Aβ-oligomers: A potential therapeutic target for Alzheimer's disease

Anti-amyloid antibody therapies in Alzheimer's disease

(2023) Robert Perneczky et al.   BRAIN

NIH Pilots Telehealth Program for COVID-19

(2023) Howard D. Larkin   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Aza-Residue Modulation of Cyclic d,l-α-Peptide Nanotube Assembly with Enhanced Anti-Amyloidogenic Activity

(2023) Maram Habashi et al.   Journal of Medicinal Chemistry

How Single Site Mutations Can Help Understanding Structure Formation of Amyloid β1−40

(2023) Benedikt Schwarze et al.   MACROMOLECULAR BIOSCIENCE

Identification of β‐aminopyrrolidine containing peptides as β‐amyloid aggregation inhibitors for Alzheimer's disease

(2022) Habbanakuppe D. Preetham et al.   JOURNAL OF PEPTIDE SCIENCE

Taylor Dispersion Analysis and Atomic Force Microscopy Provide a Quantitative Insight into the Aggregation Kinetics of Aβ (1–40)/Aβ (1–42) Amyloid Peptide Mixtures

(2022) Mihai Deleanu et al.   ACS Chemical Neuroscience

Cross-Seeding Controls Aβ Fibril Populations and Resulting Functions

(2022) Michael J. Lucas et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The development of ADAM10 endocytosis inhibitors for the treatment of Alzheimer’s disease

(2022) Stefano Musardo et al.   MOLECULAR THERAPY

Impact of Anti-amyloid-β Monoclonal Antibodies on the Pathology and Clinical Profile of Alzheimer’s Disease: A Focus on Aducanumab and Lecanemab

(2022) Mingchao Shi et al.   Frontiers in Aging Neuroscience

Amyloid-Related Imaging Abnormalities With Anti-amyloid Antibodies for the Treatment of Dementia Due to Alzheimer's Disease

(2022) Charles G. Withington et al.   Frontiers in Neurology

Ganglioside Nanocluster-Targeting Peptidyl Inhibitor Prevents Amyloid β Fibril Formation on the Neuronal Membrane

(2022) Teruhiko Matsubara et al.   ACS Chemical Neuroscience

Functionally linked potassium channel activity in cerebral endothelial and smooth muscle cells is compromised in Alzheimer’s disease

(2022) Jade L. Taylor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanoscale Characterization of Parallel and Antiparallel β-Sheet Amyloid Beta 1–42 Aggregates

(2022) Kiryl Zhaliazka et al.   ACS Chemical Neuroscience

Characterization of the Conformations of Amyloid Beta 42 in Solution That May Mediate Its Initial Hydrophobic Aggregation

(2022) Krushna Sonar et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Effects of pramipexole on beta-amyloid1–42 memory deficits and evaluation of oxidative stress and mitochondrial function markers in the hippocampus of Wistar rat

(2022) Mohd. Salman et al.   NEUROTOXICOLOGY

Alzheimer’s Disease: Challenges and a Therapeutic Opportunity to Treat It with a Neurotrophic Compound

(2022) Narjes Baazaoui et al.   Biomolecules

Multiple Actions of H2S-Releasing Peptides in Human β-Amyloid Expressing C. elegans

(2022) Rafat Ali et al.   ACS Chemical Neuroscience

Atrial Natriuretic Peptide Associated with Cardiovascular Diseases Inhibits Amyloid-β Aggregation via Cross-Seeding

(2022) Yijing Tang et al.   ACS Chemical Neuroscience

Early diagnosis and treatment of Alzheimer’s disease by targeting toxic soluble Aβ oligomers

(2022) Maram Habashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Real-Time Validation of the Effectiveness of Third-Generation Hyperbranched Poly(ɛ-lysine) Dendrons-Modified KLVFF Sequences to Bind Amyloid-β1-42 Peptides Using an Optical Waveguide Light-Mode Spectroscopy System

(2022) Valeria Perugini et al.   SENSORS

Intranasal Peptide Therapeutics: A Promising Avenue for Overcoming the Challenges of Traditional CNS Drug Development

(2022) Meenakshi Bose et al.   Cells

Adult hippocampal neurogenesis in aging and Alzheimer's disease

(2021) Kelsey R. Babcock et al.   Stem Cell Reports

Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer’s disease

(2021) Gai Ayalon et al.   Science Translational Medicine

Targeting Alzheimer’s disease with multimodal polypeptide-based nanoconjugates

(2021) A. Duro-Castano et al.   Science Advances

The approval of Aduhelm risks eroding public trust in Alzheimer research and the FDA

(2021) Jason Karlawish et al.   Nature Reviews Neurology

Amyloid-Related Imaging Abnormalities in 2 Phase 3 Studies Evaluating Aducanumab in Patients With Early Alzheimer Disease

(2021) Stephen Salloway et al.   JAMA Neurology

Combating amyloid-induced cellular toxicity and stiffness by designer peptidomimetics

(2021) Mouli Konar et al.   RSC Chemical Biology

Transthyretin Inhibits Primary and Secondary Nucleations of Amyloid-β Peptide Aggregation and Reduces the Toxicity of Its Oligomers

(2020) Seyyed Abolghasem Ghadami et al.   BIOMACROMOLECULES

Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide

(2020) Thomas C. T. Michaels et al.   Nature Chemistry

Ultrastructural evidence for self-replication of Alzheimer-associated Aβ42 amyloid along the sides of fibrils

(2020) Mattias Törnquist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complete aggregation pathway of amyloid β (1-40) and (1-42) resolved on an atomically clean interface

(2020) Peter Niraj Nirmalraj et al.   Science Advances

Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation

(2020) Patrick Flagmeier et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rational design of a conformation-specific antibody for the quantification of Aβ oligomers

(2020) Francesco A. Aprile et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aβ(1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage

(2020) Sonia Ciudad et al.   Nature Communications

Longitudinal profiling of oligomeric Aβ in human nasal discharge reflecting cognitive decline in probable Alzheimer’s disease

(2020) Seung-Jun Yoo et al.   Scientific Reports

Time-Dependent Lipid Dynamics, Organization and Peptide-Lipid Interaction in Phospholipid Bilayers with Incorporated β-Amyloid Oligomers

(2020) Wei Qiang et al.   Journal of Physical Chemistry Letters

Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors

(2020) Thomas C. T. Michaels et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The amyloid cascade and Alzheimer’s disease therapeutics: theory versus observation

(2019) Rudy J. Castellani et al.   LABORATORY INVESTIGATION

MnCO3 as a New Electrochemiluminescence Emitter for Ultrasensitive Bioanalysis of β-Amyloid1–42 Oligomers Based on Site-Directed Immobilization of Antibody

(2019) Yue Jia et al.   ACS Applied Materials & Interfaces

Amyloid-β Peptide-Lipid Bilayer Interaction investigated by Supercritical Angle Fluorescence

(2019) Valentin Dubois et al.   ACS Chemical Neuroscience

α-Sheet secondary structure in amyloid β-peptide drives aggregation and toxicity in Alzheimer’s disease

(2019) Dylan Shea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates

(2019) Tom Scheidt et al.   Science Advances

Optimal control strategies for inhibition of protein aggregation

(2019) Thomas C. T. Michaels et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Rationally Designed Humanized Antibody Selective for Amyloid Beta Oligomers in Alzheimer’s Disease

(2019) Ebrima Gibbs et al.   Scientific Reports

Aggregation States of Aβ1–40, Aβ1–42 and Aβp3–42 Amyloid Beta Peptides: A SANS Study

(2019) Giulia Festa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Observation of β-Amyloid Peptide Oligomerization by Pressure-Jump NMR Spectroscopy

(2019) C. Ashley Barnes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fibrillar and Nonfibrillar Amyloid Beta Structures Drive Two Modes of Membrane-Mediated Toxicity

(2019) Crystal M. Vander Zanden et al.   LANGMUIR

Secondary nucleation in amyloid formation

(2018) Mattias Törnquist et al.   CHEMICAL COMMUNICATIONS

The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade

(2018) Erika N. Cline et al.   JOURNAL OF ALZHEIMERS DISEASE

On the role of sidechain size and charge in the aggregation of Aβ42 with familial mutations

(2018) Xiaoting Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genesis of Neuroprotective Peptoid from Aβ30–34 Inhibits Aβ Aggregation and AChE Activity

(2018) Krishnangsu Pradhan et al.   ACS Chemical Neuroscience

β-Alanyl-L-Histidine Rescues Cognitive Deficits Caused by Feeding a High Fat Diet in a Transgenic Mouse Model of Alzheimer's Disease

(2018) Bruno Herculano et al.   JOURNAL OF ALZHEIMERS DISEASE

Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases

(2018) Claudio Soto et al.   NATURE NEUROSCIENCE

Dynamic micellar oligomers of amyloid beta peptides play a crucial role in their aggregation mechanisms

(2018) Bertrand Morel et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

SAR by kinetics for drug discovery in protein misfolding diseases

(2018) Sean Chia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Advances in developing novel therapeutic strategies for Alzheimer’s disease

(2018) Jiqing Cao et al.   Molecular Neurodegeneration

Pathways of Amyloid-β Aggregation Depend on Oligomer Shape

(2017) Bogdan Barz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication

(2017) Anna Munke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates

(2017) Sean Chia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The amyloid-β oligomer Aβ*56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation

(2017) Fatou Amar et al.   Science Signaling

Pyroglutamate-modified Aβ(3-42) affects aggregation kinetics of Aβ(1-42) by accelerating primary and secondary pathways

(2017) C. Dammers et al.   Chemical Science

The amyloid-β oligomer Aβ*56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation

(2017) Fatou Amar et al.   Science Signaling

Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method

(2017) Francesco A. Aprile et al.   Science Advances

Anti-Amyloid-β Immunotherapy in Alzheimer's Disease: ACC-001 Clinical Trials Are Ongoing

(2017) J. Michael Ryan et al.   JOURNAL OF ALZHEIMERS DISEASE

LPYFDa Neutralizes Amyloid-β-Induced Memory Impairment and Toxicity

(2017) Ivica Granic et al.   JOURNAL OF ALZHEIMERS DISEASE

Stabilization of native amyloid β-protein oligomers by Copper and Hydrogen peroxide Induced Cross-linking of Unmodified Proteins (CHICUP)

(2016) Thomas L. Williams et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Designed Glycopeptidomimetics Disrupt Protein–Protein Interactions Mediating Amyloid β-Peptide Aggregation and Restore Neuroblastoma Cell Viability

(2016) Julia Kaffy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Amyloid β-Protein Assembly and Alzheimer’s Disease: Dodecamers of Aβ42, but Not of Aβ40, Seed Fibril Formation

(2016) Nicholas J. Economou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

High-speed atomic force microscopy reveals structural dynamics of amyloid β1–42aggregates

(2016) Takahiro Watanabe-Nakayama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation

(2016) Paolo Arosio et al.   Nature Communications

Safety and tolerability of BAN2401 - a clinical study in Alzheimer’s disease with a protofibril selective Aβ antibody

(2016) Veronika Logovinsky et al.   Alzheimers Research & Therapy

Fabrication of an antibody-aptamer sandwich assay for electrochemical evaluation of levels of β-amyloid oligomers

(2016) Yanli Zhou et al.   Scientific Reports

(R)-α-trifluoromethylalanine containing short peptide in the inhibition of amyloid peptide fibrillation

(2015) Alexandra Botz et al.   BIOPOLYMERS

N-Terminal Extensions Retard Aβ42 Fibril Formation but Allow Cross-Seeding and Coaggregation with Aβ42

(2015) Olga Szczepankiewicz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

(2015) Samuel I A Cohen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

On the lag phase in amyloid fibril formation

(2015) Paolo Arosio et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins

(2015) Pietro Sormanni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer’s disease

(2015) Sergio T. Ferreira et al.   Frontiers in Cellular Neuroscience

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

(2015) Samuel I A Cohen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Long-term treatment with active Aβ immunotherapy with CAD106 in mild Alzheimer’s disease

(2015) Martin R Farlow et al.   Alzheimers Research & Therapy

Quaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration

(2015) Peng Liu et al.   Cell Reports

Rational Design and Identification of a Non-Peptidic Aggregation Inhibitor of Amyloid-β Based on a Pharmacophore Motif Obtained fromcyclo[-Lys-Leu-Val-Phe-Phe-]

(2014) Tadamasa Arai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Taurine attenuates amyloid β 1–42-induced mitochondrial dysfunction by activating of SIRT1 in SK-N-SH cells

(2014) Qinru Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Differences between amyloid-β aggregation in solution and on the membrane: insights into elucidation of the mechanistic details of Alzheimer's disease

(2014) Samuel A. Kotler et al.   CHEMICAL SOCIETY REVIEWS

Cyclic Peptides as Inhibitors of Amyloid Fibrillation

(2014) Jinghui Luo et al.   CHEMISTRY-A EUROPEAN JOURNAL

Computational and Experimental Studies on β-Sheet Breakers Targeting Aβ1–40Fibrils

(2014) Velia Minicozzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Sensitive A  Oligomer Assay Discriminates Alzheimer's and Aged Control Cerebrospinal Fluid

(2014) M. J. Savage et al.   JOURNAL OF NEUROSCIENCE

Davunetide in patients with progressive supranuclear palsy: a randomised, double-blind, placebo-controlled phase 2/3 trial

(2014) Adam L Boxer et al.   LANCET NEUROLOGY

Soluble Aβ Oligomers Are Rapidly Sequestered from Brain ISF In Vivo and Bind GM1 Ganglioside on Cellular Membranes

(2014) Soyon Hong et al.   NEURON

Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides

(2014) Georg Meisl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-based study of antiamyloidogenic cyclic d,l-α-peptides

(2014) Marina Chemerovski-Glikman et al.   TETRAHEDRON

Perspectives on future Alzheimer therapies: amyloid-β protofibrils - a new target for immunotherapy with BAN2401 in Alzheimer’s disease

(2014) Lars Lannfelt et al.   Alzheimers Research & Therapy

Designed α-sheet peptides inhibit amyloid formation by targeting toxic oligomers

(2014) Gene Hopping et al.   eLife

Single Point Mutations Induce a Switch in the Molecular Mechanism of the Aggregation of the Alzheimer’s Disease Associated Aβ42 Peptide

(2013) Benedetta Bolognesi et al.   ACS Chemical Biology

γ-AApeptide-based small-molecule ligands that inhibit Aβ aggregation

(2013) Haifan Wu et al.   CHEMICAL COMMUNICATIONS

In Vitro and Mechanistic Studies of an Antiamyloidogenic Self-Assembled Cyclic d,l-α-Peptide Architecture

(2013) Michal Richman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Proliferation of amyloid- 42 aggregates occurs through a secondary nucleation mechanism

(2013) S. I. A. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human LilrB2 Is a  -Amyloid Receptor and Its Murine Homolog PirB Regulates Synaptic Plasticity in an Alzheimer's Model

(2013) T. Kim et al.   SCIENCE

On the subject of rigor in the study of amyloid β-protein assembly

(2013) David B Teplow   Alzheimers Research & Therapy

Synapse-Binding Subpopulations of Aβ Oligomers Sensitive to Peptide Assembly Blockers and scFv Antibodies

(2012) Pauline T. Velasco et al.   ACS Chemical Neuroscience

The N-Methylated Peptide SEN304 Powerfully Inhibits Aβ(1–42) Toxicity by Perturbing Oligomer Formation

(2012) Hozefa Amijee et al.   BIOCHEMISTRY

The Amyloid Beta Peptide: A Chemist’s Perspective. Role in Alzheimer’s and Fibrillization

(2012) I. W. Hamley   CHEMICAL REVIEWS

From Macroscopic Measurements to Microscopic Mechanisms of Protein Aggregation

(2012) Samuel I.A. Cohen et al.   JOURNAL OF MOLECULAR BIOLOGY

Synthesis of d-amino acid peptides and their effect on beta-amyloid aggregation and toxicity in transgenic Caenorhabditis elegans

(2012) Seema Jagota et al.   MEDICINAL CHEMISTRY RESEARCH

A Survey of Peptides with Effective Therapeutic Potential in Alzheimer’s Disease Rodent Models or in Human Clinical Studies

(2012) N. Sun et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Sugar-based peptidomimetics inhibit amyloid β-peptide aggregation

(2011) Bertrand Dorgeret et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

AFFITOME® technology in neurodegenerative diseases: The doubling advantage

(2011) Achim Schneeberger et al.   Human vaccines & immunotherapeutics

Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments

(2011) Samuel I. A. Cohen et al.   JOURNAL OF CHEMICAL PHYSICS

Single Molecule Tracking Analysis Reveals That the Surface Mobility of Amyloid Oligomers Is Driven by Their Conformational Structure

(2011) Martino Calamai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of a New Class of Bis(thiourea)hydrazide Pseudopeptides as Potential Inhibitors of β-Sheet Aggregation

(2011) Jan J. Klein et al.   ORGANIC LETTERS

Structure-based design of conformation- and sequence-specific antibodies against amyloid  

(2011) J. M. Perchiacca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oral Treatment with the d-Enantiomeric Peptide D3 Improves the Pathology and Behavior of Alzheimer’s Disease Transgenic Mice

(2010) Susanne Aileen Funke et al.   ACS Chemical Neuroscience

Development of a Proteolytically Stable Retro-Inverso Peptide Inhibitor of β-Amyloid Oligomerization as a Potential Novel Treatment for Alzheimer’s Disease

(2010) Mark Taylor et al.   BIOCHEMISTRY

Aβ polymerization through interaction with membrane gangliosides

(2010) Katsumi Matsuzaki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Polymorphism in Alzheimer Aβ Amyloid Organization Reflects Conformational Selection in a Rugged Energy Landscape

(2010) Yifat Miller et al.   CHEMICAL REVIEWS

Mitochondrial medicine for neurodegenerative diseases

(2010) Heng Du et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Specificity and sensitivity of the Abeta oligomer ELISA

(2010) Andrea C. Klaver et al.   JOURNAL OF NEUROSCIENCE METHODS

Development of retro-inverso peptides as anti-aggregation drugs for β-amyloid in Alzheimer's disease

(2010) Balpreet Matharu et al.   PEPTIDES

Rationally designed dehydroalanine (ΔAla)-containing peptides inhibit amyloid-β (Aβ) peptide aggregation

(2009) Vijayaraghavan Rangachari et al.   BIOPOLYMERS

Amino Acid Position-specific Contributions to Amyloid β-Protein Oligomerization

(2009) Samir K. Maji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease

(2009) Summer L. Bernstein et al.   Nature Chemistry

Transport of Alzheimer Disease Amyloid-β-Binding d-Amino Acid Peptides across an In Vitro Blood–Brain Barrier Model

(2009) Hongmei Liu et al.   REJUVENATION RESEARCH

An Analytical Solution to the Kinetics of Breakable Filament Assembly

(2009) T. P. J. Knowles et al.   SCIENCE

Active and Passive Immunotherapy for Neurodegenerative Disorders

(2008) David L. Brody et al.   Annual Review of Neuroscience

Designing Peptide Inhibitors for Oligomerization and Toxicity of Alzheimer's β-Amyloid Peptide†

(2008) Brian M. Austen et al.   BIOCHEMISTRY

Reduction of Alzheimer’s Disease Amyloid Plaque Load in Transgenic Mice by D3, a D-Enantiomeric Peptide Identified by Mirror Image Phage Display

(2008) Thomas van Groen et al.   ChemMedChem

In vitro and in vivo Staining Characteristics of Small, Fluorescent, Aβ42-Binding D-Enantiomeric Peptides in Transgenic AD Mouse Models

(2008) Thomas van Groen et al.   ChemMedChem

Synthesis and activity of fibrillogenesis peptide inhibitors related to the 17–21 β-amyloid sequence

(2008) Cesare Giordano et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Characterisation of two antibodies to oligomeric Aβ and their use in ELISAs on human brain tissue homogenates

(2008) Zoë van Helmond et al.   JOURNAL OF NEUROSCIENCE METHODS

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

(2008) Dagmar E Ehrnhoefer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY