Efferocytosis induces macrophage proliferation to help resolve tissue injury

Wnt signaling enhances macrophage responses to IL-4 and promotes resolution of atherosclerosis

(2021) Ada Weinstock et al.   eLife

Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury

(2020) Arif Yurdagul et al.   Cell Metabolism

Regulatory T Cells License Macrophage Pro-Resolving Functions During Atherosclerosis Regression

(2020) Monika sharma et al.   CIRCULATION RESEARCH

The clearance of dead cells by efferocytosis

(2020) Emilio Boada-Romero et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

siRNA nanoparticles targeting CaMKIIγ in lesional macrophages improve atherosclerotic plaque stability in mice

(2020) Wei Tao et al.   Science Translational Medicine

Impact of tissue macrophage proliferation on peripheral and systemic insulin resistance in obese mice with diabetes

(2020) Yutaro Morita et al.   BMJ Open Diabetes Research & Care

Inhibition of macrophage proliferation dominates plaque regression in response to cholesterol lowering

(2020) Carmen Härdtner et al.   BASIC RESEARCH IN CARDIOLOGY

MERTK tyrosine kinase receptor together with TIM4 phosphatidylserine receptor mediates distinct signal transduction pathways for efferocytosis and cell proliferation

(2019) Chihiro Nishi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Living on the Edge: Efferocytosis at the Interface of Homeostasis and Pathology

(2019) Sho Morioka et al.   IMMUNITY

Bhlhe40 mediates tissue-specific control of macrophage proliferation in homeostasis and type 2 immunity

(2019) Nicholas N. Jarjour et al.   NATURE IMMUNOLOGY

Bhlhe40 and Bhlhe41 transcription factors regulate alveolar macrophage self‐renewal and identity

(2019) René Rauschmeier et al.   EMBO JOURNAL

Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis

(2019) Bishuang Cai et al.   Cell Metabolism

NADPH oxidase activation regulates apoptotic neutrophil clearance by murine macrophages

(2018) Juhi Bagaitkar et al.   BLOOD

Loss of Rictor in Monocyte/Macrophages Suppresses Their Proliferation and Viability Reducing Atherosclerosis in LDLR Null Mice

(2018) Vladimir R. Babaev et al.   Frontiers in Immunology

MerTK signaling in macrophages promotes the synthesis of inflammation resolution mediators by suppressing CaMKII activity

(2018) Bishuang Cai et al.   Science Signaling

The MYC transcription factor network: balancing metabolism, proliferation and oncogenesis

(2018) Patrick A. Carroll et al.   Frontiers of Medicine

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair

(2018) Shuang Zhang et al.   Cell Metabolism

Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution

(2018) Jonathan D. Proto et al.   IMMUNITY

Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release

(2018) Sho Morioka et al.   NATURE

Inflammatory Ly6Chi monocytes and their conversion to M2 macrophages drive atherosclerosis regression

(2017) Karishma Rahman et al.   JOURNAL OF CLINICAL INVESTIGATION

MerTK receptor cleavage promotes plaque necrosis and defective resolution in atherosclerosis

(2017) Bishuang Cai et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells

(2017) Lidia Bosurgi et al.   SCIENCE

Pro-Resolving Mediators in Regulating and Conferring Macrophage Function

(2017) Jesmond Dalli et al.   Frontiers in Immunology

Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation

(2016) Stanley Ching-Cheng Huang et al.   IMMUNITY

CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis

(2016) Yoko Kojima et al.   NATURE

TAM receptors regulate multiple features of microglial physiology

(2016) Lawrence Fourgeaud et al.   NATURE

Proinflammatory signal suppresses proliferation and shifts macrophage metabolism from Myc-dependent to HIF1α-dependent

(2016) Lingling Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation

(2016) Bishuang Cai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Over-expression of DNA-PKcs in renal cell carcinoma regulates mTORC2 activation, HIF-2α expression and cell proliferation

(2016) Bing Zheng et al.   Scientific Reports

Deficiency of AXL in Bone Marrow-Derived Cells Does Not Affect Advanced Atherosclerotic Lesion Progression

(2016) Manikandan Subramanian et al.   Scientific Reports

Regression of Atherosclerosis

(2015) Edward A. Fisher   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Self-renewing macrophages – A new line of enquiries in mononuclear phagocytes

(2015) Gyorgy Fejer et al.   IMMUNOBIOLOGY

Immunometabolism governs dendritic cell and macrophage function

(2015) Luke A.J. O’Neill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins

(2015) Jennifer Martinez et al.   NATURE CELL BIOLOGY

Differential signaling during macropinocytosis in response to M-CSF and PMA in macrophages

(2015) Sei Yoshida et al.   Frontiers in Physiology

Effects of High Fat Feeding and Diabetes on Regression of Atherosclerosis Induced by Low-Density Lipoprotein Receptor Gene Therapy in LDL Receptor-Deficient Mice

(2015) Florian Willecke et al.   PLoS One

Dnase2a Deficiency Uncovers Lysosomal Clearance of Damaged Nuclear DNA via Autophagy

(2014) Yuk Yuen Lan et al.   Cell Reports

Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

(2013) Daigo Hashimoto et al.   IMMUNITY

MERTK receptor tyrosine kinase is a therapeutic target in melanoma

(2013) Jennifer Schlegel et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Local proliferation dominates lesional macrophage accumulation in atherosclerosis

(2013) Clinton S Robbins et al.   NATURE MEDICINE

Induction of TGF-β1 Synthesis by Macrophages in Response to Apoptotic Cells Requires Activation of the Scavenger Receptor CD36

(2013) Weipeng Xiong et al.   PLoS One

Development and in vivo efficacy of targeted polymeric inflammation-resolving nanoparticles

(2013) N. Kamaly et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation

(2013) Luke C. Davies et al.   Nature Communications

The atypical chemokine receptor D6 controls macrophage efferocytosis and cytokine secretion during the resolution of inflammation

(2012) Ester Pashover-Schallinger et al.   FASEB JOURNAL

Role of c-MYC in alternative activation of human macrophages and tumor-associated macrophage biology

(2011) O. M. Pello et al.   BLOOD

A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation

(2011) Luke C. Davies et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Fluorescent Probes Detecting the Phagocytic Phase of Apoptosis: Enzyme-Substrate Complexes of Topoisomerase and DNA

(2011) Candace L. Minchew et al.   MOLECULES

Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein

(2011) Daeho Park et al.   NATURE

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

(2011) S. J. Jenkins et al.   SCIENCE

Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR

(2009) Noelia A-Gonzalez et al.   IMMUNITY