PD-1 and Tim-3 pathways are associated with regulatory CD8+ T-cell function in decidua and maintenance of normal pregnancy

Restoration of HBV-specific CD8+ T cell function by PD-1 blockade in inactive carrier patients is linked to T cell differentiation

(2014) Bertram Bengsch et al.   JOURNAL OF HEPATOLOGY

Embryonic Trophoblasts Induce Decidual Regulatory T Cell Differentiation and Maternal-Fetal Tolerance through Thymic Stromal Lymphopoietin Instructing Dendritic Cells

(2014) M.-R. Du et al.   JOURNAL OF IMMUNOLOGY

Tim-3 Directly Enhances CD8 T Cell Responses to Acute Listeria monocytogenes Infection

(2014) J. V. Gorman et al.   JOURNAL OF IMMUNOLOGY

CD8+ Effector T Cells at the Fetal-Maternal Interface, Balancing Fetal Tolerance and Antiviral Immunity

(2013) Tamara Tilburgs et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Fetomaternal immune cross-talk and its consequences for maternal and offspring's health

(2013) Petra C Arck et al.   NATURE MEDICINE

Multiple Pregnancy Failures: An Immunological Paradigm

(2012) Leif Matthiesen et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

BAG6/BAT3: emerging roles in quality control for nascent polypeptides

(2012) H. Kawahara et al.   JOURNAL OF BIOCHEMISTRY

TIM-3 Regulates Innate Immune Cells To Induce Fetomaternal Tolerance

(2012) L. Chabtini et al.   JOURNAL OF IMMUNOLOGY

Tim-3-Expressing CD4+ and CD8+ T Cells in Human Tuberculosis (TB) Exhibit Polarized Effector Memory Phenotypes and Stronger Anti-TB Effector Functions

(2012) Yueqin Qiu et al.   PLoS Pathogens

Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia

(2011) Q. Zhou et al.   BLOOD

Emerging Tim-3 functions in antimicrobial and tumor immunity

(2011) Kaori Sakuishi et al.   TRENDS IN IMMUNOLOGY

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

Thymic stromal lymphopoietin from trophoblasts induces dendritic cell-mediated regulatory TH2 bias in the decidua during early gestation in humans

(2010) P.-F. Guo et al.   BLOOD

Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2

(2010) Susan E. Hiby et al.   JOURNAL OF CLINICAL INVESTIGATION

Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity

(2010) Rachel H. McMahan et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

(2010) Kaori Sakuishi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Spontaneous Pregnancy Loss Mediated by Abnormal Maternal Inflammation in Rats Is Linked to Deficient Uteroplacental Perfusion

(2010) S. J. Renaud et al.   JOURNAL OF IMMUNOLOGY

Utilising T cell receptor transgenic mice to define mechanisms of maternal T cell tolerance in pregnancy

(2010) Lachlan M. Moldenhauer et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

(2010) H.-T. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4+ T Cells

(2010) J. J. O'Shea et al.   SCIENCE

Association of HIV-Specific and Total CD8+ T Memory Phenotypes in Subtype C HIV-1 Infection with Viral Set Point

(2009) W. A. Burgers et al.   JOURNAL OF IMMUNOLOGY

Negative Immune Regulator Tim-3 Is Overexpressed on T Cells in Hepatitis C Virus Infection and Its Blockade Rescues Dysfunctional CD4+ and CD8+ T Cells

(2009) L. Golden-Mason et al.   JOURNAL OF VIROLOGY

Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

(2008) R. Brad Jones et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

(2008) Shawn D Blackburn et al.   NATURE IMMUNOLOGY