Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and Cancer

Intra-articular use of hyaluronic acid in the treatment of osteoarthritis

(2016) Alberto Migliore   Clinical Interventions in Aging

Genomic imbalance of HMMR/RHAMM regulates the sensitivity and response of malignant peripheral nerve sheath tumour cells to aurora kinase inhibition.

(2015) Pooja Mohan et al.   Oncotarget

HMMR Maintains the Stemness and Tumorigenicity of Glioblastoma Stem-like Cells

(2014) J. Tilghman et al.   CANCER RESEARCH

CD44v6 Is a Marker of Constitutive and Reprogrammed Cancer Stem Cells Driving Colon Cancer Metastasis

(2014) Matilde Todaro et al.   Cell Stem Cell

Periostin Induces Intracellular Cross-talk between Kinases and Hyaluronan in Atrioventricular Valvulogenesis

(2014) Shibnath Ghatak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD44 Is Critically Involved in Infarct Healing by Regulating the Inflammatory and Fibrotic Response

(2014) P. Huebener et al.   JOURNAL OF IMMUNOLOGY

Hyaluronan and RHAMM in Wound Repair and the “Cancerization” of Stromal Tissues

(2014) Cornelia Tolg et al.   Biomed Research International

Self-assembled pH-responsive hyaluronic acid–g-poly(l-histidine) copolymer micelles for targeted intracellular delivery of doxorubicin

(2013) Lipeng Qiu et al.   Acta Biomaterialia

Novel effects of adenosine receptors on pericellular hyaluronan matrix: implications for human smooth muscle cell phenotype and interactions with monocytes during atherosclerosis

(2013) M. Grandoch et al.   BASIC RESEARCH IN CARDIOLOGY

Deregulation of hyaluronan synthesis, degradation and binding promotes breast cancer

(2013) P. Heldin et al.   JOURNAL OF BIOCHEMISTRY

The Hyaluronan Receptor for Endocytosis (HARE) Activates NF-κB-mediated Gene Expression in Response to 40–400-kDa, but Not Smaller or Larger, Hyaluronans

(2013) Madhu S. Pandey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of c-Met and CD44v6 Receptors Contributes to Autocrine TGF-β1 Signaling in Interstitial Lung Disease

(2013) Shibnath Ghatak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic control of hyaluronan synthases

(2013) Davide Vigetti et al.   MATRIX BIOLOGY

High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat

(2013) Xiao Tian et al.   NATURE

Alternative CD44 splicing in intestinal stem cells and tumorigenesis

(2013) W Guo et al.   ONCOGENE

Stem cell CD44v isoforms promote intestinal cancer formation in Apc(min) mice downstream of Wnt signaling

(2013) J Zeilstra et al.   ONCOGENE

Opposing effects of high- and low-molecular weight hyaluronan on CXCL12-induced CXCR4 signaling depend on CD44

(2013) K Fuchs et al.   Cell Death & Disease

The Roles of Hyaluronan/RHAMM/CD44 and Their Respective Interactions along the Insidious Pathways of Fibrosarcoma Progression

(2013) Dragana Nikitovic et al.   Biomed Research International

Hyaluronic Acid–Gold Nanoparticle/Interferon α Complex for Targeted Treatment of Hepatitis C Virus Infection

(2012) Min-Young Lee et al.   ACS Nano

Glycosaminoglycan polysaccharide biosynthesis and production: today and tomorrow

(2012) Paul L. DeAngelis   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

Free-Radical Degradation of High-Molar-Mass Hyaluronan Induced by Ascorbate plus Cupric Ions: Evaluation of Antioxidative Effect of Cysteine-Derived Compounds

(2012) Eva Hrabárová et al.   CHEMISTRY & BIODIVERSITY

CD44-Targeting for Antitumor Drug Delivery: A New SN-38-Hyaluronan Bioconjugate for Locoregional Treatment of Peritoneal Carcinomatosis

(2012) A. Serafino et al.   CURRENT CANCER DRUG TARGETS

Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

(2012) Michael A Jacobetz et al.   GUT

Transcutaneous immunization using a dissolving microneedle array protects against tetanus, diphtheria, malaria, and influenza

(2012) Kazuhiko Matsuo et al.   JOURNAL OF CONTROLLED RELEASE

Hyaluronic acid-bearing lipoplexes: Physico-chemical characterization and in vitro targeting of the CD44 receptor

(2012) Amélie Dufaÿ Wojcicki et al.   JOURNAL OF CONTROLLED RELEASE

The development and characteristics of novel microneedle arrays fabricated from hyaluronic acid, and their application in the transdermal delivery of insulin

(2012) Shu Liu et al.   JOURNAL OF CONTROLLED RELEASE

Hyaluronic acid promotes angiogenesis by inducing RHAMM-TGFβ receptor interaction via CD44-PKCδ

(2012) Deokbum Park et al.   MOLECULES AND CELLS

Paclitaxel-hyaluronan hydrosoluble bioconjugate: Mechanism of action in human bladder cancer cell lines

(2012) Isabella Monia Montagner et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Self-assembled nanoparticles based on hyaluronic acid-ceramide (HA-CE) and Pluronic® for tumor-targeted delivery of docetaxel

(2011) Hyun-Jong Cho et al.   BIOMATERIALS

Hyaluronan-grafted particle clusters loaded with Mitomycin C as selective nanovectors for primary head and neck cancers

(2011) Gideon Bachar et al.   BIOMATERIALS

The eradication of breast cancer and cancer stem cells using octreotide modified paclitaxel active targeting micelles and salinomycin passive targeting micelles

(2011) Yang Zhang et al.   BIOMATERIALS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Hyaluronan-CD44 interactions as potential targets for cancer therapy

(2011) Suniti Misra et al.   FEBS Journal

RHAMM and CD44 peptides-analytic tools and potential drugs

(2011) Eva et al.   Frontiers in Bioscience-Landmark

Pro-oxidative effect of peroxynitrite regarding biological systems: a special focus on high-molar-mass hyaluronan degradation

(2011) E. Hrabarova et al.   GENERAL PHYSIOLOGY AND BIOPHYSICS

Metastatic suppressor CD44 is related with oxidative stress in breast cancer cell lines

(2011) G. Calaf   INTERNATIONAL JOURNAL OF ONCOLOGY

Dual targeting folate-conjugated hyaluronic acid polymeric micelles for paclitaxel delivery

(2011) Yanhua Liu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Severe lung fibrosis requires an invasive fibroblast phenotype regulated by hyaluronan and CD44

(2011) Yuejuan Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Therapeutic potential of hyaluronan oligosaccharides for bone metastasis of breast cancer

(2011) Hiroshi Urakawa et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Understanding the Dual Nature of CD44 in Breast Cancer Progression

(2011) J. M. V. Louderbough et al.   MOLECULAR CANCER RESEARCH

A6 Peptide Activates CD44 Adhesive Activity, Induces FAK and MEK Phosphorylation, and Inhibits the Migration and Metastasis of CD44-Expressing Cells

(2011) R. S. Piotrowicz et al.   MOLECULAR CANCER THERAPEUTICS

Receptor for hyaluronan-mediated motility isoform B promotes liver metastasis in a mouse model of multistep tumorigenesis and a tail vein assay for metastasis

(2011) Y.-C. N. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multifunctional Proteins Bridge Mitosis with Motility and Cancer with Inflammation and Arthritis

(2011) Jihong Jiang et al.   TheScientificWorldJOURNAL

Luminescent Carbon Nanodots: Emergent Nanolights

(2010) Sheila N. Baker et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Co-expression of CD147 (EMMPRIN), CD44v3-10, MDR1 and monocarboxylate transporters is associated with prostate cancer drug resistance and progression

(2010) J Hao et al.   BRITISH JOURNAL OF CANCER

RHAMM is differentially expressed in the cell cycle and downregulated by the tumor suppressor p53

(2010) Sindy Sohr et al.   CELL CYCLE

Merlin, a “Magic” Linker Between the Extracellular Cues and Intracellular Signaling Pathways that Regulate Cell Motility, Proliferation, and Survival

(2010) Ivan Stamenkovic et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

High-dose RHAMM-R3 peptide vaccination for patients with acute myeloid leukemia, myelodysplastic syndrome and multiple myeloma

(2010) J. Greiner et al.   HAEMATOLOGICA

Modulation of the Local Neutrophil Response by a Novel Hyaluronic Acid-Binding Peptide Reduces Bacterial Burden during Staphylococcal Wound Infection

(2010) J. C. Lee et al.   INFECTION AND IMMUNITY

Stromal Hyaluronan Interaction with Epithelial CD44 Variants Promotes Prostate Cancer Invasiveness by Augmenting Expression and Function of Hepatocyte Growth Factor and Androgen Receptor

(2010) Shibnath Ghatak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyaluronan Stabilizes Focal Adhesions, Filopodia, and the Proliferative Phenotype in Esophageal Squamous Carcinoma Cells

(2010) Sören Twarock et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting of drugs and nanoparticles to tumors

(2010) Erkki Ruoslahti et al.   JOURNAL OF CELL BIOLOGY

Paclitaxel-Hyaluronic Acid for Intravesical Therapy of Bacillus Calmette-Guérin Refractory Carcinoma In Situ of the Bladder: Results of a Phase I Study

(2010) P.F. Bassi et al.   JOURNAL OF UROLOGY

RHAMM/ERK interaction induces proliferative activities of cementifying fibroma cells through a mechanism based on the CD44–EGFR

(2010) Hiroko Hatano et al.   LABORATORY INVESTIGATION

Peptide vaccination elicits leukemia-associated antigen-specific cytotoxic CD8+ T-cell responses in patients with chronic lymphocytic leukemia

(2010) K Giannopoulos et al.   LEUKEMIA

Dissolving polymer microneedle patches for influenza vaccination

(2010) Sean P Sullivan et al.   NATURE MEDICINE

Organizing the cell cortex: the role of ERM proteins

(2010) Richard G. Fehon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Biocompatibility, Biodistribution, and Drug-Delivery Efficiency of Mesoporous Silica Nanoparticles for Cancer Therapy in Animals

(2010) Jie Lu et al.   Small

A CD44v6 peptide reveals a role of CD44 in VEGFR-2 signaling and angiogenesis

(2009) M. Tremmel et al.   BLOOD

Stabilization of N-Myc Is a Critical Function of Aurora A in Human Neuroblastoma

(2009) Tobias Otto et al.   CANCER CELL

Hyaluronan substratum induces multidrug resistance in human mesenchymal stem cells via CD44 signaling

(2009) Chi-Mou Liu et al.   CELL AND TISSUE RESEARCH

Delivery of CD44 shRNA/Nanoparticles within Cancer Cells

(2009) Suniti Misra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyaluronan-CD44 Interaction with Protein Kinase Cϵ Promotes Oncogenic Signaling by the Stem Cell Marker Nanog and the Production of MicroRNA-21, Leading to Down-regulation of the Tumor Suppressor Protein PDCD4, Anti-apoptosis, and Chemotherapy Resistance in Breast Tumor Cells

(2009) Lilly Y. W. Bourguignon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of the expression of variant and standard CD44 in prostate cancer cells: Identification of the possible molecular mechanism of CD44/MMP9 complex formation on the cell surface

(2009) B. Desai et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Development of a hyaluronan bioconjugate for the topical treatment of melanoma

(2009) Li-Shu Zhang et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

In Situ Cross-Linkable High Molecular Weight Hyaluronan−Bisphosphonate Conjugate for Localized Delivery and Cell-Specific Targeting: A Hydrogel Linked Prodrug Approach

(2009) Oommen P. Varghese et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CD44 Variant Isoforms Promote Metastasis Formation by a Tumor Cell-Matrix Cross-talk That Supports Adhesion and Apoptosis Resistance

(2009) P. Klingbeil et al.   MOLECULAR CANCER RESEARCH

Lipoplexes Targeting the CD44 Hyaluronic Acid Receptor for Efficient Transfection of Breast Cancer Cells

(2009) Claudio Surace et al.   MOLECULAR PHARMACEUTICS

Design and development of ligand-appended polysaccharidic nanoparticles for the delivery of oxaliplatin in colorectal cancer

(2009) Anekant Jain et al.   Nanomedicine-Nanotechnology Biology and Medicine

An essential role of the aPKC–Aurora A–NDEL1 pathway in neurite elongation by modulation of microtubule dynamics

(2009) Daisuke Mori et al.   NATURE CELL BIOLOGY

Common variations in BARD1 influence susceptibility to high-risk neuroblastoma

(2009) Mario Capasso et al.   NATURE GENETICS

Graphene: Status and Prospects

(2009) A. K. Geim   SCIENCE

A Mechanism for Src Kinase-Dependent Signaling by Noncatalytic Receptors†

(2008) Jonathan A. Cooper et al.   BIOCHEMISTRY

Dissolving microneedles for transdermal drug delivery

(2008) Jeong W. Lee et al.   BIOMATERIALS

CD44-specific antibody treatment and CD44 deficiency exert distinct effects on leukocyte recruitment in experimental arthritis

(2008) G. Hutas et al.   BLOOD

Molecular mechanisms of metastasis

(2008) Georg F. Weber   CANCER LETTERS

Impact of the hyaluronan-rich tumor microenvironment on cancer initiation and progression

(2008) Naoki Itano et al.   CANCER SCIENCE

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Hyaluronan substratum holds mesenchymal stem cells in slow-cycling mode by prolonging G1 phase

(2008) Chi-Mou Liu et al.   CELL AND TISSUE RESEARCH

The Structure of Glycosaminoglycans and their Interactions with Proteins

(2008) Neha S. Gandhi et al.   Chemical Biology & Drug Design

A Pilot Human Evaluation of a Formulation of Irinotecan and Hyaluronic Acid in 5-Fluorouracil-Refractory Metastatic Colorectal Cancer Patients

(2008) Peter Gibbs et al.   CHEMOTHERAPY

Leukemia-Associated Antigens Are Critical for the Proliferation of Acute Myeloid Leukemia Cells

(2008) J. Greiner et al.   CLINICAL CANCER RESEARCH

High-Resolution DNA Copy Number Profiling of Malignant Peripheral Nerve Sheath Tumors Using Targeted Microarray-Based Comparative Genomic Hybridization

(2008) K. K. Mantripragada et al.   CLINICAL CANCER RESEARCH

Importance of Hyaluronan-CD44 Interactions in Inflammation and Tumorigenesis

(2008) Paraskevi Heldin et al.   CONNECTIVE TISSUE RESEARCH

Tissue-Specific shRNA Delivery: A Novel Approach for Gene Therapy in Cancer

(2008) Shilenath Ghatak et al.   CONNECTIVE TISSUE RESEARCH

Hyaluronan, CD44, and Cyclooxygenase-2 in Colon Cancer

(2008) Suniti Misra et al.   CONNECTIVE TISSUE RESEARCH

Intra-articular administration of hylan G-F 20 in patients with symptomatic hip osteoarthritis: tolerability and effectiveness in a large cohort study in clinical practice

(2008) Alberto Migliore et al.   CURRENT MEDICAL RESEARCH AND OPINION

Advances in minimally invasive facial rejuvenation

(2008) Fred G Fedok   Current Opinion in Otolaryngology & Head and Neck Surgery

The Development of Hyaluronan as a Drug Transporter and Excipient for Chemotherapeutic Drugs

(2008) Tracey Brown   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Hyaluronan Oligosaccharides as a Potential Anticancer Therapeutic

(2008) Bryan Toole et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Hyaluronan as an Ophthalmic Viscoelastic Device

(2008) Endre Balazs   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

In vitro and cell uptake studies for targeting of ligand anchored nanoparticles for colon tumors

(2008) Anekant Jain et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Simple Primary Structure, Complex Turnover Regulation and Multiple Roles of Hyaluronan

(2008) N. Itano   JOURNAL OF BIOCHEMISTRY

Hyaluronan Constitutively Regulates Activation of COX-2-mediated Cell Survival Activity in Intestinal Epithelial and Colon Carcinoma Cells

(2008) Suniti Misra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for CD44 Recognition by ERM Proteins

(2008) Tomoyuki Mori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Primary Murine Airway Smooth Muscle Cells Exposed to Poly(I,C) or Tunicamycin Synthesize a Leukocyte-adhesive Hyaluronan Matrix

(2008) Mark E. Lauer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyaluronan-CD44 Interaction Activates Stem Cell Marker Nanog, Stat-3-mediated MDR1 Gene Expression, and Ankyrin-regulated Multidrug Efflux in Breast and Ovarian Tumor Cells

(2008) Lilly Y. W. Bourguignon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell-surface and mitotic-spindle RHAMM: moonlighting or dual oncogenic functions?

(2008) C. A. Maxwell et al.   JOURNAL OF CELL SCIENCE

Fibroblast migration is mediated by CD44-dependent TGF  activation

(2008) P. S. Acharya et al.   JOURNAL OF CELL SCIENCE

Interaction of CD44 and hyaluronan is the dominant mechanism for neutrophil sequestration in inflamed liver sinusoids

(2008) Braedon McDonald et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Novel Types of Carborane-Carrier Hyaluronan Derivatives via “Click Chemistry”

(2008) Chiara Di Meo et al.   MACROMOLECULAR BIOSCIENCE

Hyaluronan-binding receptors: possible involvement in osteoarthritis

(2008) Sharon Dunn et al.   Modern Rheumatology

The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis

(2008) Qihong Huang et al.   NATURE CELL BIOLOGY

Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus

(2008) Ning Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Design Logic of a Cannabinoid Receptor Signaling Network That Triggers Neurite Outgrowth

(2008) K. D. Bromberg et al.   SCIENCE

Altered hyaluronan biosynthesis in cancer progression

(2008) Naoki Itano et al.   SEMINARS IN CANCER BIOLOGY

Involvement of CD44, a molecule with a thousand faces, in cancer dissemination

(2008) David Naor et al.   SEMINARS IN CANCER BIOLOGY

Association between cancer and “acid mucopolysaccharides”: An old concept comes of age, finally

(2008) Robert Stern   SEMINARS IN CANCER BIOLOGY

Src family kinases: Regulation of their activities, levels and identification of new pathways

(2007) Evan Ingley   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS