The RNA World: molecular cooperation at the origins of life

The origin and spread of a cooperative replicase in a prebiotic chemical system

(2015) Julie A. Shay et al.   JOURNAL OF THEORETICAL BIOLOGY

The “Strong” RNA World Hypothesis: Fifty Years Old

(2013) Marc Neveu et al.   ASTROBIOLOGY

Polymerase Recognition of a Watson-Crick-Like Metal-Mediated Base Pair: Purine-2,6-Dicarboxylate⋅Copper(II)⋅ Pyridine

(2013) Eun-Kyong Kim et al.   CHEMBIOCHEM

Recycling of Informational Units Leads to Selection of Replicators in a Prebiotic Soup

(2013) Nilesh Vaidya et al.   CHEMISTRY & BIOLOGY

The Origin of RNA and “My Grandfather’s Axe”

(2013) Nicholas V. Hud et al.   CHEMISTRY & BIOLOGY

Efficient Self-Assembly in Water of Long Noncovalent Polymers by Nucleobase Analogues

(2013) Brian J. Cafferty et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cold-hearted RNA heats up life

(2013) Niles Lehman   Nature Chemistry

Competition between model protocells driven by an encapsulated catalyst

(2013) Katarzyna Adamala et al.   Nature Chemistry

In-ice evolution of RNA polymerase ribozyme activity

(2013) James Attwater et al.   Nature Chemistry

Prebiotically plausible oligoribonucleotide ligation facilitated by chemoselective acetylation

(2013) Frank R. Bowler et al.   Nature Chemistry

Evidence for reactive reduced phosphorus species in the early Archean ocean

(2013) M. A. Pasek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nonenzymatic Template-Directed RNA Synthesis Inside Model Protocells

(2013) K. Adamala et al.   SCIENCE

Darwinian evolution in a translation-coupled RNA replication system within a cell-like compartment

(2013) Norikazu Ichihashi et al.   Nature Communications

From Prelife to Life: How Chemical Kinetics Become Evolutionary Dynamics

(2012) Irene A. Chen et al.   ACCOUNTS OF CHEMICAL RESEARCH

Asphalt, Water, and the Prebiotic Synthesis of Ribose, Ribonucleosides, and RNA

(2012) Steven A. Benner et al.   ACCOUNTS OF CHEMICAL RESEARCH

The origin of life is a spatially localized stochastic transition

(2012) Meng Wu et al.   Biology Direct

Enhanced Nonenzymatic Ligation of Homopurine Miniduplexes: Support for Greater Base Stacking in a Pre-RNA World

(2012) Elizabeth Kuruvilla et al.   CHEMBIOCHEM

Evolution Finds Shelter in Small Spaces

(2012) Niles Lehman   CHEMISTRY & BIOLOGY

Importance of Parasite RNA Species Repression for Prolonged Translation-Coupled RNA Self-Replication

(2012) Yohsuke Bansho et al.   CHEMISTRY & BIOLOGY

Spontaneous network formation among cooperative RNA replicators

(2012) Nilesh Vaidya et al.   NATURE

RNA catalysis through compartmentalization

(2012) Christopher A. Strulson et al.   Nature Chemistry

Prebiotic synthesis of simple sugars by photoredox systems chemistry

(2012) Dougal Ritson et al.   Nature Chemistry

Darwinian evolution of an alternative genetic system provides support for TNA as an RNA progenitor

(2012) Hanyang Yu et al.   Nature Chemistry

The Importance of Stochastic Transitions for the Origin of Life

(2012) Paul G Higgs et al.   ORIGINS OF LIFE AND EVOLUTION OF BIOSPHERES

Evolutionary dynamics of RNA-like replicator systems: A bioinformatic approach to the origin of life

(2012) Nobuto Takeuchi et al.   Physics of Life Reviews

Synthetic Genetic Polymers Capable of Heredity and Evolution

(2012) V. B. Pinheiro et al.   SCIENCE

On the Stabilization of Ribose by Silicate Minerals

(2011) Álvaro Vázquez-Mayagoitia et al.   ASTROBIOLOGY

Comparison of the Roles of Nucleotide Synthesis, Polymerization, and Recombination in the Origin of Autocatalytic Sets of RNAs

(2011) Meng Wu et al.   ASTROBIOLOGY

Template-Directed RNA Polymerization: The Taming of the Milieu

(2011) Niles Lehman et al.   CHEMBIOCHEM

Amplification, Mutation, and Sequencing of a Six-Letter Synthetic Genetic System

(2011) Zunyi Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficient enzyme-free copying of all four nucleobases templated by immobilized RNA

(2011) Christopher Deck et al.   Nature Chemistry

The Evolution of Enzyme Specificity in the Metabolic Replicator Model of Prebiotic Evolution

(2011) Balázs Könnyű et al.   PLoS One

Ribozyme-Catalyzed Transcription of an Active Ribozyme

(2011) A. Wochner et al.   SCIENCE

DNA as a Versatile Chemical Component for Catalysis, Encoding, and Stereocontrol

(2010) Scott K. Silverman   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Simple Template-Dependent Ligase Ribozyme as the RNA Replicase Emerging First in the RNA World

(2010) Wentao Ma et al.   ASTROBIOLOGY

Solution Structure, Mechanism of Replication, and Optimization of an Unnatural Base Pair

(2010) Denis A. Malyshev et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enhancing the Prebiotic Relevance of a Set of Covalently Self-Assembling, Autorecombining RNAs Through In Vitro Selection

(2010) Aaron S. Burton et al.   JOURNAL OF MOLECULAR EVOLUTION

Marginally Stable Chemical Systems as Precursors of Life

(2010) Doriano Brogioli   PHYSICAL REVIEW LETTERS

Closing the Circle: Replicating RNA with RNA

(2010) L. K. L. Cheng et al.   Cold Spring Harbor Perspectives in Biology

DNA Before Proteins? Recent Discoveries in Nucleic Acid Catalysis Strengthen the Case

(2009) Aaron S. Burton et al.   ASTROBIOLOGY

Origin of Self-Replicating Biopolymers: Autocatalytic Feedback Can Jump-Start the RNA World

(2009) Meng Wu et al.   JOURNAL OF MOLECULAR EVOLUTION

The Origin of Life: Chemical Evolution of a Metabolic System in a Mineral Honeycomb?

(2009) Sergio Branciamore et al.   JOURNAL OF MOLECULAR EVOLUTION

The basic reproductive ratio of life

(2009) Michael L. Manapat et al.   JOURNAL OF THEORETICAL BIOLOGY

Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions

(2009) Matthew W. Powner et al.   NATURE

Prelife catalysts and replicators

(2009) H. Ohtsuki et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Self-Sustained Replication of an RNA Enzyme

(2009) T. A. Lincoln et al.   SCIENCE

Multilevel Selection in Models of Prebiotic Evolution II: A Direct Comparison of Compartmentalization and Spatial Self-Organization

(2009) Nobuto Takeuchi et al.   PLoS Computational Biology

Systems Chemistry on Ribozyme Self-Construction: Evidence for Anabolic Autocatalysis in a Recombination Network

(2008) Eric J. Hayden et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The evolution of strand preference in simulated RNA replicators with strand displacement: Implications for the origin of transcription

(2008) Nobuto Takeuchi et al.   Biology Direct

Evolution of complexity in RNA-like replicator systems

(2008) Nobuto Takeuchi et al.   Biology Direct

Prebiotic replicase evolution in a surface-bound metabolic system: parasites as a source of adaptive evolution

(2008) Balázs Könnyű et al.   BMC EVOLUTIONARY BIOLOGY

Metal-ion catalyzed polymerization in the eutectic phase in water–ice: A possible approach to template-directed RNA polymerization

(2008) Pierre-Alain Monnard et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

The Structure of a TNA−TNA Complex in Solution: NMR Study of the Octamer Duplex Derived from α-(l)-Threofuranosyl-(3′-2′)-CGAATTCG

(2008) Marc-Olivier Ebert et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY