HIV Nef Expression Down-modulated GFAP Expression and Altered Glutamate Uptake and Release and Proliferation in Astrocytes

Mechanisms of neuronal dysfunction in HIV-associated neurocognitive disorders

(2021) Elena Irollo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

GFAP hyperpalmitoylation exacerbates astrogliosis and neurodegenerative pathology in PPT1-deficient mice

(2021) Wei Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippocampal astrocytic neogenin regulating glutamate uptake, a critical pathway for preventing epileptic response

(2021) Dong Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuromodulation of BAG co-chaperones by HIV-1 viral proteins and H2O2: implications for HIV-associated neurological disorders

(2021) Michael R. Duggan et al.   Cell Death Discovery

Activation of α7 nicotinic acetylcholine receptor ameliorates HIV-associated neurology and neuropathology

(2021) Xiaojie Zhao et al.   BRAIN

Interrogating the impact of combination antiretroviral therapies on HIV‐associated neurocognitive disorders

(2021) Ishta Sharma   HIV MEDICINE

A Computational Study of Astrocytic GABA Release at the Glutamatergic Synapse: EAAT-2 and GAT-3 Coupled Dynamics

(2021) Bronac Flanagan et al.   Frontiers in Cellular Neuroscience

HIV in the Brain: Identifying Viral Reservoirs and Addressing the Challenges of an HIV Cure

(2021) Michelle K. Ash et al.   Vaccines

Alzheimer’s-Like Pathology at the Crossroads of HIV-Associated Neurological Disorders

(2021) Divya T. Chemparthy et al.   Vaccines

Deficiency in Androgen Receptor Aggravates Traumatic Brain Injury-Induced Pathophysiology and Motor Deficits in Mice

(2021) Yu-Hsin Chen et al.   MOLECULES

HIV infection of astrocytes compromises inter-organelle interactions and inositol phosphate metabolism: A potential mechanism of bystander damage and viral reservoir survival

(2021) Shaily Malik et al.   PROGRESS IN NEUROBIOLOGY

HIV-1 Nef counteracts autophagy restriction by enhancing the association between BECN1 and its inhibitor BCL2 in a PRKN-dependent manner

(2020) Sergio Castro-Gonzalez et al.   Autophagy

The far-reaching HAND of cART: cART effects on astrocytes

(2020) Hemil Gonzalez et al.   Journal of Neuroimmune Pharmacology

Transcriptomic analysis of brain tissues identifies a role for CCAAT enhancer binding protein β in HIV-associated neurocognitive disorder

(2020) Saranya Canchi et al.   Journal of Neuroinflammation

Extracellular HIV-1 Tat Mediates Increased Glutamate in the CNS Leading to Onset of Senescence and Progression of HAND

(2020) Jamie Marino et al.   Frontiers in Aging Neuroscience

HIV infects astrocytes in vivo and egresses from the brain to the periphery

(2020) Victoria Lutgen et al.   PLoS Pathogens

The Glutamate System as a Crucial Regulator of CNS Toxicity and Survival of HIV Reservoirs

(2020) Anna Maria Gorska et al.   Frontiers in Cellular and Infection Microbiology

HIV Nef and Antiretroviral Therapy Have an Inhibitory Effect on Autophagy in Human Astrocytes that May Contribute to HIV-Associated Neurocognitive Disorders

(2020) Laura Cheney et al.   Cells

HIV-1 Nef promotes ubiquitination and proteasomal degradation of p53 tumor suppressor protein by using E6AP

(2020) Amjad Ali et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Variation in HIV-1 Nef function within and among viral subtypes reveals genetically separable antagonism of SERINC3 and SERINC5

(2020) Steven W. Jin et al.   PLoS Pathogens

Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H2O2− production

(2020) Heejung Chun et al.   NATURE NEUROSCIENCE

The Prevalence of Frascati-Criteria-Based HIV-Associated Neurocognitive Disorder (HAND) in HIV-Infected Adults: A Systematic Review and Meta-Analysis

(2020) Jiaqi Wei et al.   Frontiers in Neurology

Silencing of Transcription Factor Sp1 Promotes SN1 Transporter Regulation by Ammonia in Mouse Cortical Astrocytes

(2019) Katarzyna Dąbrowska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Astrocytes Maintain Glutamate Homeostasis in the CNS by Controlling the Balance between Glutamate Uptake and Release

(2019) Shaimaa Mahmoud et al.   Cells

Astrocytic endfeet re-cover blood vessels after removal by laser ablation

(2019) Hideaki Kubotera et al.   Scientific Reports

HIV-1 Nef physically associate with CAMKIIδ – ASK-1 complex to inhibit p38MAPK signalling and apoptosis in infected cells

(2019) Pradeep Kumar et al.   LIFE SCIENCES

Sp1 in Astrocyte Is Important for Neurite Outgrowth and Synaptogenesis

(2019) Chia-Yang Hung et al.   MOLECULAR NEUROBIOLOGY

Astrocytes: Role and Functions in Brain Pathologies

(2019) Rosalba Siracusa et al.   Frontiers in Pharmacology

Infusion of HIV-1 Nef-expressing astrocytes into the rat hippocampus induces enteropathy and interstitial pneumonitis and increases blood–brain-barrier permeability

(2019) Jocelyn Rivera et al.   PLoS One

Natural HIV-1 Nef Polymorphisms Impair SERINC5 Downregulation Activity

(2019) Steven W. Jin et al.   Cell Reports

Nef-induced CCL2 Expression Contributes to HIV/SIV Brain Invasion and Neuronal Dysfunction

(2019) Michael H. Lehmann et al.   Frontiers in Immunology

Role of Astrocytes in Post-traumatic Epilepsy

(2019) Songbai Xu et al.   Frontiers in Neurology

TGFβRI antagonist inhibits HIV-1 Nef-induced CC chemokine family ligand 2 (CCL2) in the brain and prevents spatial learning impairment

(2019) Gladys Chompre et al.   Journal of Neuroinflammation

Mechanisms involved in epigenetic down-regulation of Gfap under maternal hypothyroidism

(2018) Praveen Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HIV-1 Nef Antagonizes SERINC5 Restriction by Downregulation of SERINC5 via the Endosome/Lysosome System

(2018) Jing Shi et al.   JOURNAL OF VIROLOGY

Astrocytes, neurons, synapses: a tripartite view on cortical circuit development

(2018) Isabella Farhy-Tselnicker et al.   Neural Development

Astroglial Glutamate Signaling and Uptake in the Hippocampus

(2018) Christine R. Rose et al.   Frontiers in Molecular Neuroscience

Astrocytic Atrophy Following Status Epilepticus Parallels Reduced Ca2+ Activity and Impaired Synaptic Plasticity in the Rat Hippocampus

(2018) Alex Plata et al.   Frontiers in Molecular Neuroscience

Reduced astrocytic expression of GFAP in the offspring of female rats that received hypercaloric diet

(2018) Jéssica Molina et al.   NUTRITIONAL NEUROSCIENCE

Induction of HIF-1α by HIV-1 Infection in CD4+ T Cells Promotes Viral Replication and Drives Extracellular Vesicle-Mediated Inflammation

(2018) Gabriel Duette et al.   mBio

HIV blocks Type I IFN signaling through disruption of STAT1 phosphorylation

(2018) Nam V Nguyen et al.   Innate Immunity

HIV-1 Nef-induced lncRNA AK006025 regulates CXCL9/10/11 cluster gene expression in astrocytes through interaction with CBP/P300

(2018) Feng Zhou et al.   Journal of Neuroinflammation

Type I interferon-regulated gene expression and signaling in murine mixed glial cells lacking signal transducers and activators of transcription 1 or 2 or interferon regulatory factor 9

(2017) Wen Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glial fibrillary acidic protein exhibits altered turnover kinetics in a mouse model of Alexander disease

(2017) Laura R. Moody et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Importance of Autophagy in Mediating Human Immunodeficiency Virus (HIV) and Morphine-Induced Metabolic Dysfunction and Inflammation in Human Astrocytes

(2017) Myosotys Rodriguez et al.   Viruses-Basel

Comparative Analysis of Human, Mouse, and Pig Glial Fibrillary Acidic Protein Gene Structures

(2016) Kiyoung Eun et al.   ANIMAL BIOTECHNOLOGY

p53 isoforms regulate astrocyte-mediated neuroprotection and neurodegeneration

(2016) C Turnquist et al.   CELL DEATH AND DIFFERENTIATION

HIV-1 Tat Promotes Lysosomal Exocytosis in Astrocytes and Contributes to Astrocyte-mediated Tat Neurotoxicity

(2016) Yan Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 Tat Induces Unfolded Protein Response and Endoplasmic Reticulum Stress in Astrocytes and Causes Neurotoxicity through Glial Fibrillary Acidic Protein (GFAP) Activation and Aggregation

(2016) Yan Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oncostatin M promotes excitotoxicity by inhibiting glutamate uptake in astrocytes: implications in HIV-associated neurotoxicity

(2016) Shamsudheen Moidunny et al.   Journal of Neuroinflammation

Unexpected central role of the androgen receptor in the spontaneous regeneration of myelin

(2016) Bartosz Bielecki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly activated p53 contributes to selectively increased apoptosis of latently HIV-1 infected cells upon treatment of anticancer drugs

(2016) YoungHyun Shin et al.   Virology Journal

STAT1 Signaling in Astrocytes Is Essential for Control of Infection in the Central Nervous System

(2016) Shinya Hidano et al.   mBio

Dysregulation of autophagy by HIV-1 Nef in human astrocytes

(2015) A Sami Saribas et al.   CELL CYCLE

STAT3 and Its Phosphorylation are Involved in HIV-1 Tat-Induced Transactivation of Glial Fibrillary Acidic Protein

(2015) Yan Fan et al.   CURRENT HIV RESEARCH

Intermediate Filaments Play a Pivotal Role in Regulating Cell Architecture and Function

(2015) Jason Lowery et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53-Derived Host Restriction of HIV-1 Replication by Protein Kinase R-Mediated Tat Phosphorylation and Inactivation

(2015) Cheol-Hee Yoon et al.   JOURNAL OF VIROLOGY

Tip110 Regulates the Cross Talk between p53 and Hypoxia-Inducible Factor 1α under Hypoxia and Promotes Survival of Cancer Cells

(2015) Khalid Amine Timani et al.   MOLECULAR AND CELLULAR BIOLOGY

Glial fibrillary acidic protein is differentially expressed across cortical and subcortical regions in healthy brains and downregulated in the thalamus and caudate nucleus of depressed suicides

(2015) S G Torres-Platas et al.   MOLECULAR PSYCHIATRY

Human Immunodeficiency Virus Type 1 Nef Inhibits Autophagy through Transcription Factor EB Sequestration

(2015) Grant R. Campbell et al.   PLoS Pathogens

Exosomes Are Unlikely Involved in Intercellular Nef Transfer

(2015) Xiaoyu Luo et al.   PLoS One

Glutamate metabolism and HIV-associated neurocognitive disorders

(2014) Fabián J. Vázquez-Santiago et al.   JOURNAL OF NEUROVIROLOGY

Cell–cell contact viral transfer contributes to HIV infection and persistence in astrocytes

(2014) Xiaoyu Luo et al.   JOURNAL OF NEUROVIROLOGY

Monocyte chemoattractant protein-1 and the blood–brain barrier

(2013) Yao Yao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Transgenic analysis ofGFAPpromoter elements

(2013) Sujeong Yeo et al.   GLIA

Increased in vitro glial fibrillary acidic protein expression, telomerase activity, and telomere length after productive human immunodeficiency virus-1 infection in murine astrocytes

(2013) Diego Ojeda et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Hypoxia-Inducible Factor 1 Protects Hypoxic Astrocytes against Glutamate Toxicity

(2012) Yomna Badawi et al.   ASN Neuro

Beneficial effects of curcumin on GFAP filament organization and down-regulation of GFAP expression in an in vitro model of Alexander disease

(2012) Tiziana Bachetti et al.   EXPERIMENTAL CELL RESEARCH

Immune activation, viral gene product expression and neurotoxicity in the HIV-1 transgenic rat

(2012) Walter Royal et al.   JOURNAL OF NEUROIMMUNOLOGY

Astrocytes Control the Development of the Migration-Promoting Vasculature Scaffold in the Postnatal Brain via VEGF Signaling

(2012) L. Bozoyan et al.   JOURNAL OF NEUROSCIENCE

Exogenous HIV-1 Nef Upsets the IFN-γ-Induced Impairment of Human Intestinal Epithelial Integrity

(2011) Maria Giovanna Quaranta et al.   PLoS One

HIV-1 Nef Induces Proinflammatory State in Macrophages through Its Acidic Cluster Domain: Involvement of TNF Alpha Receptor Associated Factor 2

(2011) Giorgio Mangino et al.   PLoS One

Regulation of the HIV-1 promoter by HIF-1α and Vpr proteins

(2011) Satish L Deshmane et al.   Virology Journal

HIV-1 Nef increases astrocyte sensitivity towards exogenous hydrogen peroxide

(2011) Sabine Masanetz et al.   Virology Journal

Cognitive dysfunction in HIV patients despite long-standing suppression of viremia

(2010) Samanta Simioni et al.   AIDS

Transcriptional regulation of HIV-1 gene expression by p53

(2010) Ruma Mukerjee et al.   CELL CYCLE

Involvement of p300 in constitutive and HIV-1 Tat-activated expression of glial fibrillary acidic protein in astrocytes

(2010) Wei Zou et al.   GLIA

Exogenous Nef Is an Inhibitor ofMycobacterium tuberculosis-induced Tumor Necrosis Factor-α Production and Macrophage Apoptosis

(2010) Kuldeep Kumawat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Egr-1 Expression in Astrocytes by HIV-1 Tat: New Insights into Astrocyte-Mediated Tat Neurotoxicity

(2010) Yan Fan et al.   Journal of Neuroimmune Pharmacology

HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study

(2010) R. K. Heaton et al.   NEUROLOGY

Inhibition of HIV-1 Infection and Replication by Enhancing Viral Incorporation of Innate Anti-HIV-1 Protein A3G

(2009) Linden A. Green et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adult AIDS-Like Disease in a Novel Inducible Human Immunodeficiency Virus Type 1 Nef Transgenic Mouse Model: CD4+ T-Cell Activation Is Nef Dependent and Can Occur in the Absence of Lymphophenia

(2009) M. M. A. Rahim et al.   JOURNAL OF VIROLOGY

Sp1 Phosphorylation and Its Regulation of Gene Transcription

(2009) N. Y. Tan et al.   MOLECULAR AND CELLULAR BIOLOGY

Combined effects of hyperglycemic conditions and HIV-1 Nef: a potential model for induced HIV neuropathogenesis

(2009) Edward A Acheampong et al.   Virology Journal