Targeting Alzheimer’s disease with multimodal polypeptide-based nanoconjugates

Systemic Brain Delivery of Antisense Oligonucleotides across the Blood-Brain Barrier with a Glucose-Coated Polymeric Nanocarrier

(2020) Hyun Su Min et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Role of curcumin and its nanoformulations in neurotherapeutics: A comprehensive review

(2020) Mukesh Mandal et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Effective Nephroprotection Against Acute Kidney Injury with a Star-Shaped Polyglutamate-Curcuminoid Conjugate

(2020) Gina Córdoba-David et al.   Scientific Reports

Designing peptide nanoparticles for efficient brain delivery

(2020) Aroa Duro-Castano et al.   ADVANCED DRUG DELIVERY REVIEWS

Therapeutic potential of polypeptide-based conjugates: Rational design and analytical tools that can boost clinical translation

(2020) Tetiana Melnyk et al.   ADVANCED DRUG DELIVERY REVIEWS

Combinatorial entropy behaviour leads to range selective binding in ligand-receptor interactions

(2020) Meng Liu et al.   Nature Communications

Peptides in clinical development for the treatment of brain tumors

(2019) Giulia Guidotti et al.   CURRENT OPINION IN PHARMACOLOGY

110th Anniversary: Nanoparticle Mediated Drug Delivery for the Treatment of Alzheimer’s Disease: Crossing the Blood–Brain Barrier

(2019) Marissa E. Wechsler et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Emerging Signal Regulating Potential of Genistein Against Alzheimer’s Disease: A Promising Molecule of Interest

(2019) Md. Sahab Uddin et al.   Frontiers in Cell and Developmental Biology

Propargylamine-derived multi-target directed ligands for Alzheimer’s disease therapy

(2019) Maria do Carmo Carreiras et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The effect of curcumin on cognition in Alzheimer’s disease and healthy aging: A systematic review of pre-clinical and clinical studies

(2019) S.D. Voulgaropoulou et al.   BRAIN RESEARCH

Alzheimer’s Disease, the “One-Molecule, One-Target” Paradigm, and the Multitarget Directed Ligand Approach

(2018) María Jesús Oset-Gasque et al.   ACS Chemical Neuroscience

Soy isoflavones improve cardiovascular disease risk markers in women during the early menopause

(2018) T. Sathyapalan et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Envisioning the future of polymer therapeutics for brain disorders

(2018) Fernanda Rodriguez-Otormin et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Neuroprotective and Neurorescue Effects of a Novel Polymeric Nanoparticle Formulation of Curcumin (NanoCurc™) in the Neuronal Cell Culture and Animal Model: Implications for Alzheimer's disease

(2018) Balmiki Ray et al.   JOURNAL OF ALZHEIMERS DISEASE

Curcuminoid Binds to Amyloid-β1-42 Oligomer and Fibril

(2018) Daijiro Yanagisawa et al.   JOURNAL OF ALZHEIMERS DISEASE

Peripheral Administration of Antisense Oligonucleotides Targeting the Amyloid-β Protein Precursor Reverses AβPP and LRP-1 Overexpression in the Aged SAMP8 Mouse Brain

(2018) Michelle A. Erickson et al.   JOURNAL OF ALZHEIMERS DISEASE

Microenvironment Remodeling Micelles for Alzheimer's Disease Therapy by Early Modulation of Activated Microglia

(2018) Yifei Lu et al.   Advanced Science

Nanocarriers as a powerful vehicle to overcome blood-brain barrier in treating neurodegenerative diseases: Focus on recent advances

(2018) Xiaoqian Niu et al.   Asian Journal of Pharmaceutical Sciences

Genistein protects hippocampal neurons against injury by regulating calcium/calmodulin dependent protein kinase IV protein levels in Alzheimer's disease model rats

(2017) Biao Cai et al.   Neural Regeneration Research

The novel multitarget iron chelating and propargylamine drug M30 affects APP regulation and processing activities in Alzheimer's disease models

(2017) Tamar Amit et al.   NEUROPHARMACOLOGY

Endothelial LRP1 – A Potential Target for the Treatment of Alzheimer’s Disease

(2017) Steffen E. Storck et al.   PHARMACEUTICAL RESEARCH

Clearing Amyloid-β through PPARγ/ApoE Activation by Genistein is a Treatment of Experimental Alzheimer’s Disease

(2016) Vicent Bonet-Costa et al.   JOURNAL OF ALZHEIMERS DISEASE

Curcumin improves episodic memory in cadmium induced memory impairment through inhibition of acetylcholinesterase and adenosine deaminase activities in a rat model

(2016) Ayodele Jacob Akinyemi et al.   METABOLIC BRAIN DISEASE

Valproic acid ameliorates olfactory dysfunction in APP/PS1 transgenic mice of Alzheimer's disease: Ameliorations from the olfactory epithelium to the olfactory bulb

(2016) Zhi-Gang Yao et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Inhibition of amyloid fibrillation of hen egg-white lysozyme by the natural and synthetic curcuminoids

(2016) Fakhrossadat Mohammadi et al.   RSC Advances

Polymer-doxycycline conjugates as fibril disrupters: An approach towards the treatment of a rare amyloidotic disease

(2015) Inmaculada Conejos-Sánchez et al.   JOURNAL OF CONTROLLED RELEASE

Well-Defined Star-Shaped Polyglutamates with Improved Pharmacokinetic Profiles As Excellent Candidates for Biomedical Applications

(2015) Aroa Duro-Castano et al.   MOLECULAR PHARMACEUTICS

Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance

(2015) Zhen Zhao et al.   NATURE NEUROSCIENCE

Curcumin-releasing mechanically adaptive intracortical implants improve the proximal neuronal density and blood–brain barrier stability

(2014) Kelsey A. Potter et al.   Acta Biomaterialia

Inhibition of Amyloid Fibril Growth and Dissolution of Amyloid Fibrils by Curcumin-Gold Nanoparticles

(2014) Sharbari Palmal et al.   CHEMISTRY-A EUROPEAN JOURNAL

Effect of whole soy and purified isoflavone daidzein on renal function—a 6-month randomized controlled trial in equol-producing postmenopausal women with prehypertension

(2014) Zhao-min Liu et al.   CLINICAL BIOCHEMISTRY

Multifunctional nanoliposomes with curcumin–lipid derivative and brain targeting functionality with potential applications for Alzheimer disease

(2014) Spyridon Mourtas et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Monitoring Sunitinib-Induced Vascular Effects to Optimize Radiotherapy Combined with Soy Isoflavones in Murine Xenograft Tumor

(2014) Gilda Gali Hillman et al.   Translational Oncology

The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer’s disease

(2014) Takahisa Kanekiyo et al.   Frontiers in Aging Neuroscience

Early, But Not Late Onset Estrogen Replacement Therapy Prevents Oxidative Stress and Metabolic Alterations Caused by Ovariectomy

(2013) Raúl López-Grueso et al.   ANTIOXIDANTS & REDOX SIGNALING

A Longitudinal Study of Cognition, Proton MR Spectroscopy and Synaptic and Neuronal Pathology in Aging Wild-type and AβPPswe-PS1dE9 Mice

(2013) Diane Jansen et al.   PLoS One

A versatile post-polymerization modification method for polyglutamic acid: synthesis of orthogonal reactive polyglutamates and their use in “click chemistry”

(2013) Matthias Barz et al.   Polymer Chemistry

A controlled and versatile NCA polymerization method for the synthesis of polypeptides

(2013) Inmaculada Conejos-Sánchez et al.   Polymer Chemistry

Optimized Turmeric Extract Reduces ?-Amyloid and Phosphorylated Tau Protein Burden in Alzheimer's Transgenic Mice

(2012) R. Douglas Shytle et al.   Current Alzheimer Research

Amyloid-β-Induced Astrocytic Phagocytosis is Mediated by CD36, CD47 and RAGE

(2012) Raasay S. Jones et al.   Journal of Neuroimmune Pharmacology

Curcumin-conjugated nanoliposomes with high affinity for Aβ deposits: Possible applications to Alzheimer disease

(2012) Adina N. Lazar et al.   Nanomedicine-Nanotechnology Biology and Medicine

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Curcuma as a functional food in the control of cancer and inflammation

(2011) Moshe Schaffer et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Membrane Integrity and Amyloid Cytotoxicity: A Model Study Involving Mitochondria and Lysozyme Fibrillation Products

(2011) Ali Akbar Meratan et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure and permeability changes of the blood-brain barrier in APP/PS1 mice: an Alzheimer’s disease animal model

(2011) Yulin Wang et al.   Neurochemical Journal

Enhancement of transport of curcumin to brain in mice by poly(n-butylcyanoacrylate) nanoparticle

(2010) Min Sun et al.   JOURNAL OF NANOPARTICLE RESEARCH

Olfactory Dysfunction Correlates with Amyloid-  Burden in an Alzheimer's Disease Mouse Model

(2010) D. W. Wesson et al.   JOURNAL OF NEUROSCIENCE

Estradiol or genistein prevent Alzheimer's disease-associated inflammation correlating with an increase PPARγ expression in cultured astrocytes

(2009) Soraya L. Valles et al.   BRAIN RESEARCH

Isoflavone profiles of soymilk as affected by high-pressure treatments of soymilk and soybeans

(2008) Stephanie Jung et al.   FOOD CHEMISTRY

Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector Angiopep-2

(2008) Michel Demeule et al.   JOURNAL OF NEUROCHEMISTRY

A Comparative Study of β-Amyloid Peptides Aβ1-42 and Aβ25-35 Toxicity in Organotypic Hippocampal Slice Cultures

(2008) Rudimar Luiz Frozza et al.   NEUROCHEMICAL RESEARCH