The Role of Microglia in Glioblastoma

Targeting Tumor Associated Macrophages to Overcome Conventional Treatment Resistance in Glioblastoma

(2020) Hélène Grégoire et al.   Frontiers in Pharmacology

Cell lines and immune classification of glioblastoma define patient’s prognosis

(2019) Quentin Klopfenstein et al.   BRITISH JOURNAL OF CANCER

CAR T cells for brain tumors: Lessons learned and road ahead

(2019) David Akhavan et al.   IMMUNOLOGICAL REVIEWS

Similarities Between Stem Cell Niches in Glioblastoma and Bone Marrow: Rays of Hope for Novel Treatment Strategies

(2019) Vashendriya V.V. Hira et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

PD-L1/PD-1 Axis in Glioblastoma Multiforme

(2019) Jakub Litak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microglia/Brain Macrophages as Central Drivers of Brain Tumor Pathobiology

(2019) David H. Gutmann et al.   NEURON

Current Strategies to Target Tumor-Associated-Macrophages to Improve Anti-Tumor Immune Responses

(2019) Anfray et al.   Cells

Multidimensional communication in the microenvirons of glioblastoma

(2018) Marike L. Broekman et al.   Nature Reviews Neurology

In Search for Reliable Markers of Glioma-Induced Polarization of Microglia

(2018) Kacper A. Walentynowicz et al.   Frontiers in Immunology

Human glioblastoma arises from subventricular zone cells with low-level driver mutations

(2018) Joo Ho Lee et al.   NATURE

Distribution and prognostic impact of microglia/macrophage subpopulations in gliomas

(2018) Pia S. Zeiner et al.   BRAIN PATHOLOGY

Expression of neuropilin-1 is linked to glioma associated microglia and macrophages and correlates with unfavorable prognosis in high grade gliomas

(2018) Michael D. Caponegro et al.   Oncotarget

Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma

(2017) Roger Stupp et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Tumour-associated microglia/macrophages predict poor prognosis in high-grade gliomas and correlate with an aggressive tumour subtype

(2017) M. D. Sørensen et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Expression of iNOS, CD163 and ARG-1 taken as M1 and M2 markers of microglial polarization in human glioblastoma and the surrounding normal parenchyma

(2017) L. Lisi et al.   NEUROSCIENCE LETTERS

Disrupting the CD47-SIRPα anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for malignant pediatric brain tumors

(2017) Sharareh Gholamin et al.   Science Translational Medicine

CCL2 Produced by the Glioma Microenvironment Is Essential for the Recruitment of Regulatory T Cells and Myeloid-Derived Suppressor Cells

(2016) Alan L. Chang et al.   CANCER RESEARCH

The role of microglia and macrophages in glioma maintenance and progression

(2016) Dolores Hambardzumyan et al.   NATURE NEUROSCIENCE

Exploiting macrophages as targeted carrier to guide nanoparticles into glioma

(2016) Liang Pang et al.   Oncotarget

Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies

(2016) Robert L. Bowman et al.   Cell Reports

Characterization of Arginase Expression in Glioma-Associated Microglia and Macrophages

(2016) Ian Zhang et al.   PLoS One

Resident microglia rather than peripheral macrophages promote vascularization in brain tumors and are source of alternative pro-angiogenic factors

(2015) Susan Brandenburg et al.   ACTA NEUROPATHOLOGICA

A Distinct Population of Microglia Supports Adult Neurogenesis in the Subventricular Zone

(2015) A. L. Ribeiro Xavier et al.   JOURNAL OF NEUROSCIENCE

Ontogeny of CX3CR1-EGFP expressing cells unveil microglia as an integral component of the postnatal subventricular zone

(2015) Anna L. Xavier et al.   Frontiers in Cellular Neuroscience

CNS macrophages and peripheral myeloid cells in brain tumours

(2014) Rainer Glass et al.   ACTA NEUROPATHOLOGICA

Neurogenesis in the Striatum of the Adult Human Brain

(2014) Aurélie Ernst et al.   CELL

Quiescent neuronal progenitors are activated in the juvenile guinea pig lateral striatum and give rise to transient neurons

(2014) F. Luzzati et al.   DEVELOPMENT

A new angle on blood-CNS interfaces: A role for connexins?

(2014) Marijke De Bock et al.   FEBS LETTERS

Implanted neural progenitor cells regulate glial reaction to brain injury and establish gap junctions with host glial cells

(2014) Rocío Talaverón et al.   GLIA

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

(2014) Jonathan D Cherry et al.   Journal of Neuroinflammation

Neural Progenitor Cell Implants in the Lesioned Medial Longitudinal Fascicle of Adult Cats Regulate Synaptic Composition and Firing Properties of Abducens Internuclear Neurons

(2014) C. J. Morado-Diaz et al.   JOURNAL OF NEUROSCIENCE

Microglia Enhance Neurogenesis and Oligodendrogenesis in the Early Postnatal Subventricular Zone

(2014) Y. Shigemoto-Mogami et al.   JOURNAL OF NEUROSCIENCE

A comparison of long-term survivors and short-term survivors with glioblastoma, subventricular zone involvement: a predictive factor for survival?

(2014) Sebastian Adeberg et al.   Radiation Oncology

Microglia and Macrophages in Malignant Gliomas: Recent Discoveries and Implications for Promising Therapies

(2013) Anna Carolina Carvalho da Fonseca et al.   Clinical & Developmental Immunology

Therapeutic activation of macrophages and microglia to suppress brain tumor-initiating cells

(2013) Susobhan Sarkar et al.   NATURE NEUROSCIENCE

The Association of Subventricular Zone Involvement at Recurrence with Survival after Repeat Surgery in Patients with Recurrent Glioblastoma

(2013) Yukihiko SONODA et al.   NEUROLOGIA MEDICO-CHIRURGICA

The Definition of Primary and Secondary Glioblastoma

(2012) H. Ohgaki et al.   CLINICAL CANCER RESEARCH

Adult Neurogenesis in the Hypothalamus: Evidence, Functions and Implications

(2012) Ti-Fei Yuan et al.   CNS & Neurological Disorders-Drug Targets

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

Neural progenitor cells regulate microglia functions and activity

(2012) Kira I Mosher et al.   NATURE NEUROSCIENCE

Relationship of glioblastoma multiforme to the subventricular zone is associated with survival

(2012) Nazia F. Jafri et al.   NEURO-ONCOLOGY

The molecular profile of microglia under the influence of glioma

(2012) W. Li et al.   NEURO-ONCOLOGY

Immunological regulation of neurogenic niches in the adult brain

(2012) O. Gonzalez-Perez et al.   NEUROSCIENCE

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

(2012) S. B. Willingham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A dialog between glioma and microglia that promotes tumor invasiveness through the CCL2/CCR2/interleukin-6 axis

(2011) J. Zhang et al.   CARCINOGENESIS

The brain tumor microenvironment

(2011) Nikki A. Charles et al.   GLIA

Direct In Vivo Evidence for Tumor Propagation by Glioblastoma Cancer Stem Cells

(2011) Justin D. Lathia et al.   PLoS One

Characteristics of the Alternative Phenotype of Microglia/Macrophages and its Modulation in Experimental Gliomas

(2011) Konrad Gabrusiewicz et al.   PLoS One

Hypoxia Increases the Expression of Stem-Cell Markers and Promotes Clonogenicity in Glioblastoma Neurospheres

(2010) Eli E. Bar et al.   AMERICAN JOURNAL OF PATHOLOGY

AMPK: A metabolic checkpoint that regulates the growth of EGFR activated glioblastomas

(2010) Deliang Guo et al.   CELL CYCLE

Glioma Tumor Stem-Like Cells Promote Tumor Angiogenesis and Vasculogenesis via Vascular Endothelial Growth Factor and Stromal-Derived Factor 1

(2009) C. Folkins et al.   CANCER RESEARCH

Glioblastoma Subclasses Can Be Defined by Activity among Signal Transduction Pathways and Associated Genomic Alterations

(2009) Cameron Brennan et al.   PLoS One

EGFR Signals to mTOR Through PKC and Independently of Akt in Glioma

(2009) Q.-W. Fan et al.   Science Signaling

Amino Acids Activate mTOR Complex 1 via Ca2+/CaM Signaling to hVps34

(2008) Pawan Gulati et al.   Cell Metabolism

Neural Stem Cells Confer Unique Pinwheel Architecture to the Ventricular Surface in Neurogenic Regions of the Adult Brain

(2008) Zaman Mirzadeh et al.   Cell Stem Cell

The Counterbalance Theory for Evolution and Function of Paired Receptors

(2008) A. Neil Barclay et al.   IMMUNITY

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark