Importance of Autophagy in Mediating Human Immunodeficiency Virus (HIV) and Morphine-Induced Metabolic Dysfunction and Inflammation in Human Astrocytes

Electro-Magnetic Nano-Particle Bound Beclin1 siRNA Crosses the Blood–Brain Barrier to Attenuate the Inflammatory Effects of HIV-1 Infection in Vitro

(2016) Myosotys Rodriguez et al.   Journal of Neuroimmune Pharmacology

Methamphetamine potentiates HIV-1 gp120-mediated autophagy via Beclin-1 and Atg5/7 as a pro-survival response in astrocytes

(2016) Lu Cao et al.   Cell Death & Disease

Glutamate induces autophagy via the two-pore channels in neural cells

(2016) Gustavo J. S. Pereira et al.   Oncotarget

Cocaine-mediated microglial activation involves the ER stress-autophagy axis

(2015) Ming-Lei Guo et al.   Autophagy

Low Dose Administration of Glutamate Triggers a Non-Apoptotic, Autophagic Response in PC12 Cells

(2015) Eleni Stamoula et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Opiate Addiction Therapies and HIV-1 Tat: Interactive Effects on Glial [Ca2+]i, Oxyradical and Neuroinflammatory Chemokine Production and Correlative Neurotoxicity

(2015) Sylvia Fitting et al.   CURRENT HIV RESEARCH

Glial alterations from early to late stages in a model of Alzheimer's disease: Evidence of autophagy involvement in Aβ internalization

(2015) Carlos Pomilio et al.   HIPPOCAMPUS

HIV-1 differentially modulates autophagy in neurons and astrocytes

(2015) Rajeev Mehla et al.   JOURNAL OF NEUROIMMUNOLOGY

Multiple Protein Kinases via Activation of Transcription Factors NF-κB, AP-1 and C/EBP-δ Regulate the IL-6/IL-8 Production by HIV-1 Vpr in Astrocytes

(2015) Mohitkumar R. Gangwani et al.   PLoS One

Ibudilast (AV411), and its AV1013 analog, reduce HIV-1 replication and neuronal death induced by HIV-1 and morphine

(2014) Nazira El-Hage et al.   AIDS

Neurodegenerative lysosomal disorders: A continuum from development to late age

(2014) Ralph A. Nixon et al.   Autophagy

Autosis and autophagic cell death: the dark side of autophagy

(2014) Y Liu et al.   CELL DEATH AND DIFFERENTIATION

Roles of autophagy in HIV infection

(2014) Christina Dinkins et al.   IMMUNOLOGY AND CELL BIOLOGY

HIV-1 and Morphine Regulation of Autophagy in Microglia: Limited Interactions in the Context of HIV-1 Infection and Opioid Abuse

(2014) Nazira El-Hage et al.   JOURNAL OF VIROLOGY

Celastrol ameliorates HIV-1 Tat-induced inflammatory responses via NF-kappaB and AP-1 inhibition and heme oxygenase-1 induction in astrocytes

(2014) Gi Soo Youn et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A novel bivalent HIV-1 entry inhibitor reveals fundamental differences in CCR5-μ-opioid receptor interactions between human astroglia and microglia

(2013) Nazira El-Hage et al.   AIDS

An Overview of Autophagy: Morphology, Mechanism, and Regulation

(2013) Katherine R. Parzych et al.   ANTIOXIDANTS & REDOX SIGNALING

Targeting NFKB by autophagy to polarize hepatoma-associated macrophage differentiation

(2013) Chih-Peng Chang et al.   Autophagy

Excitotoxic glutamate insults block autophagic flux in hippocampal neurons

(2013) Jacqueline R. Kulbe et al.   BRAIN RESEARCH

Rapamycin prevents the mutant huntingtin-suppressed GLT-1 expression in cultured astrocytes

(2012) Lei-lei Chen et al.   ACTA PHARMACOLOGICA SINICA

Neurocognitive Impairment in HIV-Infected Naïve Patients with Advanced Disease: The Role of Virus and Intrathecal Immune Activation

(2012) Monica Airoldi et al.   Clinical & Developmental Immunology

Opiate Drug Use and the Pathophysiology of NeuroAIDS

(2012) Kurt F. Hauser et al.   CURRENT HIV RESEARCH

Multiple Roles for Mammalian Target of Rapamycin Signaling in Both Glutamatergic and GABAergic Synaptic Transmission

(2012) M. C. Weston et al.   JOURNAL OF NEUROSCIENCE

Regulation of Presynaptic Neurotransmission by Macroautophagy

(2012) Daniela Hernandez et al.   NEURON

Astrocyte dysfunction triggers neurodegeneration in a lysosomal storage disorder

(2012) C. Di Malta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Morphine potentiates neurodegenerative effects of HIV-1 Tat through actions at  -opioid receptor-expressing glia

(2011) S. Zou et al.   BRAIN

Autophagy in Dementias

(2011) Christine Lund Kragh et al.   BRAIN PATHOLOGY

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

Autophagy as a Therapeutic Target in Diabetic Nephropathy

(2011) Yuki Tanaka et al.   Experimental Diabetes Research

Hormonally Active Vitamin D3 (1α,25-Dihydroxycholecalciferol) Triggers Autophagy in Human Macrophages That Inhibits HIV-1 Infection

(2011) Grant R. Campbell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy as a therapeutic target in cardiovascular disease

(2011) Andriy Nemchenko et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

HIV-1 gp120-mediated increases in IL-8 production in astrocytes are mediated through the NF-κB pathway and can be silenced by gp120-specific siRNA

(2011) Ankit Shah et al.   Journal of Neuroinflammation

HIV-1 Coinfection and Morphine Coexposure Severely Dysregulate Hepatitis C Virus-Induced Hepatic Proinflammatory Cytokine Release and Free Radical Production: Increased Pathogenesis Coincides with Uncoordinated Host Defenses

(2011) N. El-Hage et al.   JOURNAL OF VIROLOGY

Control of autophagy as a therapy for neurodegenerative disease

(2011) Harry Harris et al.   Nature Reviews Neurology

Human immunodeficiency virus-1 Tat activates NF-κB via physical interaction with IκB-α and p65

(2011) Giuseppe Fiume et al.   NUCLEIC ACIDS RESEARCH

Innate Antiviral Response: Role in HIV-1 Infection

(2011) Paula M. Pitha   Viruses-Basel

Neuroprotective effect of ginsenoside Rb1 on glutamate-induced neurotoxicity: With emphasis on autophagy

(2010) Zhaoyao Chen et al.   NEUROSCIENCE LETTERS

Extensive astrocyte infection is prominent in human immunodeficiency virus-associated dementia

(2009) Melissa J. Churchill et al.   ANNALS OF NEUROLOGY

Key factors in mTOR regulation

(2009) Xiaochun Bai et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages

(2009) George B. Kyei et al.   JOURNAL OF CELL BIOLOGY

A Novel Protein Complex in Membrane Rafts Linking the NR2B Glutamate Receptor and Autophagy Is Disrupted following Traumatic Brain Injury

(2009) Gregory E. Bigford et al.   JOURNAL OF NEUROTRAUMA

Differential Role of Autophagy in CD4 T Cells and Macrophages during X4 and R5 HIV-1 Infection

(2009) Lucile Espert et al.   PLoS One

Inflammation in Alzheimer's disease: Amyloid-β oligomers trigger innate immunity defence via pattern recognition receptors

(2009) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

HIV-1-infected and/or immune-activated macrophages regulate astrocyte CXCL8 production through IL-1β and TNF-α: Involvement of mitogen-activated protein kinases and protein kinase R

(2008) Jialin C. Zheng et al.   JOURNAL OF NEUROIMMUNOLOGY

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE

Synergy between Coproduced CC and CXC Chemokines in Monocyte Chemotaxis through Receptor-Mediated Events

(2008) M. Gouwy et al.   MOLECULAR PHARMACOLOGY

Morphine Exacerbates HIV-1 Tat-Induced Cytokine Production in Astrocytes through Convergent Effects on [Ca2+]i, NF-κB Trafficking and Transcription

(2008) Nazira El-Hage et al.   PLoS One