Pre-existing adaptive immunity to the RNA-editing enzyme Cas13d in humans

Engineered CRISPR/Cas13d Sensing hTERT Selectively Inhibits the Progression of Bladder Cancer In Vitro

(2021) Chengle Zhuang et al.   Frontiers in Molecular Biosciences

Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2

(2021) Leo Swadling et al.   NATURE

Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza

(2020) Timothy R. Abbott et al.   CELL

Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice

(2020) Haibo Zhou et al.   CELL

Massively parallel Cas13 screens reveal principles for guide RNA design

(2020) Hans-Hermann Wessels et al.   NATURE BIOTECHNOLOGY

Modulation of metabolic functions through Cas13d-mediated gene knockdown in liver

(2020) Bingbing He et al.   Protein & Cell

SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls

(2020) Nina Le Bert et al.   NATURE

CRISPR artificial splicing factors

(2020) Menghan Du et al.   Nature Communications

Translating CRISPR-Cas Therapeutics: Approaches and Challenges

(2020) Lavina Sierra Tay et al.   CRISPR Journal

Identification of preexisting adaptive immunity to Cas9 proteins in humans

(2019) Carsten T. Charlesworth et al.   NATURE MEDICINE

Multifunctional CRISPR-Cas9 with engineered immunosilenced human T cell epitopes

(2019) Shayesteh R. Ferdosi et al.   Nature Communications

Immune-orthogonal orthologues of AAV capsids and of Cas9 circumvent the immune response to the administration of gene therapy

(2019) Ana M. Moreno et al.   Nature Biomedical Engineering

Transcriptome Engineering with RNA-Targeting Type VI-D CRISPR Effectors

(2018) Silvana Konermann et al.   CELL

Prevalence of Pre-existing Antibodies to CRISPR-Associated Nuclease Cas9 in the USA Population

(2018) Vijaya L. Simhadri et al.   Molecular Therapy-Methods & Clinical Development

High prevalence of Streptococcus pyogenes Cas9-reactive T cells within the adult human population

(2018) Dimitrios L. Wagner et al.   NATURE MEDICINE

RNA editing with CRISPR-Cas13

(2017) David B. T. Cox et al.   SCIENCE

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

(2012) Emmanuel L Gautier et al.   NATURE IMMUNOLOGY

Licensing Virus-Specific T Cells to Secrete the Neutrophil Attracting Chemokine CXCL-8 during Hepatitis B Virus Infection

(2011) Adam J. Gehring et al.   PLoS One

Dominant and diet-responsive groups of bacteria within the human colonic microbiota

(2010) Alan W Walker et al.   ISME Journal

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

Strategies to Modulate Immune Responses: A New Frontier for Gene Therapy

(2009) Valder R Arruda et al.   MOLECULAR THERAPY