Conquering CRISPR: how phages overcome bacterial adaptive immunity

The arms race between bacteria and their phage foes

(2020) Hannah G. Hampton et al.   NATURE

Clades of huge phages from across Earth’s ecosystems

(2020) Basem Al-Shayeb et al.   NATURE

An anti-CRISPR viral ring nuclease subverts type III CRISPR immunity

(2020) Januka S. Athukoralage et al.   NATURE

Critical Anti-CRISPR Locus Repression by a Bi-functional Cas9 Inhibitor

(2020) Beatriz A. Osuna et al.   Cell Host & Microbe

Current challenges and future opportunities of phage therapy

(2020) Diana P Pires et al.   FEMS MICROBIOLOGY REVIEWS

Anti-CRISPR protein applications: natural brakes for CRISPR-Cas technologies

(2020) Nicole D. Marino et al.   NATURE METHODS

Phage T7 DNA mimic protein Ocr is a potent inhibitor of BREX defence

(2020) Artem Isaev et al.   NUCLEIC ACIDS RESEARCH

Potent CRISPR-Cas9 inhibitors fromStaphylococcusgenomes

(2020) Kyle E. Watters et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A phage-encoded anti-CRISPR enables complete evasion of type VI-A CRISPR-Cas immunity

(2020) Alexander J. Meeske et al.   SCIENCE

Bacterial alginate regulators and phage homologs repress CRISPR–Cas immunity

(2020) Adair L. Borges et al.   Nature Microbiology

Structures and Strategies of Anti-CRISPR-Mediated Immune Suppression

(2020) Tanner Wiegand et al.   Annual Review of Microbiology

Imprecise Spacer Acquisition Generates CRISPR-Cas Immune Diversity through Primed Adaptation

(2019) Simon A. Jackson et al.   Cell Host & Microbe

Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus

(2019) Rebekah M. Dedrick et al.   NATURE MEDICINE

Broad-spectrum enzymatic inhibition of CRISPR-Cas12a

(2019) Gavin J. Knott et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An anti-CRISPR protein disables type V Cas12a by acetylation

(2019) Liyong Dong et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Different genetic and morphological outcomes for phages targeted by single or multiple CRISPR-Cas spacers

(2019) B. N. J. Watson et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Genetic Engineering of Bacteriophages Against Infectious Diseases

(2019) Yibao Chen et al.   Frontiers in Microbiology

CRISPR–Cas in mobile genetic elements: counter-defence and beyond

(2019) Guilhem Faure et al.   NATURE REVIEWS MICROBIOLOGY

Anti-CRISPR-Associated Proteins Are Crucial Repressors of Anti-CRISPR Transcription

(2019) Sabrina Y. Stanley et al.   CELL

The autoregulator Aca2 mediates anti-CRISPR repression

(2019) Nils Birkholz et al.   NUCLEIC ACIDS RESEARCH

7-Deazaguanine modifications protect phage DNA from host restriction systems

(2019) Geoffrey Hutinet et al.   Nature Communications

Exploitation of the Cooperative Behaviors of Anti-CRISPR Phages

(2019) Anne Chevallereau et al.   Cell Host & Microbe

A bacteriophage nucleus-like compartment shields DNA from CRISPR nucleases

(2019) Senén D. Mendoza et al.   NATURE

Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants

(2019) Kira S. Makarova et al.   NATURE REVIEWS MICROBIOLOGY

Type IV CRISPR–Cas systems are highly diverse and involved in competition between plasmids

(2019) Rafael Pinilla-Redondo et al.   NUCLEIC ACIDS RESEARCH

A jumbo phage that forms a nucleus-like structure evades CRISPR–Cas DNA targeting but is vulnerable to type III RNA-based immunity

(2019) Lucia M. Malone et al.   Nature Microbiology

The Biology of CRISPR-Cas: Backward and Forward

(2018) Frank Hille et al.   CELL

Bacteriophage Cooperation Suppresses CRISPR-Cas3 and Cas9 Immunity

(2018) Adair L. Borges et al.   CELL

Anti-CRISPR Phages Cooperate to Overcome CRISPR-Cas Immunity

(2018) Mariann Landsberger et al.   CELL

Biotechnological applications of bacteriophages: State of the art

(2018) Liliam K. Harada et al.   MICROBIOLOGICAL RESEARCH

Mycobacteriophage Fruitloop gp52 inactivates Wag31 (DivIVA) to prevent heterotypic superinfection

(2018) Ching-Chung Ko et al.   MOLECULAR MICROBIOLOGY

Cross-genus rebooting of custom-made, synthetic bacteriophage genomes in L-form bacteria

(2018) Samuel Kilcher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of widespread Type I and Type V CRISPR-Cas inhibitors

(2018) Nicole D. Marino et al.   SCIENCE

Type III CRISPR–Cas systems produce cyclic oligoadenylate second messengers

(2017) Ole Niewoehner et al.   NATURE

Bacteriophage DNA glucosylation impairs target DNA binding by type I and II but not by type V CRISPR–Cas effector complexes

(2017) Marnix Vlot et al.   NUCLEIC ACIDS RESEARCH

Crystal structure of an anti-CRISPR protein, AcrIIA1

(2017) Donghyun Ka et al.   NUCLEIC ACIDS RESEARCH

CRISPR-Cas: Adapting to change

(2017) Simon A. Jackson et al.   SCIENCE

A cyclic oligonucleotide signaling pathway in type III CRISPR-Cas systems

(2017) Migle Kazlauskiene et al.   SCIENCE

Assembly of a nucleus-like structure during viral replication in bacteria

(2017) Vorrapon Chaikeeratisak et al.   SCIENCE

Engineering of Bacteriophage T4 Genome Using CRISPR-Cas9

(2017) Pan Tao et al.   ACS Synthetic Biology

The Phage Nucleus and Tubulin Spindle Are Conserved among Large Pseudomonas Phages

(2017) Vorrapon Chaikeeratisak et al.   Cell Reports

Type III CRISPR-Cas systems can provide redundancy to counteract viral escape from type I systems

(2017) Sukrit Silas et al.   eLife

Jumbo Bacteriophages: An Overview

(2017) Yihui Yuan et al.   Frontiers in Microbiology

Naturally Occurring Off-Switches for CRISPR-Cas9

(2016) April Pawluk et al.   CELL

Biosynthesis and Function of Modified Bases in Bacteria and Their Viruses

(2016) Peter Weigele et al.   CHEMICAL REVIEWS

Impact of Different Target Sequences on Type III CRISPR-Cas Immunity

(2016) Inbal Maniv et al.   JOURNAL OF BACTERIOLOGY

Quorum Sensing Controls Adaptive Immunity through the Regulation of Multiple CRISPR-Cas Systems

(2016) Adrian G. Patterson et al.   MOLECULAR CELL

Quorum sensing controls thePseudomonas aeruginosaCRISPR-Cas adaptive immune system

(2016) Nina M. Høyland-Kroghsbo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for the inhibition of RecBCD by Gam and its synergistic antibacterial effect with quinolones

(2016) Martin Wilkinson et al.   eLife

Inactivation of CRISPR-Cas systems by anti-CRISPR proteins in diverse bacterial species

(2016) April Pawluk et al.   Nature Microbiology

CRISPR adaptation biases explain preference for acquisition of foreign DNA

(2015) Asaf Levy et al.   NATURE

A century of the phage: past, present and future

(2015) George P. C. Salmond et al.   NATURE REVIEWS MICROBIOLOGY

Temperate and lytic bacteriophages programmed to sensitize and kill antibiotic-resistant bacteria

(2015) Ido Yosef et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Covalent Modification of Bacteriophage T4 DNA Inhibits CRISPR-Cas9

(2015) Alexandra L. Bryson et al.   mBio

Degenerate target sites mediate rapid primed CRISPR adaptation

(2014) P. C. Fineran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A New Group of Phage Anti-CRISPR Genes Inhibits the Type I-E CRISPR-Cas System of Pseudomonas aeruginosa

(2014) A. Pawluk et al.   mBio

A bacteriophage encodes its own CRISPR/Cas adaptive response to evade host innate immunity

(2013) Kimberley D. Seed et al.   NATURE

Highlights of the DNA cutters: a short history of the restriction enzymes

(2013) Wil A. M. Loenen et al.   NUCLEIC ACIDS RESEARCH

CRISPR-Cas and restriction–modification systems are compatible and increase phage resistance

(2013) Marie-Ève Dupuis et al.   Nature Communications

The Bacteriophage HK97 gp15 Moron Element Encodes a Novel Superinfection Exclusion Protein

(2012) Nichole Cumby et al.   JOURNAL OF BACTERIOLOGY

Bacteriophage genes that inactivate the CRISPR/Cas bacterial immune system

(2012) Joe Bondy-Denomy et al.   NATURE

CRISPR Interference Directs Strand Specific Spacer Acquisition

(2012) Daan C. Swarts et al.   PLoS One

Molecular memory of prior infections activates the CRISPR/Cas adaptive bacterial immunity system

(2012) Kirill A. Datsenko et al.   Nature Communications

Genome Replication, Synthesis, and Assembly of the Bacteriophage T7 in a Single Cell-Free Reaction

(2012) Jonghyeon Shin et al.   ACS Synthetic Biology

Phage Encoded H-NS: A Potential Achilles Heel in the Bacterial Defence System

(2011) Connor T. Skennerton et al.   PLoS One

Interference by clustered regularly interspaced short palindromic repeat (CRISPR) RNA is governed by a seed sequence

(2011) E. Semenova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification and characterization ofE. coliCRISPR-caspromoters and their silencing by H-NS

(2010) Ümit Pul et al.   MOLECULAR MICROBIOLOGY

The structure of the KlcA and ArdB proteins reveals a novel fold and antirestriction activity against Type I DNA restriction systems in vivo but not in vitro

(2009) Dimitra Serfiotis-Mitsa et al.   NUCLEIC ACIDS RESEARCH