Immunocytokines are a promising immunotherapeutic approach against glioblastoma

Effect of Nivolumab vs Bevacizumab in Patients With Recurrent Glioblastoma

(2020) David A. Reardon et al.   JAMA Oncology

Antibody–Cytokine Fusions: Versatile Products for the Modulation of Anticancer Immunity

(2019) Dario Neri   Cancer Immunology Research

Brain Tumor Microenvironment and Host State: Implications for Immunotherapy

(2019) William Tomaszewski et al.   CLINICAL CANCER RESEARCH

Imaging necrosis during treatment is associated with worse survival in EORTC 26101 study

(2019) Martha Nowosielski et al.   NEUROLOGY

An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma

(2019) Cyril Neftel et al.   CELL

Design and characterisation of a novel interleukin-15 receptor alpha fusion protein and analysis of interleukin-15 complexation

(2019) Anja Sophie Schmid et al.   PLoS One

The antibody‐based delivery of interleukin‐12 to solid tumors boosts NK and CD8 + T cell activity and synergizes with immune checkpoint inhibitors

(2019) Emanuele Puca et al.   INTERNATIONAL JOURNAL OF CANCER

Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: Results of a phase 1 trial

(2019) E. Antonio Chiocca et al.   Science Translational Medicine

CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2012–2016

(2019) Quinn T Ostrom et al.   NEURO-ONCOLOGY

Immunophenotyping of Newly Diagnosed and Recurrent Glioblastoma Defines Distinct Immune Exhaustion Profiles in Peripheral and Tumor-infiltrating Lymphocytes

(2018) Malte Mohme et al.   CLINICAL CANCER RESEARCH

CISNE: An accurate description of dose-effect and synergism in combination therapies

(2018) Amador García-Fuente et al.   Scientific Reports

Computationally-Guided Development of a Stromal Inflammation Histologic Biomarker in Lung Squamous Cell Carcinoma

(2018) Daniel Xia et al.   Scientific Reports

Antibody-based Delivery of TNF to the Tumor Neovasculature Potentiates the Therapeutic Activity of a Peptide Anticancer Vaccine

(2018) Philipp Probst et al.   CLINICAL CANCER RESEARCH

TGF-β induces oncofetal fibronectin that, in turn, modulates TGF-β superfamily signaling in endothelial cells

(2017) Elisa Ventura et al.   JOURNAL OF CELL SCIENCE

Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial

(2017) Michael Weller et al.   LANCET ONCOLOGY

European Association for Neuro-Oncology (EANO) guideline on the diagnosis and treatment of adult astrocytic and oligodendroglial gliomas

(2017) Michael Weller et al.   LANCET ONCOLOGY

The making of bispecific antibodies

(2017) Ulrich Brinkmann et al.   mAbs

CCL2 Produced by the Glioma Microenvironment Is Essential for the Recruitment of Regulatory T Cells and Myeloid-Derived Suppressor Cells

(2016) Alan L. Chang et al.   CANCER RESEARCH

Immunocytokines for cancer treatment: past, present and future

(2016) Dario Neri et al.   CURRENT OPINION IN IMMUNOLOGY

Novel TIE-2 inhibitor BAY-826 displaysin vivoefficacy in experimental syngeneic murine glioma models

(2016) Hannah Schneider et al.   JOURNAL OF NEUROCHEMISTRY

Intralesional administration of L19-IL2/L19-TNF in stage III or stage IVM1a melanoma patients: results of a phase II study

(2015) Riccardo Danielli et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Immunotherapy response assessment in neuro-oncology: a report of the RANO working group

(2015) Hideho Okada et al.   LANCET ONCOLOGY

Antibody-Cytokine Fusion Proteins for Treatment of Cancer: Engineering Cytokines for Improved Efficacy and Safety

(2014) Patricia A. Young et al.   SEMINARS IN ONCOLOGY

GM-CSF Promotes the Immunosuppressive Activity of Glioma-Infiltrating Myeloid Cells through Interleukin-4 Receptor- 

(2013) G. Kohanbash et al.   CANCER RESEARCH

Intratumoral IL-12 combined with CTLA-4 blockade elicits T cell–mediated glioma rejection

(2013) Johannes vom Berg et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Radretumab Radioimmunotherapy in Patients with Brain Metastasis: A 124I-L19SIP Dosimetric PET Study

(2013) G. L. Poli et al.   Cancer Immunology Research

Phase I/II study of the tumour-targeting human monoclonal antibody–cytokine fusion protein L19-TNF in patients with advanced solid tumours

(2012) G. Spitaleri et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Isolated limb perfusion with the tumor-targeting human monoclonal antibody-cytokine fusion protein L19-TNF plus melphalan and mild hyperthermia in patients with locally advanced extremity melanoma

(2012) Francesco Papadia et al.   JOURNAL OF SURGICAL ONCOLOGY

Soluble factors secreted by glioblastoma cell lines facilitate recruitment, survival, and expansion of regulatory T cells: implications for immunotherapy

(2012) C. A. Crane et al.   NEURO-ONCOLOGY

GM-CSF Production by Glioblastoma Cells Has a Functional Role in Eosinophil Survival, Activation, and Growth Factor Production for Enhanced Tumor Cell Proliferation

(2011) C. S. Curran et al.   JOURNAL OF IMMUNOLOGY

Targeting Interleukin 6 Signaling Suppresses Glioma Stem Cell Survival and Tumor Growth

(2009) Hui Wang et al.   STEM CELLS