HIV in the Brain: Identifying Viral Reservoirs and Addressing the Challenges of an HIV Cure

Productive HIV infection in astrocytes can be established via a non-classical mechanism

(2020) Guan-Han Li et al.   AIDS

Block-And-Lock Strategies to Cure HIV Infection

(2020) Gerlinde Vansant et al.   Viruses-Basel

HIV infects astrocytes in vivo and egresses from the brain to the periphery

(2020) Victoria Lutgen et al.   PLoS Pathogens

Very early ART initiation during acute HIV infection is associated with normalization of cerebrospinal fluid but not plasma markers of immune activation

(2019) Joanna Hellmuth et al.   JOURNAL OF INFECTIOUS DISEASES

HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation

(2019) Ravindra K. Gupta et al.   NATURE

Correction to: Astrocytes as an HIV CNS reservoir: highlights and reflections of an NIMH-sponsored symposium

(2019) Lena Al-Harthi et al.   JOURNAL OF NEUROVIROLOGY

A (delayed) history of the brain lymphatic system

(2019) Stefano Sandrone et al.   NATURE MEDICINE

Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice

(2019) Prasanta K. Dash et al.   Nature Communications

Microglia Biology: One Century of Evolving Concepts

(2019) Marco Prinz et al.   CELL

Cross-talk between microglia and neurons regulates HIV latency

(2019) David Alvarez-Carbonell et al.   PLoS Pathogens

Novel Latency Reversal Agents for HIV-1 Cure

(2018) Adam M. Spivak et al.   Annual Review of Medicine

Astrocytes and microglia: Models and tools

(2018) Kevin A. Guttenplan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

RNA-induced epigenetic silencing inhibits HIV-1 reactivation from latency

(2018) Catalina Méndez et al.   Retrovirology

Characterization of Inducible Transcription and Translation-Competent HIV-1 Using the RNAscope ISH Technology at a Single-Cell Resolution

(2018) Wang Zhang et al.   Frontiers in Microbiology

Synthetic AAV/CRISPR vectors for blocking HIV-1 expression in persistently infected astrocytes

(2017) Christine Kunze et al.   GLIA

HIV-1-associated neurocognitive disorder: epidemiology, pathogenesis, diagnosis, and treatment

(2017) Christian Eggers et al.   JOURNAL OF NEUROLOGY

Defining total-body AIDS-virus burden with implications for curative strategies

(2017) Jacob D Estes et al.   NATURE MEDICINE

Reduced antiretroviral drug efficacy and concentration in HIV-infected microglia contributes to viral persistence in brain

(2017) Eugene L. Asahchop et al.   Retrovirology

Brain Macrophages in Simian Immunodeficiency Virus-Infected, Antiretroviral-Suppressed Macaques: a Functional Latent Reservoir

(2017) Claudia R. Avalos et al.   mBio

A CRISPR/Cas9 guidance RNA screen platform for HIV provirus disruption and HIV/AIDS gene therapy in astrocytes

(2017) Zaohua Huang et al.   Scientific Reports

In Vivo Suppression of HIV Rebound by Didehydro-Cortistatin A, a “Block-and-Lock” Strategy for HIV-1 Treatment

(2017) Cari F. Kessing et al.   Cell Reports

HIV-infected macrophages and microglia that survive acute infection become viral reservoirs by a mechanism involving Bim

(2017) Paul Castellano et al.   Scientific Reports

A SERS-based lateral flow assay biosensor for highly sensitive detection of HIV-1 DNA

(2016) Xiuli Fu et al.   BIOSENSORS & BIOELECTRONICS

β-Catenin signaling positively regulates glutamate uptake and metabolism in astrocytes

(2016) Victoria Lutgen et al.   Journal of Neuroinflammation

A new model for post-integration latency in macroglial cells to study HIV-1 reservoirs of the brain

(2015) Martha Schneider et al.   AIDS

Role of the immune system in HIV-associated neuroinflammation and neurocognitive implications

(2015) Suzi Hong et al.   BRAIN BEHAVIOR AND IMMUNITY

The meningeal lymphatic system: a route for HIV brain migration?

(2015) Susanna L. Lamers et al.   JOURNAL OF NEUROVIROLOGY

Endocytosis of human immunodeficiency virus 1 (HIV-1) in astrocytes: A fiery path to its destination

(2015) Ashok Chauhan et al.   MICROBIAL PATHOGENESIS

Comparison of digital PCR platforms and semi-nested qPCR as a tool to determine the size of the HIV reservoir

(2015) K. J. Bosman et al.   Scientific Reports

Compartmentalized Replication of R5 T Cell-Tropic HIV-1 in the Central Nervous System Early in the Course of Infection

(2015) Christa Buckheit Sturdevant et al.   PLoS Pathogens

Compartmentalization, Viral Evolution, and Viral Latency of HIV in the CNS

(2015) Maria M. Bednar et al.   Current HIV/AIDS Reports

Antiretroviral-Free HIV-1 Remission and Viral Rebound After Allogeneic Stem Cell Transplantation

(2014) Timothy J. Henrich et al.   ANNALS OF INTERNAL MEDICINE

β-Catenin/TCF-4 Signaling Regulates Susceptibility of Macrophages and Resistance of Monocytes to HIV-1 Productive Infection

(2014) Yosra Aljawai et al.   CURRENT HIV RESEARCH

Monocytes Mediate HIV Neuropathogenesis: Mechanisms that Contribute to HIV Associated Neurocognitive Disorders

(2014) Dionna Williams et al.   CURRENT HIV RESEARCH

Ontogeny and Functions of Central Nervous System Macrophages

(2014) Atsuko Katsumoto et al.   JOURNAL OF IMMUNOLOGY

Cell–cell contact viral transfer contributes to HIV infection and persistence in astrocytes

(2014) Xiaoyu Luo et al.   JOURNAL OF NEUROVIROLOGY

HIV-1 target cells in the CNS

(2014) Sarah B. Joseph et al.   JOURNAL OF NEUROVIROLOGY

HIV-1 Entry and Trans-Infection of Astrocytes Involves CD81 Vesicles

(2014) Lachlan R. Gray et al.   PLoS One

Rapid inflammasome activation in microglia contributes to brain disease in HIV/AIDS

(2014) John G Walsh et al.   Retrovirology

Exposure of human astrocytes to leukotriene C4 promotes a CX3CL1/fractalkine-mediated transmigration of HIV-1-infected CD4+ T cells across an in vitro blood–brain barrier model

(2014) Jonathan Bertin et al.   VIROLOGY

Brain alterations within the first 100 days of HIV infection

(2014) Ann B. Ragin et al.   Annals of Clinical and Translational Neurology

Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure

(2013) Ya-Chi Ho et al.   CELL

Oxidative Stress and the HIV-Infected Brain Proteome

(2013) Lerna Uzasci et al.   Journal of Neuroimmune Pharmacology

Epigenetic Regulation of HIV-1 Latency in Astrocytes

(2013) S. D. Narasipura et al.   JOURNAL OF VIROLOGY

SIV infection of rhesus macaques of Chinese origin: a suitable model for HIV infection in humans

(2013) Yu Zhou et al.   Retrovirology

Origin and differentiation of microglia

(2013) Florent Ginhoux et al.   Frontiers in Cellular Neuroscience

Astrocytes and disease: a neurodevelopmental perspective

(2012) A. V. Molofsky et al.   GENES & DEVELOPMENT

Central Nervous System Viral Invasion and Inflammation During Acute HIV Infection

(2012) Victor Valcour et al.   JOURNAL OF INFECTIOUS DISEASES

Wnt/β-catenin and its Diverse Physiological Cell Signaling Pathways in Neurodegenerative and Neuropsychiatric Disorders

(2012) Lena Al-Harthi   Journal of Neuroimmune Pharmacology

Human Immunodeficiency Virus Infection of Human Astrocytes Disrupts Blood-Brain Barrier Integrity by a Gap Junction-Dependent Mechanism

(2011) E. A. Eugenin et al.   JOURNAL OF NEUROSCIENCE

Control of HIV replication in astrocytes by a family of highly conserved host proteins with a common Rev-interacting domain (Risp)

(2010) Michelle Vincendeau et al.   AIDS

Regional Heterogeneity and Diversity in Cytokine and Chemokine Production by Astroglia: Differential Responses to HIV-1 Tat, gp120, and Morphine Revealed by Multiplex Analysis

(2010) Sylvia Fitting et al.   JOURNAL OF PROTEOME RESEARCH

Analysis of Human Immunodeficiency Virus Type 1 Viremia and Provirus in Resting CD4+ T Cells Reveals a Novel Source of Residual Viremia in Patients on Antiretroviral Therapy

(2009) T. P. Brennan et al.   JOURNAL OF VIROLOGY

Long-Term Control of HIV byCCR5Delta32/Delta32 Stem-Cell Transplantation

(2009) Gero Hütter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Validation of the CNS Penetration-Effectiveness Rank for Quantifying Antiretroviral Penetration Into the Central Nervous System

(2008) Scott Letendre   ARCHIVES OF NEUROLOGY

Cellular microRNA expression correlates with susceptibility of monocytes/macrophages to HIV-1 infection

(2008) X. Wang et al.   BLOOD

Persistence of HIV in Gut‐Associated Lymphoid Tissue despite Long‐Term Antiretroviral Therapy

(2008) Tae‐Wook Chun et al.   JOURNAL OF INFECTIOUS DISEASES