Substrate discrimination and quality control require each catalytic activity of TRAMP and the nuclear RNA exosome

Nucleolar localization of the yeast RNA exosome subunit Rrp44 hints at early pre-rRNA processing as its main function

(2020) Ellen K. Okuda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate specificity of the TRAMP nuclear surveillance complexes

(2020) Clémentine Delan-Forino et al.   Nature Communications

The 26S Proteasome Utilizes a Kinetic Gateway to Prioritize Substrate Degradation

(2019) Jared A.M. Bard et al.   CELL

SnapShot: The RNA Exosome

(2019) M. Rhyan Puno et al.   CELL

Substrate selectivity by the exonuclease Rrp6p

(2019) Armend Axhemi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex

(2018) Eva-Maria Weick et al.   CELL

Controlling nuclear RNA levels

(2018) Manfred Schmid et al.   NATURE REVIEWS GENETICS

Structural basis for MTR4–ZCCHC8 interactions that stimulate the MTR4 helicase in the nuclear exosome-targeting complex

(2018) M. Rhyan Puno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the nuclear exosome captured on a maturing preribosome

(2018) Jan Michael Schuller et al.   SCIENCE

Surveillance-ready transcription: nuclear RNA decay as a default fate

(2018) Stefan Bresson et al.   Open Biology

Distinct and evolutionary conserved structural features of the human nuclear exosome complex

(2018) Piotr Gerlach et al.   eLife

Targeting RNA for processing or destruction by the eukaryotic RNA exosome and its cofactors

(2017) John C. Zinder et al.   GENES & DEVELOPMENT

The RNA exosome and RNA exosome-linked disease

(2017) Derrick J. Morton et al.   RNA

Mpp6 Incorporation in the Nuclear Exosome Contributes to RNA Channeling through the Mtr4 Helicase

(2017) Sebastian Falk et al.   Cell Reports

Transcriptome-wide analysis of alternative routes for RNA substrates into the exosome complex

(2017) Clémentine Delan-Forino et al.   PLoS Genetics

Structure and reconstitution of yeast Mpp6-nuclear exosome complexes reveals that Mpp6 stimulates RNA decay and recruits the Mtr4 helicase

(2017) Elizabeth V Wasmuth et al.   eLife

CryoEM structure of yeast cytoplasmic exosome complex

(2016) Jun-Jie Liu et al.   CELL RESEARCH

Nuclear RNA Exosome at 3.1 Å Reveals Substrate Specificities, RNA Paths, and Allosteric Inhibition of Rrp44/Dis3

(2016) John C. Zinder et al.   MOLECULAR CELL

The regulation and functions of the nuclear RNA exosome complex

(2016) Cornelia Kilchert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The RNA Exosome Channeling and Direct Access Conformations Have Distinct In Vivo Functions

(2016) Jaeil Han et al.   Cell Reports

RNA degradation paths in a 12-subunit nuclear exosome complex

(2015) Debora Lika Makino et al.   NATURE

The eukaryotic RNA exosome

(2014) Kurt Januszyk et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The exosome‐binding factors Rrp6 and Rrp47 form a composite surface for recruiting the Mtr4 helicase

(2014) Benjamin Schuch et al.   EMBO JOURNAL

Structure of an Rrp6–RNA exosome complex bound to poly(A) RNA

(2014) Elizabeth V. Wasmuth et al.   NATURE

The Mtr4 ratchet helix and arch domain both function to promote RNA unwinding

(2014) Lacy L. Taylor et al.   NUCLEIC ACIDS RESEARCH

An overview of pre-ribosomal RNA processing in eukaryotes

(2014) Anthony K. Henras et al.   Wiley Interdisciplinary Reviews-RNA

Structural Biology of the Proteasome

(2013) Erik Kish-Trier et al.   Annual Review of Biophysics

The Complexity of Human Ribosome Biogenesis Revealed by Systematic Nucleolar Screening of Pre-rRNA Processing Factors

(2013) Lionel Tafforeau et al.   MOLECULAR CELL

Crystal structure of an RNA-bound 11-subunit eukaryotic exosome complex

(2013) Debora Lika Makino et al.   NATURE

Systematic evaluation of spliced alignment programs for RNA-seq data

(2013) Pär G Engström et al.   NATURE METHODS

The RNA exosome and proteasome: common principles of degradation control

(2013) Debora L. Makino et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Visualization of distinct substrate-recruitment pathways in the yeast exosome by EM

(2013) Jun-Jie Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The RNA exosome complex central channel controls both exonuclease and endonuclease Dis3 activities in vivo and in vitro

(2013) Karolina Drążkowska et al.   NUCLEIC ACIDS RESEARCH

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Exo- and Endoribonucleolytic Activities of Yeast Cytoplasmic and Nuclear RNA Exosomes Are Dependent on the Noncatalytic Core and Central Channel

(2012) Elizabeth V. Wasmuth et al.   MOLECULAR CELL

Transcriptome-wide Analysis of Exosome Targets

(2012) Claudia Schneider et al.   MOLECULAR CELL

Extensive Degradation of RNA Precursors by the Exosome in Wild-Type Cells

(2012) Rajani Kanth Gudipati et al.   MOLECULAR CELL

RNA unwinding by the Trf4/Air2/Mtr4 polyadenylation (TRAMP) complex

(2012) H. Jia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The RNA Helicase Mtr4p Modulates Polyadenylation in the TRAMP Complex

(2011) Huijue Jia et al.   CELL

The nuclear RNA polymerase II surveillance system targets polymerase III transcripts

(2011) Wiebke Wlotzka et al.   EMBO JOURNAL

Interaction Profiling Identifies the Human Nuclear Exosome Targeting Complex

(2011) Michal Lubas et al.   MOLECULAR CELL

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

(2010) Byung-Hoon Lee et al.   NATURE

Structure and function of the polymerase core of TRAMP, a RNA surveillance complex

(2010) S. Hamill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Yeast Exosome Functions as a Macromolecular Cage to Channel RNA Substrates for Degradation

(2009) Fabien Bonneau et al.   CELL

TRAMP Complex Enhances RNA Degradation by the Nuclear Exosome Component Rrp6

(2009) Kevin P. Callahan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Final Step in 5.8S rRNA Processing Is Cytoplasmic in Saccharomyces cerevisiae

(2009) E. Thomson et al.   MOLECULAR AND CELLULAR BIOLOGY

Different Mechanisms for Pseudouridine Formation in Yeast 5S and 5.8S rRNAs

(2008) W. A. Decatur et al.   MOLECULAR AND CELLULAR BIOLOGY

Polyadenylation Linked to Transcription Termination Directs the Processing of snoRNA Precursors in Yeast

(2008) Pawel Grzechnik et al.   MOLECULAR CELL

Evidence for core exosome independent function of the nuclear exoribonuclease Rrp6p

(2008) Kevin P. Callahan et al.   NUCLEIC ACIDS RESEARCH

Exonucleolysis is required for nuclear mRNA quality control in yeast THO mutants

(2008) J. Assenholt et al.   RNA

Competition between the Rex1 exonuclease and the La protein affects both Trf4p-mediated RNA quality control and pre-tRNA maturation

(2008) L. A. Copela et al.   RNA

Relative Structural and Functional Roles of Multiple Deubiquitylating Proteins Associated with Mammalian 26S Proteasome

(2007) Elena Koulich et al.   MOLECULAR BIOLOGY OF THE CELL