Combating amyloid-induced cellular toxicity and stiffness by designer peptidomimetics

Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer’s Disease, Parkinson’s Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis

(2021) Phuong H. Nguyen et al.   CHEMICAL REVIEWS

Peptidomimetic-Based Vesicles Inhibit Amyloid-β Fibrillation and Attenuate Cytotoxicity

(2021) Debabrata Maity et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rationally Designed Bicyclic Peptides Prevent the Conversion of Aβ42 Assemblies Into Fibrillar Structures

(2021) Tatsuya Ikenoue et al.   Frontiers in Neuroscience

Cyclic Dipeptide: A Privileged Molecular Scaffold to Derive Structural Diversity and Functional Utility

(2021) Thimmaiah Govindaraju et al.   ChemMedChem

Dynamic effect of beta-amyloid 42 on cell mechanics

(2019) Qi Gao et al.   JOURNAL OF BIOMECHANICS

Small Molecule Inhibit Metal-Dependent and Independent Multifaceted Toxicity of Alzheimer’s Disease

(2019) Sourav Samanta et al.   ACS Chemical Neuroscience

Nano-mechanical mapping of interdependent cell and ECM mechanics by AFM force spectroscopy

(2019) Prem Kumar Viji Babu et al.   Scientific Reports

Cyclic Dipeptide-Guided Aggregation-Induced Emission of Naphthalimide and Its Application for the Detection of Phenolic Drugs

(2019) Chenikkayala Balachandra et al.   JOURNAL OF ORGANIC CHEMISTRY

Elucidating the Structures of Amyloid Oligomers with Macrocyclic β-Hairpin Peptides: Insights into Alzheimer’s Disease and Other Amyloid Diseases

(2018) Adam G. Kreutzer et al.   ACCOUNTS OF CHEMICAL RESEARCH

Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

(2018) C. Cheignon et al.   Redox Biology

Reduced Extracellular Matrix Stiffness Prompts SH-SY5Y Cell Softening and Actin Turnover To Selectively Increase Aβ(1–42) Endocytosis

(2018) Terra M. Kruger et al.   ACS Chemical Neuroscience

Multistep Conformation Selection in Amyloid Assembly

(2017) Ming-Chien Hsieh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cell stiffness determined by atomic force microscopy and its correlation with cell motility

(2016) Qing Luo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Amyloid-β(1–42) Aggregation Initiates Its Cellular Uptake and Cytotoxicity

(2016) Sha Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Designed Glycopeptidomimetics Disrupt Protein–Protein Interactions Mediating Amyloid β-Peptide Aggregation and Restore Neuroblastoma Cell Viability

(2016) Julia Kaffy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Failed Alzheimer’s trial does not kill leading theory of disease

(2016) Alison Abbott et al.   NATURE

Function and toxicity of amyloid beta and recent therapeutic interventions targeting amyloid beta in Alzheimer's disease

(2015) K. Rajasekhar et al.   CHEMICAL COMMUNICATIONS

Tunable assembly of amyloid-forming peptides into nanosheets as a retrovirus carrier

(2015) Bin Dai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accurate secondary structure prediction and fold recognition for circular dichroism spectroscopy

(2015) András Micsonai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nano-Biomechanical Study of Spatio-Temporal Cytoskeleton Rearrangements that Determine Subcellular Mechanical Properties and Endothelial Permeability

(2015) Xin Wang et al.   Scientific Reports

Cyclic Peptides as Inhibitors of Amyloid Fibrillation

(2014) Jinghui Luo et al.   CHEMISTRY-A EUROPEAN JOURNAL

Chiral Metallohelical Complexes Enantioselectively Target Amyloid β for Treating Alzheimer’s Disease

(2014) Meng Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Atomic force microscopy based nanoassay: a new method to study α-Synuclein-dopamine bioaffinity interactions

(2014) Stefania Corvaglia et al.   Scientific Reports

Investigating dynamic structural and mechanical changes of neuroblastoma cells associated with glutamate-mediated neurodegeneration

(2014) Yuqiang Fang et al.   Scientific Reports

Molecular Hairpin: A Possible Model for Inhibition of Tau Aggregation by Tannic Acid

(2013) Junliang Yao et al.   BIOCHEMISTRY

In Vitro and Mechanistic Studies of an Antiamyloidogenic Self-Assembled Cyclic d,l-α-Peptide Architecture

(2013) Michal Richman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural Products

(2012) Alan D. Borthwick   CHEMICAL REVIEWS

Structural Basis for Inhibiting β-Amyloid Oligomerization by a Non-coded β-Breaker-Substituted Endomorphin Analogue

(2011) Anat Frydman-Marom et al.   ACS Chemical Biology

The generic amyloid formation inhibition effect of a designed small aromatic β-breaking peptide

(2011) Anat Frydman-Marom et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Probing aromatic, hydrophobic, and steric effects on the self-assembly of an amyloid-β fragment peptide

(2010) F. Timur Senguen et al.   Molecular BioSystems

Cell mechanics and the cytoskeleton

(2010) Daniel A. Fletcher et al.   NATURE

Single-cell mechanics provides a sensitive and quantitative means for probing amyloid-  peptide and neuronal cell interactions

(2010) V. Lulevich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease

(2009) Summer L. Bernstein et al.   Nature Chemistry

FTIR reveals structural differences between native β-sheet proteins and amyloid fibrils

(2004) Giorgia Zandomeneghi et al.   PROTEIN SCIENCE