The potential mechanisms of lactate in mediating exercise-enhanced cognitive function: a dual role as an energy supply substrate and a signaling molecule

Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease

(2022) Rui-Yuan Pan et al.   Cell Metabolism

Elevated Lactate by High-Intensity Interval Training Regulates the Hippocampal BDNF Expression and the Mitochondrial Quality Control System

(2021) Jingyun Hu et al.   Frontiers in Physiology

Erythroid mitochondrial retention triggers myeloid-dependent type I interferon in human SLE

(2021) Simone Caielli et al.   CELL

Long-term light and moderate exercise intervention similarly prevent both hippocampal and glycemic dysfunction in pre-symptomatic type 2 diabetic rats

(2021) Subrina Jesmin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A proteomic atlas of ligand–receptor interactions at the ovine maternal–fetal interface reveals the role of histone lactylation in uterine remodeling

(2021) Qianying Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Knockdown of Astrocytic Monocarboxylate Transporter 4 in the Motor Cortex Leads to Loss of Dendritic Spines and a Deficit in Motor Learning

(2021) Adam J. Lundquist et al.   MOLECULAR NEUROBIOLOGY

Hypoxic in vitro culture reduces histone lactylation and impairs pre-implantation embryonic development in mice

(2021) Wanting Yang et al.   Epigenetics & Chromatin

Protein lactylation induced by neural excitation

(2021) Hideo Hagihara et al.   Cell Reports

Monocarboxylate Transporters (SLC16): Function, Regulation, and Role in Health and Disease

(2020) Melanie A. Felmlee et al.   PHARMACOLOGICAL REVIEWS

Lactate as a fulcrum of metabolism

(2020) George A. Brooks   Redox Biology

Redistribution of Monocarboxylate 1 and 4 in Hippocampus and Spatial Memory Impairment Induced by Long-term Ketamine Administration

(2020) Runtao Ding et al.   Frontiers in Behavioral Neuroscience

L ‐lactate induces neurogenesis in the mouse ventricular‐subventricular zone via the lactate receptor HCA 1

(2020) Marvin Lambertus et al.   Acta Physiologica

Physical activity and muscle–brain crosstalk

(2019) Bente Klarlund Pedersen   Nature Reviews Endocrinology

Lactate mediates the effects of exercise on learning and memory through SIRT1-dependent activation of hippocampal brain-derived neurotrophic factor (BDNF)

(2019) Lauretta El Hayek et al.   JOURNAL OF NEUROSCIENCE

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

Long-Term Moderate Exercise Rescues Age-Related Decline in Hippocampal Neuronal Complexity and Memory

(2018) Sheng-Feng Tsai et al.   GERONTOLOGY

Abstractocyte: A Visual Tool for Exploring Nanoscale Astroglial Cells

(2018) Haneen Mohammed et al.   IEEE TRANSACTIONS ON VISUALIZATION AND COMPUTER GRAPHICS

Lactate in the brain: from metabolic end-product to signalling molecule

(2018) Pierre J. Magistretti et al.   NATURE REVIEWS NEUROSCIENCE

Joggin’ the Noggin: Towards a Physiological Understanding of Exercise-Induced Cognitive Benefits

(2018) Nikolas J. Stimpson et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Chaski, a novel Drosophila lactate/pyruvate transporter required in glia cells for survival under nutritional stress

(2018) María Graciela Delgado et al.   Scientific Reports

Region- and Age-Specific Changes in Glutamate Transport in the AβPP23 Mouse Model for Alzheimer's Disease

(2018) Anneleen Schallier et al.   JOURNAL OF ALZHEIMERS DISEASE

Reduced AMPK activation and increased HCAR activation drive anti-inflammatory response and neuroprotection in glaucoma

(2018) Mohammad Harun-Or-Rashid et al.   Journal of Neuroinflammation

Is the “lactormone” a key-factor for exercise-related neuroplasticity? A hypothesis based on an alternative lactate neurobiological pathway

(2018) Renato Sobral-Monteiro-Junior et al.   MEDICAL HYPOTHESES

Regulation of cerebral blood flow and metabolism during exercise

(2017) Kurt J. Smith et al.   EXPERIMENTAL PHYSIOLOGY

Astrocytic glycogen-derived lactate fuels the brain during exhaustive exercise to maintain endurance capacity

(2017) Takashi Matsui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1

(2017) Cecilie Morland et al.   Nature Communications

Direct Neuronal Glucose Uptake Is Required for Contextual Fear Acquisition in the Dorsal Hippocampus

(2017) Liang Kong et al.   Frontiers in Molecular Neuroscience

Inhibition of Lactate Transport Erases Drug Memory and Prevents Drug Relapse

(2016) Yan Zhang et al.   BIOLOGICAL PSYCHIATRY

Moderate exercise ameliorates dysregulated hippocampal glycometabolism and memory function in a rat model of type 2 diabetes

(2016) Takeru Shima et al.   DIABETOLOGIA

Altered Energy Metabolism Pathways in the Posterior Cingulate in Young Adult Apolipoprotein E ɛ4 Carriers

(2016) Michelle Perkins et al.   JOURNAL OF ALZHEIMERS DISEASE

Hyperpalatable Diet and Physical Exercise Modulate the Expression of the Glial Monocarboxylate Transporters MCT1 and 4

(2016) Luis V. Portela et al.   MOLECULAR NEUROBIOLOGY

A critical role for VEGF and VEGFR2 in NMDA receptor synaptic function and fear-related behavior

(2016) P De Rossi et al.   MOLECULAR PSYCHIATRY

Astrocytes: New Targets for the Treatment of Neurodegenerative Diseases

(2015) Charles Finsterwald et al.   CURRENT PHARMACEUTICAL DESIGN

Is L-Lactate a Novel Signaling Molecule in the Brain?

(2015) Valentina Mosienko et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Three-dimensional immersive virtual reality for studying cellular compartments in 3D models from EM preparations of neural tissues

(2015) Corrado Calì et al.   JOURNAL OF COMPARATIVE NEUROLOGY

The lactate receptor, G-protein-coupled receptor 81/hydroxycarboxylic acid receptor 1: Expression and action in brain

(2015) Cecilie Morland et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Brain Glycogen Decreases During Intense Exercise Without Hypoglycemia: The Possible Involvement of Serotonin

(2015) Takashi Matsui et al.   NEUROCHEMICAL RESEARCH

Changes in lactate content and monocarboxylate transporter 2 expression in Aβ25-35-treated rat model of Alzheimer’s disease

(2015) Weitian Lu et al.   NEUROLOGICAL SCIENCES

A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

(2015) Pierre J. Magistretti et al.   NEURON

Acute exercise increases brain region-specific expression of MCT1, MCT2, MCT4, GLUT1, and COX IV proteins

(2014) Masaki Takimoto et al.   JOURNAL OF APPLIED PHYSIOLOGY

Lactate Transport and Signaling in the Brain: Potential Therapeutic Targets and Roles in Body—Brain Interaction

(2014) Linda Hildegard Bergersen   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons

(2014) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lactate-mediated glia-neuronal signalling in the mammalian brain

(2014) F. Tang et al.   Nature Communications

Lactate Receptor Sites Link Neurotransmission, Neurovascular Coupling, and Brain Energy Metabolism

(2013) K. H. Lauritzen et al.   CEREBRAL CORTEX

The SLC16 gene family – Structure, role and regulation in health and disease

(2013) Andrew P. Halestrap   MOLECULAR ASPECTS OF MEDICINE

Plastic changes in the astrocyte GLUT1 glucose transporter and beta-tubulin microtubule protein following voluntary exercise in mice

(2012) Angela Allen et al.   BEHAVIOURAL BRAIN RESEARCH

Deleterious effects of neuronal accumulation of glycogen in flies and mice

(2012) Jordi Duran et al.   EMBO Molecular Medicine

Pre-Ischemic Treadmill Training for Prevention of Ischemic Brain Injury via Regulation of Glutamate and Its Transporter GLT-1

(2012) Xiaojiao Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exercise counteracts declining hippocampal function in aging and Alzheimer's disease

(2012) Karlie A. Intlekofer et al.   NEUROBIOLOGY OF DISEASE

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

(2011) Akinobu Suzuki et al.   CELL

Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

(2011) Mireille Bélanger et al.   Cell Metabolism

Food for thought: the importance of glucose and other energy substrates for sustaining brain function under varying levels of activity

(2011) L. Pellerin   DIABETES & METABOLISM

The monocarboxylate transporter family-Role and regulation

(2011) Andrew P. Halestrap et al.   IUBMB LIFE

Sweet Sixteen for ANLS

(2011) Luc Pellerin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuronal basis of age-related working memory decline

(2011) Min Wang et al.   NATURE

Lactate kinetics in human tissues at rest and during exercise

(2010) Gerrit van Hall   Acta Physiologica

Neuron-glia metabolic coupling and plasticity

(2010) Pierre J. Magistretti   EXPERIMENTAL PHYSIOLOGY

Linking supply to demand: the neuronal monocarboxylate transporter MCT2 and the α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionic acid receptor GluR2/3 subunit are associated in a common trafficking process

(2009) Karin Pierre et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Brain-Derived Neurotrophic Factor Enhances the Expression of the Monocarboxylate Transporter 2 through Translational Activation in Mouse Cultured Cortical Neurons

(2009) Camille Robinet et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cell-cell and intracellular lactate shuttles

(2009) George A. Brooks   JOURNAL OF PHYSIOLOGY-LONDON

Current Trends in Lactate Metabolism

(2009) L. BRUCE GLADDEN   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Role of GPR81 in lactate-mediated reduction of adipose lipolysis

(2008) Tian-Quan Cai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lactate fuels the human brain during exercise

(2008) Bjørn Quistorff et al.   FASEB JOURNAL

Preferential transport and metabolism of glucose in Bergmann glia over Purkinje cells: A multiphoton study of cerebellar slices

(2008) L.F. Barros et al.   GLIA

ERK phosphorylation: Spatial and temporal regulation by G protein-coupled receptors

(2008) Lauren T. May et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Lactate Inhibits Lipolysis in Fat Cells through Activation of an Orphan G-protein-coupled Receptor, GPR81

(2008) Changlu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Redox proteomic identification of 4-Hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: Insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease

(2008) Tanea Reed et al.   NEUROBIOLOGY OF DISEASE