Journal
ADVANCED HEALTHCARE MATERIALS
Volume 6, Issue 24, Pages -Publisher
WILEY
DOI: 10.1002/adhm.201700707
Keywords
collagen peptides; immunomodulatory biomaterials; inflammation; LAIR-1; macrophages
Funding
- UC Irvine (award from the Henry Samueli School of Engineering Interdisciplinary Innovation Initiative)
- UC Irvine (award from the Council on Research, Computing and Libraries)
- UC Irvine (award from the Ayala School of Biological Sciences)
- National Institute of Health [DP2DE023319, R21EB022240]
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Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is an inhibitory receptor broadly expressed on immune cells, with its ligands residing within the extracellular matrix protein collagen. In this study, surfaces are modified with a LAIR-1 ligand peptide (LP), and it is observed that macrophages cultured on LAIR-1 LP-conjugated surfaces exhibit significantly reduced secretion of inflammatory cytokines in response to proinflammatory stimuli that reflect an injured environment. These downregulated mediators include TNF-alpha, MIP-1 alpha, MIP-1 beta, MIP-2, RANTES, and MIG. Knockdown of LAIR-1 using siRNA abrogates this inhibition of cytokine secretion, supporting the specificity of the inhibitory effect to this receptor. These results are the first to demonstrate that integration of LAIR-1 ligands with biomaterials could suppress inflammatory responses.
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