CRISPR-Cas13 technology portfolio and alliance with other genetic tools

Structure and engineering of the type III-E CRISPR-Cas7-11 effector complex

(2022) Kazuki Kato et al.   CELL

Dynamic modulation of enzyme activity by synthetic CRISPR–Cas6 endonucleases

(2022) Alexander A. Mitkas et al.   Nature Chemical Biology

CRISPR/Cas13 effectors have differing extents of off-target effects that limit their utility in eukaryotic cells

(2022) Yuxi Ai et al.   NUCLEIC ACIDS RESEARCH

Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome

(2022) Piotr Gerlach et al.   MOLECULAR CELL

Pre-existing adaptive immunity to the RNA-editing enzyme Cas13d in humans

(2022) Xin-Zi Emily Tang et al.   NATURE MEDICINE

Rescue of autosomal dominant hearing loss by in vivo delivery of mini dCas13X-derived RNA base editor

(2022) Qingquan Xiao et al.   Science Translational Medicine

High-Fidelity CRISPR/Cas13a trans-Cleavage-Triggered Rolling Circle Amplified DNAzyme for Visual Profiling of MicroRNA

(2021) Ting Zhou et al.   ANALYTICAL CHEMISTRY

Aptamer-Linked CRISPR/Cas12a-Based Immunoassay

(2021) Hui Li et al.   ANALYTICAL CHEMISTRY

A CRISPR/Cas13a-powered catalytic electrochemical biosensor for successive and highly sensitive RNA diagnostics

(2021) Yan Sheng et al.   BIOSENSORS & BIOELECTRONICS

Structural basis for self-cleavage prevention by tag:anti-tag pairing complementarity in type VI Cas13 CRISPR systems

(2021) Beibei Wang et al.   MOLECULAR CELL

The Card1 nuclease provides defence during type-III CRISPR immunity

(2021) Jakob T. Rostøl et al.   NATURE

Detection of SARS-CoV-2 and Its Mutated Variants via CRISPR-Cas13-Based Transcription Amplification

(2021) Yuxi Wang et al.   ANALYTICAL CHEMISTRY

CRISPR-based DNA and RNA detection with liquid-liquid phase separation

(2021) Willem Kasper Spoelstra et al.   BIOPHYSICAL JOURNAL

Treatment of influenza and SARS-CoV-2 infections via mRNA-encoded Cas13a in rodents

(2021) Emmeline L. Blanchard et al.   NATURE BIOTECHNOLOGY

The CRISPR ancillary effector Can2 is a dual-specificity nuclease potentiating type III CRISPR defence

(2021) Wenlong Zhu et al.   NUCLEIC ACIDS RESEARCH

Mini review: genome and transcriptome editing using CRISPR-cas systems for haematological malignancy gene therapy

(2021) Esther K. Elliott et al.   TRANSGENIC RESEARCH

CRISPR Enzyme Kinetics for Molecular Diagnostics

(2021) Ashwin Ramachandran et al.   ANALYTICAL CHEMISTRY

CRISPR-based detection of SARS-CoV-2: A review from sample to result

(2021) Reza Nouri et al.   BIOSENSORS & BIOELECTRONICS

Detect and destroy: CRISPR-based technologies for the response against viruses

(2021) Catherine A. Freije et al.   Cell Host & Microbe

Programmable RNA editing with compact CRISPR–Cas13 systems from uncultivated microbes

(2021) Chunlong Xu et al.   NATURE METHODS

A programmable pAgo nuclease with universal guide and target specificity from the mesophilic bacterium Kurthia massiliensis

(2021) Ekaterina Kropocheva et al.   NUCLEIC ACIDS RESEARCH

RNase R is associated in a functional complex with the RhpA DEAD-box RNA helicase in Helicobacter pylori

(2021) Alejandro Tejada-Arranz et al.   NUCLEIC ACIDS RESEARCH

Substrate discrimination and quality control require each catalytic activity of TRAMP and the nuclear RNA exosome

(2021) Mom Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synergistic action of the gut microbiota in environmental RNA interference in a leaf beetle

(2021) Letian Xu et al.   Microbiome

Programmable RNA N 1 ‐Methyladenosine Demethylation by a Cas13d‐Directed Demethylase

(2021) Shanshan Xie et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Programmable RNA targeting with the single-protein CRISPR effector Cas7-11

(2021) Ahsen Özcan et al.   NATURE

Compact RNA editors with small Cas13 proteins

(2021) Soumya Kannan et al.   NATURE BIOTECHNOLOGY

Non-invasive and high-throughput interrogation of exon-specific isoform expression

(2021) Dong-Jiunn Jeffery Truong et al.   NATURE CELL BIOLOGY

Accelerated RNA detection using tandem CRISPR nucleases

(2021) Tina Y. Liu et al.   Nature Chemical Biology

Structural basis of RNA processing by human mitochondrial RNase P

(2021) Arjun Bhatta et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification of over 200-fold more hairpin ribozymes than previously known in diverse circular RNAs

(2021) Christina E Weinberg et al.   NUCLEIC ACIDS RESEARCH

CRISPRloci: comprehensive and accurate annotation of CRISPR–Cas systems

(2021) Omer S Alkhnbashi et al.   NUCLEIC ACIDS RESEARCH

The Rsm (Csr) post-transcriptional regulatory pathway coordinately controls multiple CRISPR–Cas immune systems

(2021) Aroa Rey Campa et al.   NUCLEIC ACIDS RESEARCH

The gRAMP CRISPR-Cas effector is an RNA endonuclease complexed with a caspase-like peptidase

(2021) Sam P. B. van Beljouw et al.   SCIENCE

CRISPR-Cas13 System as a Promising and Versatile Tool for Cancer Diagnosis, Therapy, and Research

(2021) Fahreddin Palaz et al.   ACS Synthetic Biology

Expanding RNA target effectors

(2021) Lei Tang   NATURE METHODS

RNA-Targeting CRISPR–Cas Systems and Their Applications

(2020) Michal Burmistrz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Directed RNase H Cleavage of Nascent Transcripts Causes Transcription Termination

(2020) Fan Lai et al.   MOLECULAR CELL

Capturing RNA–protein interaction via CRUIS

(2020) Ziheng Zhang et al.   NUCLEIC ACIDS RESEARCH

A CRISPR/Cas13-based approach demonstrates biological relevance of vlinc class of long non-coding RNAs in anticancer drug response

(2020) Dongyang Xu et al.   Scientific Reports

CRISPR-Cas13a Cleavage of Dengue Virus NS3 Gene Efficiently Inhibits Viral Replication

(2020) Hao Li et al.   Molecular Therapy-Nucleic Acids

The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2

(2020)   Nature Microbiology

Anti-CRISPRs: Protein Inhibitors of CRISPR-Cas Systems

(2020) Alan R. Davidson et al.   Annual Review of Biochemistry

Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza

(2020) Timothy R. Abbott et al.   CELL

CRISPR-Cas13 Inhibitors Block RNA Editing in Bacteria and Mammalian Cells

(2020) Ping Lin et al.   MOLECULAR CELL

Massively multiplexed nucleic acid detection with Cas13

(2020) Cheri M. Ackerman et al.   NATURE

Massively parallel Cas13 screens reveal principles for guide RNA design

(2020) Hans-Hermann Wessels et al.   NATURE BIOTECHNOLOGY

Targeted mRNA demethylation using an engineered dCas13b-ALKBH5 fusion protein

(2020) Jiexin Li et al.   NUCLEIC ACIDS RESEARCH

A phage-encoded anti-CRISPR enables complete evasion of type VI-A CRISPR-Cas immunity

(2020) Alexander J. Meeske et al.   SCIENCE

m6A Editing: New Tool to Improve Crop Quality?

(2020) Hong-xiang Zheng et al.   TRENDS IN PLANT SCIENCE

A redox-based electrogenetic CRISPR system to connect with and control biological information networks

(2020) Narendranath Bhokisham et al.   Nature Communications

Modulation of metabolic functions through Cas13d-mediated gene knockdown in liver

(2020) Bingbing He et al.   Protein & Cell

Bacterial alginate regulators and phage homologs repress CRISPR–Cas immunity

(2020) Adair L. Borges et al.   Nature Microbiology

A CRISPR-based assay for the detection of opportunistic infections post-transplantation and for the monitoring of transplant rejection

(2020) Michael M. Kaminski et al.   Nature Biomedical Engineering

CRISPR-Cas13d Induces Efficient mRNA Knockdown in Animal Embryos

(2020) Gopal Kushawah et al.   DEVELOPMENTAL CELL

Programmable m6A modification of cellular RNAs with a Cas13-directed methyltransferase

(2020) Christopher Wilson et al.   NATURE BIOTECHNOLOGY

Shutting down RNA-targeting CRISPR

(2020) Rodolphe Barrangou et al.   SCIENCE

Photoactivatable RNA N 6 ‐Methyladenosine Editing with CRISPR‐Cas13

(2020) Jie Zhao et al.   Small

Development of CRISPR-Cas13a-based antimicrobials capable of sequence-specific killing of target bacteria

(2020) Kotaro Kiga et al.   Nature Communications

Structure-based design of gRNA for Cas13

(2020) Srinivas Bandaru et al.   Scientific Reports

Abrogation of PRRSV infectivity by CRISPR-Cas13b-mediated viral RNA cleavage in mammalian cells

(2020) Jin Cui et al.   Scientific Reports

Guide-free Cas9 from pathogenic Campylobacter jejuni bacteria causes severe damage to DNA

(2020) Chinmoy Saha et al.   Science Advances

CRISPR/Cas13d-Mediated Microbial RNA Knockdown

(2020) Kun Zhang et al.   Frontiers in Bioengineering and Biotechnology

RNA–protein interaction mapping via MS2- or Cas13-based APEX targeting

(2020) Shuo Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deployable CRISPR-Cas13a diagnostic tools to detect and report Ebola and Lassa virus cases in real-time

(2020) Kayla G. Barnes et al.   Nature Communications

CRISPR-Cas13a Inhibits HIV-1 Infection

(2020) Lijuan Yin et al.   Molecular Therapy-Nucleic Acids

Clinical validation of a Cas13-based assay for the detection of SARS-CoV-2 RNA

(2020) Maturada Patchsung et al.   Nature Biomedical Engineering

Amplification-free detection of SARS-CoV-2 with CRISPR-Cas13a and mobile phone microscopy

(2020) Parinaz Fozouni et al.   CELL

Screening for functional circular RNAs using the CRISPR–Cas13 system

(2020) Siqi Li et al.   NATURE METHODS

CRISPRidentify: identification of CRISPR arrays using machine learning approach

(2020) Alexander Mitrofanov et al.   NUCLEIC ACIDS RESEARCH

A programmable omnipotent Argonaute nuclease from mesophilic bacteria Kurthia massiliensis

(2020) Yang Liu et al.   NUCLEIC ACIDS RESEARCH

Streamlined inactivation, amplification, and Cas13-based detection of SARS-CoV-2

(2020) Jon Arizti-Sanz et al.   Nature Communications

A Singular and Widespread Group of Mobile Genetic Elements: RNA Circles with Autocatalytic Ribozymes

(2020) Marcos de la Peña et al.   Cells

Light-up RNA aptamer signaling-CRISPR-Cas13a-based mix-and-read assays for profiling viable pathogenic bacteria

(2020) Ting Zhang et al.   BIOSENSORS & BIOELECTRONICS

Conquering CRISPR: how phages overcome bacterial adaptive immunity

(2020) Lucia M Malone et al.   CURRENT OPINION IN BIOTECHNOLOGY

Non-specific degradation of transcripts promotes plasmid clearance during type III-A CRISPR–Cas immunity

(2019) Jakob T. Rostøl et al.   Nature Microbiology

Rapid and Fully Microfluidic Ebola Virus Detection with CRISPR-Cas13a

(2019) Peiwu Qin et al.   ACS Sensors

High-Resolution Structure of Cas13b and Biochemical Characterization of RNA Targeting and Cleavage

(2019) Ian M. Slaymaker et al.   Cell Reports

Generation of virus-resistant potato plants by RNA genome targeting

(2019) Xiaohui Zhan et al.   PLANT BIOTECHNOLOGY JOURNAL

Room Temperature Detection of Plasma Epstein–Barr Virus DNA with CRISPR–Cas13

(2019) Yetao Wu et al.   CLINICAL CHEMISTRY

Advances in CRISPR-Cas systems for RNA targeting, tracking and editing

(2019) Fei Wang et al.   BIOTECHNOLOGY ADVANCES

High-Fidelity and Rapid Quantification of miRNA Combining crRNA Programmability and CRISPR/Cas13a trans-Cleavage Activity

(2019) Yuanyue Shan et al.   ANALYTICAL CHEMISTRY

Recent trends in CRISPR-Cas system: genome, epigenome, and transcriptome editing and CRISPR delivery systems

(2019) Taegeun Bae et al.   Genes & Genomics

Cas13-induced cellular dormancy prevents the rise of CRISPR-resistant bacteriophage

(2019) Alexander J. Meeske et al.   NATURE

Programmable RNA-Guided RNA Effector Proteins Built from Human Parts

(2019) Simone Rauch et al.   CELL

mRNA levels can be reduced by antisense oligonucleotides via no-go decay pathway

(2019) Xue-hai Liang et al.   NUCLEIC ACIDS RESEARCH

A cytosine deaminase for programmable single-base RNA editing

(2019) Omar O. Abudayyeh et al.   SCIENCE

Two HEPN domains dictate CRISPR RNA maturation and target cleavage in Cas13d

(2019) Bo Zhang et al.   Nature Communications

SnapShot: The RNA Exosome

(2019) M. Rhyan Puno et al.   CELL

SHERLOCK: nucleic acid detection with CRISPR nucleases

(2019) Max J. Kellner et al.   Nature Protocols

CRISPR-mediated live imaging of genome editing and transcription

(2019) Haifeng Wang et al.   SCIENCE

Structure of Csx1-cOA4 complex reveals the basis of RNA decay in Type III-B CRISPR-Cas

(2019) Rafael Molina et al.   Nature Communications

Dynamic Imaging of RNA in Living Cells by CRISPR-Cas13 Systems

(2019) Liang-Zhong Yang et al.   MOLECULAR CELL

Programmable Inhibition and Detection of RNA Viruses Using Cas13

(2019) Catherine A. Freije et al.   MOLECULAR CELL

Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants

(2019) Kira S. Makarova et al.   NATURE REVIEWS MICROBIOLOGY

Bacterial RNA Degradosomes: Molecular Machines under Tight Control

(2019) Alejandro Tejada-Arranz et al.   TRENDS IN BIOCHEMICAL SCIENCES

A CRISPR-Cas13a system for efficient and specific therapeutic targeting of mutant KRAS for pancreatic cancer treatment

(2018) Xiao Zhao et al.   CANCER LETTERS

Transcriptome Engineering with RNA-Targeting Type VI-D CRISPR Effectors

(2018) Silvana Konermann et al.   CELL

RNA-Targeted Therapeutics

(2018) Stanley T. Crooke et al.   Cell Metabolism

Molecular Mechanisms of RNA Targeting by Cas13-containing Type VI CRISPR–Cas Systems

(2018) Mitchell R. O'Connell   JOURNAL OF MOLECULAR BIOLOGY

Cas13d Is a Compact RNA-Targeting Type VI CRISPR Effector Positively Modulated by a WYL-Domain-Containing Accessory Protein

(2018) Winston X. Yan et al.   MOLECULAR CELL

CRISPR RNA-Dependent Binding and Cleavage of Endogenous RNAs by the Campylobacter jejuni Cas9

(2018) Gaurav Dugar et al.   MOLECULAR CELL

Programmable RNA Cleavage and Recognition by a Natural CRISPR-Cas9 System from Neisseria meningitidis

(2018) Beth A. Rousseau et al.   MOLECULAR CELL

Next-generation biocontainment systems for engineered organisms

(2018) Jeong Wook Lee et al.   Nature Chemical Biology

Implementation of the CRISPR-Cas13a system in fission yeast and its repurposing for precise RNA editing

(2018) Xinyun Jing et al.   NUCLEIC ACIDS RESEARCH

Programmable RNA recognition using a CRISPR-associated Argonaute

(2018) Audrone Lapinaite et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Field-deployable viral diagnostics using CRISPR-Cas13

(2018) Cameron Myhrvold et al.   SCIENCE

Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6

(2018) Jonathan S. Gootenberg et al.   SCIENCE

CRISPR–Cas13a: Prospects for Plant Virus Resistance

(2018) Muhammad Zuhaib Khan et al.   TRENDS IN BIOTECHNOLOGY

CRISPR/Cas13 as a Tool for RNA Interference

(2018) Zahir Ali et al.   TRENDS IN PLANT SCIENCE

DNA Unwinding Is the Primary Determinant of CRISPR-Cas9 Activity

(2018) Shanzhong Gong et al.   Cell Reports

RNA-dependent RNA targeting by CRISPR-Cas9

(2018) Steven C Strutt et al.   eLife

Structural Basis for the RNA-Guided Ribonuclease Activity of CRISPR-Cas13d

(2018) Cheng Zhang et al.   CELL

Targeted m6A Reader Proteins To Study Epitranscriptomic Regulation of Single RNAs

(2018) Simone Rauch et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

RNA Guide Complementarity Prevents Self-Targeting in Type VI CRISPR Systems

(2018) Alexander J. Meeske et al.   MOLECULAR CELL

Molecular mechanisms of CRISPR–Cas spacer acquisition

(2018) Jon McGinn et al.   NATURE REVIEWS MICROBIOLOGY

RNA Binding and HEPN-Nuclease Activation Are Decoupled in CRISPR-Cas13a

(2018) Akshay Tambe et al.   Cell Reports

Structural insights into Cas13b-guided CRISPR RNA maturation and recognition

(2018) Bo Zhang et al.   CELL RESEARCH

Functionally diverse type V CRISPR-Cas systems

(2018) Winston X. Yan et al.   SCIENCE

Engineering RNA Virus Interference via the CRISPR/Cas13 Machinery in Arabidopsis

(2018) Rashid Aman et al.   Viruses-Basel

Targeting RNA for processing or destruction by the eukaryotic RNA exosome and its cofactors

(2017) John C. Zinder et al.   GENES & DEVELOPMENT

Cas13b Is a Type VI-B CRISPR-Associated RNA-Guided RNase Differentially Regulated by Accessory Proteins Csx27 and Csx28

(2017) Aaron A. Smargon et al.   MOLECULAR CELL

RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes

(2017) Alexandra East-Seletsky et al.   MOLECULAR CELL

Type III CRISPR–Cas systems produce cyclic oligoadenylate second messengers

(2017) Ole Niewoehner et al.   NATURE

RNA targeting with CRISPR–Cas13

(2017) Omar O. Abudayyeh et al.   NATURE

Prokaryotic Argonaute proteins: novel genome-editing tools?

(2017) Jorrit W. Hegge et al.   NATURE REVIEWS MICROBIOLOGY

Diversity and evolution of class 2 CRISPR–Cas systems

(2017) Sergey Shmakov et al.   NATURE REVIEWS MICROBIOLOGY

Guide-bound structures of an RNA-targeting A-cleaving CRISPR–Cas13a enzyme

(2017) Gavin J Knott et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNA editing with CRISPR-Cas13

(2017) David B. T. Cox et al.   SCIENCE

A cyclic oligonucleotide signaling pathway in type III CRISPR-Cas systems

(2017) Migle Kazlauskiene et al.   SCIENCE

Nucleic acid detection with CRISPR-Cas13a/C2c2

(2017) Jonathan S. Gootenberg et al.   SCIENCE

Guide-bound structures of an RNA-targeting A-cleaving CRISPR–Cas13a enzyme

(2017) Gavin J Knott et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNA-activated DNA cleavage by the Type III-B CRISPR–Cas effector complex

(2016) Michael A. Estrella et al.   GENES & DEVELOPMENT

Quorum Sensing Controls Adaptive Immunity through the Regulation of Multiple CRISPR-Cas Systems

(2016) Adrian G. Patterson et al.   MOLECULAR CELL

The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA

(2016) Ines Fonfara et al.   NATURE

Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection

(2016) Alexandra East-Seletsky et al.   NATURE

Multiplex gene editing by CRISPR–Cpf1 using a single crRNA array

(2016) Bernd Zetsche et al.   NATURE BIOTECHNOLOGY

The regulation and functions of the nuclear RNA exosome complex

(2016) Cornelia Kilchert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A bacterial Argonaute with noncanonical guide RNA specificity

(2016) Emine Kaya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quorum sensing controls thePseudomonas aeruginosaCRISPR-Cas adaptive immune system

(2016) Nina M. Høyland-Kroghsbo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector

(2016) Omar O. Abudayyeh et al.   SCIENCE

Major bacterial lineages are essentially devoid of CRISPR-Cas viral defence systems

(2016) David Burstein et al.   Nature Communications

RNA degradation paths in a 12-subunit nuclear exosome complex

(2015) Debora Lika Makino et al.   NATURE

Recognition of duplex RNA by the deaminase domain of the RNA editing enzyme ADAR2

(2015) Kelly J. Phelps et al.   NUCLEIC ACIDS RESEARCH

Argonaute of the archaeon Pyrococcus furiosus is a DNA-guided nuclease that targets cognate DNA

(2015) Daan C. Swarts et al.   NUCLEIC ACIDS RESEARCH

Structures of the CRISPR-Cmr complex reveal mode of RNA target positioning

(2015) D. W. Taylor et al.   SCIENCE

Cutting it close: CRISPR-associated endoribonuclease structure and function

(2015) Megan L. Hochstrasser et al.   TRENDS IN BIOCHEMICAL SCIENCES

Broccoli: Rapid Selection of an RNA Mimic of Green Fluorescent Protein by Fluorescence-Based Selection and Directed Evolution

(2014) Grigory S. Filonov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural Model of a CRISPR RNA-Silencing Complex Reveals the RNA-Target Cleavage Activity in Cmr4

(2014) Christian Benda et al.   MOLECULAR CELL

RNA Targeting by the Type III-A CRISPR-Cas Csm Complex of Thermus thermophilus

(2014) Raymond H.J. Staals et al.   MOLECULAR CELL

Programmable RNA Shredding by the Type III-A CRISPR-Cas System of Streptococcus thermophilus

(2014) Gintautas Tamulaitis et al.   MOLECULAR CELL

DNA-guided DNA interference by a prokaryotic Argonaute

(2014) Daan C. Swarts et al.   NATURE

Programmable RNA recognition and cleavage by CRISPR/Cas9

(2014) Mitchell R. O’Connell et al.   NATURE

DNA interrogation by the CRISPR RNA-guided endonuclease Cas9

(2014) Samuel H. Sternberg et al.   NATURE

The RNA World: molecular cooperation at the origins of life

(2014) Paul G. Higgs et al.   NATURE REVIEWS GENETICS

Unravelling the structural and mechanistic basis of CRISPR–Cas systems

(2014) John van der Oost et al.   NATURE REVIEWS MICROBIOLOGY

The evolutionary journey of Argonaute proteins

(2014) Daan C Swarts et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The social fabric of the RNA degradosome

(2013) Katarzyna J. Bandyra et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Bacterial Argonaute Samples the Transcriptome to Identify Foreign DNA

(2013) Ivan Olovnikov et al.   MOLECULAR CELL

The RNA exosome and proteasome: common principles of degradation control

(2013) Debora L. Makino et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Evolution of CRISPR RNA recognition and processing by Cas6 endonucleases

(2013) O. Niewoehner et al.   NUCLEIC ACIDS RESEARCH

Highlights of the DNA cutters: a short history of the restriction enzymes

(2013) Wil A. M. Loenen et al.   NUCLEIC ACIDS RESEARCH

TALENs: a widely applicable technology for targeted genome editing

(2012) J. Keith Joung et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Evolution and classification of the CRISPR–Cas systems

(2011) Kira S. Makarova et al.   NATURE REVIEWS MICROBIOLOGY

Genome editing with engineered zinc finger nucleases

(2010) Fyodor D. Urnov et al.   NATURE REVIEWS GENETICS

The Many Pathways of RNA Degradation

(2009) Jonathan Houseley et al.   CELL

Engineering splicing factors with designed specificities

(2009) Yang Wang et al.   NATURE METHODS

Cas6 is an endoribonuclease that generates guide RNAs for invader defense in prokaryotes

(2008) J. Carte et al.   GENES & DEVELOPMENT

Endonucleolytic RNA cleavage by a eukaryotic exosome

(2008) Alice Lebreton et al.   NATURE