The role of efferocytosis‐fueled macrophage metabolism in the resolution of inflammation

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Lactate as a Myokine and Exerkine: Drivers and Signals of Physiology and Metabolism

(2023) George A. Brooks et al.   JOURNAL OF APPLIED PHYSIOLOGY

Remodeling articular immune homeostasis with an efferocytosis-informed nanoimitator mitigates rheumatoid arthritis in mice

(2023) Shengchang Zhang et al.   Nature Communications

PFKFB2-mediated glycolysis promotes lactate-driven continual efferocytosis by macrophages

(2023) Maaike Schilperoort et al.   Nature Metabolism

Moderate L-lactate administration suppresses adipose tissue macrophage M1 polarization to alleviate obesity-associated insulin resistance

(2022) Hao Cai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polyamine import and accumulation causes immunomodulation in macrophages engulfing apoptotic cells

(2022) Alexandra L. McCubbrey et al.   Cell Reports

Pentose Phosphate Pathway Regulates Tolerogenic Apoptotic Cell Clearance and Immune Tolerance

(2022) Dan He et al.   Frontiers in Immunology

Role of indoleamine 2,3-dioxygenase 1 (IDO1) and kynurenine pathway in the regulation of the aging process

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Enriched Marine Oil Supplement Increases Specific Plasma Specialized Pro-Resolving Mediators in Adults with Obesity

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Drugging the efferocytosis process: concepts and opportunities

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An exercise-inducible metabolite that suppresses feeding and obesity

(2022) Veronica L. Li et al.   NATURE

The potential mechanisms of lactate in mediating exercise-enhanced cognitive function: a dual role as an energy supply substrate and a signaling molecule

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Chimeric efferocytic receptors improve apoptotic cell clearance and alleviate inflammation

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Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments

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Senescent cells suppress macrophage-mediated corpse removal via upregulation of the CD47-QPCT/L axis

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CD47-SIRPα axis blockade in NASH promotes necroptotic hepatocyte clearance by liver macrophages and decreases hepatic fibrosis

(2022) Hongxue Shi et al.   Science Translational Medicine

Effect of CD47 Blockade on Vascular Inflammation

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Macrophage Dicer promotes tolerogenic apoptotic cell clearance and immune tolerance by inhibiting pentose phosphate pathway activity

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Putting the brakes on phagocytosis: “don't‐eat‐me” signaling in physiology and disease

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Lactate-Dependent Regulation of Immune Responses by Dendritic Cells and Macrophages

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Efferocytosis induces macrophage proliferation to help resolve tissue injury

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Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis

(2021) Wei Chen et al.   Nature Reviews Cardiology

Mesenchymal stromal cell apoptosis is required for their therapeutic function

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Lactate supports a metabolic-epigenetic link in macrophage polarization

(2021) Jordan T. Noe et al.   Science Advances

Efferocytosis during Skeletal Muscle Regeneration

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Oleoylethanolamide stabilizes atherosclerotic plaque through regulating macrophage polarization via AMPK-PPARα pathway

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Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury

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Metabolites released from apoptotic cells act as tissue messengers

(2020) Christopher B. Medina et al.   NATURE

Blocking elevated p38 MAPK restores efferocytosis and inflammatory resolution in the elderly

(2020) Roel P. H. De Maeyer et al.   NATURE IMMUNOLOGY

Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Macrophage Polarization

(2020) Jing Zhang et al.   Cell Metabolism

Amino Assets: How Amino Acids Support Immunity

(2020) Beth Kelly et al.   Cell Metabolism

siRNA nanoparticles targeting CaMKIIγ in lesional macrophages improve atherosclerotic plaque stability in mice

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Apoptotic cell therapy for cytokine storm associated with acute severe sepsis

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Treatment With a Marine Oil Supplement Alters Lipid Mediators and Leukocyte Phenotype in Healthy Patients and Those With Peripheral Artery Disease

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CircFLNA Acts as a Sponge of miR-646 to Facilitate the Proliferation, Metastasis, Glycolysis, and Apoptosis Inhibition of Gastric Cancer by Targeting PFKFB2

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(2019) Magnus Bäck et al.   Nature Reviews Cardiology

Serine Metabolism Supports Macrophage IL-1β Production

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Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation

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Living on the Edge: Efferocytosis at the Interface of Homeostasis and Pathology

(2019) Sho Morioka et al.   IMMUNITY

Bhlhe40 mediates tissue-specific control of macrophage proliferation in homeostasis and type 2 immunity

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Lactate Stimulates a Potential for Hypertrophy and Regeneration of Mouse Skeletal Muscle

(2019) Ohno et al.   Nutrients

Human and murine macrophages exhibit differential metabolic responses to lipopolysaccharide - A divergent role for glycolysis

(2019) Vijith Vijayan et al.   Redox Biology

Resolvin D1 promotes the targeting and clearance of necroptotic cells

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CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy

(2019) Amira A. Barkal et al.   NATURE

The Metabolic Signature of Macrophage Responses

(2019) Antonella Viola et al.   Frontiers in Immunology

One-Carbon Metabolism Supports S-Adenosylmethionine and Histone Methylation to Drive Inflammatory Macrophages

(2019) Weiwei Yu et al.   MOLECULAR CELL

Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain

(2019) Magdalena Miranda et al.   Frontiers in Cellular Neuroscience

Lactate and pyruvate promote oxidative stress resistance through hormetic ROS signaling

(2019) Arnaud Tauffenberger et al.   Cell Death & Disease

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Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction

(2019) Jean-Claude Tardif et al.   NEW ENGLAND JOURNAL OF MEDICINE

Enriched Marine Oil Supplements Increase Peripheral Blood Specialized Pro-Resolving Mediators Concentrations and Reprogram Host Immune Responses

(2019) Patricia R. Souza et al.   CIRCULATION RESEARCH

Interpreting an apoptotic corpse as anti-inflammatory involves a chloride sensing pathway

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The challenges and promise of targeting the Liver X Receptors for treatment of inflammatory disease

(2018) Michael B. Fessler   PHARMACOLOGY & THERAPEUTICS

HIF1α-dependent glycolysis promotes macrophage functional activities in protecting against bacterial and fungal infection

(2018) Chunxiao Li et al.   Scientific Reports

Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers

(2018) Michael P. Murphy et al.   CELL

Exercise-induced muscle damage: What is it, what causes it and what are the nutritional solutions?

(2018) Daniel J. Owens et al.   European Journal of Sport Science

Anti-TNF Therapy in Crohn’s Disease

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Dietary DHA amplifies LXA4 circuits in tissues and lymph node PMN and is protective in immune-driven dry eye disease

(2018) Yuan Gao et al.   Mucosal Immunology

MerTK signaling in macrophages promotes the synthesis of inflammation resolution mediators by suppressing CaMKII activity

(2018) Bishuang Cai et al.   Science Signaling

Palmitoylethanolamide Promotes a Proresolving Macrophage Phenotype and Attenuates Atherosclerotic Plaque Formation

(2018) Petteri Rinne et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair

(2018) Shuang Zhang et al.   Cell Metabolism

Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release

(2018) Sho Morioka et al.   NATURE

Identification of specialized pro-resolving mediator clusters from healthy adults after intravenous low-dose endotoxin and omega-3 supplementation: a methodological validation

(2018) Paul C. Norris et al.   Scientific Reports

In vitro and in vivo Effects of Lactate on Metabolism and Cytokine Production of Human Primary PBMCs and Monocytes

(2018) Jacqueline M. Ratter et al.   Frontiers in Immunology

CAMKIIγ suppresses an efferocytosis pathway in macrophages and promotes atherosclerotic plaque necrosis

(2017) Amanda C. Doran et al.   JOURNAL OF CLINICAL INVESTIGATION

Higher phagocytic activity of thioglycollate-elicited peritoneal macrophages is related to metabolic status of the cells

(2017) Sofia Pavlou et al.   Journal of Inflammation-London

HIF1α-Induced Glycolysis Metabolism Is Essential to the Activation of Inflammatory Macrophages

(2017) Ting Wang et al.   MEDIATORS OF INFLAMMATION

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity

(2017) Sydney R. Gordon et al.   NATURE

Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease

(2017) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells

(2017) Lidia Bosurgi et al.   SCIENCE

Macrophage Immunometabolism: Where Are We (Going)?

(2017) Jan Van den Bossche et al.   TRENDS IN IMMUNOLOGY

Peritoneal tissue-resident macrophages are metabolically poised to engage microbes using tissue-niche fuels

(2017) Luke C. Davies et al.   Nature Communications

Targeted Nanotherapeutics Encapsulating Liver X Receptor Agonist GW3965 Enhance Antiatherogenic Effects without Adverse Effects on Hepatic Lipid Metabolism in Ldlr−/− Mice

(2017) Mikyung Yu et al.   Advanced Healthcare Materials

SIRT1/Adenosine Monophosphate-Activated Protein Kinase α Signaling Enhances Macrophage Polarization to an Anti-inflammatory Phenotype in Rheumatoid Arthritis

(2017) So Youn Park et al.   Frontiers in Immunology

Pro-Resolving Mediators in Regulating and Conferring Macrophage Function

(2017) Jesmond Dalli et al.   Frontiers in Immunology

Targeted Interleukin-10 Nanotherapeutics Developed with a Microfluidic Chip Enhance Resolution of Inflammation in Advanced Atherosclerosis

(2016) Nazila Kamaly et al.   ACS Nano

Hypoxia-Inducible Factor-1α Expression in Macrophages Promotes Development of AtherosclerosisHighlights

(2016) Annemarie Aarup et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Omega-3 fatty acid supplementation influences the whole blood transcriptome in women with obesity, associated with pro-resolving lipid mediator production

(2016) Anna Polus et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease and cancer

(2016) R B Birge et al.   CELL DEATH AND DIFFERENTIATION

Macrophage Apoptosis and Efferocytosis in the Pathogenesis of Atherosclerosis

(2016) MacRae F. Linton et al.   CIRCULATION JOURNAL

The Dynamics of Apoptotic Cell Clearance

(2016) Michael R. Elliott et al.   DEVELOPMENTAL CELL

Specialized proresolving lipid mediators in patients with coronary artery disease and their potential for clot remodeling

(2016) Tarec K. Elajami et al.   FASEB JOURNAL

Erythropoeitin Signaling in Macrophages Promotes Dying Cell Clearance and Immune Tolerance

(2016) Bangwei Luo et al.   IMMUNITY

Effect of Evolocumab on Progression of Coronary Disease in Statin-Treated Patients

(2016) Stephen J. Nicholls et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis

(2016) Yoko Kojima et al.   NATURE

Cardioprotection and lifespan extension by the natural polyamine spermidine

(2016) Tobias Eisenberg et al.   NATURE MEDICINE

MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation

(2016) Bishuang Cai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Xkr8 phospholipid scrambling complex in apoptotic phosphatidylserine exposure

(2016) Jun Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques

(2016) Gabrielle Fredman et al.   Nature Communications

Bone marrow-derived and peritoneal macrophages have different inflammatory response to oxLDL and M1/M2 marker expression – implications for atherosclerosis research

(2016) Line S. Bisgaard et al.   Scientific Reports

Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages

(2016) Jan Van den Bossche et al.   Cell Reports

Resolvin E1 (RvE1) Attenuates Atherosclerotic Plaque Formation in Diet and Inflammation-Induced Atherogenesis

(2015) H. Hasturk et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

MicroRNA-34a Negatively Regulates Efferocytosis by Tissue Macrophages in Part via SIRT1

(2015) Alexandra L. McCubbrey et al.   JOURNAL OF IMMUNOLOGY

Phagocytosis of apoptotic cells in homeostasis

(2015) Sanja Arandjelovic et al.   NATURE IMMUNOLOGY

The amino acid sensor GCN2 inhibits inflammatory responses to apoptotic cells promoting tolerance and suppressing systemic autoimmunity

(2015) Buvana Ravishankar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice

(2015) Gabrielle Fredman et al.   Science Translational Medicine

Reversal of Hypoxia in Murine Atherosclerosis Prevents Necrotic Core Expansion by Enhancing Efferocytosis

(2014) Elke Marsch et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Fatty acid oxidation is dispensable for human macrophage IL-4-induced polarization

(2014) Dmitry Namgaladze et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The return of metabolism: biochemistry and physiology of the pentose phosphate pathway

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Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities

(2014) David Gosselin et al.   CELL

Adenosine 5'-Monophosphate-Activated Protein Kinase Promotes Macrophage Polarization to an Anti-Inflammatory Functional Phenotype

(2014) D. Sag et al.   JOURNAL OF IMMUNOLOGY

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages

(2014) Stanley Ching-Cheng Huang et al.   NATURE IMMUNOLOGY

Extracellular ATP drives systemic inflammation, tissue damage and mortality

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“Of Mice and Men”: Arginine Metabolism in Macrophages

(2014) Anita C. Thomas et al.   Frontiers in Immunology

Impaired Clearance of Apoptotic Cells in Chronic Inflammatory Diseases: Therapeutic Implications

(2014) Zsuzsa Szondy et al.   Frontiers in Immunology

Lipopolysaccharide downregulates CD91/low-density lipoprotein receptor-related protein 1 expression through SREBP-1 overexpression in human macrophages

(2013) P. Costales et al.   ATHEROSCLEROSIS

D-series resolvin attenuates vascular smooth muscle cell activation and neointimal hyperplasia following vascular injury

(2013) Takuya Miyahara et al.   FASEB JOURNAL

Mitochondria and AMP-activated Protein Kinase-dependent Mechanism of Efferocytosis

(2013) Shaoning Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microenvironments in Tuberculous Granulomas Are Delineated by Distinct Populations of Macrophage Subsets and Expression of Nitric Oxide Synthase and Arginase Isoforms

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Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Local proliferation dominates lesional macrophage accumulation in atherosclerosis

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Anti-Inflammatory Therapy in Chronic Disease: Challenges and Opportunities

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Xk-Related Protein 8 and CED-8 Promote Phosphatidylserine Exposure in Apoptotic Cells

(2013) J. Suzuki et al.   SCIENCE

Clearing the Dead: Apoptotic Cell Sensing, Recognition, Engulfment, and Digestion

(2013) A. Hochreiter-Hufford et al.   Cold Spring Harbor Perspectives in Biology

Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators

(2012) J. Dalli et al.   BLOOD

The Sedoheptulose Kinase CARKL Directs Macrophage Polarization through Control of Glucose Metabolism

(2012) Arvand Haschemi et al.   Cell Metabolism

New Evidence of Neuroprotection by Lactate after Transient Focal Cerebral Ischaemia: Extended Benefit after Intracerebroventricular Injection and Efficacy of Intravenous Administration

(2012) Carole Berthet et al.   CEREBROVASCULAR DISEASES

Resolvins D1, D2, and Other Mediators of Self-Limited Resolution of Inflammation in Human Blood following n-3 Fatty Acid Supplementation

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The CD47–SIRPα pathway in cancer immune evasion and potential therapeutic implications

(2012) Mark P Chao et al.   CURRENT OPINION IN IMMUNOLOGY

12/15-Lipoxygenase Orchestrates the Clearance of Apoptotic Cells and Maintains Immunologic Tolerance

(2012) Stefan Uderhardt et al.   IMMUNITY

Apoptotic cell clearance by bronchial epithelial cells critically influences airway inflammation

(2012) Ignacio J. Juncadella et al.   NATURE

Tolerance to apoptotic cells is regulated by indoleamine 2,3-dioxygenase

(2012) B. Ravishankar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LXRα Regulates Macrophage Arginase 1 Through PU.1 and Interferon Regulatory Factor 8

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Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein

(2011) Daeho Park et al.   NATURE

Impaired Phagocytosis in Localized Aggressive Periodontitis: Rescue by Resolvin E1

(2011) Gabrielle Fredman et al.   PLoS One

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

(2011) S. J. Jenkins et al.   SCIENCE

Saturated-efferocytosis generates pro-resolving CD11blow macrophages: Modulation by resolvins and glucocorticoids

(2010) Sagie Schif-Zuck et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Two single nucleotide polymorphisms in ALOX15 are associated with risk of coronary artery disease in a Chinese Han population

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CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells

(2009) Ravindra Majeti et al.   CELL

Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR

(2009) Noelia A-Gonzalez et al.   IMMUNITY

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis

(2008) L. A. Truman et al.   BLOOD

15-Lipoxygenase gene variants are associated with carotid plaque but not carotid intima-media thickness

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A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease

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