HIV Nef and Antiretroviral Therapy Have an Inhibitory Effect on Autophagy in Human Astrocytes that May Contribute to HIV-Associated Neurocognitive Disorders

HIV-1 Nef counteracts autophagy restriction by enhancing the association between BECN1 and its inhibitor BCL2 in a PRKN-dependent manner

(2020) Sergio Castro-Gonzalez et al.   Autophagy

Changes in cognition precede changes in HRQoL among HIV+ males: Longitudinal analysis of the multicenter AIDS cohort study.

(2019) Jacob D. Jones et al.   NEUROPSYCHOLOGY

Morphine counteracts the antiviral effect of antiretroviral drugs and causes upregulation of p62/SQSTM1 and histone-modifying enzymes in HIV-infected astrocytes

(2019) Myosotys Rodriguez et al.   JOURNAL OF NEUROVIROLOGY

Persistent HIV-infected cells in cerebrospinal fluid are associated with poorer neurocognitive performance

(2019) Serena Spudich et al.   JOURNAL OF CLINICAL INVESTIGATION

Antiretroviral-Mediated Microglial Activation Involves Dysregulated Autophagy and Lysosomal Dysfunction

(2019) Ashutosh Tripathi et al.   Cells

Selective autophagy as a potential therapeutic target for neurodegenerative disorders

(2018) Aurora Scrivo et al.   LANCET NEUROLOGY

Overexpression of α-synuclein in an astrocyte cell line promotes autophagy inhibition and apoptosis

(2017) Adolfo Garcia Erustes et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Nef is secreted in exosomes from Nef.GFP-expressing and HIV-1-infected human astrocytes

(2017) Pia Pužar Dominkuš et al.   JOURNAL OF NEUROVIROLOGY

Extensive uptake of α-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage

(2017) Veronica Lindström et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

In vitro α-synuclein neurotoxicity and spreading among neurons and astrocytes using Lewy body extracts from Parkinson disease brains

(2017) Fabio Cavaliere et al.   NEUROBIOLOGY OF DISEASE

Cognitive change trajectories in virally suppressed HIV-infected individuals indicate high prevalence of disease activity

(2017) Chloe Gott et al.   PLoS One

Implication of Different HIV-1 Genes in the Modulation of Autophagy

(2017) Zhenlong Liu et al.   Viruses-Basel

Importance of Autophagy in Mediating Human Immunodeficiency Virus (HIV) and Morphine-Induced Metabolic Dysfunction and Inflammation in Human Astrocytes

(2017) Myosotys Rodriguez et al.   Viruses-Basel

Interplay between Autophagy, Exosomes and HIV-1 Associated Neurological Disorders: New Insights for Diagnosis and Therapeutic Applications

(2017) Chet Ojha et al.   Viruses-Basel

HIV-1 Nef is released in extracellular vesicles derived from astrocytes: evidence for Nef-mediated neurotoxicity

(2017) A Sami Saribas et al.   Cell Death & Disease

HIV-1 Nef-induced cardiotoxicity through dysregulation of autophagy

(2017) Manish K. Gupta et al.   Scientific Reports

Astrocyte Senescence and Metabolic Changes in Response to HIV Antiretroviral Therapy Drugs

(2017) Justin Cohen et al.   Frontiers in Aging Neuroscience

Cell Death-Autophagy Loop and Glutamate-Glutamine Cycle in Amyotrophic Lateral Sclerosis

(2017) Shu Yuan et al.   Frontiers in Molecular Neuroscience

HIV protease inhibitors disrupt astrocytic glutamate transporter function and neurobehavioral performance

(2016) Pornpun Vivithanaporn et al.   AIDS

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Disturbance of proteasomal and autophagic protein degradation pathways by amyotrophic lateral sclerosis-linked mutations in ubiquilin 2

(2016) Mayuko Osaka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy

(2016) Christopher P Webster et al.   EMBO JOURNAL

TFEB at a glance

(2016) Gennaro Napolitano et al.   JOURNAL OF CELL SCIENCE

Intracellular Nef Detected in Peripheral Blood Mononuclear Cells from HIV Patients

(2015) Ting Wang et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Dysregulation of autophagy by HIV-1 Nef in human astrocytes

(2015) A Sami Saribas et al.   CELL CYCLE

The Contribution of Extracellular Nef to HIV-Induced Pathogenesis

(2015) Eleonora Olivetta et al.   CURRENT DRUG TARGETS

p62 links autophagy and Nrf2 signaling

(2015) Tao Jiang et al.   FREE RADICAL BIOLOGY AND MEDICINE

HIV-1 Tat Alters Neuronal Autophagy by Modulating Autophagosome Fusion to the Lysosome: Implications for HIV-Associated Neurocognitive Disorders

(2015) J. Fields et al.   JOURNAL OF NEUROSCIENCE

Proteostasis and aging

(2015) Susmita Kaushik et al.   NATURE MEDICINE

Human Immunodeficiency Virus Type 1 Nef Inhibits Autophagy through Transcription Factor EB Sequestration

(2015) Grant R. Campbell et al.   PLoS Pathogens

Differing roles of autophagy in HIV-associated neurocognitive impairment and encephalitis with implications for morphine co-exposure

(2015) Seth M. Dever et al.   Frontiers in Microbiology

Autophagy and amino acid metabolism in the brain: implications for epilepsy

(2014) Eloy Bejarano et al.   AMINO ACIDS

Decreased neuronal autophagy in HIV dementia: A mechanism of indirect neurotoxicity

(2014) Mehrdad Alirezaei et al.   Autophagy

To be or not to be? Examples of incorrect identification of autophagic compartments in conventional transmission electron microscopy of mammalian cells

(2014) Eeva-Liisa Eskelinen   Autophagy

MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis

(2014) Xiaojie Zhang et al.   Autophagy

Neurocognitive Change in the Era of HIV Combination Antiretroviral Therapy: The Longitudinal CHARTER Study

(2014) R. K. Heaton et al.   CLINICAL INFECTIOUS DISEASES

The Role of the Selective Adaptor p62 and Ubiquitin-Like Proteins in Autophagy

(2014) Mónika Lippai et al.   Biomed Research International

Effects of HIV protease, nucleoside/non-nucleoside reverse transcriptase inhibitors on Bax, Bcl-2 and apoptosis in two cervical cell lines

(2013) Gbenga Anthony Adefolaju et al.   BIOMEDICINE & PHARMACOTHERAPY

Age-dependent molecular alterations in the autophagy pathway in HIVE patients and in a gp120 tg mouse model: reversal with beclin-1 gene transfer

(2013) Jerel Fields et al.   JOURNAL OF NEUROVIROLOGY

Ubiquilin 2mutations in Italian patients with amyotrophic lateral sclerosis and frontotemporal dementia

(2012) Cinzia Gellera et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Astrocytic expression of HIV-1 Nef impairs spatial and recognition memory

(2012) Gladys Chompre et al.   NEUROBIOLOGY OF DISEASE

Brain Cell Reservoirs of Latent Virus in Presymptomatic HIV-Infected Individuals

(2011) Katherine A. Thompson et al.   AMERICAN JOURNAL OF PATHOLOGY

Rapamycin treatment augments motor neuron degeneration in SOD1G93Amouse model of amyotrophic lateral sclerosis

(2011) Xiaojie Zhang et al.   Autophagy

Autophagy and cytokines

(2011) James Harris   CYTOKINE

Antiretroviral drug treatment of CNS HIV-1 infection

(2011) A. Yilmaz et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Mutant A53T α-Synuclein Induces Neuronal Death by Increasing Mitochondrial Autophagy

(2011) Vinay Choubey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nef Inhibits Glucose Uptake in Adipocytes and Contributes to Insulin Resistance in Human Immunodeficiency Virus Type I Infection

(2011) Laura Cheney et al.   JOURNAL OF INFECTIOUS DISEASES

Autophagy Is Increased in Postmortem Brains of Persons With HIV-1-Associated Encephalitis

(2011) Dejiang Zhou et al.   JOURNAL OF INFECTIOUS DISEASES

Prevalence of non-confounded HIV-associated neurocognitive impairment in the context of plasma HIV RNA suppression

(2011) Lucette A. Cysique et al.   JOURNAL OF NEUROVIROLOGY

Astrocyte–neuron metabolic relationships: for better and for worse

(2011) Igor Allaman et al.   TRENDS IN NEUROSCIENCES

HIV Type 1 Nef Is Released from Infected Cells in CD45+ Microvesicles and Is Present in the Plasma of HIV-Infected Individuals

(2010) A.D. Raymond et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein impairs macroautophagy: implications for Parkinson’s disease

(2010) Ashley R. Winslow et al.   JOURNAL OF CELL BIOLOGY

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

(2010) Marta Martinez-Vicente et al.   NATURE NEUROSCIENCE

Neurologic disease burden in treated HIV/AIDS predicts survival: A population-based study

(2010) P. Vivithanaporn et al.   NEUROLOGY

HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study

(2010) R. K. Heaton et al.   NEUROLOGY

Extensive astrocyte infection is prominent in human immunodeficiency virus-associated dementia

(2009) Melissa J. Churchill et al.   ANNALS OF NEUROLOGY

In search of an “autophagomometer”

(2009) David C. Rubinsztein et al.   Autophagy

Life and death partners: apoptosis, autophagy and the cross-talk between them

(2009) A Eisenberg-Lerner et al.   CELL DEATH AND DIFFERENTIATION

The HIV protease inhibitor saquinavir induces endoplasmic reticulum stress, autophagy, and apoptosis in ovarian cancer cells

(2009) Karen McLean et al.   GYNECOLOGIC ONCOLOGY

Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2

(2009) Cole J. Ferguson et al.   HUMAN MOLECULAR GENETICS

Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages

(2009) George B. Kyei et al.   JOURNAL OF CELL BIOLOGY

HIV Nef is Secreted in Exosomes and Triggers Apoptosis in Bystander CD4+ T Cells

(2009) Metka Lenassi et al.   TRAFFIC

Effect of Antiretroviral Therapy on Apoptosis Markers and Morphology in Peripheral Lymph Nodes of HIV-Infected Individuals

(2008) S. Ehrhard et al.   INFECTION

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Disruption of Neuronal Autophagy by Infected Microglia Results in Neurodegeneration

(2008) Mehrdad Alirezaei et al.   PLoS One