Targeting RNA for processing or destruction by the eukaryotic RNA exosome and its cofactors

Cytoplasmic RNA decay pathways - Enzymes and mechanisms

(2016) Anna Łabno et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

CryoEM structure of yeast cytoplasmic exosome complex

(2016) Jun-Jie Liu et al.   CELL RESEARCH

A conserved virus-induced cytoplasmic TRAMP-like complex recruits the exosome to target viral RNA for degradation

(2016) Jerome M. Molleston et al.   GENES & DEVELOPMENT

Collaborative Control of Cell Cycle Progression by the RNA Exonuclease Dis3 and Ras Is Conserved Across Species

(2016) Mark J. Snee et al.   GENETICS

Functional characterization of a chr13q22.1 pancreatic cancer risk locus reveals long-range interaction and allele-specific effects onDIS3expression

(2016) Jason W. Hoskins et al.   HUMAN MOLECULAR GENETICS

RNA Exosome Complex Regulates Stability of the Hepatitis B Virus X-mRNA Transcript in a Non-stop-mediated (NSD) RNA Quality Control Mechanism

(2016) Hussein H. Aly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosome Cofactors Connect Transcription Termination to RNA Processing by Guiding Terminated Transcripts to the Appropriate Exonuclease within the Nuclear Exosome

(2016) Kyumin Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear RNA Exosome at 3.1 Å Reveals Substrate Specificities, RNA Paths, and Allosteric Inhibition of Rrp44/Dis3

(2016) John C. Zinder et al.   MOLECULAR CELL

Structure of a Cytoplasmic 11-Subunit RNA Exosome Complex

(2016) Eva Kowalinski et al.   MOLECULAR CELL

Identification of a Nuclear Exosome Decay Pathway for Processed Transcripts

(2016) Nicola Meola et al.   MOLECULAR CELL

The regulation and functions of the nuclear RNA exosome complex

(2016) Cornelia Kilchert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects

(2016) Siddharth Shukla et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Rrp6 C-terminal domain binds RNA and activates the nuclear RNA exosome

(2016) Elizabeth V. Wasmuth et al.   NUCLEIC ACIDS RESEARCH

A short splicing isoform of HBS1L links the cytoplasmic exosome and SKI complexes in humans

(2016) Katarzyna Kalisiak et al.   NUCLEIC ACIDS RESEARCH

Purification and analysis of endogenous human RNA exosome complexes

(2016) Michal Domanski et al.   RNA

Relative contributions of the structural and catalytic roles of Rrp6 in exosomal degradation of individual mRNAs

(2016) Kaustav Mukherjee et al.   RNA

The cryo-EM structure of a ribosome–Ski2-Ski3-Ski8 helicase complex

(2016) Christian Schmidt et al.   SCIENCE

C1D family proteins in coordinating RNA processing, chromosome condensation and DNA damage response

(2016) Rebecca A. Jackson et al.   Cell Division

Structure of the RBM7–ZCCHC8 core of the NEXT complex reveals connections to splicing factors

(2016) Sebastian Falk et al.   Nature Communications

Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects

(2016) Siddharth Shukla et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The RNA Exosome Channeling and Direct Access Conformations Have Distinct In Vivo Functions

(2016) Jaeil Han et al.   Cell Reports

Collaborative Control of Cell Cycle Progression by the RNA Exonuclease Dis3 and Ras Is Conserved Across Species

(2016) Mark J. Snee et al.   GENETICS

The Exosome Is Recruited to RNA Substrates through Specific Adaptor Proteins

(2015) Matthias Thoms et al.   CELL

Gateway Arch to the RNA Exosome

(2015) Jillian S. Losh et al.   CELL

Functional Anatomy of the Human Microprocessor

(2015) Tuan Anh Nguyen et al.   CELL

Human Mpn1 promotes post-transcriptional processing and stability of U6atac

(2015) Vadim Shchepachev et al.   FEBS LETTERS

Coordinated Ribosomal ITS2 RNA Processing by the Las1 Complex Integrating Endonuclease, Polynucleotide Kinase, and Exonuclease Activities

(2015) Lisa Gasse et al.   MOLECULAR CELL

DGCR8 Acts as an Adaptor for the Exosome Complex to Degrade Double-Stranded Structured RNAs

(2015) Sara Macias et al.   MOLECULAR CELL

RNA degradation paths in a 12-subunit nuclear exosome complex

(2015) Debora Lika Makino et al.   NATURE

A strategy for dissecting the architectures of native macromolecular assemblies

(2015) Yi Shi et al.   NATURE METHODS

The ribonuclease DIS3 promotes let-7 miRNA maturation by degrading the pluripotency factor LIN28B mRNA

(2015) Simona Segalla et al.   NUCLEIC ACIDS RESEARCH

Interaction between the RNA-dependent ATPase and poly(A) polymerase subunits of the TRAMP complex is mediated by short peptides and important for snoRNA processing

(2015) Jillian S. Losh et al.   NUCLEIC ACIDS RESEARCH

Saccharomyces cerevisiae Ski7 Is a GTP-Binding Protein Adopting the Characteristic Conformation of Active Translational GTPases

(2015) Eva Kowalinski et al.   STRUCTURE

Quorum sensing triggers the stochastic escape of individual cells from Pseudomonas putida biofilms

(2015) Gerardo Cárcamo-Oyarce et al.   Nature Communications

A Polyadenylation-Dependent 3′ End Maturation Pathway Is Required for the Synthesis of the Human Telomerase RNA

(2015) Duy Nguyen et al.   Cell Reports

Human Telomerase RNA Processing and Quality Control

(2015) Chi-Kang Tseng et al.   Cell Reports

The exosome complex establishes a barricade to erythroid maturation

(2014) S. C. McIver et al.   BLOOD

Oncogenic KRAS signalling in pancreatic cancer

(2014) S Eser et al.   BRITISH JOURNAL OF CANCER

Widespread Genetic Heterogeneity in Multiple Myeloma: Implications for Targeted Therapy

(2014) Jens G. Lohr et al.   CANCER CELL

The eukaryotic RNA exosome

(2014) Kurt Januszyk et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The exosome‐binding factors Rrp6 and Rrp47 form a composite surface for recruiting the Mtr4 helicase

(2014) Benjamin Schuch et al.   EMBO JOURNAL

The Molecular Architecture of the TRAMP Complex Reveals the Organization and Interplay of Its Two Catalytic Activities

(2014) Sebastian Falk et al.   MOLECULAR CELL

Structure of an Rrp6–RNA exosome complex bound to poly(A) RNA

(2014) Elizabeth V. Wasmuth et al.   NATURE

Noncoding RNA transcription targets AID to divergently transcribed loci in B cells

(2014) Evangelos Pefanis et al.   NATURE

The Mtr4 ratchet helix and arch domain both function to promote RNA unwinding

(2014) Lacy L. Taylor et al.   NUCLEIC ACIDS RESEARCH

Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex

(2014) E. D. Egan et al.   RNA

Cellular functions of the microprocessor

(2013) Sara Macias et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mtr4-like Protein Coordinates Nuclear RNA Processing for Heterochromatin Assembly and for Telomere Maintenance

(2013) Nathan N. Lee et al.   CELL

The Yeast Ski Complex: Crystal Structure and RNA Channeling to the Exosome Complex

(2013) Felix Halbach et al.   CELL

Exonuclease hDIS3L2 specifies an exosome-independent 3′-5′ degradation pathway of human cytoplasmic mRNA

(2013) Michal Lubas et al.   EMBO JOURNAL

Ribosome Biogenesis in the Yeast Saccharomyces cerevisiae

(2013) John L. Woolford et al.   GENETICS

Crystal structure of an RNA-bound 11-subunit eukaryotic exosome complex

(2013) Debora Lika Makino et al.   NATURE

The human cap-binding complex is functionally connected to the nuclear RNA exosome

(2013) Peter Refsing Andersen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The RNA exosome complex central channel controls both exonuclease and endonuclease Dis3 activities in vivo and in vitro

(2013) Karolina Drążkowska et al.   NUCLEIC ACIDS RESEARCH

Multiple myeloma-associated hDIS3 mutations cause perturbations in cellular RNA metabolism and suggest hDIS3 PIN domain as a potential drug target

(2013) R. Tomecki et al.   NUCLEIC ACIDS RESEARCH

The Exosome Cofactor Rrp47 Is Critical for the Stability and Normal Expression of Its Associated Exoribonuclease Rrp6 in Saccharomyces cerevisiae

(2013) Monika Feigenbutz et al.   PLoS One

Rrp47 functions in RNA surveillance and stable RNA processing when divorced from the exoribonuclease and exosome-binding domains of Rrp6

(2013) W. Garland et al.   RNA

Intraclonal heterogeneity and distinct molecular mechanisms characterize the development of t(4;14) and t(11;14) myeloma

(2012) B. A. Walker et al.   BLOOD

Progenitor Function in Self-Renewing Human Epidermis is Maintained by the Exosome

(2012) Devendra S. Mistry et al.   Cell Stem Cell

Exo- and Endoribonucleolytic Activities of Yeast Cytoplasmic and Nuclear RNA Exosomes Are Dependent on the Noncatalytic Core and Central Channel

(2012) Elizabeth V. Wasmuth et al.   MOLECULAR CELL

Transcriptome-wide Analysis of Exosome Targets

(2012) Claudia Schneider et al.   MOLECULAR CELL

Extensive Degradation of RNA Precursors by the Exosome in Wild-Type Cells

(2012) Rajani Kanth Gudipati et al.   MOLECULAR CELL

Mpn1, Mutated in Poikiloderma with Neutropenia Protein 1, Is a Conserved 3′-to-5′ RNA Exonuclease Processing U6 Small Nuclear RNA

(2012) Vadim Shchepachev et al.   Cell Reports

Interaction Profiling Identifies the Human Nuclear Exosome Targeting Complex

(2011) Michal Lubas et al.   MOLECULAR CELL

Initial genome sequencing and analysis of multiple myeloma

(2011) Michael A. Chapman et al.   NATURE

The crystal structure of S. cerevisiae Ski2, a DExH helicase associated with the cytoplasmic functions of the exosome

(2011) F. Halbach et al.   RNA

Rrp47 and the function of the Sas10/C1D domain

(2010) Phil Mitchell   BIOCHEMICAL SOCIETY TRANSACTIONS

The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L

(2010) Rafal Tomecki et al.   EMBO JOURNAL

The crystal structure of Mtr4 reveals a novel arch domain required for rRNA processing

(2010) Ryan N Jackson et al.   EMBO JOURNAL

Dis3-like 1: a novel exoribonuclease associated with the human exosome

(2010) Raymond H J Staals et al.   EMBO JOURNAL

The C-terminal Region of the Exosome-associated Protein Rrp47 Is Specifically Required for Box C/D Small Nucleolar RNA 3′-Maturation

(2010) Joe L. Costello et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and function of the polymerase core of TRAMP, a RNA surveillance complex

(2010) S. Hamill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural analysis reveals the characteristic features of Mtr4, a DExH helicase involved in nuclear RNA processing and surveillance

(2010) J. R. Weir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Capture and sequence analysis of RNAs with terminal 2',3'-cyclic phosphates

(2010) K. Schutz et al.   RNA

The Yeast Exosome Functions as a Macromolecular Cage to Channel RNA Substrates for Degradation

(2009) Fabien Bonneau et al.   CELL

The N-terminal PIN domain of the exosome subunit Rrp44 harbors endonuclease activity and tethers Rrp44 to the yeast core exosome

(2009) Claudia Schneider et al.   NUCLEIC ACIDS RESEARCH

Endonucleolytic RNA cleavage by a eukaryotic exosome

(2008) Alice Lebreton et al.   NATURE

The exosome contains domains with specific endoribonuclease, exoribonuclease and cytoplasmic mRNA decay activities

(2008) Daneen Schaeffer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Exonucleolysis is required for nuclear mRNA quality control in yeast THO mutants

(2008) J. Assenholt et al.   RNA

RNA Exosome Depletion Reveals Transcription Upstream of Active Human Promoters

(2008) Pascal Preker et al.   SCIENCE