Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion
Authors
Keywords
-
Journal
Nature Communications
Volume 11, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-09-10
DOI
10.1038/s41467-020-18298-8
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Cancer statistics, 2019
- (2019) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Collagen fiber structure guides 3D motility of cytotoxic T lymphocytes
- (2019) Hawley C. Pruitt et al. MATRIX BIOLOGY
- Comparative analysis of the phase III clinical trials of anti-PD1 monotherapy in head and neck squamous cell carcinoma patients (CheckMate 141 and KEYNOTE 040)
- (2019) Sara I. Pai et al. Journal for ImmunoTherapy of Cancer
- Understanding and overcoming the resistance of cancer to PD-1/PD-L1 blockade
- (2019) Amy L. Shergold et al. PHARMACOLOGICAL RESEARCH
- Collagen type I induces EGFR-TKI resistance in EGFR-mutated cancer cells by mTOR activation through Akt-independent pathway
- (2018) Shota Yamazaki et al. CANCER SCIENCE
- The fibrotic tumor stroma
- (2018) Mitsuo Yamauchi et al. JOURNAL OF CLINICAL INVESTIGATION
- Immunohistochemical and Image Analysis-Based Study Shows That Several Immune Checkpoints are Co-expressed in Non–Small Cell Lung Carcinoma Tumors
- (2018) Edwin Roger Parra et al. Journal of Thoracic Oncology
- Neoadjuvant PD-1 Blockade in Resectable Lung Cancer
- (2018) Patrick M. Forde et al. NEW ENGLAND JOURNAL OF MEDICINE
- CD38-mediated immunosuppression as a mechanism of tumor cell escape from PD-1/PD-L1 blockade
- (2018) Limo Chen et al. Cancer Discovery
- TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
- (2018) Sanjeev Mariathasan et al. NATURE
- SHP2 Inhibition Prevents Adaptive Resistance to MEK Inhibitors in Multiple Cancer Models
- (2018) Carmine Fedele et al. Cancer Discovery
- Transforming Growth Factor-β Signaling in Regulatory T Cells Controls T Helper-17 Cells and Tissue-Specific Immune Responses
- (2017) Joanne E. Konkel et al. IMMUNITY
- Fibroblast-specific inhibition of TGF-β1 signaling attenuates lung and tumor fibrosis
- (2017) Ying Wei et al. JOURNAL OF CLINICAL INVESTIGATION
- Tumour heterogeneity and resistance to cancer therapies
- (2017) Ibiayi Dagogo-Jack et al. Nature Reviews Clinical Oncology
- Proliferation of PD-1+ CD8 T cells in peripheral blood after PD-1–targeted therapy in lung cancer patients
- (2017) Alice O. Kamphorst et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lung cancer in patients with idiopathic pulmonary fibrosis
- (2017) Theodoros Karampitsakos et al. PULMONARY PHARMACOLOGY & THERAPEUTICS
- Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer
- (2017) Julienne L. Carstens et al. Nature Communications
- Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma
- (2016) Willy Hugo et al. CELL
- Image Analysis-based Assessment of PD-L1 and Tumor-Associated Immune Cells Density Supports Distinct Intratumoral Microenvironment Groups in Non-small Cell Lung Carcinoma Patients
- (2016) E. R. Parra et al. CLINICAL CANCER RESEARCH
- Epithelial-Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma
- (2016) Y. Lou et al. CLINICAL CANCER RESEARCH
- ZEB1 induces LOXL2-mediated collagen stabilization and deposition in the extracellular matrix to drive lung cancer invasion and metastasis
- (2016) D H Peng et al. ONCOGENE
- Novel TGF-β inhibitors ready for prime time in onco-immunology
- (2016) Armand de Gramont et al. OncoImmunology
- Growth and metastasis of lung adenocarcinoma is potentiated by BMP4-mediated immunosuppression
- (2016) Limo Chen et al. OncoImmunology
- An Integrated Molecular Analysis of Lung Adenocarcinomas Identifies Potential Therapeutic Targets among TTF1-Negative Tumors, Including DNA Repair Proteins and Nrf2
- (2015) R. J. G. Cardnell et al. CLINICAL CANCER RESEARCH
- The regulation of immune cell trafficking by the extracellular matrix
- (2015) Rupert Hallmann et al. CURRENT OPINION IN CELL BIOLOGY
- Pembrolizumab for the Treatment of Non–Small-Cell Lung Cancer
- (2015) Edward B. Garon et al. NEW ENGLAND JOURNAL OF MEDICINE
- Nivolumab versus Docetaxel in Advanced Squamous-Cell Non–Small-Cell Lung Cancer
- (2015) Julie Brahmer et al. NEW ENGLAND JOURNAL OF MEDICINE
- Targeting the TGFβ pathway for cancer therapy
- (2015) Cindy Neuzillet et al. PHARMACOLOGY & THERAPEUTICS
- Co-occurring Genomic Alterations Define Major Subsets of KRAS-Mutant Lung Adenocarcinoma with Distinct Biology, Immune Profiles, and Therapeutic Vulnerabilities
- (2015) F. Skoulidis et al. Cancer Discovery
- Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin
- (2014) Katherine A. Hoadley et al. CELL
- Prevailing Role of Contact Guidance in Intrastromal T-cell Trapping in Human Pancreatic Cancer
- (2014) N. Hartmann et al. CLINICAL CANCER RESEARCH
- Comparison of LAIR-1 genetic pathways in murine vs human internal organs
- (2014) Shuqiu Sun et al. GENE
- The Soluble Leukocyte-Associated Ig-Like Receptor (LAIR)-2 Antagonizes the Collagen/LAIR-1 Inhibitory Immune Interaction
- (2014) R. J. Lebbink et al. JOURNAL OF IMMUNOLOGY
- Extracellular matrix assembly: a multiscale deconstruction
- (2014) Janna K. Mouw et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- A pan-cancer proteomic perspective on The Cancer Genome Atlas
- (2014) Rehan Akbani et al. Nature Communications
- Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors
- (2012) Hélène Salmon et al. JOURNAL OF CLINICAL INVESTIGATION
- TGFβ signalling in context
- (2012) Joan Massagué NATURE REVIEWS MOLECULAR CELL BIOLOGY
- FcRL4 acts as an adaptive to innate molecular switch dampening BCR signaling and enhancing TLR signaling
- (2011) H. W. Sohn et al. BLOOD
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Novel SHP-1 Inhibitors Tyrosine Phosphatase Inhibitor-1 and Analogs with Preclinical Anti-Tumor Activities as Tolerated Oral Agents
- (2010) S. Kundu et al. JOURNAL OF IMMUNOLOGY
- SHP-1 in T Cells Limits the Production of CD8 Effector Cells without Impacting the Formation of Long-Lived Central Memory Cells
- (2010) C. C. Fowler et al. JOURNAL OF IMMUNOLOGY
- LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling
- (2010) Y. Gao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Technical Assessment of the Utility of Reverse Phase Protein Arrays for the Study of the Functional Proteome in Non-microdissected Human Breast Cancers
- (2010) Bryan T. Hennessy et al. Clinical Proteomics
- Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression
- (2009) D. L. Gibbons et al. GENES & DEVELOPMENT
- Identification of multiple potent binding sites for human leukocyte associated Ig-like receptor LAIR on collagens II and III
- (2009) Robert Jan Lebbink et al. MATRIX BIOLOGY
- The inhibitory collagen receptor LAIR-1 (CD305)
- (2007) L. Meyaard JOURNAL OF LEUKOCYTE BIOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started