PFKFB2-mediated glycolysis promotes lactate-driven continual efferocytosis by macrophages

Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments

(2022) Shogo Kumagai et al.   CANCER CELL

Diabetes Suppresses Glucose Uptake and Glycolysis in Macrophages

(2022) Yunosuke Matsuura et al.   CIRCULATION RESEARCH

Myeloid Cell PKM2 Deletion Enhances Efferocytosis and Reduces Atherosclerosis

(2022) Prakash Doddapattar et al.   CIRCULATION RESEARCH

Drugging the efferocytosis process: concepts and opportunities

(2022) Parul Mehrotra et al.   NATURE REVIEWS DRUG DISCOVERY

Live cell tracking of macrophage efferocytosis during Drosophila embryo development in vivo

(2022) Michael H. Raymond et al.   SCIENCE

Interaction of ARRDC4 With GLUT1 Mediates Metabolic Stress in the Ischemic Heart

(2022) Yoshinobu Nakayama et al.   CIRCULATION RESEARCH

Metabolic reprogramming in macrophage responses

(2021) Yang Liu et al.   Biomarker Research

Deficiency of macrophage PHACTR1 impairs efferocytosis and promotes atherosclerotic plaque necrosis

(2021) Canan Kasikara et al.   JOURNAL OF CLINICAL INVESTIGATION

Efferocytosis induces macrophage proliferation to help resolve tissue injury

(2021) Brennan D. Gerlach et al.   Cell Metabolism

Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury

(2020) Arif Yurdagul et al.   Cell Metabolism

Mutation of regulatory phosphorylation sites in PFKFB2 worsens renal fibrosis

(2020) Mardiana Lee et al.   Scientific Reports

CircFLNA Acts as a Sponge of miR-646 to Facilitate the Proliferation, Metastasis, Glycolysis, and Apoptosis Inhibition of Gastric Cancer by Targeting PFKFB2

(2020) Juan Qu et al.   Cancer Management and Research

Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1

(2019) Alex J. Freemerman et al.   JOURNAL OF IMMUNOLOGY

MERTK tyrosine kinase receptor together with TIM4 phosphatidylserine receptor mediates distinct signal transduction pathways for efferocytosis and cell proliferation

(2019) Chihiro Nishi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Living on the Edge: Efferocytosis at the Interface of Homeostasis and Pathology

(2019) Sho Morioka et al.   IMMUNITY

The Metabolic Signature of Macrophage Responses

(2019) Antonella Viola et al.   Frontiers in Immunology

Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers

(2018) Michael P. Murphy et al.   CELL

Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release

(2018) Sho Morioka et al.   NATURE

HIF1α-Induced Glycolysis Metabolism Is Essential to the Activation of Inflammatory Macrophages

(2017) Ting Wang et al.   MEDIATORS OF INFLAMMATION

Macrophage Immunometabolism: Where Are We (Going)?

(2017) Jan Van den Bossche et al.   TRENDS IN IMMUNOLOGY

Phosphorylation of TXNIP by AKT Mediates Acute Influx of Glucose in Response to Insulin

(2017) Althea N. Waldhart et al.   Cell Reports

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

PFKFB3-Driven Macrophage Glycolytic Metabolism Is a Crucial Component of Innate Antiviral Defense

(2016) Hui Jiang et al.   JOURNAL OF IMMUNOLOGY

Crystal structure of heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB2) and the inhibitory influence of citrate on substrate binding

(2016) Robert B. Crochet et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages

(2016) Jan Van den Bossche et al.   Cell Reports

HIF-1  and PFKFB3 Mediate a Tight Relationship Between Proinflammatory Activation and Anerobic Metabolism in Atherosclerotic Macrophages

(2015) A. Tawakol et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

(2015) Eva M. Palsson-McDermott et al.   Cell Metabolism

A Broken Krebs Cycle in Macrophages

(2015) Luke A.J. O’Neill   IMMUNITY

Metabolic Reprogramming of Macrophages

(2014) Alex J. Freemerman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Testing the Role of Myeloid Cell Glucose Flux in Inflammation and Atherosclerosis

(2014) Tomohiro Nishizawa et al.   Cell Reports

Low density receptor-related protein 1 (LRP1) promotes anti-inflammatory phenotype in murine macrophages

(2013) Petra May et al.   CELL AND TISSUE RESEARCH

Akt-dependent Activation of the Heart 6-Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase (PFKFB2) Isoenzyme by Amino Acids

(2013) Laura Novellasdemunt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer-generated lactic acid: a regulatory, immunosuppressive metabolite?

(2013) Stephen Yiu Chuen Choi et al.   JOURNAL OF PATHOLOGY

AMPK-Dependent Degradation of TXNIP upon Energy Stress Leads to Enhanced Glucose Uptake via GLUT1

(2013) Ning Wu et al.   MOLECULAR CELL

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

Annexin A1 regulates neutrophil clearance by macrophages in the mouse bone marrow

(2011) Jesmond Dalli et al.   FASEB JOURNAL

Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein

(2011) Daeho Park et al.   NATURE

TAM receptors and the clearance of apoptotic cells

(2010) Greg Lemke et al.   Annals of the New York Academy of Sciences

Macrophage LRP-1 Controls Plaque Cellularity by Regulating Efferocytosis and Akt Activation

(2010) Patricia G. Yancey et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophages

(2010) Matvey Gorovoy et al.   JOURNAL OF LEUKOCYTE BIOLOGY

An essential role for calcium flux in phagocytes for apoptotic cell engulfment and the anti-inflammatory response

(2009) M A Gronski et al.   CELL DEATH AND DIFFERENTIATION

Mertk Receptor Mutation Reduces Efferocytosis Efficiency and Promotes Apoptotic Cell Accumulation and Plaque Necrosis in Atherosclerotic Lesions of Apoe −/− Mice

(2008) Edward Thorp et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY