Chimeric efferocytic receptors improve apoptotic cell clearance and alleviate inflammation

The clinical landscape for AAV gene therapies

(2021) Dmitry A. Kuzmin et al.   NATURE REVIEWS DRUG DISCOVERY

Efferocytosis by Paneth cells within the intestine

(2021) Laura S. Shankman et al.   CURRENT BIOLOGY

The clearance of dead cells by efferocytosis

(2020) Emilio Boada-Romero et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure of the DOCK2−ELMO1 complex provides insights into regulation of the auto-inhibited state

(2020) Leifu Chang et al.   Nature Communications

Live-imaging of astrocyte morphogenesis and function in zebrafish neural circuits

(2020) Jiakun Chen et al.   NATURE NEUROSCIENCE

The proteostasis network and its decline in ageing

(2019) Mark S. Hipp et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Adeno-associated virus vector as a platform for gene therapy delivery

(2019) Dan Wang et al.   NATURE REVIEWS DRUG DISCOVERY

Living on the Edge: Efferocytosis at the Interface of Homeostasis and Pathology

(2019) Sho Morioka et al.   IMMUNITY

Interpreting an apoptotic corpse as anti-inflammatory involves a chloride sensing pathway

(2019) Justin S. A. Perry et al.   NATURE CELL BIOLOGY

Endoplasmic reticulum stress in ischemic and nephrotoxic acute kidney injury

(2018) Mingjuan Yan et al.   ANNALS OF MEDICINE

Apoptosis and Clearance of Apoptotic Cells

(2018) Shigekazu Nagata   Annual Review of Immunology

Glucose-regulated protein 78 substrate-binding domain alters its conformation upon EGCG inhibitor binding to nucleotide-binding domain: Molecular dynamics studies

(2018) K. R. D. Sagara N. S. Gurusinghe et al.   Scientific Reports

Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release

(2018) Sho Morioka et al.   NATURE

Endoplasmic reticulum stress is activated in post-ischemic kidneys to promote chronic kidney disease

(2018) Shaoqun Shu et al.   EBioMedicine

Phagocytosis imprints heterogeneity in tissue-resident macrophages

(2017) Noelia A-Gonzalez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Endoplasmic reticulum stress, the unfolded protein response and autophagy in kidney diseases

(2017) Andrey V. Cybulsky   Nature Reviews Nephrology

Mouse macrophages show different requirements for phosphatidylserine receptor Tim4 in efferocytosis

(2017) Yuichi Yanagihashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance

(2016) Michaël Cerezo et al.   CANCER CELL

The Dynamics of Apoptotic Cell Clearance

(2016) Michael R. Elliott et al.   DEVELOPMENTAL CELL

Boosting Apoptotic Cell Clearance by Colonic Epithelial Cells Attenuates Inflammation In Vivo

(2016) Chang Sup Lee et al.   IMMUNITY

Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation

(2016) Claudia Z. Han et al.   NATURE

Different tissue phagocytes sample apoptotic cells to direct distinct homeostasis programs

(2016) Ryan J. Cummings et al.   NATURE

TAM receptors regulate multiple features of microglial physiology

(2016) Lawrence Fourgeaud et al.   NATURE

Apoptosis inhibitor of macrophage protein enhances intraluminal debris clearance and ameliorates acute kidney injury in mice

(2016) Satoko Arai et al.   NATURE MEDICINE

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

BAI1 regulates spatial learning and synaptic plasticity in the hippocampus

(2015) Dan Zhu et al.   JOURNAL OF CLINICAL INVESTIGATION

Proteostasis in endoplasmic reticulum—new mechanisms in kidney disease

(2014) Reiko Inagi et al.   Nature Reviews Nephrology

Distinct roles for BAI1 and TIM-4 in the engulfment of dying neurons by microglia

(2014) Fargol Mazaheri et al.   Nature Communications

503unc, a small and muscle-specific zebrafish promoter

(2013) Joachim Berger et al.   GENESIS

Apoptotic cell clearance by bronchial epithelial cells critically influences airway inflammation

(2012) Ignacio J. Juncadella et al.   NATURE

Astrocytes regulate adult hippocampal neurogenesis through ephrin-B signaling

(2012) Randolph S Ashton et al.   NATURE NEUROSCIENCE

Two Types of Tet-On Transgenic Lines for Doxycycline-Inducible Gene Expression in Zebrafish Rod Photoreceptors and a Gateway-Based Tet-On Toolkit

(2012) Leah J. Campbell et al.   PLoS One

Microenvironmental influences of apoptosis in vivo and in vitro

(2010) Christopher D. Gregory et al.   APOPTOSIS

The Rac1 Regulator ELMO1 Controls Vascular Morphogenesis in Zebrafish

(2010) Daniel Epting et al.   CIRCULATION RESEARCH

An Evolutionarily Conserved Autoinhibitory Molecular Switch in ELMO Proteins Regulates Rac Signaling

(2010) Manishha Patel et al.   CURRENT BIOLOGY

Unexpected requirement for ELMO1 in clearance of apoptotic germ cells in vivo

(2010) Michael R. Elliott et al.   NATURE

Mechanisms of Cisplatin Nephrotoxicity

(2010) Ronald P. Miller et al.   Toxins

The Phosphatidylserine Receptor TIM-4 Does Not Mediate Direct Signaling

(2009) Daeho Park et al.   CURRENT BIOLOGY

Kidney injury molecule–1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells

(2008) Takaharu Ichimura et al.   JOURNAL OF CLINICAL INVESTIGATION

Epithelial Cells Remove Apoptotic Epithelial Cells During Post-Lactation Involution of the Mouse Mammary Gland1

(2007) Jenifer Monks et al.   BIOLOGY OF REPRODUCTION

Drosophila ELMO/CED-12 interacts with Myoblast city to direct myoblast fusion and ommatidial organization

(2007) Erika R. Geisbrecht et al.   DEVELOPMENTAL BIOLOGY