Astrocytes: Role and Functions in Brain Pathologies

Astrocytes in Neuropathologies Affecting the Frontal Cortex

(2019) Ulla-Kaisa Peteri et al.   Frontiers in Cellular Neuroscience

Potassium channel dysfunction in neurons and astrocytes in Huntington's disease

(2018) Xiao Zhang et al.   CNS Neuroscience & Therapeutics

The Versatile Tanycyte: A Hypothalamic Integrator of Reproduction and Energy Metabolism

(2018) Vincent Prevot et al.   ENDOCRINE REVIEWS

Evidence supporting a role for astrocytes in the regulation of cognitive flexibility and neuronal oscillations through the Ca2+ binding protein S100β

(2018) Adam T. Brockett et al.   PLoS One

Regenerative Approaches in Huntington’s Disease: From Mechanistic Insights to Therapeutic Protocols

(2018) Jenny Sassone et al.   Frontiers in Neuroscience

Protective effect of 3H-1, 2-dithiole-3-thione on cellular model of Alzheimer's disease involves Nrf2/ARE signaling pathway

(2017) Lan Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mutant Huntingtin Inhibits αB-Crystallin Expression and Impairs Exosome Secretion from Astrocytes

(2017) Yan Hong et al.   JOURNAL OF NEUROSCIENCE

Alzheimer Disease

(2017) Richard J. Caselli et al.   MAYO CLINIC PROCEEDINGS

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Review: Astrocytes in Alzheimer's disease and other age-associated dementias: a supporting player with a central role

(2017) C. J. Garwood et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Inhibitory effect of punicalagin on lipopolysaccharide-induced neuroinflammation, oxidative stress and memory impairment via inhibition of nuclear factor-kappaB

(2017) Young Eun Kim et al.   NEUROPHARMACOLOGY

Differential HspBP1 expression accounts for the greater vulnerability of neurons than astrocytes to misfolded proteins

(2017) Ting Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unravelling and Exploiting Astrocyte Dysfunction in Huntington’s Disease

(2017) Baljit S. Khakh et al.   TRENDS IN NEUROSCIENCES

Involvement of Astrocytes in Alzheimer’s Disease from a Neuroinflammatory and Oxidative Stress Perspective

(2017) Rodrigo E. González-Reyes et al.   Frontiers in Molecular Neuroscience

Pelargonidin improves memory deficit in amyloid β25-35 rat model of Alzheimer’s disease by inhibition of glial activation, cholinesterase, and oxidative stress

(2016) Hamid Sohanaki et al.   BIOMEDICINE & PHARMACOTHERAPY

Expression of brain-derived neurotrophic factor in astrocytes - Beneficial effects of glatiramer acetate in the R6/2 and YAC128 mouse models of Huntington's disease

(2016) Christiane Reick et al.   EXPERIMENTAL NEUROLOGY

Corticostriatal Dysfunction in Huntington’s Disease: The Basics

(2016) Kendra D. Bunner et al.   Frontiers in Human Neuroscience

Cannabinoids prevent the amyloid β-induced activation of astroglial hemichannels: A neuroprotective mechanism

(2016) Rosario Gajardo-Gómez et al.   GLIA

Frequency of nuclear mutant huntingtin inclusion formation in neurons and glia is cell-type-specific

(2016) Anne H.P. Jansen et al.   GLIA

Monascin from Monascus-Fermented Products Reduces Oxidative Stress and Amyloid-β Toxicity via DAF-16/FOXO in Caenorhabditis elegans

(2016) Yeu-Ching Shi et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Tocotrienol-Rich Fraction Modulates Amyloid Pathology and Improves Cognitive Function in AβPP/PS1 Mice

(2016) Nor Faeizah Ibrahim et al.   JOURNAL OF ALZHEIMERS DISEASE

Compartment-Dependent Degradation of Mutant Huntingtin Accounts for Its Preferential Accumulation in Neuronal Processes

(2016) T. Zhao et al.   JOURNAL OF NEUROSCIENCE

Mutant Huntingtin Impairs BDNF Release from Astrocytes by Disrupting Conversion of Rab3a-GTP into Rab3a-GDP

(2016) Y. Hong et al.   JOURNAL OF NEUROSCIENCE

Dysfunctional Calcium and Glutamate Signaling in Striatal Astrocytes from Huntington's Disease Model Mice

(2016) R. Jiang et al.   JOURNAL OF NEUROSCIENCE

Anthocyanins Reversed D-Galactose-Induced Oxidative Stress and Neuroinflammation Mediated Cognitive Impairment in Adult Rats

(2016) Shafiq Ur Rehman et al.   MOLECULAR NEUROBIOLOGY

Natural Phytochemicals in the Treatment and Prevention of Dementia: An Overview

(2016) Rosaliana Libro et al.   MOLECULES

Effects of triptolide on hippocampal microglial cells and astrocytes in the APP/PS1 double transgenic mouse model of Alzheimer′s disease

(2016) Jian-ming Li et al.   Neural Regeneration Research

Reactive astrocytes and therapeutic potential in focal ischemic stroke

(2016) Gourav Roy Choudhury et al.   NEUROBIOLOGY OF DISEASE

Crucial role of astrocytes in temporal lobe epilepsy

(2016) C. Steinhäuser et al.   NEUROSCIENCE

Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke

(2016) Zhongwu Liu et al.   PROGRESS IN NEUROBIOLOGY

Astrocytes: Key Regulators of Neuroinflammation

(2016) Emanuela Colombo et al.   TRENDS IN IMMUNOLOGY

Real-time imaging of glutamate clearance reveals normal striatal uptake in Huntington disease mouse models

(2016) Matthew P. Parsons et al.   Nature Communications

The effect of resveratrol on beta amyloid-induced memory impairment involves inhibition of phosphodiesterase-4 related signaling

(2016) Gang Wang et al.   Oncotarget

Frontal white matter hyperintensities, clasmatodendrosis and gliovascular abnormalities in ageing and post-stroke dementia

(2015) Aiqing Chen et al.   BRAIN

Astrocytes: New Targets for the Treatment of Neurodegenerative Diseases

(2015) Charles Finsterwald et al.   CURRENT PHARMACEUTICAL DESIGN

S100B interacts with the serotonin 5-HT7 receptor to regulate a depressive-like behavior

(2015) Nikolas Stroth et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Peroxisome proliferator activated receptor-γ agonists protect oligodendrocyte progenitors against tumor necrosis factor-alpha-induced damage: Effects on mitochondrial functions and differentiation

(2015) C. De Nuccio et al.   EXPERIMENTAL NEUROLOGY

Gene transfer engineering for astrocyte-specific silencing in the CNS

(2015) N Merienne et al.   GENE THERAPY

Diversity of astrocyte functions and phenotypes in neural circuits

(2015) Baljit S Khakh et al.   NATURE NEUROSCIENCE

Inhibition of p53 attenuates ischemic stress-induced activation of astrocytes

(2015) Kee-Chan Ahn et al.   NEUROREPORT

Reappraisal of Bergmann glial cells as modulators of cerebellar circuit function

(2015) Chris I. De Zeeuw et al.   Frontiers in Cellular Neuroscience

S100B Inhibitor Pentamidine Attenuates Reactive Gliosis and Reduces Neuronal Loss in a Mouse Model of Alzheimer’s Disease

(2015) Carla Cirillo et al.   Biomed Research International

WIN 55,212-2, Agonist of Cannabinoid Receptors, Prevents Amyloid β1-42 Effects on Astrocytes in Primary Culture

(2015) Diana Aguirre-Rueda et al.   PLoS One

Astrocytes and Huntington’s Disease

(2014) Baljit S. Khakh et al.   ACS Chemical Neuroscience

The Cell Biology of Neurogenesis: Toward an Understanding of the Development and Evolution of the Neocortex

(2014) Elena Taverna et al.   Annual Review of Cell and Developmental Biology

Small-molecule activator of glutamate transporter EAAT2 translation provides neuroprotection

(2014) Qiongman Kong et al.   JOURNAL OF CLINICAL INVESTIGATION

GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease

(2014) Seonmi Jo et al.   NATURE MEDICINE

Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice

(2014) Xiaoping Tong et al.   NATURE NEUROSCIENCE

Omega-3 polyunsaturated fatty acids enhance cerebral angiogenesis and provide long-term protection after stroke

(2014) Jiayin Wang et al.   NEUROBIOLOGY OF DISEASE

Amyloid-� Immunotherapy Reduces Amyloid Plaques and Astroglial Reaction in Aged Domestic Dogs

(2014) Maria Neus Bosch et al.   Neurodegenerative Diseases

The mTOR signaling pathway and neuronal stem/progenitor cell proliferation in the hippocampus are altered during the development of absence epilepsy in a genetic animal model

(2014) Emilio Russo et al.   NEUROLOGICAL SCIENCES

Localization of excitatory amino acid transporters EAAT1 and EAAT2 in human postmortem cortex: A light and electron microscopic study

(2014) R.C. Roberts et al.   NEUROSCIENCE

Novel astrocyte targets

(2014) Vincenzo Crunelli et al.   NEUROSCIENTIST

“Glial inhibition” of memory in Alzheimer’s disease

(2014) Ti-Fei Yuan et al.   Science China-Life Sciences

Astrocyte-enriched miR-29a targets PUMA and reduces neuronal vulnerability to forebrain ischemia

(2013) Yi-Bing Ouyang et al.   GLIA

Amyloid beta deregulates astroglial mGluR5-mediated calcium signaling via calcineurin and Nf-kB

(2013) Dmitry Lim et al.   GLIA

P2Y1R-Initiated, IP3R-Dependent Stimulation of Astrocyte Mitochondrial Metabolism Reduces and Partially Reverses Ischemic Neuronal Damage in Mouse

(2013) Wei Zheng et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mechanisms of epileptogenesis: a convergence on neural circuit dysfunction

(2013) Ethan M. Goldberg et al.   NATURE REVIEWS NEUROSCIENCE

Neuroprotection by astrocytes in brain ischemia: Importance of microRNAs

(2013) Yi-Bing Ouyang et al.   NEUROSCIENCE LETTERS

A  induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

(2013) M. Talantova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature

(2013) T. Wyss-Coray et al.   Cold Spring Harbor Perspectives in Medicine

Astrocyte dysfunction in temporal lobe epilepsy: K+ channels and gap junction coupling

(2012) Christian Steinhäuser et al.   GLIA

Tumor necrosis factor-α synthesis inhibitor 3,6′-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer’s disease

(2012) David Tweedie et al.   Journal of Neuroinflammation

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor- -Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease

(2012) S. Mandrekar-Colucci et al.   JOURNAL OF NEUROSCIENCE

Genetics of Epilepsy

(2012) Massimo Pandolfo   SEMINARS IN NEUROLOGY

Vascular β-amyloid and early astrocyte alterations impair cerebrovascular function and cerebral metabolism in transgenic arcAβ mice

(2011) Mario Merlini et al.   ACTA NEUROPATHOLOGICA

Insulin increases glutamate transporter GLT1 in cultured astrocytes

(2011) Yi-Fei Ji et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structure–activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators

(2011) Xuechao Xing et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Proinflammatory role of aquaporin-4 in autoimmune neuroinflammation

(2011) Lihua Li et al.   FASEB JOURNAL

Blocking IL-1 Signaling Rescues Cognition, Attenuates Tau Pathology, and Restores Neuronal  -Catenin Pathway Function in an Alzheimer's Disease Model

(2011) M. Kitazawa et al.   JOURNAL OF IMMUNOLOGY

Pharmacological evaluation of glutamate transporter 1 (GLT-1) mediated neuroprotection following cerebral ischemia/reperfusion injury

(2010) Rajkumar Verma et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Carnosine protects against permanent cerebral ischemia in histidine decarboxylase knockout mice by reducing glutamate excitotoxicity

(2010) Yao Shen et al.   FREE RADICAL BIOLOGY AND MEDICINE

BDNF regulation under GFAP promoter provides engineered astrocytes as a new approach for long-term protection in Huntington's disease

(2010) A Giralt et al.   GENE THERAPY

Increased expression of cholesterol 24S-hydroxylase results in disruption of glial glutamate transporter EAAT2 association with lipid rafts: a potential role in Alzheimer’s disease

(2010) Guilian Tian et al.   JOURNAL OF NEUROCHEMISTRY

Functional and physical interactions between formyl-peptide-receptors and scavenger receptor MARCO and their involvement in amyloid beta 1-42-induced signal transduction in glial cells

(2010) Lars-Ove Brandenburg et al.   JOURNAL OF NEUROCHEMISTRY

Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy

(2010) Xiaoxing Huang et al.   NEUROBIOLOGY OF DISEASE

Glutamine synthetase down-regulation reduces astrocyte protection against glutamate excitotoxicity to neurons

(2010) Jian Zou et al.   NEUROCHEMISTRY INTERNATIONAL

An Excitatory Loop with Astrocytes Contributes to Drive Neurons to Seizure Threshold

(2010) Marta Gómez-Gonzalo et al.   PLOS BIOLOGY

Astrocytic dysfunction: Insights on the role in neurodegeneration

(2009) Daniela Rossi et al.   BRAIN RESEARCH BULLETIN

Antioxidant effects of Epicatechin on the hippocampal toxicity caused by Amyloid-beta 25-35 in rats

(2009) Elvis Cuevas et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Estrogen and tamoxifen reverse manganese-induced glutamate transporter impairment in astrocytes

(2009) Eun-Sook Y. Lee et al.   JOURNAL OF NEUROCHEMISTRY

Aging-dependent changes of microglial cells and their relevance for neurodegenerative disorders

(2009) Rommy von Bernhardi et al.   JOURNAL OF NEUROCHEMISTRY

Intracellular Zn2+ Accumulation Contributes to Synaptic Failure, Mitochondrial Depolarization, and Cell Death in an Acute Slice Oxygen-Glucose Deprivation Model of Ischemia

(2009) Y. V. Medvedeva et al.   JOURNAL OF NEUROSCIENCE

Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic

(2009) Zheng Gang Zhang et al.   LANCET NEUROLOGY

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

Key factors in the discovery and development of new antiepileptic drugs

(2009) Meir Bialer et al.   NATURE REVIEWS DRUG DISCOVERY

Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms

(2009) Jennifer Bradford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Photothrombosis ischemia stimulates a sustained astrocytic Ca2+signalingin vivo

(2008) Shinghua Ding et al.   GLIA

Neuroprotective and neurotoxic properties of glial cells in the pathogenesis of Alzheimer's disease

(2008) D. Farfara et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Astrocytes in the Epileptic Brain

(2008) Jonathon Wetherington et al.   NEURON