CD47-SIRPα axis blockade in NASH promotes necroptotic hepatocyte clearance by liver macrophages and decreases hepatic fibrosis

Anti‐CD47 antibody treatment attenuates liver inflammation and fibrosis in experimental non‐alcoholic steatohepatitis models

(2022) Taesik Gwag et al.   LIVER INTERNATIONAL

Epigenetic Silencing of RIPK3 in Hepatocytes Prevents MLKL-mediated Necroptosis From Contributing to Liver Pathologies

(2022) Simon P. Preston et al.   GASTROENTEROLOGY

The prevalence and incidence of NAFLD worldwide: a systematic review and meta-analysis

(2022) Kiarash Riazi et al.   Lancet Gastroenterology & Hepatology

Differential role of MLKL in alcohol-associated and non–alcohol-associated fatty liver diseases in mice and humans

(2021) Tatsunori Miyata et al.   JCI Insight

Mechanisms and disease consequences of nonalcoholic fatty liver disease

(2021) Rohit Loomba et al.   CELL

Prospective evaluation of the prevalence of non-alcoholic fatty liver disease and steatohepatitis in a large middle-aged US cohort

(2021) Stephen A. Harrison et al.   JOURNAL OF HEPATOLOGY

Histone deacetylase inhibitor givinostat attenuates nonalcoholic steatohepatitis and liver fibrosis

(2021) He-ming Huang et al.   ACTA PHARMACOLOGICA SINICA

Hepatocyte TLR4 triggers inter-hepatocyte Jagged1/Notch signaling to determine NASH-induced fibrosis

(2021) Junjie Yu et al.   Science Translational Medicine

Prospective Study of Outcomes in Adults with Nonalcoholic Fatty Liver Disease

(2021) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanisms of Fibrosis Development in NASH

(2020) Robert F. Schwabe et al.   GASTROENTEROLOGY

Macrophages show higher levels of engulfment after disruption of cis interactions between CD47 and the checkpoint receptor SIRPα

(2020) Brandon H. Hayes et al.   JOURNAL OF CELL SCIENCE

New drugs for non‐alcoholic steatohepatitis

(2020) Ana‐Carolina Cardoso et al.   LIVER INTERNATIONAL

CD47 Deficiency in Mice Exacerbates Chronic Fatty Diet-Induced Steatohepatitis Through Its Role in Regulating Hepatic Inflammation and Lipid Metabolism

(2020) Hui-Chao Tao et al.   Frontiers in Immunology

Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis

(2020) Xiaobo Wang et al.   Cell Metabolism

MLKL-dependent signaling regulates autophagic flux in a murine model of non-alcohol-associated fatty liver and steatohepatitis

(2020) Xiaoqin Wu et al.   JOURNAL OF HEPATOLOGY

Lytic cell death in metabolic liver disease

(2020) Jérémie Gautheron et al.   JOURNAL OF HEPATOLOGY

Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol

(2020) Kausik K. Ray et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hepatocyte mitochondria-derived danger signals directly activate hepatic stellate cells and drive progression of liver fibrosis

(2020) Ping An et al.   Nature Communications

Targeting macrophage checkpoint inhibitor SIRPα for anticancer therapy

(2020) Jie Liu et al.   JCI Insight

Pathway enrichment analysis and visualization of omics data using g:Profiler, GSEA, Cytoscape and EnrichmentMap

(2019) Jüri Reimand et al.   Nature Protocols

First-in-Human, First-in-Class Phase I Trial of the Anti-CD47 Antibody Hu5F9-G4 in Patients With Advanced Cancers

(2019) Branimir I. Sikic et al.   JOURNAL OF CLINICAL ONCOLOGY

Living on the Edge: Efferocytosis at the Interface of Homeostasis and Pathology

(2019) Sho Morioka et al.   IMMUNITY

Resolvin D1 promotes the targeting and clearance of necroptotic cells

(2019) Brennan D. Gerlach et al.   CELL DEATH AND DIFFERENTIATION

Patisiran Pharmacokinetics, Pharmacodynamics, and Exposure‐Response Analyses in the Phase 3 APOLLO Trial in Patients With Hereditary Transthyretin‐Mediated (hATTR) Amyloidosis

(2019) Xiaoping Zhang et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis

(2019) Shinya Tsurusaki et al.   Cell Death & Disease

Comparison of murine steatohepatitis models identifies a dietary intervention with robust fibrosis, ductular reaction and rapid progression to cirrhosis, cancer

(2019) Guangyan Wei et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease

(2019) Amine Majdi et al.   JOURNAL OF HEPATOLOGY

Ferroptosis Affects the Progression of Nonalcoholic Steatohepatitis via the Modulation of Lipid Peroxidation–Mediated Cell Death in Mice

(2019) Jing Qi et al.   AMERICAN JOURNAL OF PATHOLOGY

Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis

(2019) Bishuang Cai et al.   Cell Metabolism

The molecular basis for current targets of NASH therapies

(2019) Kamran Qureshi et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

A randomized, placebo-controlled trial of emricasan in patients with NASH and F1-F3 fibrosis

(2019) Stephen A. Harrison et al.   JOURNAL OF HEPATOLOGY

Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice

(2018) Bing Xu et al.   JOURNAL OF HEPATOLOGY

Apoptosis and necroptosis in the liver: a matter of life and death

(2018) Robert F. Schwabe et al.   Nature Reviews Gastroenterology & Hepatology

Heavy-tailed prior distributions for sequence count data: removing the noise and preserving large differences

(2018) Anqi Zhu et al.   BIOINFORMATICS

Non-alcoholic fatty liver disease – A global public health perspective

(2018) Zobair M. Younossi   JOURNAL OF HEPATOLOGY

Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis

(2018) Changyu Zhu et al.   Science Translational Medicine

Hepatic neuregulin 4 signaling defines an endocrine checkpoint for steatosis-to-NASH progression

(2017) Liang Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

The STAT3–IL-10–IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury

(2017) Lara Campana et al.   JOURNAL OF IMMUNOLOGY

Salmon provides fast and bias-aware quantification of transcript expression

(2017) Rob Patro et al.   NATURE METHODS

Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis

(2016) Xiaobo Wang et al.   Cell Metabolism

Receptor interacting protein 3 protects mice from high-fat diet-induced liver injury

(2016) Sanjoy Roychowdhury et al.   HEPATOLOGY

Lipotoxic lethal and sublethal stress signaling in hepatocytes: relevance to NASH pathogenesis

(2016) Petra Hirsova et al.   JOURNAL OF LIPID RESEARCH

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

(2016) Elena Buzzetti et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis

(2016) Giovanni Quarato et al.   MOLECULAR CELL

CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis

(2016) Yoko Kojima et al.   NATURE

Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis

(2015) Marta B. Afonso et al.   CLINICAL SCIENCE

Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease

(2015) Paul Angulo et al.   GASTROENTEROLOGY

CD47 Deficiency Protects Mice From Diet-induced Obesity and Improves Whole Body Glucose Tolerance and Insulin Sensitivity

(2015) Hasiyeti Maimaitiyiming et al.   Scientific Reports

A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis

(2014) J. Gautheron et al.   EMBO Molecular Medicine

Cell Death and Cell Death Responses in Liver Disease: Mechanisms and Clinical Relevance

(2014) Tom Luedde et al.   GASTROENTEROLOGY

The Interaction Between Signal Regulatory Protein Alpha (SIRPα) and CD47: Structure, Function, and Therapeutic Target

(2013) A. Neil Barclay et al.   Annual Review of Immunology

Selection and evaluation of clinically relevant AAV variants in a xenograft liver model

(2013) Leszek Lisowski et al.   NATURE

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

(2013) Zhenyu Cai et al.   NATURE CELL BIOLOGY

Safety and Efficacy of RNAi Therapy for Transthyretin Amyloidosis

(2013) Teresa Coelho et al.   NEW ENGLAND JOURNAL OF MEDICINE

The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis

(2012) Jixi Li et al.   CELL

Macrophage-mediated phagocytosis of apoptotic cholangiocytes contributes to reversal of experimental biliary fibrosis

(2010) Yury Popov et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis

(2009) Rafal P. Witek et al.   HEPATOLOGY

Inhibition of “self” engulfment through deactivation of myosin-II at the phagocytic synapse between human cells

(2008) Richard K. Tsai et al.   JOURNAL OF CELL BIOLOGY