Oxidative phosphorylation selectively orchestrates tissue macrophage homeostasis

TFAM-Dependent Mitochondrial Metabolism Is Required for Alveolar Macrophage Maintenance and Homeostasis

(2022) Xiaochen Gao et al.   JOURNAL OF IMMUNOLOGY

PERK is a critical metabolic hub for immunosuppressive function in macrophages

(2022) Lydia N. Raines et al.   NATURE IMMUNOLOGY

Tissue-resident macrophages: guardians of organ homeostasis

(2021) Samuel Philip Nobs et al.   TRENDS IN IMMUNOLOGY

Metabolism of tissue macrophages in homeostasis and pathology

(2021) Stefanie K. Wculek et al.   Cellular & Molecular Immunology

IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation

(2021) Maria Faas et al.   IMMUNITY

Macrophage polarization state affects lipid composition and the channeling of exogenous fatty acids into endogenous lipid pools

(2021) Pooranee K. Morgan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial stress is relayed to the cytosol by an OMA1–DELE1–HRI pathway

(2020) Xiaoyan Guo et al.   NATURE

A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol

(2020) Evelyn Fessler et al.   NATURE

Mitochondrial TCA cycle metabolites control physiology and disease

(2020) Inmaculada Martínez-Reyes et al.   Nature Communications

Serine Catabolism Feeds NADH when Respiration Is Impaired

(2020) Lifeng Yang et al.   Cell Metabolism

Construction of a human cell landscape at single-cell level

(2020) Xiaoping Han et al.   NATURE

T cells with dysfunctional mitochondria induce multimorbidity and premature senescence

(2020) Gabriela Desdín-Micó et al.   SCIENCE

Rewiring of Lipid Metabolism in Adipose Tissue Macrophages in Obesity: Impact on Insulin Resistance and Type 2 Diabetes

(2020) Veronica D. Dahik et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cellpose: a generalist algorithm for cellular segmentation

(2020) Carsen Stringer et al.   NATURE METHODS

Mitochondrial complex III is essential for suppressive function of regulatory T cells

(2019) Samuel E. Weinberg et al.   NATURE

The cis-Regulatory Atlas of the Mouse Immune System

(2019) Hideyuki Yoshida et al.   CELL

The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation

(2019) Freya R. Svedberg et al.   NATURE IMMUNOLOGY

Macrophages as Key Players during Adipose Tissue–Liver Crosstalk in Nonalcoholic Fatty Liver Disease

(2019) Hannelie Korf et al.   SEMINARS IN LIVER DISEASE

Metabolic adaptations of tissue-resident immune cells

(2019) George Caputa et al.   NATURE IMMUNOLOGY

Tissue Resident Alveolar Macrophages Do Not Rely on Glycolysis for LPS-induced Inflammation

(2019) Parker S Woods et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Structure and mechanism of mitochondrial proton-translocating transhydrogenase

(2019) Domen Kampjut et al.   NATURE

Regulation of Mother-to-Offspring Transmission of mtDNA Heteroplasmy

(2019) Ana Latorre-Pellicer et al.   Cell Metabolism

Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase

(2019) Mario A. Lauterbach et al.   IMMUNITY

Macrophages and lipid metabolism

(2018) Anneleen Remmerie et al.   CELLULAR IMMUNOLOGY

Unique metabolic activation of adipose tissue macrophages in obesity promotes inflammatory responses

(2018) Lily Boutens et al.   DIABETOLOGIA

Coenzyme Q10 serves to couple mitochondrial oxidative phosphorylation and fatty acid β-oxidation, and attenuates NLRP3 inflammasome activation

(2018) Suphannee Chokchaiwong et al.   FREE RADICAL RESEARCH

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Distinct macrophage populations direct inflammatory versus physiological changes in adipose tissue

(2018) David A. Hill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage phenotype and bioenergetics are controlled by oxidized phospholipids identified in lean and obese adipose tissue

(2018) Vlad Serbulea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adipocyte-specific expression of C-type natriuretic peptide suppresses lipid metabolism and adipocyte hypertrophy in adipose tissues in mice fed high-fat diet

(2018) Cho-Rong Bae et al.   Scientific Reports

p38α blocks brown adipose tissue thermogenesis through p38δ inhibition

(2018) Nuria Matesanz et al.   PLOS BIOLOGY

Statin as a novel pharmacotherapy of pulmonary alveolar proteinosis

(2018) Cormac McCarthy et al.   Nature Communications

Von Hippel-Lindau Protein Is Required for Optimal Alveolar Macrophage Terminal Differentiation, Self-Renewal, and Function

(2018) Helena M. Izquierdo et al.   Cell Reports

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair

(2018) Shuang Zhang et al.   Cell Metabolism

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis

(2018) Saul Soberanes et al.   Cell Metabolism

Peritoneal tissue-resident macrophages are metabolically poised to engage microbes using tissue-niche fuels

(2017) Luke C. Davies et al.   Nature Communications

Surfactant Lipids at the Host–Environment Interface. Metabolic Sensors, Suppressors, and Effectors of Inflammatory Lung Disease

(2016) Michael B. Fessler et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

New insight on obesity and adipose-derived stem cells using comprehensive metabolomics

(2016) A. Mastrangelo et al.   BIOCHEMICAL JOURNAL

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense

(2016) Johan Garaude et al.   NATURE IMMUNOLOGY

Mitochondrial Respiration Controls Lysosomal Function during Inflammatory T Cell Responses

(2015) Francesc Baixauli et al.   Cell Metabolism

Macrophage Mitochondrial Energy Status Regulates Cholesterol Efflux and Is Enhanced by Anti-miR33 in AtherosclerosisNovelty and Significance

(2015) Denuja Karunakaran et al.   CIRCULATION RESEARCH

Mitochondrial regulation of macrophage cholesterol homeostasis

(2015) Annette Graham   FREE RADICAL BIOLOGY AND MEDICINE

Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis

(2015) Simone Cardaci et al.   NATURE CELL BIOLOGY

Orchestrating high-throughput genomic analysis with Bioconductor

(2015) Wolfgang Huber et al.   NATURE METHODS

Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis

(2014) Rajesh R. Rao et al.   CELL

Mitochondrial Complex I Activity Suppresses Inflammation and Enhances Bone Resorption by Shifting Macrophage-Osteoclast Polarization

(2014) Zixue Jin et al.   Cell Metabolism

Local Proliferation of Macrophages Contributes to Obesity-Associated Adipose Tissue Inflammation

(2014) Shinya U. Amano et al.   Cell Metabolism

Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages

(2014) Christoph Schneider et al.   NATURE IMMUNOLOGY

Endoplasmic Reticulum Stress Promotes Macrophage-derived Foam Cell Formation by Up-regulating Cluster of Differentiation 36 (CD36) Expression

(2013) Shutong Yao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CHOP is a multifunctional transcription factor in the ER stress response

(2012) H. Nishitoh   JOURNAL OF BIOCHEMISTRY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Functional Heterogeneity of CD11c-positive Adipose Tissue Macrophages in Diet-induced Obese Mice

(2010) Pingping Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GAGE: generally applicable gene set enrichment for pathway analysis

(2009) Weijun Luo et al.   BMC BIOINFORMATICS

IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

(2009) Dan Han et al.   CELL

Mice with Mitochondrial Complex I Deficiency Develop a Fatal Encephalomyopathy

(2008) Shane E. Kruse et al.   Cell Metabolism