Polyamine import and accumulation causes immunomodulation in macrophages engulfing apoptotic cells

Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury

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Phagocytosis of Necrotic Debris at Sites of Injury and Inflammation

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Metabolites released from apoptotic cells act as tissue messengers

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The clearance of dead cells by efferocytosis

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Metabolic Reprogramming of Mouse Bone Marrow Derived Macrophages Following Erythrophagocytosis

(2020) Alexis Catala et al.   Frontiers in Physiology

Hypusination Orchestrates the Antimicrobial Response of Macrophages

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Red Blood Cell Metabolic Responses to Torpor and Arousal in the Hibernator Arctic Ground Squirrel

(2019) Sarah Gehrke et al.   JOURNAL OF PROTEOME RESEARCH

The role of polyamines in the regulation of macrophage polarization and function

(2019) Yvonne L. Latour et al.   AMINO ACIDS

Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation

(2019) Daniel J. Puleston et al.   Cell Metabolism

Apoptosis and Clearance of Apoptotic Cells

(2018) Shigekazu Nagata   Annual Review of Immunology

Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses

(2018) Kshipra Singh et al.   CANCER RESEARCH

Apoptotic cells trigger the ABCA1/STAT6 pathway leading to PPAR-γ expression and activation in macrophages

(2018) Myeong-Joo Kim et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Spermidine in health and disease

(2018) Frank Madeo et al.   SCIENCE

Inflammaging: a new immune–metabolic viewpoint for age-related diseases

(2018) Claudio Franceschi et al.   Nature Reviews Endocrinology

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair

(2018) Shuang Zhang et al.   Cell Metabolism

The antizyme family for regulating polyamines

(2018) Chaim Kahana   JOURNAL OF BIOLOGICAL CHEMISTRY

Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release

(2018) Sho Morioka et al.   NATURE

Phagocytosis imprints heterogeneity in tissue-resident macrophages

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Amino acid substrates impose polyamine, eIF5A, or hypusine requirement for peptide synthesis

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Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications

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A three-minute method for high-throughput quantitative metabolomics and quantitative tracing experiments of central carbon and nitrogen pathways

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Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells

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Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease and cancer

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Spermidine alleviates experimental autoimmune encephalomyelitis through inducing inhibitory macrophages

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Clearance of apoptotic neutrophils and resolution of inflammation

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Three-minute method for amino acid analysis by UHPLC and high-resolution quadrupole orbitrap mass spectrometry

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Apoptotic cells trigger a membrane-initiated pathway to increase ABCA1

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Phagocytosis of apoptotic cells in homeostasis

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Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

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Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages

(2014) Meera Rath et al.   Frontiers in Immunology

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Metabolic Connections during Apoptotic Cell Engulfment

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Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein

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Neutrophil Extracellular Trap (NET)-Mediated Killing of Pseudomonas aeruginosa: Evidence of Acquired Resistance within the CF Airway, Independent of CFTR

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Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells

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Synthesis of conjugated spermine derivatives with 7-nitrobenzoxadiazole (NBD), rhodamine and bodipy as new fluorescent probes for the polyamine transport system

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Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR

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Lipophilic Lysine−Spermine Conjugates Are Potent Polyamine Transport Inhibitors for Use in Combination with a Polyamine Biosynthesis Inhibitor

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Long-Term Oral Polyamine Intake Increases Blood Polyamine Concentrations

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PPAR-δ senses and orchestrates clearance of apoptotic cells to promote tolerance

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