Dynamic micellar oligomers of amyloid beta peptides play a crucial role in their aggregation mechanisms

What is Responsible for Atypical Dependence of the Rate of Amyloid Formation on Protein Concentration: Fibril-Catalyzed Initiation of New Fibrils or Competition with Oligomers?

(2018) Alexei V. Finkelstein et al.   Journal of Physical Chemistry Letters

Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide

(2018) Samuel I. A. Cohen et al.   Nature Chemistry

Critical aggregation concentration for the formation of early Amyloid-β (1–42) oligomers

(2018) Mercedes Novo et al.   Scientific Reports

Growth-incompetent monomers of human calcitonin lead to a noncanonical direct relationship between peptide concentration and aggregation lag time

(2017) Kian Kamgar-Parsi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduced Lipid Bilayer Thickness Regulates the Aggregation and Cytotoxicity of Amyloid-β

(2017) Kyle J. Korshavn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stabilization, Assembly, and Toxicity of Trimers Derived from Aβ

(2017) Adam G. Kreutzer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Model membrane size-dependent amyloidogenesis of Alzheimer's amyloid-β peptides

(2017) Misaki Kinoshita et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

In situ fibrillizing amyloid-beta 1-42 induces neurite degeneration and apoptosis of differentiated SH-SY5Y cells

(2017) Jekaterina Krishtal et al.   PLoS One

The influence of N-terminal acetylation on micelle-induced conformational changes and aggregation of α-Synuclein

(2017) David Ruzafa et al.   PLoS One

Importance of the Dimethylamino Functionality on a Multifunctional Framework for Regulating Metals, Amyloid-β, and Oxidative Stress in Alzheimer’s Disease

(2016) Jeffrey S. Derrick et al.   INORGANIC CHEMISTRY

Biophysical insights into the membrane interaction of the core amyloid-forming Aβ40 fragment K16–K28 and its role in the pathogenesis of Alzheimer's disease

(2016) Swapna Bera et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Aβ42 assembles into specific β-barrel pore-forming oligomers in membrane-mimicking environments

(2016) Montserrat Serra-Batiste et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer’s disease

(2016) Johnny Habchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Species-Specific Primary Structure Differences in Aβ42 Assembly and Neurotoxicity

(2015) Robin Roychaudhuri et al.   ACS Chemical Neuroscience

Design and Characterization of Chemically Stabilized Aβ42 Oligomers

(2015) Ghiam Yamin et al.   BIOCHEMISTRY

Mechanism of Nucleated Conformational Conversion of Aβ42

(2015) Ziao Fu et al.   BIOCHEMISTRY

Solution NMR Studies of Recombinant Aβ(1-42): From the Presence of a Micellar Entity to Residual β-Sheet Structure in the Soluble Species

(2015) Marielle Aulikki Wälti et al.   CHEMBIOCHEM

Probing the Sources of the Apparent Irreproducibility of Amyloid Formation: Drastic Changes in Kinetics and a Switch in Mechanism Due to Micellelike Oligomer Formation at Critical Concentrations of IAPP

(2015) Jeffrey R. Brender et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Isotope-edited FTIR reveals distinct aggregation and structural behaviors of unmodified and pyroglutamylated amyloid β peptides

(2015) Greg Goldblatt et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Use of dynamic light scattering and small-angle X-ray scattering to characterize new surfactants in solution conditions for membrane-protein crystallization

(2015) Mohamed Dahani et al.   Acta Crystallographica Section F-Structural Biology Communications

High-resolution NMR characterization of low abundance oligomers of amyloid-β without purification

(2015) Samuel A. Kotler et al.   Scientific Reports

Reactivity of Metal-Free and Metal-Associated Amyloid-β with Glycosylated Polyphenols and Their Esterified Derivatives

(2015) Kyle J. Korshavn et al.   Scientific Reports

Hydrogen/Deuterium Exchange-Protected Oligomers Populated during Aβ Fibril Formation Correlate with Neuronal Cell Death

(2014) Bernat Serra-Vidal et al.   ACS Chemical Biology

Capping of Aβ42 Oligomers by Small Molecule Inhibitors

(2014) Ziao Fu et al.   BIOCHEMISTRY

Mixed oligomers and monomeric amyloid-β disrupts endothelial cells integrity and reduces monomeric amyloid-β transport across hCMEC/D3 cell line as an in vitro blood–brain barrier model

(2014) Hisham Qosa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Differences between amyloid-β aggregation in solution and on the membrane: insights into elucidation of the mechanistic details of Alzheimer's disease

(2014) Samuel A. Kotler et al.   CHEMICAL SOCIETY REVIEWS

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides

(2014) Georg Meisl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interaction and reactivity of synthetic aminoisoflavones with metal-free and metal-associated amyloid-β

(2014) Alaina S. DeToma et al.   Chemical Science

A Micellar On-Pathway Intermediate Step Explains the Kinetics of Prion Amyloid Formation

(2014) Erwan Hingant et al.   PLoS Computational Biology

Parallel β-Sheet Fibril and Antiparallel β-Sheet Oligomer: New Insights into Amyloid Formation of Hen Egg White Lysozyme under Heat and Acidic Condition from FTIR Spectroscopy

(2013) Ye Zou et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Modulation of the stability of amyloidogenic precursors by anion binding strongly influences the rate of amyloid nucleation

(2013) David Ruzafa et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Study of aqueous phase aggregation of FTY720 (fingolimod hydrochloride) and its effect on DMPC liposomes using fluorescent molecular probes

(2013) Jitendriya Swain et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Mapping the structure of amyloid nucleation precursors by protein engineering kinetic analysis

(2013) David Ruzafa et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Insights into antiamyloidogenic properties of the green tea extract (-)-epigallocatechin-3-gallate toward metal-associated amyloid-  species

(2013) S.-J. Hyung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proliferation of amyloid- 42 aggregates occurs through a secondary nucleation mechanism

(2013) S. I. A. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toxic prefibrillar α-synuclein amyloid oligomers adopt a distinctive antiparallel β-sheet structure

(2012) María Soledad Celej et al.   BIOCHEMICAL JOURNAL

Conformational Differences between Two Amyloid β Oligomers of Similar Size and Dissimilar Toxicity

(2012) Ali Reza A. Ladiwala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Oligomers of Heterogeneous Size as Precursors of Amyloid Fibril Nucleation of an SH3 Domain: An Experimental Kinetics Study

(2012) David Ruzafa et al.   PLoS One

Amyloid-β forms fibrils by nucleated conformational conversion of oligomers

(2011) Jiyong Lee et al.   Nature Chemical Biology

Non-Esterified Fatty Acids Generate Distinct Low-Molecular Weight Amyloid-β (Aβ42) Oligomers along Pathway Different from Fibril Formation

(2011) Amit Kumar et al.   PLoS One

A standardized and biocompatible preparation of aggregate-free amyloid beta peptide for biophysical and biological studies of Alzheimer's disease

(2011) K. Broersen et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer’s disease

(2010) Erik Portelius et al.   ACTA NEUROPATHOLOGICA

Strategies to increase the reproducibility of protein fibrillization in plate reader assays

(2010) Lise Giehm et al.   ANALYTICAL BIOCHEMISTRY

Environmental Conditions Affect the Kinetics of Nucleation of Amyloid Fibrils and Determine Their Morphology

(2010) Bertrand Morel et al.   BIOPHYSICAL JOURNAL

Polymorphism in Alzheimer Aβ Amyloid Organization Reflects Conformational Selection in a Rugged Energy Landscape

(2010) Yifat Miller et al.   CHEMICAL REVIEWS

Aβ42 Neurotoxicity Is Mediated by Ongoing Nucleated Polymerization Process Rather than by Discrete Aβ42 Species

(2010) Asad Jan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Micelle-Like Architecture of the Monomer Ensemble of Alzheimer’s Amyloid-β Peptide in Aqueous Solution and Its Implications for Aβ Aggregation

(2010) Andreas Vitalis et al.   JOURNAL OF MOLECULAR BIOLOGY

In Vitro Formation of Amyloid from α-Synuclein Is Dominated by Reactions at Hydrophobic Interfaces

(2010) Jeremy Pronchik et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Preparation and characterization of toxic Aβ aggregates for structural and functional studies in Alzheimer's disease research

(2010) Asad Jan et al.   Nature Protocols

The secretases: enzymes with therapeutic potential in Alzheimer disease

(2010) Bart De Strooper et al.   Nature Reviews Neurology

Mechanism of amyloid plaque formation suggests an intracellular basis of A  pathogenicity

(2010) R. P. Friedrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid β-Protein Aggregation Produces Highly Reproducible Kinetic Data and Occurs by a Two-Phase Process

(2009) Erik Hellstrand et al.   ACS Chemical Neuroscience

Soluble state high resolution atomic force microscopy study of Alzheimer’s β-amyloid oligomers

(2009) Gajendra S. Shekhawat et al.   APPLIED PHYSICS LETTERS

Biophysical Analyses of Synthetic Amyloid-β(1−42) Aggregates before and after Covalent Cross-Linking. Implications for Deducing the Structure of Endogenous Amyloid-β Oligomers

(2009) Brenda D. Moore et al.   BIOCHEMISTRY

Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease

(2009) Summer L. Bernstein et al.   Nature Chemistry

Structure-neurotoxicity relationships of amyloid  -protein oligomers

(2009) K. Ono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide

(2009) X. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Analytical Solution to the Kinetics of Breakable Filament Assembly

(2009) T. P. J. Knowles et al.   SCIENCE