Putting the brakes on phagocytosis: “don't‐eat‐me” signaling in physiology and disease
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Putting the brakes on phagocytosis: “don't‐eat‐me” signaling in physiology and disease
Authors
Keywords
-
Journal
EMBO REPORTS
Volume 22, Issue 6, Pages -
Publisher
EMBO
Online
2021-05-27
DOI
10.15252/embr.202152564
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Effect of CD47 Blockade on Vascular Inflammation
- (2021) Kai-Uwe Jarr et al. NEW ENGLAND JOURNAL OF MEDICINE
- Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury
- (2020) Arif Yurdagul et al. Cell Metabolism
- Macrophages show higher levels of engulfment after disruption of cis interactions between CD47 and the checkpoint receptor SIRPα
- (2020) Brandon H. Hayes et al. JOURNAL OF CELL SCIENCE
- Molecular mechanism of SHP2 activation by PD-1 stimulation
- (2020) M. Marasco et al. Science Advances
- Metabolites released from apoptotic cells act as tissue messengers
- (2020) Christopher B. Medina et al. NATURE
- Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis
- (2020) Antoine Roquilly et al. NATURE IMMUNOLOGY
- CD47 Ligation Repositions the Inhibitory Receptor SIRPA to Suppress Integrin Activation and Phagocytosis
- (2020) Meghan A. Morrissey et al. IMMUNITY
- Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade
- (2020) Ying Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Upregulation of CD47 Is a Host Checkpoint Response to Pathogen Recognition
- (2020) Michal Caspi Tal et al. mBio
- Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity
- (2020) Lu Cui et al. Nature Communications
- Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity
- (2020) Darienne R. Myers et al. Frontiers in Immunology
- Revisiting the PD-1 pathway
- (2020) Nikolaos Patsoukis et al. Science Advances
- LncRNA MIAT sponges miR-149-5p to inhibit efferocytosis in advanced atherosclerosis through CD47 upregulation
- (2019) Zi-ming Ye et al. Cell Death & Disease
- First-in-Human, First-in-Class Phase I Trial of the Anti-CD47 Antibody Hu5F9-G4 in Patients With Advanced Cancers
- (2019) Branimir I. Sikic et al. JOURNAL OF CLINICAL ONCOLOGY
- Signaling Regulatory Protein (SIRP)α-CD47 Blockade Joins the Ranks of Immune Checkpoint Inhibition
- (2019) André Veillette et al. JOURNAL OF CLINICAL ONCOLOGY
- Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association
- (2019) Emelia J. Benjamin et al. CIRCULATION
- Living on the Edge: Efferocytosis at the Interface of Homeostasis and Pathology
- (2019) Sho Morioka et al. IMMUNITY
- CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
- (2019) John V. Pluvinage et al. NATURE
- Resolvin D1 promotes the targeting and clearance of necroptotic cells
- (2019) Brennan D. Gerlach et al. CELL DEATH AND DIFFERENTIATION
- CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy
- (2019) Amira A. Barkal et al. NATURE
- TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer’s Disease
- (2019) Ana Griciuc et al. NEURON
- Increased lymphocyte activation and atherosclerosis in CD47-deficient mice
- (2019) Daniel Engelbertsen et al. Scientific Reports
- Phosphatidylserine on viable sperm and phagocytic machinery in oocytes regulate mammalian fertilization
- (2019) Claudia M. Rival et al. Nature Communications
- SHP-2 in Lymphocytes' Cytokine and Inhibitory Receptor Signaling
- (2019) Charlène Niogret et al. Frontiers in Immunology
- Interpreting an apoptotic corpse as anti-inflammatory involves a chloride sensing pathway
- (2019) Justin S. A. Perry et al. NATURE CELL BIOLOGY
- Moesin and myosin IIA modulate phagolysosomal biogenesis in macrophages
- (2018) Carolina P. Gomez et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Transmembrane Pickets Connect Cyto- and Pericellular Skeletons Forming Barriers to Receptor Engagement
- (2018) Spencer A. Freeman et al. CELL
- Origin and specialization of splenic macrophages
- (2018) Noelia A-Gonzalez et al. CELLULAR IMMUNOLOGY
- Shp-2 Is Dispensable for Establishing T Cell Exhaustion and for PD-1 Signaling In Vivo
- (2018) Giorgia Rota et al. Cell Reports
- Clearance of Apoptotic Cells by Tissue Epithelia: A Putative Role for Hepatocytes in Liver Efferocytosis
- (2018) Scott P. Davies et al. Frontiers in Immunology
- Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release
- (2018) Sho Morioka et al. NATURE
- CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development
- (2018) Emily K. Lehrman et al. NEURON
- CD47 Blockade by Hu5F9-G4 and Rituximab in Non-Hodgkin’s Lymphoma
- (2018) Ranjana Advani et al. NEW ENGLAND JOURNAL OF MEDICINE
- Membrane nanoclusters of FcγRI segregate from inhibitory SIRPα upon activation of human macrophages
- (2017) Filipa B. Lopes et al. JOURNAL OF CELL BIOLOGY
- Shp1 function in myeloid cells
- (2017) Clare L. Abram et al. JOURNAL OF LEUKOCYTE BIOLOGY
- PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity
- (2017) Sydney R. Gordon et al. NATURE
- Unifying mechanism for different fibrotic diseases
- (2017) Gerlinde Wernig et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer
- (2017) Paola A. Betancur et al. Nature Communications
- BRAF/MEK inhibitors promote CD47 expression that is reversible by ERK inhibition in melanoma
- (2017) Fen Liu et al. Oncotarget
- Context-dependent compensation among phosphatidylserine-recognition receptors
- (2017) Kristen K. Penberthy et al. Scientific Reports
- Enhanced efferocytosis by dendritic cells underlies memory T-cell expansion and susceptibility to autoimmune disease in CD300f-deficient mice
- (2016) L Tian et al. CELL DEATH AND DIFFERENTIATION
- The Dynamics of Apoptotic Cell Clearance
- (2016) Michael R. Elliott et al. DEVELOPMENTAL CELL
- ‘This way please’: Apoptotic cells regulate phagocyte migration before and after engulfment
- (2016) Amiram Ariel et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Maxed out macs: physiologic cell clearance as a function of macrophage phagocytic capacity
- (2016) Clive S. Zent et al. FEBS Journal
- Boosting Apoptotic Cell Clearance by Colonic Epithelial Cells Attenuates Inflammation In Vivo
- (2016) Chang Sup Lee et al. IMMUNITY
- Cardiac myofibroblast engulfment of dead cells facilitates recovery after myocardial infarction
- (2016) Michio Nakaya et al. JOURNAL OF CLINICAL INVESTIGATION
- CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer
- (2016) Kipp Weiskopf et al. JOURNAL OF CLINICAL INVESTIGATION
- CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis
- (2016) Yoko Kojima et al. NATURE
- The lectin Siglec-G inhibits dendritic cell cross-presentation by impairing MHC class I–peptide complex formation
- (2016) Yuanyuan Ding et al. NATURE IMMUNOLOGY
- MYC regulates the antitumor immune response through CD47 and PD-L1
- (2016) S. C. Casey et al. SCIENCE
- Attenuation of the programmed cell death-1 pathway increases the M1 polarization of macrophages induced by zymosan
- (2016) W Chen et al. Cell Death & Disease
- PD-1/PD-L pathway inhibits M.tb-specific CD4+ T-cell functions and phagocytosis of macrophages in active tuberculosis
- (2016) Lei Shen et al. Scientific Reports
- PD-1 Blunts the Function of Ovarian Tumor–Infiltrating Dendritic Cells by Inactivating NF-κB
- (2015) Lavakumar Karyampudi et al. CANCER RESEARCH
- Of ITIMs, ITAMs, and ITAMis: revisiting immunoglobulin Fc receptor signaling
- (2015) Andrew Getahun et al. IMMUNOLOGICAL REVIEWS
- Loss of Cell Surface CD47 Clustering Formation and Binding Avidity to SIRPα Facilitate Apoptotic Cell Clearance by Macrophages
- (2015) Zhiyuan Lv et al. JOURNAL OF IMMUNOLOGY
- NF-κB Regulates PD-1 Expression in Macrophages
- (2015) Alexander P. R. Bally et al. JOURNAL OF IMMUNOLOGY
- Phagocytosis of apoptotic cells in homeostasis
- (2015) Sanja Arandjelovic et al. NATURE IMMUNOLOGY
- HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells
- (2015) Huimin Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Hitchhiker’s Guide to Myeloid Cell Subsets: Practical Implementation of a Novel Mononuclear Phagocyte Classification System
- (2015) Martin Guilliams et al. Frontiers in Immunology
- Polymorphism in the Innate Immune Receptor SIRPα Controls CD47 Binding and Autoimmunity in the Nonobese Diabetic Mouse
- (2014) Andrea Sut Ling Wong et al. JOURNAL OF IMMUNOLOGY
- Myeloid-Specific Disruption of Tyrosine Phosphatase Shp2 Promotes Alternative Activation of Macrophages and Predisposes Mice to Pulmonary Fibrosis
- (2014) Bo Tao et al. JOURNAL OF IMMUNOLOGY
- p85α recruitment by the CD300f phosphatidylserine receptor mediates apoptotic cell clearance required for autoimmunity suppression
- (2014) Linjie Tian et al. Nature Communications
- The Interaction Between Signal Regulatory Protein Alpha (SIRPα) and CD47: Structure, Function, and Therapeutic Target
- (2013) A. Neil Barclay et al. Annual Review of Immunology
- The CD300 molecules: an emerging family of regulators of the immune system
- (2013) F. Borrego BLOOD
- Induction of Siglec-G by RNA Viruses Inhibits the Innate Immune Response by Promoting RIG-I Degradation
- (2013) Weilin Chen et al. CELL
- Enhanced Efferocytosis of Apoptotic Cardiomyocytes Through Myeloid-Epithelial-Reproductive Tyrosine Kinase Links Acute Inflammation Resolution to Cardiac Repair After Infarction
- (2013) Elaine Wan et al. CIRCULATION RESEARCH
- Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion
- (2013) Amelia E. Hochreiter-Hufford et al. NATURE
- A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application
- (2013) Taku Okazaki et al. NATURE IMMUNOLOGY
- Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta
- (2013) Ana Griciuc et al. NEURON
- Siglecs and Immune Regulation
- (2012) Shiv Pillai et al. Annual Review of Immunology
- Human CD300a binds to phosphatidylethanolamine and phosphatidylserine, and modulates the phagocytosis of dead cells
- (2012) V. R. Simhadri et al. BLOOD
- Engulfment of hematopoietic stem cells caused by down-regulation of CD47 is critical in the pathogenesis of hemophagocytic lymphohistiocytosis
- (2012) T. Kuriyama et al. BLOOD
- CD47 functions as a molecular switch for erythrocyte phagocytosis
- (2012) P. Burger et al. BLOOD
- Regulation of the Inflammatory Response in Cardiac Repair
- (2012) Nikolaos G. Frangogiannis CIRCULATION RESEARCH
- Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor
- (2012) Chigusa Nakahashi-Oda et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Increased Susceptibility to Salmonella Infection in Signal Regulatory Protein -Deficient Mice
- (2012) L.-X. Li et al. JOURNAL OF IMMUNOLOGY
- Apoptotic cell clearance by bronchial epithelial cells critically influences airway inflammation
- (2012) Ignacio J. Juncadella et al. NATURE
- Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
- (2012) Dorothy P. Schafer et al. NEURON
- The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors
- (2012) S. B. Willingham et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
- (2012) C. Schulz et al. SCIENCE
- Identification of phosphatidylserine as a ligand for the CD300a immunoreceptor
- (2011) Chigusa Nakahashi-Oda et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The CD47 pathway is deregulated in human immune thrombocytopenia
- (2011) Lucia Catani et al. EXPERIMENTAL HEMATOLOGY
- CD300a and CD300f differentially regulate the MyD88 and TRIF-mediated TLR signalling pathways through activation of SHP-1 and/or SHP-2 in human monocytic cell lines
- (2011) Eun-Ju Kim et al. IMMUNOLOGY
- An essential role for the association of CD47 to SHPS-1 in skeletal remodeling
- (2011) Laura A Maile et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Cutting Edge: Mouse CD300f (CMRF-35-Like Molecule-1) Recognizes Outer Membrane-Exposed Phosphatidylserine and Can Promote Phagocytosis
- (2011) S.-C. Choi et al. JOURNAL OF IMMUNOLOGY
- Signal Regulatory Protein Regulates the Homeostasis of T Lymphocytes in the Spleen
- (2011) M. Sato-Hashimoto et al. JOURNAL OF IMMUNOLOGY
- Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction
- (2011) Guo-Yun Chen et al. NATURE BIOTECHNOLOGY
- Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
- (2011) Adam C Naj et al. NATURE GENETICS
- Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
- (2011) Paul Hollingworth et al. NATURE GENETICS
- Functional CD47/signal regulatory protein alpha (SIRPα) interaction is required for optimal human T- and natural killer- (NK) cell homeostasis in vivo
- (2011) Nicolas Legrand et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulation by SIRP of dendritic cell homeostasis in lymphoid tissues
- (2010) Y. Saito et al. BLOOD
- CD47 promotes both phosphatidylserine-independent and phosphatidylserine-dependent phagocytosis of apoptotic murine thymocytes by non-activated macrophages
- (2009) Anna Nilsson et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis
- (2009) Siddhartha Jaiswal et al. CELL
- CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells
- (2009) Ravindra Majeti et al. CELL
- SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels
- (2009) Ulrike Lorenz IMMUNOLOGICAL REVIEWS
- Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
- (2009) Michael R. Elliott et al. NATURE
- PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis
- (2009) X. Huang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CD24 and Siglec-10 Selectively Repress Tissue Damage-Induced Immune Responses
- (2009) G.-Y. Chen et al. SCIENCE
- Functions and molecular mechanisms of the CD47–SIRPα signalling pathway
- (2009) Takashi Matozaki et al. TRENDS IN CELL BIOLOGY
- Surfactant Proteins A and D Suppress Alveolar Macrophage Phagocytosis via Interaction with SIRPα
- (2008) William J. Janssen et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Immunoreceptor tyrosine-based inhibition motifs: a quest in the past and future
- (2008) Marc Daëron et al. IMMUNOLOGICAL REVIEWS
- Inhibition of “self” engulfment through deactivation of myosin-II at the phagocytic synapse between human cells
- (2008) Richard K. Tsai et al. JOURNAL OF CELL BIOLOGY
- Refinement of the retinogeniculate pathway
- (2008) William Guido JOURNAL OF PHYSIOLOGY-LONDON
- The CD300a (IRp60) inhibitory receptor is rapidly up-regulated on human neutrophils in response to inflammatory stimuli and modulates CD32a (FcγRIIa) mediated signaling
- (2007) Yelina Alvarez et al. MOLECULAR IMMUNOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search