Moderate L-lactate administration suppresses adipose tissue macrophage M1 polarization to alleviate obesity-associated insulin resistance

Lactate as a fulcrum of metabolism

(2020) George A. Brooks   Redox Biology

Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Macrophage Polarization

(2020) Jing Zhang et al.   Cell Metabolism

Resveratrol prevents sarcopenic obesity by reversing mitochondrial dysfunction and oxidative stress via the PKA/LKB1/AMPK pathway

(2019) Yujie Huang et al.   Aging-US

Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production

(2019) Elsa Sanchez-Lopez et al.   Cell Metabolism

SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity

(2019) Noelia Keiran et al.   NATURE IMMUNOLOGY

Obesity, risk of diabetes and role of physical activity, exercise training and cardiorespiratory fitness

(2019) Salvatore Carbone et al.   PROGRESS IN CARDIOVASCULAR DISEASES

PKA Activates AMPK Through LKB1 Signaling in Follicular Thyroid Cancer

(2019) Suresh Kari et al.   Frontiers in Endocrinology

An Integrated View of Immunometabolism

(2018) Yun Sok Lee et al.   CELL

The Science and Translation of Lactate Shuttle Theory

(2018) George A. Brooks   Cell Metabolism

C1QTNF1 attenuates angiotensin II-induced cardiac hypertrophy via activation of the AMPKa pathway

(2018) Leiming Wu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Exercise in the management of obesity

(2018) Anatoli Petridou et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Moderate-intensity endurance-exercise training in patients with sickle-cell disease without severe chronic complications (EXDRE): an open-label randomised controlled trial

(2018) Barnabas Gellen et al.   Lancet Haematology

Glutamine Metabolism in Macrophages: A Novel Target for Obesity/Type 2 Diabetes

(2018) Wenkai Ren et al.   Advances in Nutrition

Lactate: A Metabolic Driver in the Tumour Landscape

(2018) Luigi Ippolito et al.   TRENDS IN BIOCHEMICAL SCIENCES

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

Gpr132 sensing of lactate mediates tumor–macrophage interplay to promote breast cancer metastasis

(2017) Peiwen Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPK as a Therapeutic Target for Treating Metabolic Diseases

(2017) Emily A. Day et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Metformin-treated cancer cells modulate macrophage polarization through AMPK-NF-κB signaling

(2017) Chi-Fu Chiang et al.   Oncotarget

AMPK activation caused by reduced liver lactate metabolism protects against hepatic steatosis in MCT1 haploinsufficient mice

(2017) Lionel Carneiro et al.   Molecular Metabolism

Adipocyte Ceramides Regulate Subcutaneous Adipose Browning, Inflammation, and Metabolism

(2016) Bhagirath Chaurasia et al.   Cell Metabolism

Dietary luteolin activates browning and thermogenesis in mice through an AMPK/PGC1α pathway-mediated mechanism

(2016) X Zhang et al.   INTERNATIONAL JOURNAL OF OBESITY

TGF-β induces M2-like macrophage polarization via SNAIL-mediated suppression of a pro-inflammatory phenotype

(2016) Fan Zhang et al.   Oncotarget

Decreased extracellular pH inhibits osteogenesis through proton-sensing GPR4-mediated suppression of yes-associated protein

(2016) Shi-Cong Tao et al.   Scientific Reports

Fumagillin Prodrug Nanotherapy Suppresses Macrophage Inflammatory Response via Endothelial Nitric Oxide

(2014) Hui-fang Zhou et al.   ACS Nano

Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat

(2014) Yifu Qiu et al.   CELL

What We Talk About When We Talk About Fat

(2014) Evan D. Rosen et al.   CELL

Metabolic Dysfunction Drives a Mechanistically Distinct Proinflammatory Phenotype in Adipose Tissue Macrophages

(2014) Mario Kratz et al.   Cell Metabolism

Leptin-Mediated Increases in Catecholamine Signaling Reduce Adipose Tissue Inflammation via Activation of Macrophage HDAC4

(2014) Bing Luan et al.   Cell Metabolism

Browning of White Adipose Cells by Intermediate Metabolites: An Adaptive Mechanism to Alleviate Redox Pressure

(2014) A. Carriere et al.   DIABETES

Implication of the Tpl2 Kinase in Inflammatory Changes and Insulin Resistance Induced by the Interaction Between Adipocytes and Macrophages

(2014) Franck Ceppo et al.   ENDOCRINOLOGY

Adenosine 5'-Monophosphate-Activated Protein Kinase Promotes Macrophage Polarization to an Anti-Inflammatory Functional Phenotype

(2014) D. Sag et al.   JOURNAL OF IMMUNOLOGY

Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKα1/SIRT1

(2014) Jing Dong et al.   JOURNAL OF LIPID RESEARCH

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Lactic Acidosis

(2014) Jeffrey A. Kraut et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Origins and Drivers of Insulin Resistance

(2013) Andrew M.F. Johnson et al.   CELL

Regulation of inflammation by extracellular acidification and proton-sensing GPCRs

(2013) Fumikazu Okajima   CELLULAR SIGNALLING

AMPK, insulin resistance, and the metabolic syndrome

(2013) Neil B. Ruderman et al.   JOURNAL OF CLINICAL INVESTIGATION

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

Momordica charantia (Bitter Melon) Reduces Obesity-Associated Macrophage and Mast Cell Infiltration as well as Inflammatory Cytokine Expression in Adipose Tissues

(2013) Bin Bao et al.   PLoS One

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages

(2013) Wei Ying et al.   Jove-Journal of Visualized Experiments

Regulation of Glucose Transporter Translocation in Health and Diabetes

(2012) Jonathan S. Bogan   Annual Review of Biochemistry

The cellular and signaling networks linking the immune system and metabolism in disease

(2012) Olivia Osborn et al.   NATURE MEDICINE

Phytochemicals and their impact on adipose tissue inflammation and diabetes

(2012) Andreas Leiherer et al.   VASCULAR PHARMACOLOGY

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

An Autocrine Lactate Loop Mediates Insulin-Dependent Inhibition of Lipolysis through GPR81

(2010) Kashan Ahmed et al.   Cell Metabolism

AMPK: An Emerging Drug Target for Diabetes and the Metabolic Syndrome

(2009) Bei B. Zhang et al.   Cell Metabolism

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

(2009) Satoshi Nishimura et al.   NATURE MEDICINE

Cancer Cell Metabolism: Warburg and Beyond

(2008) Peggy P. Hsu et al.   CELL

G2A Deficiency in Mice Promotes Macrophage Activation and Atherosclerosis

(2008) David T. Bolick et al.   CIRCULATION RESEARCH