The development of ADAM10 endocytosis inhibitors for the treatment of Alzheimer’s disease
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The development of ADAM10 endocytosis inhibitors for the treatment of Alzheimer’s disease
Authors
Keywords
synapse, ADAM10, cell-permeable peptide, endocytosis, Alzheimer’s disease, synaptic dysfunction, cognitive deficits, sAPPα
Journal
MOLECULAR THERAPY
Volume -, Issue -, Pages -
Publisher
Elsevier BV
Online
2022-04-04
DOI
10.1016/j.ymthe.2022.03.024
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Aducanumab produced a clinically meaningful benefit in association with amyloid lowering
- (2021) Jeffrey Cummings et al. Alzheimers Research & Therapy
- The clinical promise of biomarkers of synapse damage or loss in Alzheimer’s disease
- (2020) Martí Colom-Cadena et al. Alzheimers Research & Therapy
- In vivo measurement of widespread synaptic loss in Alzheimer's disease with SV2A PET
- (2020) Adam P. Mecca et al. Alzheimers & Dementia
- SULT4A1 modulates synaptic development and function by promoting the formation of PSD-95/NMDAR complex
- (2020) Lorenza Culotta et al. JOURNAL OF NEUROSCIENCE
- Aducanumab, gantenerumab, BAN2401, and ALZ-801—the first wave of amyloid-targeting drugs for Alzheimer’s disease with potential for near term approval
- (2020) Martin Tolar et al. Alzheimers Research & Therapy
- Bioinformatics and Biosimulations as Toolbox for Peptides and Peptidomimetics Design: Where Are We?
- (2020) Ilda D’Annessa et al. Frontiers in Molecular Biosciences
- Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
- (2019) Brian W. Kunkle et al. NATURE GENETICS
- Inhibiting pathologically active ADAM10 rescues synaptic and cognitive decline in Huntington’s disease
- (2019) Elena Vezzoli et al. JOURNAL OF CLINICAL INVESTIGATION
- Amyloid-β Oligomers Regulate ADAM10 Synaptic Localization Through Aberrant Plasticity Phenomena
- (2019) Elena Marcello et al. MOLECULAR NEUROBIOLOGY
- Distinct in vivo roles of secreted APP ectodomain variants APPsα and APPsβ in regulation of spine density, synaptic plasticity, and cognition
- (2018) Max C Richter et al. EMBO JOURNAL
- The importance of data structure in statistical analysis of dendritic spine morphology
- (2018) Veerle Paternoster et al. JOURNAL OF NEUROSCIENCE METHODS
- Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β
- (2018) Joseph W. Arndt et al. Scientific Reports
- GWAS on family history of Alzheimer’s disease
- (2018) Riccardo E. Marioni et al. Translational Psychiatry
- Synaptic dysfunction in Alzheimer's disease: From the role of amyloid β-peptide to the α-secretase ADAM10
- (2017) Stefano Musardo et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- ADAM10 as a therapeutic target for brain diseases: from developmental disorders to Alzheimer’s disease
- (2017) Elena Marcello et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Therapeutic Potential of Secreted Amyloid Precursor Protein APPsα
- (2017) Bruce G. Mockett et al. Frontiers in Molecular Neuroscience
- Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function
- (2016) Peer-Hendrik Kuhn et al. eLife
- Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer’s disease mouse model
- (2015) Romain Fol et al. ACTA NEUROPATHOLOGICA
- Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis
- (2015) Celeste M. Karch et al. BIOLOGICAL PSYCHIATRY
- MD and Docking Studies Reveal That the Functional Switch of CYFIP1 is Mediated by a Butterfly-like Motion
- (2015) Daniele Di Marino et al. Journal of Chemical Theory and Computation
- Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X Syndrome
- (2015) Emanuela Pasciuto et al. NEURON
- The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain
- (2015) Paul Saftig et al. PROGRESS IN NEUROBIOLOGY
- A unique binding mode of the eukaryotic translation initiation factor 4E for guiding the design of novel peptide inhibitors
- (2015) Daniele Di Marino et al. PROTEIN SCIENCE
- Increased CSF APPs- levels in patients with Alzheimer disease treated with acitretin
- (2014) K. Endres et al. NEUROLOGY
- The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease
- (2014) Tara L. Spires-Jones et al. NEURON
- SAP97-mediated ADAM10 trafficking from Golgi outposts depends on PKC phosphorylation
- (2014) C Saraceno et al. Cell Death & Disease
- ADAM10 as a Biomarker for Alzheimers Disease: A Study with Brazilian Elderly
- (2013) Patricia Regina Manzine et al. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
- Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer’s disease
- (2013) Elena Marcello et al. JOURNAL OF CLINICAL INVESTIGATION
- Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial
- (2012) Michael D Hill et al. LANCET NEUROLOGY
- ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons
- (2010) Peer-Hendrik Kuhn et al. EMBO JOURNAL
- An Arginine Stretch Limits ADAM10 Exit from the Endoplasmic Reticulum
- (2010) Elena Marcello et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Synaptic Localization and Activity of ADAM10 Regulate Excitatory Synapses through N-Cadherin Cleavage
- (2010) M. Malinverno et al. JOURNAL OF NEUROSCIENCE
- SAP97-mediated local trafficking is altered in Alzheimer disease patients' hippocampus
- (2010) Elena Marcello et al. NEUROBIOLOGY OF AGING
- Synthetic amyloid- oligomers impair long-term memory independently of cellular prion protein
- (2010) C. Balducci et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Endogenous secreted amyloid precursor protein-α regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory
- (2008) Chanel J. Taylor et al. NEUROBIOLOGY OF DISEASE
- Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease
- (2008) Tara L. Spires-Jones et al. NEUROBIOLOGY OF DISEASE
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now