Lactate and pyruvate promote oxidative stress resistance through hormetic ROS signaling

Impairing L-Threonine Catabolism Promotes Healthspan through Methylglyoxal-Mediated Proteohormesis

(2018) Meenakshi Ravichandran et al.   Cell Metabolism

Lactate in the brain: from metabolic end-product to signalling molecule

(2018) Pierre J. Magistretti et al.   NATURE REVIEWS NEUROSCIENCE

Dual action of L-Lactate on the activity of NR2B-containing NMDA receptors: from potentiation to neuroprotection

(2018) P. Jourdain et al.   Scientific Reports

NRF2 transcriptionally activates the heat shock factor 1 promoter under oxidative stress and affects survival and migration potential of MCF7 cells

(2018) Soumyadip Paul et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging

(2017) Johnathan Labbadia et al.   Cell Reports

The Role of Co-chaperones in Synaptic Proteostasis and Neurodegenerative Disease

(2017) Erica L. Gorenberg et al.   Frontiers in Neuroscience

mTOR as a Key Regulator in Maintaining Skeletal Muscle Mass

(2017) Mee-Sup Yoon   Frontiers in Physiology

Mitochondrial metabolites extend lifespan

(2016) Robert J. Mishur et al.   AGING CELL

Fragile lifespan expansion by dietary mitohormesis in C. elegans

(2016) Arnaud Tauffenberger et al.   Aging-US

Oxidation of NADH and ROS production by respiratory complex I

(2016) Andrei D. Vinogradov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The role of insulin/IGF-1 signaling in the longevity of model invertebrates, C. elegans and D. melanogaster

(2016) Ozlem Altintas et al.   BMB Reports

In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons

(2016) Philipp Mächler et al.   Cell Metabolism

Effective PI3K modulators for improved therapy against malignant tumors and for neuroprotection of brain damage after tumor therapy (Review)

(2016) Satoru Matsuda et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Bioenergetics and redox adaptations of astrocytes to neuronal activity

(2016) Juan P. Bolaños   JOURNAL OF NEUROCHEMISTRY

tPA promotes cortical neuron survival via mTOR-dependent mechanisms

(2016) Julia A. Grummisch et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Cysteine Sulfenylation Directs IRE-1 to Activate the SKN-1/Nrf2 Antioxidant Response

(2016) John M. Hourihan et al.   MOLECULAR CELL

The Mitochondrial Basis of Aging

(2016) Nuo Sun et al.   MOLECULAR CELL

L-Lactate protects neurons against excitotoxicity: implication of an ATP-mediated signaling cascade

(2016) P. Jourdain et al.   Scientific Reports

DLK-1, SEK-3 and PMK-3 Are Required for the Life Extension Induced by Mitochondrial Bioenergetic Disruption in C. elegans

(2016) Erin Munkácsy et al.   PLoS Genetics

Attenuation of rotenone toxicity in SY5Y cells by taurine and N-acetyl cysteine alone or in combination

(2015) Faisal K. Alkholifi et al.   BRAIN RESEARCH

SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans

(2015) T. Keith Blackwell et al.   FREE RADICAL BIOLOGY AND MEDICINE

Repression of the Heat Shock Response Is a Programmed Event at the Onset of Reproduction

(2015) Johnathan Labbadia et al.   MOLECULAR CELL

Proteostasis and aging

(2015) Susmita Kaushik et al.   NATURE MEDICINE

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

(2015) Pierre J. Magistretti et al.   NEURON

L-Lactate Protects Skin Fibroblasts against Aging-Associated Mitochondrial DysfunctionviaMitohormesis

(2015) Jaroslav Zelenka et al.   Oxidative Medicine and Cellular Longevity

Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions

(2015) Robert Haas et al.   PLOS BIOLOGY

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

Mitohormesis

(2014) Jeanho Yun et al.   Cell Metabolism

Unraveling the Truth About Antioxidants: Mitohormesis explains ROS-induced health benefits

(2014) Michael Ristow   NATURE MEDICINE

Lactate Regulates Rat Male Germ Cell Function through Reactive Oxygen Species

(2014) María Noel Galardo et al.   PLoS One

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity

(2013) Rebecca C. Taylor et al.   CELL

Rapid cell death is preceded by amyloid plaque-mediated oxidative stress

(2013) H. Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integration of the Unfolded Protein and Oxidative Stress Responses through SKN-1/Nrf

(2013) Kira M. Glover-Cutter et al.   PLoS Genetics

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Impaired Insulin/IGF1 Signaling Extends Life Span by Promoting Mitochondrial L-Proline Catabolism to Induce a Transient ROS Signal

(2012) Kim Zarse et al.   Cell Metabolism

Sodium L-lactate differently affects brain-derived neurothrophic factor, inducible nitric oxide synthase, and heat shock protein 70 kDa production in human astrocytes and SH-SY5Y cultures

(2012) Marinella Coco et al.   JOURNAL OF NEUROSCIENCE RESEARCH

TDP-1/TDP-43 Regulates Stress Signaling and Age-Dependent Proteotoxicity in Caenorhabditis elegans

(2012) Alexandra Vaccaro et al.   PLoS Genetics

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

(2011) Akinobu Suzuki et al.   CELL

In Vivo Mapping of Hydrogen Peroxide and Oxidized Glutathione Reveals Chemical and Regional Specificity of Redox Homeostasis

(2011) Simone C. Albrecht et al.   Cell Metabolism

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

N-acetylcysteine, reactive oxygen species and beyond

(2010) Shi-Yong Sun   CANCER BIOLOGY & THERAPY

The mitochondrial UPR - protecting organelle protein homeostasis

(2010) C. M. Haynes et al.   JOURNAL OF CELL SCIENCE

A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans

(2010) Wen Yang et al.   PLOS BIOLOGY

Awareness of Hormesis Will Enhance Future Research in Basic and Applied Neuroscience

(2009) Mark P. Mattson   CRITICAL REVIEWS IN TOXICOLOGY

Choice of DMEM, formulated with or without pyruvate, plays an important role in assessing the in vitro cytotoxicity of oxidants and prooxidant nutraceuticals

(2009) H. Babich et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Neuroprotective Role of Lactate after Cerebral Ischemia

(2009) Carole Berthet et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Axon Regeneration Requires a Conserved MAP Kinase Pathway

(2009) M. Hammarlund et al.   SCIENCE

Protective effect of quercetin on ER stress caused by calcium dynamics dysregulation in intestinal epithelial cells

(2009) Yayoi Natsume et al.   TOXICOLOGY

Early Mitochondrial Dysfunction in Long-livedMclk1+/-Mice

(2008) Jérôme Lapointe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence for the Mitochondrial Lactate Oxidation Complex in Rat Neurons: Demonstration of an Essential Component of Brain Lactate Shuttles

(2008) Takeshi Hashimoto et al.   PLoS One