The complex interactions between the cellular and non-cellular components of the brain tumor microenvironmental landscape and their therapeutic implications

Glioblastoma Microenvironment and Cellular Interactions

(2022) Carmen-Bianca Crivii et al.   Cancers

TGIF1 overexpression promotes glioma progression and worsens patient prognosis

(2022) Baoya Wang et al.   Cancer Medicine

Tumor Microenvironment in Glioma Invasion

(2022) Sho Tamai et al.   Brain Sciences

The 2021 World Health Organization Classification of Tumors of the Central Nervous System: What Neuroradiologists Need to Know

(2022) A.G. Osborn et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer

(2022) Yang Chen et al.   CANCER CELL

Clinical implications of the 2021 edition of the WHO classification of central nervous system tumours

(2022) Craig Horbinski et al.   Nature Reviews Neurology

Spatiotemporal analysis of glioma heterogeneity reveals COL1A1 as an actionable target to disrupt tumor progression

(2022) Andrea Comba et al.   Nature Communications

Tumor-associated microglia and macrophages in glioblastoma: From basic insights to therapeutic opportunities

(2022) Guoqing Wang et al.   Frontiers in Immunology

Multimodal imaging of the dynamic brain tumor microenvironment during glioblastoma progression and in response to treatment

(2022) Anoek Zomer et al.   iScience

A Novel Glucose Metabolism-Related Gene Signature for Overall Survival Prediction in Patients with Glioblastoma

(2021) Chaocai Zhang et al.   Biomed Research International

Prognostic and Therapeutic Roles of the Insulin Growth Factor System in Glioblastoma

(2021) Elena Tirrò et al.   Frontiers in Oncology

The Role of Microglia in Glioblastoma

(2021) Noelia Geribaldi-Doldán et al.   Frontiers in Oncology

Glioblastomas with primitive neuronal component harbor a distinct methylation and copy-number profile with inactivation of TP53, PTEN, and RB1

(2021) Abigail K. Suwala et al.   ACTA NEUROPATHOLOGICA

The Fibronectin Expression Determines the Distinct Progressions of Malignant Gliomas via Transforming Growth Factor-Beta Pathway

(2021) Chih-Wei Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tenascin C Promotes Glioma Cell Malignant Behavior and Inhibits Chemosensitivity to Paclitaxel via Activation of the PI3K/AKT Signaling Pathway

(2021) Qingping Zhang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization

(2021) Ana Rita Pombo Antunes et al.   NATURE NEUROSCIENCE

Targeting Neuroinflammation in Brain Cancer: Uncovering Mechanisms, Pharmacological Targets, and Neuropharmaceutical Developments

(2021) Mahmoud S. Alghamri et al.   Frontiers in Pharmacology

Identification of collagen genes related to immune infiltration and epithelial-mesenchymal transition in glioma

(2021) Wen Yin et al.   Cancer Cell International

The 2021 WHO Classification of Tumors of the Central Nervous System: a summary

(2021) David N Louis et al.   NEURO-ONCOLOGY

Hypoxia-induced phenotypic transition from highly invasive to less invasive tumors in glioma stem-like cells: Significance of CD44 and osteopontin as therapeutic targets in glioblastoma

(2021) Masahiro Nishikawa et al.   Translational Oncology

Mechanisms of Invasion in Glioblastoma: Extracellular Matrix, Ca2+ Signaling, and Glutamate

(2021) Jae-Seon So et al.   Frontiers in Cellular Neuroscience

COL4A1 as a novel oncogene associated with the clinical characteristics of malignancy predicts poor prognosis in glioma

(2021) Hongbo Wang et al.   Experimental and Therapeutic Medicine

Immune Checkpoint Inhibitors in Human Glioma Microenvironment

(2021) Amina Ghouzlani et al.   Frontiers in Immunology

Deep immune profiling reveals targetable mechanisms of immune evasion in immune checkpoint inhibitor-refractory glioblastoma

(2021) Erin F Simonds et al.   Journal for ImmunoTherapy of Cancer

Uncovering Spatiotemporal Heterogeneity of High-Grade Gliomas: From Disease Biology to Therapeutic Implications

(2021) Andrea Comba et al.   Frontiers in Oncology

MMP2 and TLRs modulate immune responses in the tumor microenvironment

(2021) Luciana R. Muniz-Bongers et al.   JCI Insight

Enhanced Microglia Activation and Glioma Tumor Progression by Inflammagen Priming in Mice with Tumor Necrosis Factor Receptor Type 2 Deficiency

(2021) Chih-Kai Liao et al.   Life-Basel

Brain Metastasis in Soft Tissue Sarcoma at Initial Presentation

(2021) RYO ITOGA et al.   ANTICANCER RESEARCH

The extracellular matrix viscoelasticity as a regulator of cell and tissue dynamics

(2021) Alberto Elosegui-Artola   CURRENT OPINION IN CELL BIOLOGY

T cell dysfunction in glioblastoma: a barrier and an opportunity for the development of successful immunotherapies

(2021) Josephina A. Jansen et al.   CURRENT OPINION IN NEUROLOGY

Emerging roles for CNS fibroblasts in health, injury and disease

(2021) Cayce E. Dorrier et al.   NATURE REVIEWS NEUROSCIENCE

G-CSF secreted by mutant IDH1 glioma stem cells abolishes myeloid cell immunosuppression and enhances the efficacy of immunotherapy

(2021) Mahmoud S. Alghamri et al.   Science Advances

Type V collagen alpha 1 chain promotes the malignancy of glioblastoma through PPRC1-ESM1 axis activation and extracellular matrix remodeling

(2021) Hsing-Fang Tsai et al.   Cell Death Discovery

A small‐molecule CD44 dimerizing inhibitor for glioblastoma treatment

(2020) Chongwu Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cellular uptake of collagens and implications for immune cell regulation in disease

(2020) Henrik J. Jürgensen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Phase 1b/2a study of galunisertib, a small molecule inhibitor of transforming growth factor-beta receptor I, in combination with standard temozolomide-based radiochemotherapy in patients with newly diagnosed malignant glioma

(2020) Antje Wick et al.   INVESTIGATIONAL NEW DRUGS

High Expression of CD44 Predicts a Poor Prognosis in Glioblastomas

(2020) Daolin Si et al.   Cancer Management and Research

Immunotherapy for gliomas: shedding light on progress in preclinical and clinical development

(2020) Maria B. Garcia-Fabiani et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Human fibronectin Extra Domain B (ED‐B) as a biomarker for targeted therapy in cancer

(2020) Relinde I.Y. Lieverse et al.   Molecular Oncology

A mode of cell adhesion and migration facilitated by CD44-dependent microtentacles

(2020) Kayla J. Wolf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myeloid-derived suppressor cell subsets drive glioblastoma growth in a sex-specific manner

(2020) Defne Bayik et al.   Cancer Discovery

Tumor-penetrating peptide for systemic targeting of Tenascin-C

(2020) Prakash Lingasamy et al.   Scientific Reports

Self-organization in brain tumors: How cell morphology and cell density influence glioma pattern formation

(2020) Sara Jamous et al.   PLoS Computational Biology

The Emerging Role of Myeloid-Derived Suppressor Cells in the Glioma Immune Suppressive Microenvironment

(2020) Yajing Mi et al.   Frontiers in Immunology

Biomechanical Contributions to Macrophage Activation in the Tumor Microenvironment

(2020) Erica J. Hoffmann et al.   Frontiers in Oncology

Single-Cell Transcriptomic Analyses of the Developing Meninges Reveal Meningeal Fibroblast Diversity and Function

(2020) John DeSisto et al.   DEVELOPMENTAL CELL

Immune suppression in gliomas

(2020) Matthew M. Grabowski et al.   JOURNAL OF NEURO-ONCOLOGY

Laminin Subunit Alpha-4 and Osteopontin Are Glioblastoma-Selective Secreted Proteins That Are Increased in the Cerebrospinal Fluid of Glioblastoma Patients

(2020) Tomohiro Kohata et al.   JOURNAL OF PROTEOME RESEARCH

Glioblastoma Myeloid-Derived Suppressor Cell Subsets Express Differential Macrophage Migration Inhibitory Factor Receptor Profiles That Can Be Targeted to Reduce Immune Suppression

(2020) Tyler J. Alban et al.   Frontiers in Immunology

Therapeutic Strategies for Overcoming Immunotherapy Resistance Mediated by Immunosuppressive Factors of the Glioblastoma Microenvironment

(2020) Tsubasa Miyazaki et al.   Cancers

Targeting the Extra-Cellular Matrix—Tumor Cell Crosstalk for Anti-Cancer Therapy: Emerging Alternatives to Integrin Inhibitors

(2020) Girieca Lorusso et al.   Frontiers in Oncology

On-Target Anti-TGF-β Therapies Are Not Succeeding in Clinical Cancer Treatments: What Are Remaining Challenges?

(2020) Adilson Fonseca Teixeira et al.   Frontiers in Cell and Developmental Biology

Astrocytes are necessary for blood–brain barrier maintenance in the adult mouse brain

(2020) Benjamin P. Heithoff et al.   GLIA

The CNS and the Brain Tumor Microenvironment: Implications for Glioblastoma Immunotherapy

(2020) Fiona A. Desland et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of extracellular matrix viscoelasticity on cellular behaviour

(2020) Ovijit Chaudhuri et al.   NATURE

Tenascin C promotes cancer cell plasticity in mesenchymal glioblastoma

(2020) Inbar Angel et al.   ONCOGENE

Immunocytokines are a promising immunotherapeutic approach against glioblastoma

(2020) Tobias Weiss et al.   Science Translational Medicine

Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion

(2020) David H. Peng et al.   Nature Communications

Leukocyte Associated Immunoglobulin Like Receptor 1 Regulation and Function on Monocytes and Dendritic Cells During Inflammation

(2020) Tiago Carvalheiro et al.   Frontiers in Immunology

Modification of Extracellular Matrix Enhances Oncolytic Adenovirus Immunotherapy in Glioblastoma

(2020) Juri Kiyokawa et al.   CLINICAL CANCER RESEARCH

Immune-stimulatory (TK/Flt3L) gene therapy opens the door to a promising new treatment strategy against brainstem gliomas

(2020) Syed M. Faisal et al.   Oncotarget

Distinguishing Glioblastoma Subtypes by Methylation Signatures

(2020) Yu-Hang Zhang et al.   Frontiers in Genetics

TERT promoter mutation confers favorable prognosis regardless of 1p/19q status in adult diffuse gliomas with IDH1/2 mutations

(2020) Hideyuki Arita et al.   Acta Neuropathologica Communications

Recurrent Glioblastoma: From Molecular Landscape to New Treatment Perspectives

(2020) Cristina Birzu et al.   Cancers

Inhibition of 2-hydroxyglutarate elicits metabolic reprogramming and mutant IDH1 glioma immunity in mice

(2020) Padma Kadiyala et al.   JOURNAL OF CLINICAL INVESTIGATION

Collagen density regulates the activity of tumor-infiltrating T cells

(2019) Dorota E. Kuczek et al.   Journal for ImmunoTherapy of Cancer

Ex vivo Dynamics of Human Glioblastoma Cells in a Microvasculature-on-a-Chip System Correlates with Tumor Heterogeneity and Subtypes

(2019) Yang Xiao et al.   Advanced Science

Actomyosin contractility-dependent matrix stretch and recoil induces rapid cell migration

(2019) William Y. Wang et al.   Nature Communications

IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response

(2019) Felipe J. Núñez et al.   Science Translational Medicine

Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma

(2019) Timothy F. Cloughesy et al.   NATURE MEDICINE

DDR1 (discoidin domain receptor tyrosine kinase 1) drives glioblastoma therapy resistance by modulating autophagy

(2019) Anne Vehlow et al.   Autophagy

Bioengineered scaffolds for 3D culture demonstrate extracellular matrix-mediated mechanisms of chemotherapy resistance in glioblastoma

(2019) Weikun Xiao et al.   MATRIX BIOLOGY

Mechanical Durotactic Environment Enhances Specific Glioblastoma Cell Responses

(2019) Ilaria Elena Palamà et al.   Cancers

Dynamic fibroblast contractions attract remote macrophages in fibrillar collagen matrix

(2019) Pardis Pakshir et al.   Nature Communications

Tumor-associated reactive astrocytes aid the evolution of immunosuppressive environment in glioblastoma

(2019) Dieter Henrik Heiland et al.   Nature Communications

Fibronectin in malignancy: Cancer-specific alterations, protumoral effects, and therapeutic implications

(2019) Jonathan W Rick et al.   SEMINARS IN ONCOLOGY

Human Mesenchymal glioblastomas are characterized by an increased immune cell presence compared to Proneural and Classical tumors

(2019) Ioannis Kaffes et al.   OncoImmunology

Glioma Cell Migration Dynamics in Brain Tissue Assessed by Multimodal Optical Imaging

(2019) Chao J. Liu et al.   BIOPHYSICAL JOURNAL

Investigating the Contribution of Collagen to the Tumor Biomechanical Phenotype with Noninvasive Magnetic Resonance Elastography

(2019) Jin Li et al.   CANCER RESEARCH

Ultrastructural and Molecular Characterization of Platelet-derived growth factor Beta-Positive Leptomeningeal Cells in the Adult Rat Brain

(2019) Tae-Ryong Riew et al.   MOLECULAR NEUROBIOLOGY

Mapping microglia states in the human brain through the integration of high-dimensional techniques

(2019) Roman Sankowski et al.   NATURE NEUROSCIENCE

Microglia/Brain Macrophages as Central Drivers of Brain Tumor Pathobiology

(2019) David H. Gutmann et al.   NEURON

3D extracellular matrix microenvironment in bioengineered tissue models of primary pediatric and adult brain tumors

(2019) Disha Sood et al.   Nature Communications

Glioblastoma cell adhesion properties through bacterial cellulose nanocrystals in polycaprolactone/gelatin electrospun nanofibers

(2019) Semra Unal et al.   CARBOHYDRATE POLYMERS

Mechanisms of Plastic Deformation in Collagen Networks Induced by Cellular Forces

(2018) Ehsan Ban et al.   BIOPHYSICAL JOURNAL

Glioma infiltration and extracellular matrix: key players and modulators

(2018) Valéria Pereira Ferrer et al.   GLIA

Adaptive adhesion systems mediate glioma cell invasion in complex environments

(2018) Pavlo G. Gritsenko et al.   JOURNAL OF CELL SCIENCE

STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis

(2018) Neibla Priego et al.   NATURE MEDICINE

WHO 2016 Classification of gliomas

(2018) P. Wesseling et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Glial Tissue Mechanics and Mechanosensing by Glial Cells

(2018) Katarzyna Pogoda et al.   Frontiers in Cellular Neuroscience

Immune Microenvironment in Glioblastoma Subtypes

(2018) Zhihong Chen et al.   Frontiers in Immunology

Modelling glioma invasion using 3D bioprinting and scaffold-free 3D culture

(2018) Derek M. van Pel et al.   Journal of Cell Communication and Signaling

Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, Efficacy, and Limitations

(2018) Judith A. Seidel et al.   Frontiers in Oncology

The comparison genomics analysis with glioblastoma multiforme (GBM) cells under 3D and 2D cell culture conditions

(2018) Liang Ma et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Astrocytes, the rising stars of the glioblastoma microenvironment

(2018) Mayra Brandao et al.   GLIA

The mechanical and pharmacological regulation of glioblastoma cell migration in 3D matrices

(2018) Pranita Kaphle et al.   JOURNAL OF CELLULAR PHYSIOLOGY

CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2011–2015

(2018) Quinn T Ostrom et al.   NEURO-ONCOLOGY

Mechanisms of Neural Crest Migration

(2018) András Szabó et al.   Annual Review of Genetics

Harnessing the immune system in glioblastoma

(2018) Nicholas F. Brown et al.   BRITISH JOURNAL OF CANCER

From single cells to tissue self-organization

(2018) Aline Xavier da Silveira dos Santos et al.   FEBS Journal

Role of Extracellular Matrix in Development and Cancer Progression

(2018) Cameron Walker et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Innate Immunity Cells and the Neurovascular Unit

(2018) Ivan Presta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

(2018) Derin B. Keskin et al.   NATURE

Extracellular matrix differences in glioblastoma patients with different prognoses

(2018) J�zsef Virga et al.   Oncology Letters

T-cell exhaustion in glioblastoma

(2018) Karolina Woroniecka et al.   Oncotarget

Microtubule-Based Control of Motor-Clutch System Mechanics in Glioma Cell Migration

(2018) Louis S. Prahl et al.   Cell Reports

Tumor-Associated Fibronectin Targeted Liposomal Nanoplatform for Cyclophilin A siRNA Delivery and Targeted Malignant Glioblastoma Therapy

(2018) Phei Er Saw et al.   Frontiers in Pharmacology

Chondroitin sulfates and their binding molecules in the central nervous system

(2017) L Djerbal et al.   GLYCOCONJUGATE JOURNAL

Association of collagen architecture with glioblastoma patient survival

(2017) Kelli B. Pointer et al.   JOURNAL OF NEUROSURGERY

Immune microenvironment of gliomas

(2017) Anna Gieryng et al.   LABORATORY INVESTIGATION

Immunosuppressive Myeloid Cells’ Blockade in the Glioma Microenvironment Enhances the Efficacy of Immune-Stimulatory Gene Therapy

(2017) Neha Kamran et al.   MOLECULAR THERAPY

Visualization and targeting of LGR5+ human colon cancer stem cells

(2017) Mariko Shimokawa et al.   NATURE

Targeting glioma stem cells through combined BMI1 and EZH2 inhibition

(2017) Xun Jin et al.   NATURE MEDICINE

Clonal expansion and epigenetic reprogramming following deletion or amplification of mutantIDH1

(2017) Tali Mazor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shifting the optimal stiffness for cell migration

(2017) Benjamin L. Bangasser et al.   Nature Communications

Notch signaling regulates metabolic heterogeneity in glioblastoma stem cells

(2017) N. Sumru Bayin et al.   Oncotarget

Incorporation of a Ligand Peptide for Immune Inhibitory Receptor LAIR-1 on Biomaterial Surfaces Inhibits Macrophage Inflammatory Responses

(2017) Yoon Kyung Kim et al.   Advanced Healthcare Materials

Integrin-Mediated Interactions Control Macrophage Polarization in 3D Hydrogels

(2017) Byung-Hyun Cha et al.   Advanced Healthcare Materials

Single-Cell RNA-Seq Analysis of Infiltrating Neoplastic Cells at the Migrating Front of Human Glioblastoma

(2017) Spyros Darmanis et al.   Cell Reports

Biphasic Dependence of Glioma Survival and Cell Migration on CD44 Expression Level

(2017) Rebecca L. Klank et al.   Cell Reports

Antigen Loss Variants: Catching Hold of Escaping Foes

(2017) Maulik Vyas et al.   Frontiers in Immunology

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Col1a1+ perivascular cells in the brain are a source of retinoic acid following stroke

(2016) Kathleen K. Kelly et al.   BMC NEUROSCIENCE

CCL2 Produced by the Glioma Microenvironment Is Essential for the Recruitment of Regulatory T Cells and Myeloid-Derived Suppressor Cells

(2016) Alan L. Chang et al.   CANCER RESEARCH

Rapid Reprogramming of Primary Human Astrocytes into Potent Tumor-Initiating Cells with Defined Genetic Factors

(2016) F. Li et al.   CANCER RESEARCH

Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth

(2016) Baoli Hu et al.   CELL

Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma

(2016) Michele Ceccarelli et al.   CELL

Immunocytokines for cancer treatment: past, present and future

(2016) Dario Neri et al.   CURRENT OPINION IN IMMUNOLOGY

Synthesis and deposition of basement membrane proteins by primary brain capillary endothelial cells in a murine model of the blood-brain barrier

(2016) Maj Schneider Thomsen et al.   JOURNAL OF NEUROCHEMISTRY

The Epithelial-to-Mesenchymal Transition-Like Process in Glioblastoma: An Updated Systematic Review and In Silico Investigation

(2016) Isabele C. Iser et al.   MEDICINAL RESEARCH REVIEWS

Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer

(2016) Qing Chen et al.   NATURE

Tissue mechanics promote IDH1-dependent HIF1α–tenascin C feedback to regulate glioblastoma aggression

(2016) Yekaterina A. Miroshnikova et al.   NATURE CELL BIOLOGY

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

(2016) Hanane Laklai et al.   NATURE MEDICINE

A polarizing question: do M1 and M2 microglia exist?

(2016) Richard M Ransohoff   NATURE NEUROSCIENCE

Advances in the molecular genetics of gliomas — implications for classification and therapy

(2016) Guido Reifenberger et al.   Nature Reviews Clinical Oncology

A novel 3D human glioblastoma cell culture system for modeling drug and radiation responses

(2016) Natividad Gomez-Roman et al.   NEURO-ONCOLOGY

A Phase II randomized study of galunisertib monotherapy or galunisertib plus lomustine compared with lomustine monotherapy in patients with recurrent glioblastoma

(2016) Alba A. Brandes et al.   NEURO-ONCOLOGY

Structural basis of collagen recognition by human osteoclast-associated receptor and design of osteoclastogenesis inhibitors

(2016) Joel Haywood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells

(2016) K. Sadtler et al.   SCIENCE

Cancer Stem Cell-Secreted Macrophage Migration Inhibitory Factor Stimulates Myeloid Derived Suppressor Cell Function and Facilitates Glioblastoma Immune Evasion

(2016) Balint Otvos et al.   STEM CELLS

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Molecular mechanisms of the effect of TGF-β1 on U87 human glioblastoma cells

(2016) Igor Bryukhovetskiy et al.   Oncology Letters

Understanding cytoskeleton regulators in glioblastoma multiforme for therapy design

(2016) Satish Kitambi et al.   Drug Design Development and Therapy

First-in-human phase I clinical trial of RG7356, an anti-CD44 humanized antibody, in patients with advanced, CD44-expressing solid tumors

(2016) C. Willemien Menke-van der Houven van Oordt et al.   Oncotarget

Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies

(2016) Robert L. Bowman et al.   Cell Reports

Differential response of patient-derived primary glioblastoma cells to environmental stiffness

(2016) Thomas James Grundy et al.   Scientific Reports

Intratumoral heterogeneity identified at the epigenetic, genetic and transcriptional level in glioblastoma

(2016) Nicole R. Parker et al.   Scientific Reports

Resident microglia rather than peripheral macrophages promote vascularization in brain tumors and are source of alternative pro-angiogenic factors

(2015) Susan Brandenburg et al.   ACTA NEUROPATHOLOGICA

Blood−brain barrier breakdown and neovascularization processes after stroke and traumatic brain injury

(2015) Roshini Prakash et al.   CURRENT OPINION IN NEUROLOGY

Cancer stem cells in glioblastoma

(2015) Justin D. Lathia et al.   GENES & DEVELOPMENT

Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth

(2015) Lin Zhang et al.   NATURE

Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth

(2015) Wenchao Zhou et al.   NATURE CELL BIOLOGY

Integrated genomic characterization of IDH1-mutant glioma malignant progression

(2015) Hanwen Bai et al.   NATURE GENETICS

Higher-Resolution Magnetic Resonance Elastography in Meningiomas to Determine Intratumoral Consistency

(2015) Joshua D. Hughes et al.   NEUROSURGERY

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas

(2015)   NEW ENGLAND JOURNAL OF MEDICINE

Extracellular vesicle-transported Semaphorin3A promotes vascular permeability in glioblastoma

(2015) L Treps et al.   ONCOGENE

Expression of cortactin in human gliomas and its effect on migration and invasion of glioma cells

(2015) LEILEI WANG et al.   ONCOLOGY REPORTS

The role of astrocytes in the progression of brain cancer: complicating the picture of the tumor microenvironment

(2015) Amanda L. Placone et al.   TUMOR BIOLOGY

In Vivo Measurement of Brain Tumor Elasticity Using Intraoperative Shear Wave Elastography

(2015) D. Chauvet et al.   ULTRASCHALL IN DER MEDIZIN

PD-1 and Tim-3 pathways are associated with regulatory CD8+ T-cell function in decidua and maintenance of normal pregnancy

(2015) S-C Wang et al.   Cell Death & Disease

Tenascin-C and integrins in cancer

(2015) Toshimichi Yoshida et al.   Cell Adhesion & Migration

Genetic and Functional Diversity of Propagating Cells in Glioblastoma

(2015) Sara G.M. Piccirillo et al.   Stem Cell Reports

Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and Cancer

(2015) Suniti Misra et al.   Frontiers in Immunology

Expression of EGFRvIII in Glioblastoma: Prognostic Significance Revisited

(2015) Nicola Montano et al.   NEOPLASIA

Integrated DNA methylation and copy-number profiling identify three clinically and biologically relevant groups of anaplastic glioma

(2014) Benedikt Wiestler et al.   ACTA NEUROPATHOLOGICA

Natural Killer Cells Eradicate Galectin-1-Deficient Glioma in the Absence of Adaptive Immunity

(2014) G. J. Baker et al.   CANCER RESEARCH

Osteopontin-CD44 Signaling in the Glioma Perivascular Niche Enhances Cancer Stem Cell Phenotypes and Promotes Aggressive Tumor Growth

(2014) Alexander Pietras et al.   Cell Stem Cell

Contributions of chondroitin sulfate proteoglycans to neurodevelopment, injury, and cancer

(2014) Daniel J Silver et al.   CURRENT OPINION IN NEUROBIOLOGY

HIF Transcription Factors, Inflammation, and Immunity

(2014) Asis Palazon et al.   IMMUNITY

Collective motion of cells: from experiments to models

(2014) Előd Méhes et al.   Integrative Biology

Extracellular matrix elasticity and topography: Material-based cues that affect cell function via conserved mechanisms

(2014) Isaac A. Janson et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

(2014) Muhammad Zaeem Noman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MTSS1 suppresses cell migration and invasion by targeting CTTN in glioblastoma

(2014) Shoudan Zhang et al.   JOURNAL OF NEURO-ONCOLOGY

A co-culture model with brain tumor-specific bioluminescence demonstrates astrocyte-induced drug resistance in glioblastoma

(2014) Ning Yang et al.   Journal of Translational Medicine

Culture Dimensionality Influences the Resistance of Glioblastoma Stem-like Cells to Multikinase Inhibitors

(2014) G. Fernandez-Fuente et al.   MOLECULAR CANCER THERAPEUTICS

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MGMT testing—the challenges for biomarker-based glioma treatment

(2014) Wolfgang Wick et al.   Nature Reviews Neurology

Microenvironmental Stiffness Enhances Glioma Cell Proliferation by Stimulating Epidermal Growth Factor Receptor Signaling

(2014) Vaibhavi Umesh et al.   PLoS One

Six-color intravital two-photon imaging of brain tumors and their dynamic microenvironment

(2014) Clément Ricard et al.   Frontiers in Cellular Neuroscience

Gliomas and the vascular fragility of the blood brain barrier

(2014) Luiz Gustavo Dubois et al.   Frontiers in Cellular Neuroscience

The impact of microglial activation on blood-brain barrier in brain diseases

(2014) Anna Carolina Carvalho da Fonseca et al.   Frontiers in Cellular Neuroscience

Disruption of astrocyte–vascular coupling and the blood–brain barrier by invading glioma cells

(2014) Stacey Watkins et al.   Nature Communications

Activation of Toll-like Receptor-2 by Endogenous Matrix Metalloproteinase-2 Modulates Dendritic-Cell-Mediated Inflammatory Responses

(2014) Emmanuelle Godefroy et al.   Cell Reports

Stem Cell Niches in Glioblastoma: A Neuropathological View

(2014) Davide Schiffer et al.   Biomed Research International

Mechanisms of Glioma Formation: Iterative Perivascular Glioma Growth and Invasion Leads to Tumor Progression, VEGF-Independent Vascularization, and Resistance to Antiangiogenic Therapy

(2014) Gregory J. Baker et al.   NEOPLASIA

Role of Collagen Matrix in Tumor Angiogenesis and Glioblastoma Multiforme Progression

(2013) Tadanori Mammoto et al.   AMERICAN JOURNAL OF PATHOLOGY

Mimicking white matter tract topography using core–shell electrospun nanofibers to examine migration of malignant brain tumors

(2013) Shreyas S. Rao et al.   BIOMATERIALS

Porous chitosan-hyaluronic acid scaffolds as a mimic of glioblastoma microenvironment ECM

(2013) Stephen J. Florczyk et al.   BIOMATERIALS

A Mechanism of Hypoxia-Mediated Escape from Adaptive Immunity in Cancer Cells

(2013) I. B. Barsoum et al.   CANCER RESEARCH

Glioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth

(2013) Lin Cheng et al.   CELL

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

Neutrophils Promote the Malignant Glioma Phenotype through S100A4

(2013) J. Liang et al.   CLINICAL CANCER RESEARCH

Proteoglycans and their roles in brain cancer

(2013) Anna Wade et al.   FEBS Journal

Molecular definition of the pro-tumorigenic phenotype of glioma-activated microglia

(2013) Aleksandra Ellert-Miklaszewska et al.   GLIA

Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force

(2013) Katarina Wolf et al.   JOURNAL OF CELL BIOLOGY

Phenotypic Polarization of Activated Astrocytes: The Critical Role of Lipocalin-2 in the Classical Inflammatory Activation of Astrocytes

(2013) E. Jang et al.   JOURNAL OF IMMUNOLOGY

Chondroitin Sulfate Proteoglycans Potently Inhibit Invasion and Serve as a Central Organizer of the Brain Tumor Microenvironment

(2013) D. J. Silver et al.   JOURNAL OF NEUROSCIENCE

The Pathobiology of Collagens in Glioma

(2013) Leo S. Payne et al.   MOLECULAR CANCER RESEARCH

Mutational heterogeneity in cancer and the search for new cancer-associated genes

(2013) Michael S. Lawrence et al.   NATURE

Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen

(2013) Andrew L Doedens et al.   NATURE IMMUNOLOGY

Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake

(2013) William A Flavahan et al.   NATURE NEUROSCIENCE

Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics

(2013) A. Sottoriva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

“The development tumor model” to study and monitor the entire progression of both primary and metastatic tumors

(2013) Enrico Brognaro   TUMOR BIOLOGY

The role of astrocytes in CNS tumors: pre-clinical models and novel imaging approaches

(2013) Emma R. O'Brien et al.   Frontiers in Cellular Neuroscience

Mechanisms of Glioma-Associated Neovascularization

(2012) Matthew E. Hardee et al.   AMERICAN JOURNAL OF PATHOLOGY

Functional Diversity of Laminins

(2012) Anna Domogatskaya et al.   Annual Review of Cell and Developmental Biology

Discoidin domain receptor 2 regulates neutrophil chemotaxis in 3D collagen matrices

(2012) P. V. Afonso et al.   BLOOD

Fellow travellers: emergent properties of collective cell migration

(2012) Pernille Rørth   EMBO REPORTS

Cancer stem cells as ‘units of selection’

(2012) Mel Greaves   Evolutionary Applications

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues

(2012) Brendon M. Baker et al.   JOURNAL OF CELL SCIENCE

Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors

(2012) Hélène Salmon et al.   JOURNAL OF CLINICAL INVESTIGATION

Defining the mode of tumour growth by clonal analysis

(2012) Gregory Driessens et al.   NATURE

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

(2012) Masato Sasaki et al.   NATURE

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

(2012) S. B. Willingham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential macrophage programming in the tumor microenvironment

(2012) Brian Ruffell et al.   TRENDS IN IMMUNOLOGY

Elucidating the mechanobiology of malignant brain tumors using a brain matrix-mimetic hyaluronic acid hydrogel platform

(2011) Badriprasad Ananthanarayanan et al.   BIOMATERIALS

Inhibition of Collagen XVI Expression Reduces Glioma Cell Invasiveness

(2011) Richard Bauer et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

(2011) T. R. Cox et al.   Disease Models & Mechanisms

Galectin-1 and immunotherapy for brain cancer

(2011) Tina Verschuere et al.   Expert Review of Neurotherapeutics

Discoidin domain receptor 1 expression in activated T cells is regulated by the ERK MAP kinase signaling pathway

(2011) Nizar Chetoui et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Tumor-expressed collagens can modulate immune cell function through the inhibitory collagen receptor LAIR-1

(2011) Tomasz P. Rygiel et al.   MOLECULAR IMMUNOLOGY

Myeloid-derived suppressor cell accumulation and function in patients with newly diagnosed glioblastoma

(2011) B. Raychaudhuri et al.   NEURO-ONCOLOGY

A Theory and a Model to Understand Glioblastoma Development Both in the Bulk and in the Microinfiltrated Brain Parenchyma

(2011) Enrico Brognaro   NEUROCHEMICAL RESEARCH

Hypoxia Potentiates Glioma-Mediated Immunosuppression

(2011) Jun Wei et al.   PLoS One

Recruited Cells Can Become Transformed and Overtake PDGF-Induced Murine Gliomas In Vivo during Tumor Progression

(2011) Elena I. Fomchenko et al.   PLoS One

The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence

(2011) J. I. Alvarez et al.   SCIENCE

Extracellular Matrix Degradation and Remodeling in Development and Disease

(2011) P. Lu et al.   Cold Spring Harbor Perspectives in Biology

Molecular diagnostics of gliomas: state of the art

(2010) Markus J. Riemenschneider et al.   ACTA NEUROPATHOLOGICA

Assembly of Fibronectin Extracellular Matrix

(2010) Purva Singh et al.   Annual Review of Cell and Developmental Biology

A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2α

(2010) Sascha Seidel et al.   BRAIN

Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma

(2010) Houtan Noushmehr et al.   CANCER CELL

Perivascular Nitric Oxide Activates Notch Signaling and Promotes Stem-like Character in PDGF-Induced Glioma Cells

(2010) Nikki Charles et al.   Cell Stem Cell

Magnetic resonance elastography: A review

(2010) Yogesh K. Mariappan et al.   CLINICAL ANATOMY

Tumors as Organs: Complex Tissues that Interface with the Entire Organism

(2010) Mikala Egeblad et al.   DEVELOPMENTAL CELL

The extracellular matrix at a glance

(2010) C. Frantz et al.   JOURNAL OF CELL SCIENCE

Extracellular Matrix of Glioblastoma Inhibits Polarization and Transmigration of T Cells: The Role of Tenascin-C in Immune Suppression

(2010) J.-Y. Huang et al.   JOURNAL OF IMMUNOLOGY

Implication of discoidin domain receptor 1 in T cell migration in three-dimensional collagen

(2010) Lamia Naouel Hachehouche et al.   MOLECULAR IMMUNOLOGY

Glioma cancer stem cells induce immunosuppressive macrophages/microglia

(2010) Adam Wu et al.   NEURO-ONCOLOGY

Diagnosis, treatment, and prognosis of glioma: Five new things

(2010) L. P. Taylor   NEUROLOGY

A Role for Fibrillar Collagen Deposition and the Collagen Internalization Receptor Endo180 in Glioma Invasion

(2010) Ivo J. Huijbers et al.   PLoS One

The Collagen Family

(2010) S. Ricard-Blum   Cold Spring Harbor Perspectives in Biology

IDH1 Mutations Are Early Events in the Development of Astrocytomas and Oligodendrogliomas

(2009) Takuya Watanabe et al.   AMERICAN JOURNAL OF PATHOLOGY

Venular Basement Membranes Ubiquitously Express Matrix Protein Low-Expression Regions

(2009) Mathieu-Benoît Voisin et al.   AMERICAN JOURNAL OF PATHOLOGY

Galectins and Gliomas

(2009) Marie Le Mercier et al.   BRAIN PATHOLOGY

Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells

(2009) Zhizhong Li et al.   CANCER CELL

Tenascin-C Is a Novel RBPJ -Induced Target Gene for Notch Signaling in Gliomas

(2009) B. Sivasankaran et al.   CANCER RESEARCH

Proteolytic Cleavage of Protein Tyrosine Phosphatase   Regulates Glioblastoma Cell Migration

(2009) A. M. Burgoyne et al.   CANCER RESEARCH

The Mechanical Rigidity of the Extracellular Matrix Regulates the Structure, Motility, and Proliferation of Glioma Cells

(2009) T. A. Ulrich et al.   CANCER RESEARCH

Brain tumor hypoxia: tumorigenesis, angiogenesis, imaging, pseudoprogression, and as a therapeutic target

(2009) Randy L. Jensen   JOURNAL OF NEURO-ONCOLOGY

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

Quantitative Analysis of Complex Glioma Cell Migration on Electrospun Polycaprolactone Using Time-Lapse Microscopy

(2009) Jed Johnson et al.   TISSUE ENGINEERING PART C-METHODS

Common astrocytic programs during brain development, injury and cancer

(2009) Daniel J. Silver et al.   TRENDS IN NEUROSCIENCES

The role of tenascin-C in tissue injury and tumorigenesis

(2009) Kim S. Midwood et al.   Journal of Cell Communication and Signaling

The interface between glial progenitors and gliomas

(2008) Peter Canoll et al.   ACTA NEUROPATHOLOGICA

HIF1α Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion

(2008) Rose Du et al.   CANCER CELL

Targeting Cancer Stem Cells through L1CAM Suppresses Glioma Growth

(2008) S. Bao et al.   CANCER RESEARCH

Hypoxia controls CD4+CD25+ regulatory T-cell homeostasis via hypoxia-inducible factor-1α

(2008) Jeremy Ben-Shoshan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Collagen XVI expression is upregulated in glioblastomas and promotes tumor cell adhesion

(2008) Volker Senner et al.   FEBS LETTERS

Extracellular matrix of the central nervous system: from neglect to challenge

(2008) Dieter R. Zimmermann et al.   HISTOCHEMISTRY AND CELL BIOLOGY

The Counterbalance Theory for Evolution and Function of Paired Receptors

(2008) A. Neil Barclay et al.   IMMUNITY

Rapid leukocyte migration by integrin-independent flowing and squeezing

(2008) Tim Lämmermann et al.   NATURE

A pilot study: 131I-Antitenascin monoclonal antibody 81c6 to deliver a 44-Gy resection cavity boost

(2008) David A. Reardon et al.   NEURO-ONCOLOGY

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE

Hyaluronan in human tumors: Pathobiological and prognostic messages from cell-associated and stromal hyaluronan

(2008) Raija H. Tammi et al.   SEMINARS IN CANCER BIOLOGY

The inhibitory collagen receptor LAIR-1 (CD305)

(2007) L. Meyaard   JOURNAL OF LEUKOCYTE BIOLOGY

Tenascin-C expression relates to clinicopathological features in pilocytic and diffuse astrocytomas

(2007) C. Maris et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY