Glutamate metabolism and HIV-associated neurocognitive disorders

Lipoic acid increases glutamate uptake, glutamine synthetase activity and glutathione content in C6 astrocyte cell line

(2013) Juliana Kleinkauf-Rocha et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Cerebrospinal Fluid and Neuroimaging Biomarker Abnormalities Suggest Early Neurological Injury in a Subset of Individuals During Primary HIV Infection

(2013) M. J. Peluso et al.   JOURNAL OF INFECTIOUS DISEASES

IL-1β and TNF-α induce neurotoxicity through glutamate production: a potential role for neuronal glutaminase

(2013) Ling Ye et al.   JOURNAL OF NEUROCHEMISTRY

Targeting the Glutamatergic System for the Treatment of HIV-Associated Neurocognitive Disorders

(2013) Michelle C. Potter et al.   Journal of Neuroimmune Pharmacology

Age-dependent molecular alterations in the autophagy pathway in HIVE patients and in a gp120 tg mouse model: reversal with beclin-1 gene transfer

(2013) Jerel Fields et al.   JOURNAL OF NEUROVIROLOGY

Progressive cerebral injury in the setting of chronic HIV infection and antiretroviral therapy

(2013) Assawin Gongvatana et al.   JOURNAL OF NEUROVIROLOGY

Regulation of astrocyte glutamine synthetase in epilepsy

(2013) Tore Eid et al.   NEUROCHEMISTRY INTERNATIONAL

Chronic ceftriaxone treatment rescues hippocampal memory deficit in AQP4 knockout mice via activation of GLT-1

(2013) Jun Yang et al.   NEUROPHARMACOLOGY

Activity and metabolism-related Ca2+ and mitochondrial dynamics in co-cultured human fetal cortical neurons and astrocytes

(2013) W. Fu et al.   NEUROSCIENCE

BDNF Regulates the Expression and Distribution of Vesicular Glutamate Transporters in Cultured Hippocampal Neurons

(2013) Carlos V. Melo et al.   PLoS One

Curcumin Protects Microglia and Primary Rat Cortical Neurons against HIV-1 gp120-Mediated Inflammation and Apoptosis

(2013) Luyan Guo et al.   PLoS One

Curcumin is an inhibitor of calcium/calmodulin dependent protein kinase II

(2012) M. Mayadevi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Neurocognitive Impairment in HIV-Infected Naïve Patients with Advanced Disease: The Role of Virus and Intrathecal Immune Activation

(2012) Monica Airoldi et al.   Clinical & Developmental Immunology

Gene expression of glutamate metabolizing enzymes in the hippocampal formation in human temporal lobe epilepsy

(2012) Tore Eid et al.   EPILEPSIA

Tianeptine modulates amygdalar glutamate neurochemistry and synaptic proteins in rats subjected to repeated stress

(2012) Gerardo G. Piroli et al.   EXPERIMENTAL NEUROLOGY

Neuronal toxicity in HIV CNS disease

(2012) Jane Kovalevich et al.   Future Virology

Central Nervous System Viral Invasion and Inflammation During Acute HIV Infection

(2012) Victor Valcour et al.   JOURNAL OF INFECTIOUS DISEASES

The chemokine, macrophage inflammatory protein-2γ, reduces the expression of glutamate transporter-1 on astrocytes and increases neuronal sensitivity to glutamate excitotoxicity

(2012) Jie Fang et al.   Journal of Neuroinflammation

L-glutamate released from activated microglia downregulates astrocytic L-glutamate transporter expression in neuroinflammation: the ‘collusion’ hypothesis for increased extracellular L-glutamate concentration in neuroinflammation

(2012) Junpei Takaki et al.   Journal of Neuroinflammation

Effects of fluoxetine, tianeptine and olanzapine on unpredictable chronic mild stress-induced depression-like behavior in mice

(2012) Oguz Mutlu et al.   LIFE SCIENCES

siRNA knock down of glutamate dehydrogenase in astrocytes affects glutamate metabolism leading to extensive accumulation of the neuroactive amino acids glutamate and aspartate

(2012) Dorte M. Skytt et al.   NEUROCHEMISTRY INTERNATIONAL

The complex regulation of human glud1 and glud2 glutamate dehydrogenases and its implications in nerve tissue biology

(2012) Cleanthe Spanaki et al.   NEUROCHEMISTRY INTERNATIONAL

Neurotoxins released from interferon-gamma-stimulated human astrocytes

(2012) M. Lee et al.   NEUROSCIENCE

Interferon-α Regulates Glutaminase 1 Promoter through STAT1 Phosphorylation: Relevance to HIV-1 Associated Neurocognitive Disorders

(2012) Lixia Zhao et al.   PLoS One

The National NeuroAIDS Tissue Consortium Brain Gene Array: Two Types of HIV-Associated Neurocognitive Impairment

(2012) Benjamin B. Gelman et al.   PLoS One

Change in Brain Magnetic Resonance Spectroscopy after Treatment during Acute HIV Infection

(2012) Napapon Sailasuta et al.   PLoS One

Glutathione synthesis and its role in redox signaling

(2012) Hongqiao Zhang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Persistence of HIV-associated cognitive impairment, inflammation, and neuronal injury in era of highly active antiretroviral treatment

(2011) Jarek Harezlak et al.   AIDS

IFN-  Mediates Enhancement of HIV Replication in Astrocytes by Inducing an Antagonist of the  -Catenin Pathway (DKK1) in a STAT 3-Dependent Manner

(2011) W. Li et al.   JOURNAL OF IMMUNOLOGY

Reversible dementia in a patient with central nervous system escape of human immunodeficiency virus

(2011) Isaac I. Bogoch et al.   JOURNAL OF INFECTION

Central Nervous System Immune Activation Characterizes Primary Human Immunodeficiency Virus 1 Infection Even in Participants With Minimal Cerebrospinal Fluid Viral Burden

(2011) Serena Spudich et al.   JOURNAL OF INFECTIOUS DISEASES

HIV-1 and IL-1β regulate astrocytic CD38 through mitogen-activated protein kinases and nuclear factor-κB signaling mechanisms

(2011) Manmeet K Mamik et al.   Journal of Neuroinflammation

Glutaminase Dysregulation in HIV-1-Infected Human Microglia Mediates Neurotoxicity: Relevant to HIV-1-Associated Neurocognitive Disorders

(2011) Y. Huang et al.   JOURNAL OF NEUROSCIENCE

Human Immunodeficiency Virus Infection of Human Astrocytes Disrupts Blood-Brain Barrier Integrity by a Gap Junction-Dependent Mechanism

(2011) E. A. Eugenin et al.   JOURNAL OF NEUROSCIENCE

Cerebral metabolite abnormalities in human immunodeficiency virus are associated with cortical and subcortical volumes

(2011) Ronald A Cohen et al.   JOURNAL OF NEUROVIROLOGY

Protein changes in CSF of HIV-infected patients: evidence for loss of neuroprotection

(2011) Rick B. Meeker et al.   JOURNAL OF NEUROVIROLOGY

HIV-associated dementia in the era of highly active antiretroviral therapy (HAART)

(2011) Chenglai Xia et al.   MICROBES AND INFECTION

Inhibition of glutamine synthesis induces glutamate dehydrogenase-dependent ammonia fixation into alanine in co-cultures of astrocytes and neurons

(2011) Sherry Dadsetan et al.   NEUROCHEMISTRY INTERNATIONAL

HIV-1 gp120 induces antioxidant response element-mediated expression in primary astrocytes: Role in HIV associated neurocognitive disorder

(2011) Pichili Vijaya Bhaskar Reddy et al.   NEUROCHEMISTRY INTERNATIONAL

Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission

(2011) O. Pascual et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 Replication in the Central Nervous System Occurs in Two Distinct Cell Types

(2011) Gretja Schnell et al.   PLoS Pathogens

The protective effect of tianeptine on Gp120-induced apoptosis in astroglial cells: role of GS and NOS, and NF-κB suppression

(2010) Elzbieta Janda et al.   BRITISH JOURNAL OF PHARMACOLOGY

Astrocytic glutamate transporter-dependent neuroprotection against glutamate toxicity: An in vitro study of maslinic acid

(2010) Yisong Qian et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases

(2010) Moonhee Lee et al.   FASEB JOURNAL

Memantine for AIDS Dementia Complex: Open-Label Report of ACTG 301

(2010) Yu Zhao et al.   HIV CLINICAL TRIALS

HIV-1 phylogenetic analysis shows HIV-1 transits through the meninges to brain and peripheral tissues

(2010) Susanna L. Lamers et al.   INFECTION GENETICS AND EVOLUTION

Brain Glutamine Synthesis Requires Neuronal Aspartate: A Commentary

(2010) Leif Hertz   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Brain Glutamine Synthesis Requires Neuronal-Born Aspartate as Amino Donor for Glial Glutamate Formation

(2010) Beatriz Pardo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Lower brain glutamate is associated with cognitive deficits in HIV patients: A new mechanism for HIV-associated neurocognitive disorder

(2010) Thomas Ernst et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Neurometabolite Abnormalities in Simian Immunodeficiency Virus-Infected Macaques with Chronic Morphine Administration

(2010) Christine C. Cloak et al.   Journal of Neuroimmune Pharmacology

Cliniconeuropathologic correlates of human immunodeficiency virus in the era of antiretroviral therapy

(2010) I Everall et al.   JOURNAL OF NEUROVIROLOGY

Neurocognitive functioning in acute or early HIV infection

(2010) David J. Moore et al.   JOURNAL OF NEUROVIROLOGY

HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors

(2010) Robert K. Heaton et al.   JOURNAL OF NEUROVIROLOGY

STAT3 inhibitors attenuate interferon-γ-induced neurotoxicity and inflammatory molecule production by human astrocytes

(2010) Sadayuki Hashioka et al.   NEUROBIOLOGY OF DISEASE

Glutamine synthetase down-regulation reduces astrocyte protection against glutamate excitotoxicity to neurons

(2010) Jian Zou et al.   NEUROCHEMISTRY INTERNATIONAL

Neurologic disease burden in treated HIV/AIDS predicts survival: A population-based study

(2010) P. Vivithanaporn et al.   NEUROLOGY

Metabolic Control of Vesicular Glutamate Transport and Release

(2010) Narinobu Juge et al.   NEURON

Characterisation of the Expression of NMDA Receptors in Human Astrocytes

(2010) Ming-Chak Lee et al.   PLoS One

IL-6 stimulates system A amino acid transporter activity in trophoblast cells through STAT3 and increased expression of SNAT2

(2009) H. N. Jones et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Extensive astrocyte infection is prominent in human immunodeficiency virus-associated dementia

(2009) Melissa J. Churchill et al.   ANNALS OF NEUROLOGY

In vivo proton magnetic resonance spectroscopy reveals region specific metabolic responses to SIV infection in the macaque brain

(2009) Eva-Maria Ratai et al.   BMC NEUROSCIENCE

High extracellular glutamate modulates expression of glutamate transporters and glutamine synthetase in cultured astrocytes

(2009) Claudia Lehmann et al.   BRAIN RESEARCH

Tumor necrosis factor-α modulates glutamate transport in the CNS and is a critical determinant of outcome from viral encephalomyelitis

(2009) Jessica Carmen et al.   BRAIN RESEARCH

HIV-1 associated dementia: update on pathological mechanisms and therapeutic approaches

(2009) Marcus Kaul   CURRENT OPINION IN NEUROLOGY

Gain-of-function variant in GLUD2 glutamate dehydrogenase modifies Parkinson's disease onset

(2009) Andreas Plaitakis et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

In vitroglutaminase regulation and mechanisms of glutamate generation in HIV-1-infected macrophage

(2009) Nathan Erdmann et al.   JOURNAL OF NEUROCHEMISTRY

Reduced Expression of Excitatory Amino Acid Transporter 2 and Diffuse Microglial Activation in the Cerebral Cortex in AIDS Cases With or Without HIV Encephalitis

(2009) Hui Qin Xing et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Interferon-  Causes Neuronal Dysfunction in Encephalitis

(2009) A. R. Sas et al.   JOURNAL OF NEUROSCIENCE

CD38 regulation in activated astrocytes: Implications for neuroinflammation and HIV-1 brain infection

(2009) Wei Kou et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Curcumin improves spatial memory impairment induced by human immunodeficiency virus type 1 glycoprotein 120 V3 loop peptide in rats

(2009) Hongmei Tang et al.   LIFE SCIENCES

Selective up-regulation of GLT-1 in cultured astrocytes exposed to soluble mediators released by activated microglia

(2009) Sébastien Tilleux et al.   NEUROCHEMISTRY INTERNATIONAL

Responses of astrocyte to simultaneous glutamate and arachidonic acid treatment

(2009) Zhen Yu Xu et al.   NEUROCHEMISTRY INTERNATIONAL

Changes in MRS neuronal markers and T cell phenotypes observed during early HIV infection

(2009) M. R. Lentz et al.   NEUROLOGY

Dynamics of cognitive change in impaired HIV-positive patients initiating antiretroviral therapy

(2009) L. A. Cysique et al.   NEUROLOGY

Neuroprotective and Antiinflammatory Properties of a Novel Demethylated Curcuminoid

(2008) Savita Khanna et al.   ANTIOXIDANTS & REDOX SIGNALING

Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB

(2008) Rui Wang et al.   BRAIN RESEARCH

Proinflammatory cytokines and HIV-1 synergistically enhance CXCL10 expression in human astrocytes

(2008) Rachel Williams et al.   GLIA

Mechanism of Ceftriaxone Induction of Excitatory Amino Acid Transporter-2 Expression and Glutamate Uptake in Primary Human Astrocytes

(2008) Seok-Geun Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Down-regulation of astrocytic GLAST by microglia-related inflammation is abrogated in dibutyryl cAMP-differentiated cultures

(2008) Sébastien Tilleux et al.   JOURNAL OF NEUROCHEMISTRY

HIV-infected macrophages mediate neuronal apoptosis through mitochondrial glutaminase

(2008) Changhai Tian et al.   JOURNAL OF NEUROCHEMISTRY

Necrotic neurons enhance microglial neurotoxicity through induction of glutaminase by a MyD88-dependent pathway

(2008) Teresa F Pais et al.   Journal of Neuroinflammation

Factor analysis reveals differences in brain metabolism in macaques with SIV/AIDS and those with SIV-induced encephalitis

(2008) Margaret R. Lentz et al.   NMR IN BIOMEDICINE

Evidence of reduced glutamate in the frontal lobe of HIV-seropositive patients

(2008) Napapon Sailasuta et al.   NMR IN BIOMEDICINE

HIV's double strike at the brain: neuronal toxicity and compromised neurogenesis

(2007) Marcus Kaul   Frontiers in Bioscience-Landmark

Proposed cycles for functional glutamate trafficking in synaptic neurotransmission

(2007) Paul K. Maciejewski et al.   NEUROCHEMISTRY INTERNATIONAL

Mechanisms of glutamate release from astrocytes

(2007) Erik B. Malarkey et al.   NEUROCHEMISTRY INTERNATIONAL