Glioblastoma Myeloid-Derived Suppressor Cell Subsets Express Differential Macrophage Migration Inhibitory Factor Receptor Profiles That Can Be Targeted to Reduce Immune Suppression

Ibudilast sensitizes glioblastoma to temozolomide by targeting Macrophage Migration Inhibitory Factor (MIF)

(2019) Wendy Ha et al.   Scientific Reports

Evolving complexity of MIF signaling

(2019) Stanislovas S. Jankauskas et al.   CELLULAR SIGNALLING

Macrophage migration inhibitory factor (MIF) as a therapeutic target for rheumatoid arthritis and systemic lupus erythematosus

(2019) Joshua B. Bilsborrow et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

CCR2 inhibition reduces tumor myeloid cells and unmasks a checkpoint inhibitor effect to slow progression of resistant murine gliomas

(2019) Joseph A. Flores-Toro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immature myeloid cells in the tumor microenvironment: Implications for immunotherapy

(2018) Neha Kamran et al.   CLINICAL IMMUNOLOGY

Blockade of MIF–CD74 Signalling on Macrophages and Dendritic Cells Restores the Antitumour Immune Response Against Metastatic Melanoma

(2018) Carlos R. Figueiredo et al.   Frontiers in Immunology

Phase 2 Trial of Ibudilast in Progressive Multiple Sclerosis

(2018) Robert J. Fox et al.   NEW ENGLAND JOURNAL OF MEDICINE

Macrophage Migration Inhibitory Factor Limits Renal Inflammation and Fibrosis by Counteracting Tubular Cell Cycle Arrest

(2017) Sonja Djudjaj et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Immunosuppressive Myeloid Cells’ Blockade in the Glioma Microenvironment Enhances the Efficacy of Immune-Stimulatory Gene Therapy

(2017) Neha Kamran et al.   MOLECULAR THERAPY

Macrophage migration inhibitory factor downregulation: a novel mechanism of resistance to anti-angiogenic therapy

(2017) B A Castro et al.   ONCOGENE

Ibudilast: a non-selective phosphodiesterase inhibitor in brain disorders

(2017) Joanna Schwenkgrub et al.   Postepy Higieny I Medycyny Doswiadczalnej

Resistance to CTLA-4 checkpoint inhibition reversed through selective elimination of granulocytic myeloid cells

(2017) Paul E. Clavijo et al.   Oncotarget

Comprehensive analysis of PD-L1 expression in glioblastoma multiforme

(2017) Dieter Henrik Heiland et al.   Oncotarget

Single-Cell RNA-Seq Analysis of Infiltrating Neoplastic Cells at the Migrating Front of Human Glioblastoma

(2017) Spyros Darmanis et al.   Cell Reports

Immune Checkpoint in Glioblastoma: Promising and Challenging

(2017) Jing Huang et al.   Frontiers in Pharmacology

The phosphodiesterase inhibitor, ibudilast, attenuates neuroinflammation in the MPTP model of Parkinson’s disease

(2017) Joanna Schwenkgrub et al.   PLoS One

Targeting MIF in Cancer: Therapeutic Strategies, Current Developments, and Future Opportunities

(2016) Ciaran O'Reilly et al.   MEDICINAL RESEARCH REVIEWS

Elevated levels of polymorphonuclear myeloid-derived suppressor cells in patients with glioblastoma highly express S100A8/9 and arginase and suppress T cell function

(2016) Paul R. Gielen et al.   NEURO-ONCOLOGY

CXCL2/MIF-CXCR2 signaling promotes the recruitment of myeloid-derived suppressor cells and is correlated with prognosis in bladder cancer

(2016) H Zhang et al.   ONCOGENE

MIFallele-dependent regulation of the MIF coreceptor CD44 and role in rheumatoid arthritis

(2016) Seung-Ah Yoo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Stem Cell-Secreted Macrophage Migration Inhibitory Factor Stimulates Myeloid Derived Suppressor Cell Function and Facilitates Glioblastoma Immune Evasion

(2016) Balint Otvos et al.   STEM CELLS

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

(2016) Vincenzo Bronte et al.   Nature Communications

Macrophage migration inhibitory factor: a potential therapeutic target for rheumatoid arthritis

(2016) Kyoung-Woon Kim et al.   KOREAN JOURNAL OF INTERNAL MEDICINE

An integrated signal transduction network of macrophage migration inhibitory factor

(2016) Tejaswini Subbannayya et al.   Journal of Cell Communication and Signaling

Macrophage Migration Inhibitor Factor Upregulates MCP-1 Expression in an Autocrine Manner in Hepatocytes during Acute Mouse Liver Injury

(2016) Jieshi Xie et al.   Scientific Reports

Modulating of ocular inflammation with macrophage migration inhibitory factor is associated with notch signalling in experimental autoimmune uveitis

(2015) H. Yang et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Macrophage Migration Inhibitory Factor Is Detrimental in Pneumococcal Pneumonia and a Target for Therapeutic Immunomodulation

(2015) Jeffrey N. Weiser et al.   JOURNAL OF INFECTIOUS DISEASES

Myeloid derived suppressor cell infiltration of murine and human gliomas is associated with reduction of tumor infiltrating lymphocytes

(2015) Baisakhi Raychaudhuri et al.   JOURNAL OF NEURO-ONCOLOGY

Increase in Both CD14-Positive and CD15-Positive Myeloid-Derived Suppressor Cell Subpopulations in the Blood of Patients With Glioma But Predominance of CD15-Positive Myeloid-Derived Suppressor Cells in Glioma Tissue

(2015) Paul R. Gielen et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The Integral Role of CD74 in Antigen Presentation, MIF Signal Transduction, and B Cell Survival and Homeostasis

(2015) Richard Bucala et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

CD4+T effector memory cell dysfunction is associated with the accumulation of granulocytic myeloid-derived suppressor cells in glioblastoma patients

(2015) Daniel Dubinski et al.   NEURO-ONCOLOGY

MIF Is Necessary for Late-Stage Melanoma Patient MDSC Immune Suppression and Differentiation

(2015) K. Yaddanapudi et al.   Cancer Immunology Research

Increasing glioma-associated monocytes leads to increased intratumoral and systemic myeloid-derived suppressor cells in a murine model

(2014) Michael Chae et al.   NEURO-ONCOLOGY

GM-CSF Promotes the Immunosuppressive Activity of Glioma-Infiltrating Myeloid Cells through Interleukin-4 Receptor- 

(2013) G. Kohanbash et al.   CANCER RESEARCH

Macrophage migration inhibitory factor (MIF) is a critical mediator of the innate immune response to Mycobacterium tuberculosis

(2013) R. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MIF: metastasis/MDSC-inducing factor?

(2013) Kendra D. Simpson et al.   OncoImmunology

Clinical Perspectives on Targeting of Myeloid Derived Suppressor Cells in the Treatment of Cancer

(2013) Yana G. Najjar et al.   Frontiers in Oncology

Macrophage Migration Inhibitory Factor Promotes Tumor Growth and Metastasis by Inducing Myeloid-Derived Suppressor Cells in the Tumor Microenvironment

(2012) K. D. Simpson et al.   JOURNAL OF IMMUNOLOGY

Myeloid-derived suppressor cell accumulation and function in patients with newly diagnosed glioblastoma

(2011) B. Raychaudhuri et al.   NEURO-ONCOLOGY

Macrophage migration inhibitory factor regulates neutrophil chemotactic responses in inflammatory arthritis in mice

(2010) Leilani L. Santos et al.   ARTHRITIS AND RHEUMATISM

Optimization of N-benzyl-benzoxazol-2-ones as receptor antagonists of macrophage migration inhibitory factor (MIF)

(2010) Alissa A. Hare et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Small-Molecule Macrophage Migration Inhibitory Factor Antagonist Protects against Glomerulonephritis in Lupus-Prone NZB/NZW F1 and MRL/lpr Mice

(2010) L. Leng et al.   JOURNAL OF IMMUNOLOGY

Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast

(2010) Y. Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation and cancer: macrophage migration inhibitory factor (MIF)--the potential missing link

(2010) H. Conroy et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Ibudilast: a review of its pharmacology, efficacy and safety in respiratory and neurological disease

(2009) P Rolan et al.   EXPERT OPINION ON PHARMACOTHERAPY

Cross-species comparisons of the pharmacokinetics of ibudilast

(2009) L. M. Sanftner et al.   XENOBIOTICA

Ibudilast in healthy volunteers: safety, tolerability and pharmacokinetics with single and multiple doses

(2008) Paul Rolan et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

A Novel, Macrophage Migration Inhibitory Factor Suicide Substrate Inhibits Motility and Growth of Lung Cancer Cells

(2008) M. Winner et al.   CANCER RESEARCH

Discovery of Human Macrophage Migration Inhibitory Factor (MIF)-CD74 Antagonists via Virtual Screening

(2008) Zoe Cournia et al.   JOURNAL OF MEDICINAL CHEMISTRY

Independent association of extent of resection with survival in patients with malignant brain astrocytoma

(2008) Matthew J. McGirt et al.   JOURNAL OF NEUROSURGERY

Regulatory T cells and the PD-L1/PD-1 pathway mediate immune suppression in malignant human brain tumors

(2008) Joannes F.M. Jacobs et al.   NEURO-ONCOLOGY