Alzheimer’s Disease: Challenges and a Therapeutic Opportunity to Treat It with a Neurotrophic Compound

Adult Hippocampal Neurogenesis in Alzheimer’s Disease: An Overview of Human and Animal Studies with Implications for Therapeutic Perspectives Aimed at Memory Recovery

(2022) Stefano Farioli-Vecchioli et al.   NEURAL PLASTICITY

Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson’s disease

(2022) Danna Jennings et al.   Science Translational Medicine

New approaches to symptomatic treatments for Alzheimer’s disease

(2021) Jeffrey Cummings   Molecular Neurodegeneration

Donanemab in Early Alzheimer’s Disease

(2021) Mark A. Mintun et al.   NEW ENGLAND JOURNAL OF MEDICINE

Adult hippocampal neurogenesis in aging and Alzheimer's disease

(2021) Kelsey R. Babcock et al.   Stem Cell Reports

Molecular mechanisms of altered adult hippocampal neurogenesis in Alzheimer's disease

(2021) Hang Liu et al.   MECHANISMS OF AGEING AND DEVELOPMENT

A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer’s disease with lecanemab, an anti-Aβ protofibril antibody

(2021) Chad J. Swanson et al.   Alzheimers Research & Therapy

Peptide based therapy for neurological disorders

(2021) Asmita Yadav et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Neurotrophic Treatment Initiated During Early Postnatal Development Prevents the Alzheimer-Like Behavior and Synaptic Dysfunction

(2021) Wei Wei et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer’s Disease: Innovative Therapeutic Approaches Based on Peptides and Nanoparticles

(2021) Isabela F. L. Mota et al.   NEUROSCIENTIST

Controversy and Progress in Alzheimer’s Disease — FDA Approval of Aducanumab

(2021) Gil D. Rabinovici   NEW ENGLAND JOURNAL OF MEDICINE

Interneuron Accumulation of Phosphorylated tau Impairs Adult Hippocampal Neurogenesis by Suppressing GABAergic Transmission

(2020) Jie Zheng et al.   Cell Stem Cell

Neuroinflammation and Neurogenesis in Alzheimer’s Disease and Potential Therapeutic Approaches

(2020) Pi-Shan Sung et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Circuit Integration Initiation of New Hippocampal Neurons in the Adult Brain

(2020) Chih-Hao Yang et al.   Cell Reports

Hippocampal Neurogenesis Is Enhanced in Adult Tau Deficient Mice

(2020) Marangelie Criado-Marrero et al.   Cells

Prenatal to early postnatal neurotrophic treatment prevents Alzheimer-like behavior and pathology in mice

(2020) Wei Wei et al.   Alzheimers Research & Therapy

Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease

(2019) Elena P. Moreno-Jiménez et al.   NATURE MEDICINE

Human Hippocampal Neurogenesis Persists in Aged Adults and Alzheimer’s Disease Patients

(2019) Matthew K. Tobin et al.   Cell Stem Cell

Targeting Apolipoprotein E for Alzheimer’s Disease: An Industry Perspective

(2019) Georgette L. Suidan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Insult-induced aberrant hippocampal neurogenesis: Functional consequences and possible therapeutic strategies

(2019) P. Bielefeld et al.   BEHAVIOURAL BRAIN RESEARCH

Inhibition of AMD-Like Pathology With a Neurotrophic Compound in Aged Rats and 3xTg-AD Mice

(2019) Yinghua Liu et al.   Frontiers in Aging Neuroscience

Therapeutic peptides: Historical perspectives, current development trends, and future directions

(2018) Jolene L. Lau et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A Novel Therapeutic Approach to Treat Alzheimer’s Disease by Neurotrophic Support During the Period of Synaptic Compensation

(2018) Narjes Baazaoui et al.   JOURNAL OF ALZHEIMERS DISEASE

Regional Comparison of the Neurogenic Effects of CNTF-Derived Peptides and Cerebrolysin in AβPP Transgenic Mice

(2018) Edward Rockenstein et al.   JOURNAL OF ALZHEIMERS DISEASE

Tau Isoform with Three Microtubule Binding Domains is a Marker of New Axons Generated from the Subgranular Zone in the Hippocampal Dentate Gyrus: Implications for Alzheimer's Disease

(2018) María Llorens-Martin et al.   JOURNAL OF ALZHEIMERS DISEASE

Clinical Symptoms and Symptom Signatures of Alzheimer's Disease Subgroups

(2018) Khalid Iqbal et al.   JOURNAL OF ALZHEIMERS DISEASE

Role of Ciliary Neurotrophic Factor in the Proliferation and Differentiation of Neural Stem Cells

(2018) Jun Ding et al.   JOURNAL OF ALZHEIMERS DISEASE

Hippocampal neurogenesis confers stress resilience by inhibiting the ventral dentate gyrus

(2018) Christoph Anacker et al.   NATURE

New approaches for the treatment of Alzheimer’s disease

(2018) Paul V. Fish et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Advances in developing novel therapeutic strategies for Alzheimer’s disease

(2018) Jiqing Cao et al.   Molecular Neurodegeneration

Impact of Neuroinflammation on Hippocampal Neurogenesis: Relevance to Aging and Alzheimer’s Disease

(2017) Jorge Valero et al.   JOURNAL OF ALZHEIMERS DISEASE

Synaptic Compensation as a Probable Cause of Prolonged Mild Cognitive Impairment in Alzheimer’s Disease: Implications from a Transgenic Mouse Model of the Disease

(2017) Narjes Baazaoui et al.   JOURNAL OF ALZHEIMERS DISEASE

Prevention of Amyloid-β and Tau Pathologies, Associated Neurodegeneration, and Cognitive Deficit by Early Treatment with a Neurotrophic Compound

(2017) Narjes Baazaoui et al.   JOURNAL OF ALZHEIMERS DISEASE

Depletion of adult neurogenesis exacerbates cognitive deficits in Alzheimer’s disease by compromising hippocampal inhibition

(2017) Carolyn Hollands et al.   Molecular Neurodegeneration

Tau-dependent suppression of adult neurogenesis in the stressed hippocampus

(2017) C Dioli et al.   MOLECULAR PSYCHIATRY

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer’s disease

(2017) David Baglietto-Vargas et al.   Scientific Reports

Prevention of dendritic and synaptic deficits and cognitive impairment with a neurotrophic compound

(2017) Narjes Baazaoui et al.   Alzheimers Research & Therapy

Best practice in the management of behavioural and psychological symptoms of dementia

(2017) Olivier Pierre Tible et al.   Therapeutic Advances in Neurological Disorders

Differential Changes in Synaptic Proteins in the Alzheimer Frontal Cortex with Marked Increase in PSD-95 Postsynaptic Protein

(2017) Geneviève Leuba et al.   JOURNAL OF ALZHEIMERS DISEASE

Beneficial Effect of a CNTF Tetrapeptide on Adult Hippocampal Neurogenesis, Neuronal Plasticity, and Spatial Memory in Mice

(2017) Julie Blanchard et al.   JOURNAL OF ALZHEIMERS DISEASE

IGF-1 mediated Neurogenesis Involves a Novel RIT1/Akt/Sox2 Cascade

(2017) Sajad Mir et al.   Scientific Reports

Early neurotrophic pharmacotherapy rescues developmental delay and Alzheimer’s-like memory deficits in the Ts65Dn mouse model of Down syndrome

(2017) Syed Faraz Kazim et al.   Scientific Reports

Effects of Citalopram on Neuropsychiatric Symptoms in Alzheimer’s Dementia: Evidence From the CitAD Study

(2016) Anne K. Leonpacher et al.   AMERICAN JOURNAL OF PSYCHIATRY

Chronic peripheral inflammation, hippocampal neurogenesis, and behavior

(2016) Vera Chesnokova et al.   BRAIN BEHAVIOR AND IMMUNITY

Neuropsychiatric Disturbances in Alzheimer's Disease: What Have We Learned from Neuropathological Studies?

(2016) Debby Van Dam et al.   Current Alzheimer Research

Pivotal role of glycogen synthase kinase-3: A therapeutic target for Alzheimer's disease

(2016) Mudasir Maqbool et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Designed Glycopeptidomimetics Disrupt Protein–Protein Interactions Mediating Amyloid β-Peptide Aggregation and Restore Neuroblastoma Cell Viability

(2016) Julia Kaffy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Neurotrophic factor small-molecule mimetics mediated neuroregeneration and synaptic repair: emerging therapeutic modality for Alzheimer’s disease

(2016) Syed Faraz Kazim et al.   Molecular Neurodegeneration

Tau-Centric Targets and Drugs in Clinical Development for the Treatment of Alzheimer’s Disease

(2016) Francesco Panza et al.   Biomed Research International

Effects of Microglia on Neurogenesis

(2015) Kaoru Sato   GLIA

Human tau expression reduces adult neurogenesis in a mouse model of tauopathy

(2015) Yutaro Komuro et al.   NEUROBIOLOGY OF AGING

Adult Neurogenesis in Humans

(2015) Olaf Bergmann et al.   Cold Spring Harbor Perspectives in Biology

Sera from Children with Autism Induce Autistic Features Which Can Be Rescued with a CNTF Small Peptide Mimetic in Rats

(2015) Syed Faraz Kazim et al.   PLoS One

Effect of Citalopram on Agitation in Alzheimer Disease

(2014) Anton P. Porsteinsson et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

β-Amyloid Fibrils in Alzheimer Disease Are Not Inert When Bound to Copper Ions but Can Degrade Hydrogen Peroxide and Generate Reactive Oxygen Species

(2014) Jennifer Mayes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Regulatory Mechanism of Neurogenesis by IGF-1 in Adult Mice

(2014) Honghua Yuan et al.   MOLECULAR NEUROBIOLOGY

Shifting balance from neurodegeneration to regeneration of the brain: a novel therapeutic approach to Alzheimer disease and related neurodegenerative conditions

(2014) Khalid Iqbal et al.   Neural Regeneration Research

Rescue of cognitive-aging by administration of a neurogenic and/or neurotrophic compound

(2014) Silvia Bolognin et al.   NEUROBIOLOGY OF AGING

Disease modifying effect of chronic oral treatment with a neurotrophic peptidergic compound in a triple transgenic mouse model of Alzheimer's disease

(2014) Syed Faraz Kazim et al.   NEUROBIOLOGY OF DISEASE

Hippocampal Neurogenesis Regulates Forgetting During Adulthood and Infancy

(2014) K. G. Akers et al.   SCIENCE

Chronic treatment with a CNTF-derived peptide reverses dendritic and synaptic plasticity deficits, cognitive impairment and tau pathology in an Alzheimer's disease mouse model

(2013) Syed Faraz Kazim et al.   Alzheimers & Dementia

Dynamics of Hippocampal Neurogenesis in Adult Humans

(2013) Kirsty L. Spalding et al.   CELL

Agitation and aggression in people with Alzheimerʼs disease

(2013) Clive Ballard et al.   CURRENT OPINION IN PSYCHIATRY

Role of Neuroinflammation in Adult Neurogenesis and Alzheimer Disease: Therapeutic Approaches

(2013) Almudena Fuster-Matanzo et al.   MEDIATORS OF INFLAMMATION

Alzheimer disease therapy—moving from amyloid-β to tau

(2013) Ezio Giacobini et al.   Nature Reviews Neurology

BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases

(2013) Bai Lu et al.   NATURE REVIEWS NEUROSCIENCE

Impact of N-tau on adult hippocampal neurogenesis, anxiety, and memory

(2013) Andrea Pristerà et al.   NEUROBIOLOGY OF AGING

Activated microglia enhance neurogenesis via trypsinogen secretion

(2013) A. M. Nikolakopoulou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proliferation of amyloid- 42 aggregates occurs through a secondary nucleation mechanism

(2013) S. I. A. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Are Tau Aggregates Toxic or Protective in Tauopathies?

(2013) Catherine M. Cowan et al.   Frontiers in Neurology

Glycogen Synthase Kinase 3 Inhibition Promotes Adult Hippocampal Neurogenesis in Vitro and in Vivo

(2012) Jose A. Morales-Garcia et al.   ACS Chemical Neuroscience

The Circadian System in Alzheimer’s Disease: Disturbances, Mechanisms, and Opportunities

(2012) Andrew N. Coogan et al.   BIOLOGICAL PSYCHIATRY

Young Dentate Granule Cells Mediate Pattern Separation, whereas Old Granule Cells Facilitate Pattern Completion

(2012) Toshiaki Nakashiba et al.   CELL

Depression and the risk for dementia

(2012) Lars Vedel Kessing   CURRENT OPINION IN PSYCHIATRY

Microglia and mast cells: two tracks on the road to neuroinflammation

(2012) Stephen D. Skaper et al.   FASEB JOURNAL

Alzheimer’s disease: An update of the roles of receptors, astrocytes and primary cilia (Review)

(2012) UBALDO ARMATO et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Paired Helical Filaments from Alzheimer Disease Brain Induce Intracellular Accumulation of Tau Protein in Aggresomes

(2012) Ismael Santa-Maria et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Innate immunity in the central nervous system

(2012) Richard M. Ransohoff et al.   JOURNAL OF CLINICAL INVESTIGATION

Neural progenitor cells regulate microglia functions and activity

(2012) Kira I Mosher et al.   NATURE NEUROSCIENCE

The many faces of insulin-like peptide signalling in the brain

(2012) Ana M. Fernandez et al.   NATURE REVIEWS NEUROSCIENCE

Immunological regulation of neurogenic niches in the adult brain

(2012) O. Gonzalez-Perez et al.   NEUROSCIENCE

An experimental rat model of sporadic Alzheimer’s disease and rescue of cognitive impairment with a neurotrophic peptide

(2011) Silvia Bolognin et al.   ACTA NEUROPATHOLOGICA

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

ApoE is required for maintenance of the dentate gyrus neural progenitor pool

(2011) C.-P. Yang et al.   DEVELOPMENT

Neurodegenerative disease and adult neurogenesis

(2011) Beate Winner et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Rescue of Synaptic Failure and Alleviation of Learning and Memory Impairments in a Trisomic Mouse Model of Down Syndrome

(2011) Julie Blanchard et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Adult hippocampal neurogenesis and its role in Alzheimer's disease

(2011) Yangling Mu et al.   Molecular Neurodegeneration

BDNF Promotes EGF-Induced Proliferation and Migration of Human Fetal Neural Stem/Progenitor Cells via the PI3K/Akt Pathway

(2011) Qi Zhang et al.   MOLECULES

Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation

(2011) Amar Sahay et al.   NATURE

Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting Aβ and tau pathologies in 3xTg-AD mice

(2010) Julie Blanchard et al.   ACTA NEUROPATHOLOGICA

Nonmotor manifestations of Parkinson's disease

(2010) Tanya Simuni et al.   ANNALS OF NEUROLOGY

Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis

(2010) Amanda Sierra et al.   Cell Stem Cell

Neurotrophic peptides incorporating adamantane improve learning and memory, promote neurogenesis and synaptic plasticity in mice

(2010) Bin Li et al.   FEBS LETTERS

Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents

(2010) Stephen M. Massa et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of neuroinflammation on the regenerative capacity of brain stem cells

(2010) Isabella Russo et al.   JOURNAL OF NEUROCHEMISTRY

Increased BMP6 Levels in the Brains of Alzheimer's Disease Patients and APP Transgenic Mice Are Accompanied by Impaired Neurogenesis

(2010) L. Crews et al.   JOURNAL OF NEUROSCIENCE

Young hippocampal neurons are critical for recent and remote spatial memory in adult mice

(2010) T. Goodman et al.   NEUROSCIENCE

When neurogenesis encounters aging and disease

(2010) Orly Lazarov et al.   TRENDS IN NEUROSCIENCES

Synaptic degeneration in Alzheimer’s disease

(2009) Thomas Arendt   ACTA NEUROPATHOLOGICA

Mild Cognitive Impairment

(2009) Ronald C. Petersen et al.   ARCHIVES OF NEUROLOGY

Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease

(2009) Binggui Sun et al.   Cell Stem Cell

GABAergic Interneuron Dysfunction Impairs Hippocampal Neurogenesis in Adult Apolipoprotein E4 Knockin Mice

(2009) Gang Li et al.   Cell Stem Cell

Neurogenesis and Alzheimer's disease: At the crossroads

(2009) Orly Lazarov et al.   EXPERIMENTAL NEUROLOGY

VEGFR-1 Regulates Adult Olfactory Bulb Neurogenesis and Migration of Neural Progenitors in the Rostral Migratory Stream In Vivo

(2009) I. M. Wittko et al.   JOURNAL OF NEUROSCIENCE

Primate-specific alterations in neural stem/progenitor cells in the aged hippocampus

(2009) Ken Aizawa et al.   NEUROBIOLOGY OF AGING

Enhancement of dentate gyrus neurogenesis, dendritic and synaptic plasticity and memory by a neurotrophic peptide

(2009) Muhammad Omar Chohan et al.   NEUROBIOLOGY OF AGING

A novel GSK-3β inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo

(2009) L. Serenó et al.   NEUROBIOLOGY OF DISEASE

Huntingtin as an essential integrator of intracellular vesicular trafficking

(2009) Juliane P. Caviston et al.   TRENDS IN CELL BIOLOGY

Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3)

(2009) Eléonore Beurel et al.   TRENDS IN IMMUNOLOGY

Developing drugs that can cross the blood-brain barrier: applications to Alzheimer's disease

(2008) William A Banks   BMC NEUROSCIENCE

Tumor Necrosis Factor α Inhibits Oxidative Phosphorylation through Tyrosine Phosphorylation at Subunit I of CytochromecOxidase

(2008) Lobelia Samavati et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Failure of Neuronal Maturation in Alzheimer Disease Dentate Gyrus

(2008) Bin Li et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Ciliary Neurotrophic Factor Mediates Dopamine D2 Receptor-Induced CNS Neurogenesis in Adult Mice

(2008) P. Yang et al.   JOURNAL OF NEUROSCIENCE

Interleukin-6 Mediates the Increase in NADPH-Oxidase in the Ketamine Model of Schizophrenia

(2008) M. M. Behrens et al.   JOURNAL OF NEUROSCIENCE

Dendritic Spine Loss and Synaptic Alterations in Alzheimer’s Disease

(2008) Marlen Knobloch et al.   MOLECULAR NEUROBIOLOGY

Postsynaptic density protein PSD-95 expression in Alzheimer's disease and okadaic acid induced neuritic retraction

(2008) Geneviève Leuba et al.   NEUROBIOLOGY OF DISEASE

Point and 5-year period prevalence of neuropsychiatric symptoms in dementia: the Cache County Study

(2007) Martin Steinberg et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY