System in Europe
- (2016) Philippe Kolly et al. LIVER INTERNATIONAL
- The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)
- (2016) Elena Buzzetti et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis
- (2016) Chi Ma et al. NATURE
- p62/SQSTM1 enhances breast cancer stem-like properties by stabilizing MYC mRNA
- (2016) L-Z Xu et al. ONCOGENE
- Ubiquitin-Dependent And Independent Signals In Selective Autophagy
- (2016) Aliaksandr Khaminets et al. TRENDS IN CELL BIOLOGY
- Prognostic value of DNA repair based stratification of hepatocellular carcinoma
- (2016) Zhuo Lin et al. Scientific Reports
- Fatty liver diseases, bile acids, and FXR
- (2016) Yan Zhu et al. Acta Pharmaceutica Sinica B
- Bile Acids and Dysbiosis in Non-Alcoholic Fatty Liver Disease
- (2016) Marialena Mouzaki et al. PLoS One
- Kupffer Cells Undergo Fundamental Changes during the Development of Experimental NASH and Are Critical in Initiating Liver Damage and Inflammation
- (2016) D. T. Reid et al. PLoS One
- Selective internal radiation therapy for liver malignancies
- (2015) J. A. G. Moir et al. BRITISH JOURNAL OF SURGERY
- Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation
- (2015) Valentina Tremaroli et al. Cell Metabolism
- Temporal Trends of Nonalcoholic Fatty Liver Disease–Related Hepatocellular Carcinoma in the Veteran Affairs Population
- (2015) Sahil Mittal et al. Clinical Gastroenterology and Hepatology
- Fibrosis Progression in Nonalcoholic Fatty Liver vs Nonalcoholic Steatohepatitis: A Systematic Review and Meta-analysis of Paired-Biopsy Studies
- (2015) Siddharth Singh et al. Clinical Gastroenterology and Hepatology
- The Ras/MAPK pathway and hepatocarcinoma: pathogenesis and therapeutic implications
- (2015) Bénédicte Delire et al. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
- Weight Loss Through Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis
- (2015) Eduardo Vilar-Gomez et al. GASTROENTEROLOGY
- Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease
- (2015) Paul Angulo et al. GASTROENTEROLOGY
- Genetic Landscape and Biomarkers of Hepatocellular Carcinoma
- (2015) Jessica Zucman-Rossi et al. GASTROENTEROLOGY
- Intestinal microbiota contributes to individual susceptibility to alcoholic liver disease
- (2015) M Llopis et al. GUT
- Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease
- (2015) Paola Dongiovanni et al. HEPATOLOGY
- Nrf2, but not β-catenin, mutation represents an early event in rat hepatocarcinogenesis
- (2015) Patrizia Zavattari et al. HEPATOLOGY
- Biopsy for liver cancer: How to balance research needs with evidence-based clinical practice
- (2015) Morris Sherman et al. HEPATOLOGY
- Liver cancer biopsy - back to the future?!
- (2015) Michael Torbenson et al. HEPATOLOGY
- Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up
- (2015) Mattias Ekstedt et al. HEPATOLOGY
- Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: Implications for prognosis and clinical management
- (2015) Stuart McPherson et al. JOURNAL OF HEPATOLOGY
- The story of HCC in NAFLD: from epidemiology, across pathogenesis, to prevention and treatment
- (2015) Cristina Margini et al. LIVER INTERNATIONAL
- Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets
- (2015) Kornelius Schulze et al. NATURE GENETICS
- Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance
- (2015) Sungsoon Fang et al. NATURE MEDICINE
- Clinically significant chronic liver disease in people with Type 2 diabetes: the Edinburgh Type 2 Diabetes Study
- (2015) J.R. Morling et al. QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
- Diagnosis and Assessment of NAFLD: Definitions and Histopathological Classification
- (2015) Carolin Lackner et al. SEMINARS IN LIVER DISEASE
- The Genetics of Nonalcoholic Fatty Liver Disease: Spotlight on PNPLA3 and TM6SF2
- (2015) Christopher Day et al. SEMINARS IN LIVER DISEASE
- NFκB1 is a suppressor of neutrophil-driven hepatocellular carcinoma
- (2015) C. L. Wilson et al. Nature Communications
- Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction
- (2015) Changtao Jiang et al. Nature Communications
- Implication of Gut Microbiota in Nonalcoholic Fatty Liver Disease
- (2015) Jerome Boursier et al. PLoS Pathogens
- Surveillance, Diagnosis, Treatment, and Outcome of Liver Cancer in Japan
- (2015) Masatoshi Kudo Liver Cancer
- Farnesoid X receptor, the bile acid sensing nuclear receptor, in liver regeneration
- (2015) Guodong Li et al. Acta Pharmaceutica Sinica B
- EASL–EORTC Clinical Practice Guidelines: Management of hepatocellular carcinoma
- (2015) et al. JOURNAL OF HEPATOLOGY
- The Effect of PNPLA3 on Fibrosis Progression and Development of Hepatocellular Carcinoma: A Meta-analysis
- (2014) Amit G Singal et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development
- (2014) Hayato Nakagawa et al. CANCER CELL
- Metabolic Activation of Intrahepatic CD8+ T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes
- (2014) Monika Julia Wolf et al. CANCER CELL
- Inhibition of De Novo NAD + Synthesis by Oncogenic URI Causes Liver Tumorigenesis through DNA Damage
- (2014) Krishna S. Tummala et al. CANCER CELL
- Circulating biomarkers in hepatocellular carcinoma
- (2014) Karen L. Morris et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- DNA-PK--A Candidate Driver of Hepatocarcinogenesis and Tissue Biomarker That Predicts Response to Treatment and Survival
- (2014) L. Cornell et al. CLINICAL CANCER RESEARCH
- Intratumor Heterogeneity in Hepatocellular Carcinoma
- (2014) J. Friemel et al. CLINICAL CANCER RESEARCH
- Prevention of spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice by intestinal-specific farnesoid X receptor reactivation
- (2014) Chiara Degirolamo et al. HEPATOLOGY
- Evolving Concepts in the Pathogenesis of NASH: Beyond Steatosis and Inflammation
- (2014) William Peverill et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease
- (2014) Changtao Jiang et al. JOURNAL OF CLINICAL INVESTIGATION
- Serum immunoglobulin levels predict fibrosis in patients with non-alcoholic fatty liver disease
- (2014) Stuart McPherson et al. JOURNAL OF HEPATOLOGY
- Carriage of the PNPLA3 rs738409 C >G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma
- (2014) Y.-L. Liu et al. JOURNAL OF HEPATOLOGY
- Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5·24 million UK adults
- (2014) Krishnan Bhaskaran et al. LANCET
- FXR is a molecular target for the effects of vertical sleeve gastrectomy
- (2014) Karen K. Ryan et al. NATURE
- Trans-ancestry mutational landscape of hepatocellular carcinoma genomes
- (2014) Yasushi Totoki et al. NATURE GENETICS
- Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease
- (2014) Julia Kozlitina et al. NATURE GENETICS
- Obesity and cancer—mechanisms underlying tumour progression and recurrence
- (2014) Jiyoung Park et al. Nature Reviews Endocrinology
- Detection of Circulating Tumor Cells in Hepatocellular Carcinoma Using Antibodies against Asialoglycoprotein Receptor, Carbamoyl Phosphate Synthetase 1 and Pan-Cytokeratin
- (2014) Jun Li et al. PLoS One
- TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease
- (2014) Yang-Lin Liu et al. Nature Communications
- A simple prognostic scoring system for patients receiving transarterial embolisation for hepatocellular cancer
- (2013) L. Kadalayil et al. ANNALS OF ONCOLOGY
- Deregulation of DNA-dependent protein kinase catalytic subunit contributes to human hepatocarcinogenesis development and has a putative prognostic value
- (2013) M Evert et al. BRITISH JOURNAL OF CANCER
- Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist
- (2013) Sama I. Sayin et al. Cell Metabolism
- Efficacy and Safety of the Farnesoid X Receptor Agonist Obeticholic Acid in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease
- (2013) Sunder Mudaliar et al. GASTROENTEROLOGY
- Keratin 19: a key role player in the invasion of human hepatocellular carcinomas
- (2013) Olivier Govaere et al. GUT
- Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease
- (2013) Cynthia A. Moylan et al. HEPATOLOGY
- MicroRNA/gene profiling unveils early molecular changes and nuclear factor erythroid related factor 2 (NRF2) activation in a rat model recapitulating human hepatocellular carcinoma (HCC)
- (2013) Annalisa Petrelli et al. HEPATOLOGY
- Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease
- (2013) Karima Begriche et al. HEPATOLOGY
- The ART of decision making: Retreatment with transarterial chemoembolization in patients with hepatocellular carcinoma
- (2013) Wolfgang Sieghart et al. HEPATOLOGY
- The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease
- (2013) Victoria L. Gadd et al. HEPATOLOGY
- Nonalcoholic steatohepatitis is the most rapidly growing indication for liver transplantation in patients with hepatocellular carcinoma in the U.S.
- (2013) Robert J. Wong et al. HEPATOLOGY
- An improved mouse model that rapidly develops fibrosis in non-alcoholic steatohepatitis
- (2013) Masahiko Matsumoto et al. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
- Hepatic glucose sensing is required to preserve β cell glucose competence
- (2013) Pascal Seyer et al. JOURNAL OF CLINICAL INVESTIGATION
- Increased hepatic oxidative DNA damage in patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma
- (2013) Shingo Tanaka et al. JOURNAL OF GASTROENTEROLOGY
- A systematic review of follow-up biopsies reveals disease progression in patients with non-alcoholic fatty liver
- (2013) Raluca Pais et al. JOURNAL OF HEPATOLOGY
- Targeting the mTOR pathway in hepatocellular carcinoma: Current state and future trends
- (2013) Matthias S. Matter et al. JOURNAL OF HEPATOLOGY
- Hepatocellular cancer: The impact of obesity, type 2 diabetes and a multidisciplinary team
- (2013) Jessica Dyson et al. JOURNAL OF HEPATOLOGY
- Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy
- (2013) Yoshinobu Ichimura et al. MOLECULAR CELL
- Richness of human gut microbiome correlates with metabolic markers
- (2013) Emmanuelle Le Chatelier et al. NATURE
- Gut metagenome in European women with normal, impaired and diabetic glucose control
- (2013) Fredrik H. Karlsson et al. NATURE
- Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis
- (2013) Quentin M. Anstee et al. Nature Reviews Gastroenterology & Hepatology
- DNA Damage in Inflammation-Related Carcinogenesis and Cancer Stem Cells
- (2013) Shiho Ohnishi et al. Oxidative Medicine and Cellular Longevity
- B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile
- (2013) J. DeFuria et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The innate immune response during liver inflammation and metabolic disease
- (2013) Veerle Bieghs et al. TRENDS IN IMMUNOLOGY
- Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity
- (2013) Fei Li et al. Nature Communications
- Non-alcoholic fatty liver disease (NAFLD) is associated with low level of physical activity: a population-based study
- (2012) L. Gerber et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Role of Class II Nuclear Receptors in Liver Carcinogenesis
- (2012) Guodong Li et al. Anti-Cancer Agents in Medicinal Chemistry
- Failure Rates in the Hepatocellular Carcinoma Surveillance Process
- (2012) A. G. Singal et al. Cancer Prevention Research
- The Proinflammatory Myeloid Cell Receptor TREM-1 Controls Kupffer Cell Activation and Development of Hepatocellular Carcinoma
- (2012) Juan Wu et al. CANCER RESEARCH
- The DNA damage checkpoint protein ATM promotes hepatocellular apoptosis and fibrosis in a mouse model of non-alcoholic fatty liver disease
- (2012) Erin K. Daugherity et al. CELL CYCLE
- Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c
- (2012) Asami Hagiwara et al. Cell Metabolism
- Association Between Nonalcoholic Fatty Liver Disease and Risk for Hepatocellular Cancer, Based on Systematic Review
- (2012) Donna L. White et al. Clinical Gastroenterology and Hepatology
- Development of FXR, PXR and CAR Agonists and Antagonists for Treatment of Liver Disorders
- (2012) Stefano Fiorucci et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Nutrition, Intestinal Permeability, and Blood Ethanol Levels Are Altered in Patients with Nonalcoholic Fatty Liver Disease (NAFLD)
- (2012) Valentina Volynets et al. DIGESTIVE DISEASES AND SCIENCES
- Sterile Inflammation in the Liver
- (2012) Paul Kubes et al. GASTROENTEROLOGY
- Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome
- (2012) Anne Vrieze et al. GASTROENTEROLOGY
- Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice
- (2012) Tiphaine Le Roy et al. GUT
- Divergent metabolic outcomes arising from targeted manipulation of the gut microbiota in diet-induced obesity
- (2012) Eileen F Murphy et al. GUT
- The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association
- (2012) Naga Chalasani et al. HEPATOLOGY
- Circulating stem cell-like epithelial cell adhesion molecule-positive tumor cells indicate poor prognosis of hepatocellular carcinoma after curative resection
- (2012) Yun-Fan Sun et al. HEPATOLOGY
- Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH
- (2012) Lixin Zhu et al. HEPATOLOGY
- Hepatocellular carcinoma in non-alcoholic fatty liver disease: An emerging menace
- (2012) György Baffy et al. JOURNAL OF HEPATOLOGY
- Hepatocellular Carcinoma Risk Prediction Model for the General Population: The Predictive Power of Transaminases
- (2012) Chi-Pang Wen et al. JNCI-Journal of the National Cancer Institute
- FXR signaling in the enterohepatic system
- (2012) Tsutomu Matsubara et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- A metagenome-wide association study of gut microbiota in type 2 diabetes
- (2012) Junjie Qin et al. NATURE
- Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma
- (2012) Cécile Guichard et al. NATURE GENETICS
- Surveillance for Hepatocellular Carcinoma
- (2012) Cristina Della Corte et al. SEMINARS IN ONCOLOGY
- The Role of Diet and Nutrient Composition in Nonalcoholic Fatty Liver Disease
- (2012) Erin Marie McCarthy et al. Journal of the Academy of Nutrition and Dietetics
- Large-Scale Long-Term Follow-Up Study of Japanese Patients With Non-Alcoholic Fatty Liver Disease for the Onset of Hepatocellular Carcinoma
- (2011) Yusuke Kawamura et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Fast food diet mouse: novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition
- (2011) Michael Charlton et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases
- (2011) Beckley K. Davis et al. Annual Review of Immunology
- ATM and the Molecular Pathogenesis of Ataxia Telangiectasia
- (2011) Peter J. McKinnon Annual Review of Pathology-Mechanisms of Disease
- Global cancer statistics
- (2011) Ahmedin Jemal et al. CA-A CANCER JOURNAL FOR CLINICIANS
- URI Is an Oncogene Amplified in Ovarian Cancer Cells and Is Required for Their Survival
- (2011) Jean-Philippe Theurillat et al. CANCER CELL
- Characteristics of Patients With Nonalcoholic Steatohepatitis Who Develop Hepatocellular Carcinoma
- (2011) Kohichiroh Yasui et al. Clinical Gastroenterology and Hepatology
- Farnesoid X Receptor Deficiency Improves Glucose Homeostasis in Mouse Models of Obesity
- (2011) J. Prawitt et al. DIABETES
- Autophagy-deficient mice develop multiple liver tumors
- (2011) A. Takamura et al. GENES & DEVELOPMENT
- Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution
- (2011) Keiko Taguchi et al. GENES TO CELLS
- Human hepatocellular carcinomas with “Stemness”-related marker expression: keratin 19 expression and a poor prognosis
- (2011) Haeryoung Kim et al. HEPATOLOGY
- Nuclear receptors in liver disease
- (2011) Martin Wagner et al. HEPATOLOGY
- Pathologic criteria for nonalcoholic steatohepatitis: Interprotocol agreement and ability to predict liver-related mortality
- (2011) Zobair M. Younossi et al. HEPATOLOGY
- Lowering Bile Acid Pool Size with a Synthetic Farnesoid X Receptor (FXR) Agonist Induces Obesity and Diabetes through Reduced Energy Expenditure
- (2011) Mitsuhiro Watanabe et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- DSS induced colitis increases portal LPS levels and enhances hepatic inflammation and fibrogenesis in experimental NASH
- (2011) Erwin Gäbele et al. JOURNAL OF HEPATOLOGY
- Obesity, inflammation, and liver cancer
- (2011) Beicheng Sun et al. JOURNAL OF HEPATOLOGY
- The global obesity pandemic: shaped by global drivers and local environments
- (2011) Boyd A Swinburn et al. LANCET
- Submaximal cardiopulmonary exercise testing predicts 90-day survival after liver transplantation
- (2011) James M. Prentis et al. LIVER TRANSPLANTATION
- Serum and Urine Metabolite Profiling Reveals Potential Biomarkers of Human Hepatocellular Carcinoma
- (2011) Tianlu Chen et al. MOLECULAR & CELLULAR PROTEOMICS
- Decreased nucleotide excision repair in steatotic livers associates with myeloperoxidase-immunoreactivity
- (2011) Marten A. Schults et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
- (2011) Tae-Won Kang et al. NATURE
- AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
- (2011) Joungmok Kim et al. NATURE CELL BIOLOGY
- The ATM protein kinase and cellular redox signaling: beyond the DNA damage response
- (2011) Scott Ditch et al. TRENDS IN BIOCHEMICAL SCIENCES
- CD4+ T Cells Contribute to the Remodeling of the Microenvironment Required for Sustained Tumor Regression upon Oncogene Inactivation
- (2010) Kavya Rakhra et al. CANCER CELL
- Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression
- (2010) Eek Joong Park et al. CELL
- Population-based risk factors and resource utilization for HCC: US perspective
- (2010) A. Sanyal et al. CURRENT MEDICAL RESEARCH AND OPINION
- Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice
- (2010) Kouichi Miura et al. GASTROENTEROLOGY
- Non-alcoholic fatty liver disease as a risk factor for hepatocellular carcinoma: mechanisms and implications
- (2010) F. Stickel et al. GUT
- Disease progression of non-alcoholic fatty liver disease: a prospective study with paired liver biopsies at 3 years
- (2010) V. W.-S. Wong et al. GUT
- The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis
- (2010) Mustafa S. Ascha et al. HEPATOLOGY
- Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease
- (2010) Luca Valenti et al. HEPATOLOGY
- Non-alcoholic fatty liver disease progresses to hepatocellular carcinoma in the absence of apparent cirrhosis
- (2010) Judith Ertle et al. INTERNATIONAL JOURNAL OF CANCER
- Oxidative stress parameters in paediatric non-alcoholic fatty liver disease
- (2010) Nobili INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults
- (2010) Nadja Larsen et al. PLoS One
- Systemic gut microbial modulation of bile acid metabolism in host tissue compartments
- (2010) J. R. Swann et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ATM Activation by Oxidative Stress
- (2010) Z. Guo et al. SCIENCE
- Novel Insights into the Pathophysiology of Nonalcoholic Fatty Liver Disease
- (2010) Ariel Feldstein SEMINARS IN LIVER DISEASE
- A Role of DNA-PK for the Metabolic Gene Regulation in Response to Insulin
- (2009) Roger H.F. Wong et al. CELL
- Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease
- (2009) Luca Miele et al. HEPATOLOGY
- Myeloid derived suppressor cells inhibit natural killer cells in patients with hepatocellular carcinoma via the NKp30 receptor
- (2009) Bastian Hoechst et al. HEPATOLOGY
- Autophagy regulates lipid metabolism
- (2009) Rajat Singh et al. NATURE
- Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation
- (2009) Philippe Lefebvre et al. PHYSIOLOGICAL REVIEWS
- Autoimmunity and oxidatively modified autoantigens
- (2008) Biji T. Kurien et al. AUTOIMMUNITY REVIEWS
- Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome
- (2008) Peter J. Turnbaugh et al. Cell Host & Microbe
- Fast-food-based hyper-alimentation can induce rapid and profound elevation of serum alanine aminotransferase in healthy subjects
- (2008) S. Kechagias et al. GUT
- Defective DNA strand break repair causes chromosomal instability and accelerates liver carcinogenesis in mice
- (2008) Narci C. Teoh et al. HEPATOLOGY
- Nonalcoholic steatohepatitis induced by a high-fat diet promotes diethylnitrosamine-initiated early hepatocarcinogenesis in rats
- (2008) Yan Wang et al. INTERNATIONAL JOURNAL OF CANCER
- Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial
- (2008) Ann-Lii Cheng et al. LANCET ONCOLOGY
- Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
- (2008) Stefano Romeo et al. NATURE GENETICS
- Sorafenib in Advanced Hepatocellular Carcinoma
- (2008) Josep M. Llovet et al. NEW ENGLAND JOURNAL OF MEDICINE
- Activation and Dysregulation of the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease
- (2007) Puneet Puri et al. GASTROENTEROLOGY
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started