Journal
FRONTIERS IN IMMUNOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2020.00737
Keywords
MDSC; glioma; immunosuppression; tumor microenvironment; therapeutic target
Categories
Funding
- National Natural Science Foundation of China [81873740, 81601376]
- Shaanxi Youth Talents Project, Scientific Research Program - Shaanxi Provincial Education Department [19JS057]
- Natural Science Basic Research Plan in Shaanxi Province of China [2020JQ-879, 2020JQ-877]
- Xi'an Medical University's Key Disciplines of Molecular Immunology [2018GJFY05, 2018DOC02, 2018PT08, 18NBZD08, 18NBZD09]
- Foundation of Xi'an Medical University's [2018GJFY05, 2018DOC02, 2018PT08, 18NBZD08, 18NBZD09]
- Youth Innovation Team of Shaanxi Universities
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Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of myeloid progenitor and precursor cells at different stages of differentiation, which play an important role in tumor immunosuppression. Glioma is the most common and deadliest primary malignant tumor of the brain, and ample evidence supports key contributions of MDSCs to the immunosuppressive tumor microenvironment, which is a key factor stimulating glioma progression. In this review, we summarize the source and characterization of MDSCs, discuss their immunosuppressive functions, and current approaches that target MDSCs for tumor control. Overall, the review provides insights into the roles of MDSC immunosuppression in the glioma microenvironment and suggests that MDSC control is a powerful cellular therapeutic target for currently incurable glioma tumors.
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