HIV infection of astrocytes compromises inter-organelle interactions and inositol phosphate metabolism: A potential mechanism of bystander damage and viral reservoir survival

Emr1 regulates the number of foci of the endoplasmic reticulum-mitochondria encounter structure complex

(2021) Faiz Rasul et al.   Nature Communications

Astrocytes are HIV reservoirs in the brain: a cell type with poor HIV‐infectivity and replication but efficient cell‐to‐cell viral transfer

(2021) Valdebenito Silvana et al.   JOURNAL OF NEUROCHEMISTRY

Productive HIV infection in astrocytes can be established via a non-classical mechanism

(2020) Guan-Han Li et al.   AIDS

Insights into the Gene Expression Profiles of Active and Restricted Red/Green-HIV+ Human Astrocytes: Implications for Shock or Lock Therapies in the Brain

(2020) Venkata Viswanadh Edara et al.   JOURNAL OF VIROLOGY

HIV gp120 Protein Increases the Function of Connexin 43 Hemichannels and Pannexin-1 Channels in Astrocytes: Repercussions on Astroglial Function

(2020) Rosario Gajardo-Gómez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

HIV infects astrocytes in vivo and egresses from the brain to the periphery

(2020) Victoria Lutgen et al.   PLoS Pathogens

Role of Tunneling Nanotube–like Structures during the Early Events of HIV Infection: Novel Features of Tissue Compartmentalization and Mechanism of HIV Spread

(2020) George Okafo et al.   JOURNAL OF IMMUNOLOGY

DIABLO/SMAC mimetics selectively kill HIV-1-infected resting memory CD4+ T cells: a potential role in a cure strategy for HIV-1 infection

(2019) Grant R. Campbell et al.   Autophagy

Astrocyte function from information processing to cognition and cognitive impairment

(2019) Mirko Santello et al.   NATURE NEUROSCIENCE

HIV-1 reservoirs in urethral macrophages of patients under suppressive antiretroviral therapy

(2019) Yonatan Ganor et al.   Nature Microbiology

Connexin Hemichannels in Astrocytes: Role in CNS Disorders

(2019) LingYan Xing et al.   Frontiers in Molecular Neuroscience

Connexin and Pannexin-Based Channels in Oligodendrocytes: Implications in Brain Health and Disease

(2019) Sebastián Vejar et al.   Frontiers in Cellular Neuroscience

Lipid transporter TMEM24/C2CD2L is a Ca2+-regulated component of ER–plasma membrane contacts in mammalian neurons

(2019) Elizabeth Wen Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inositol polyphosphate multikinase mediates extinction of fear memory

(2019) Jina Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human VPS13A is associated with multiple organelles and influences mitochondrial morphology and lipid droplet motility

(2019) Wondwossen M Yeshaw et al.   eLife

Tracking intra‐ and inter‐organelle signaling of mitochondria

(2019) Corina T. Madreiter‐Sokolowski et al.   FEBS Journal

Recessive mutations in >VPS13D cause childhood onset movement disorders

(2018) Julie Gauthier et al.   ANNALS OF NEUROLOGY

Mutations in VPS13D lead to a new recessive ataxia with spasticity and mitochondrial defects

(2018) Eunju Seong et al.   ANNALS OF NEUROLOGY

The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and Future

(2018) Benjamin A. Plog et al.   Annual Review of Pathology-Mechanisms of Disease

Dysregulation of autophagy in rat liver with mitochondrial DNA depletion induced by the nucleoside analogue zidovudine

(2018) Ana Santos-Llamas et al.   ARCHIVES OF TOXICOLOGY

The role of connexin and pannexin containing channels in the innate and acquired immune response

(2018) Silvana Valdebenito et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Building ER-PM contacts: keeping calm and ready on alarm

(2018) Christopher J Stefan   CURRENT OPINION IN CELL BIOLOGY

Inositol 1,4,5-trisphosphate receptors and neurodegenerative disorders

(2018) Polina A. Egorova et al.   FEBS Journal

miR-181a-5p Promotes Proliferation and Invasion and Inhibits Apoptosis of Cervical Cancer Cells via Regulating Inositol Polyphosphate-5-Phosphatase A (INPP5A)

(2018) Meng Yang et al.   ONCOLOGY RESEARCH

The Role of Phospholipase C Signaling in Macrophage-Mediated Inflammatory Response

(2018) Liqian Zhu et al.   Journal of Immunology Research

VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites

(2018) Nikit Kumar et al.   JOURNAL OF CELL BIOLOGY

Macrophages but not Astrocytes Harbor HIV DNA in the Brains of HIV-1-Infected Aviremic Individuals on Suppressive Antiretroviral Therapy

(2018) Allen Ko et al.   Journal of Neuroimmune Pharmacology

Here, there, and everywhere: The importance of ER membrane contact sites

(2018) Haoxi Wu et al.   SCIENCE

Frequent loss of inositol polyphosphate-5-phosphatase in oropharyngeal squamous cell carcinoma

(2017) A.B. Patel et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Role of Connexin and Pannexin containing channels in HIV infection and NeuroAIDS

(2017) Shaily Malik et al.   NEUROSCIENCE LETTERS

Contacts between the endoplasmic reticulum and other membranes in neurons

(2017) Yumei Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytes Resist HIV-1 Fusion but Engulf Infected Macrophage Material

(2017) Rebecca A. Russell et al.   Cell Reports

Connexin43 Containing Gap Junction Channels Facilitate HIV Bystander Toxicity: Implications in NeuroHIV

(2017) Shaily Malik et al.   Frontiers in Molecular Neuroscience

Regulation of Exocytotic Fusion Pores by SNARE Protein Transmembrane Domains

(2017) Zhenyong Wu et al.   Frontiers in Molecular Neuroscience

Inositol polyphosphate multikinase promotes Toll-like receptor–induced inflammation by stabilizing TRAF6

(2017) Eunha Kim et al.   Science Advances

Drosophila Vps13 Is Required for Protein Homeostasis in the Brain

(2017) Jan J. Vonk et al.   PLoS One

HIV-infected macrophages and microglia that survive acute infection become viral reservoirs by a mechanism involving Bim

(2017) Paul Castellano et al.   Scientific Reports

Tunneling nanotubes (TNT) mediate long-range gap junctional communication: Implications for HIV cell to cell spread

(2017) George Okafo et al.   Scientific Reports

Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy

(2016) Suzanne Lesage et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Regulation of calcium and phosphoinositides at endoplasmic reticulum–membrane junctions

(2016) Eamonn J. Dickson et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Endosome-ER Contacts Control Actin Nucleation and Retromer Function through VAP-Dependent Regulation of PI4P

(2016) Rui Dong et al.   CELL

Mechanisms of HIV Neuropathogenesis: Role of Cellular Communication Systems

(2016) Shaily Malik et al.   CURRENT HIV RESEARCH

5′-Inositol phosphatase SHIP2 recruits Mena to stabilize invadopodia for cancer cell invasion

(2016) Charles V. Rajadurai et al.   JOURNAL OF CELL BIOLOGY

HIV-tat alters Connexin43 expression and trafficking in human astrocytes: role in NeuroAIDS

(2016) Joan W. Berman et al.   Journal of Neuroinflammation

Roles of inositol 1,4,5-trisphosphate receptors in spinocerebellar ataxias

(2016) Masayoshi Tada et al.   NEUROCHEMISTRY INTERNATIONAL

Cognitive Impairment and Persistent CNS Injury in Treated HIV

(2016) Phillip Chan et al.   Current HIV/AIDS Reports

Regulating G protein activity by lipase-independent functions of phospholipase C

(2015) Irene Litosch   LIFE SCIENCES

The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane

(2015) Jeremy M. Baskin et al.   NATURE CELL BIOLOGY

Deletion of Inpp5a causes ataxia and cerebellar degeneration in mice

(2015) Andy W. Yang et al.   NEUROGENETICS

PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-plasma membrane contacts

(2015) J. Chung et al.   SCIENCE

HIV-Associated Neurocognitive Disorders: The Relationship of HIV Infection with Physical and Social Comorbidities

(2015) Ellen M. Tedaldi et al.   Biomed Research International

Differing roles of autophagy in HIV-associated neurocognitive impairment and encephalitis with implications for morphine co-exposure

(2015) Seth M. Dever et al.   Frontiers in Microbiology

Inositol 1,4,5-trisphosphate receptor-isoform diversity in cell death and survival

(2014) Hristina Ivanova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Role of Connexin/Pannexin containing channels in infectious diseases

(2014) Eliseo A. Eugenin   FEBS LETTERS

Roles of autophagy in HIV infection

(2014) Christina Dinkins et al.   IMMUNOLOGY AND CELL BIOLOGY

A role for eisosomes in maintenance of plasma membrane phosphoinositide levels

(2014) Florian Fröhlich et al.   MOLECULAR BIOLOGY OF THE CELL

The junctophilin family of proteins: from bench to bedside

(2014) Andrew P. Landstrom et al.   TRENDS IN MOLECULAR MEDICINE

PI(4,5)P2-Dependent and Ca2+-Regulated ER-PM Interactions Mediated by the Extended Synaptotagmins

(2013) Francesca Giordano et al.   CELL

Targeting tumour necrosis factor-α in hypoxia and synaptic signalling

(2013) J. J. O’Connor   IRISH JOURNAL OF MEDICAL SCIENCE

Cytochromecdysregulation induced by HIV infection of astrocytes results in bystander apoptosis of uninfected astrocytes by an IP3and calcium-dependent mechanism

(2013) Eliseo A. Eugenin et al.   JOURNAL OF NEUROCHEMISTRY

HIV increases the release of dickkopf-1 protein from human astrocytes by a Cx43 hemichannel-dependent mechanism

(2013) Juan Andres Orellana et al.   JOURNAL OF NEUROCHEMISTRY

Epigenetic Regulation of HIV-1 Latency in Astrocytes

(2013) S. D. Narasipura et al.   JOURNAL OF VIROLOGY

IL-1β induces GFAP expression in vitro and in vivo and protects neurons from traumatic injury-associated apoptosis in rat brain striatum via NFκB/Ca2+–calmodulin/ERK mitogen-activated protein kinase signaling pathway

(2013) C. Sticozzi et al.   NEUROSCIENCE

Inositol polyphosphate multikinase is a coactivator for serum response factor-dependent induction of immediate early genes

(2013) E. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inositol polyphosphate multikinase signaling in the regulation of metabolism

(2012) Joo-Young Lee et al.   Annals of the New York Academy of Sciences

Inositol polyphosphate multikinase: An emerging player for the central action of AMP-activated protein kinase

(2012) Megan J. Dailey et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Astrocyte calcium signaling and epilepsy

(2012) Giorgio Carmignoto et al.   GLIA

Intercellular Ca2+ Waves: Mechanisms and Function

(2012) Luc Leybaert et al.   PHYSIOLOGICAL REVIEWS

Amino Acid Signaling to mTOR Mediated by Inositol Polyphosphate Multikinase

(2011) Seyun Kim et al.   Cell Metabolism

Human Immunodeficiency Virus Infection of Human Astrocytes Disrupts Blood-Brain Barrier Integrity by a Gap Junction-Dependent Mechanism

(2011) E. A. Eugenin et al.   JOURNAL OF NEUROSCIENCE

HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors

(2010) Robert K. Heaton et al.   JOURNAL OF NEUROVIROLOGY

GABA uptake-dependent Ca2+ signaling in developing olfactory bulb astrocytes

(2009) M. Doengi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A nitric oxide/Ca2+/calmodulin/ERK1/2 mitogen-activated protein kinase pathway is involved in the mitogenic effect of IL-1β in human astrocytoma cells

(2008) A Meini et al.   BRITISH JOURNAL OF PHARMACOLOGY

Glial connexins and gap junctions in CNS inflammation and disease

(2008) Tammy Kielian   JOURNAL OF NEUROCHEMISTRY