The Contribution of Lipotoxicity to Diabetic Kidney Disease

Adaptive and maladaptive roles of lipid droplets in health and disease

(2022) Jeffrey D. Pressly et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Fatty acid transport protein 2 interacts with ceramide synthase 2 to promote ceramide synthesis

(2022) Jiyoon L. Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resveratrol ameliorates diabetic kidney injury by reducing lipotoxicity and modulates expression of components of the junctional adhesion molecule-like/sirtuin 1 lipid metabolism pathway

(2022) Wei Gu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Lipid droplet-mitochondria coupling via perilipin 5 augments respiratory capacity but is dispensable for FA oxidation

(2022) Benedikt Kien et al.   JOURNAL OF LIPID RESEARCH

DGAT2 Inhibition Potentiates Lipid Droplet Formation To Reduce Cytotoxicity in APOL1 Kidney Risk Variants

(2022) Justin Chun et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Molecular Mechanism of Lipotoxicity as an Interesting Aspect in the Development of Pathological States—Current View of Knowledge

(2022) Katarzyna Lipke et al.   Cells

Network meta-analysis of mineralocorticoid receptor antagonists for diabetic kidney disease

(2022) Yichuan Wu et al.   Frontiers in Pharmacology

KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease

(2021) Yutaro Mori et al.   Cell Metabolism

Pleiotropic Effects of Sodium-Glucose Cotransporter-2 Inhibitors: Renoprotective Mechanisms beyond Glycemic Control

(2021) Tomoaki Takata et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Adipose triglyceride lipase protects renal cell endocytosis in a Drosophila dietary model of chronic kidney disease

(2021) Aleksandra Lubojemska et al.   PLOS BIOLOGY

Targeting the Standardized Blood Pressure: New Guidelines for Blood Pressure Management in Chronic Kidney Disease

(2021) George Thomas et al.   ANNALS OF INTERNAL MEDICINE

Dehydrozingerone inhibits renal lipotoxicity in high‐fat diet–induced obese mice

(2021) Eun Soo Lee et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Effects of Dapagliflozin in Stage 4 Chronic Kidney Disease

(2021) Glenn M. Chertow et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity

(2021) Haejin Yoon et al.   MOLECULAR CELL

Pemafibrate Protects against Fatty Acid-Induced Nephropathy by Maintaining Renal Fatty Acid Metabolism

(2021) Daiki Aomura et al.   Metabolites

Novel therapeutic strategies for cardiorenal protection in patients with type 2 diabetes and chronic kidney disease

(2021) Panagiotis I. Georgianos et al.   Current Vascular Pharmacology

GPR43 activation-mediated lipotoxicity contributes to podocyte injury in diabetic nephropathy by modulating the ERK/EGR1 pathway

(2021) Jian Lu et al.   International Journal of Biological Sciences

Therapeutic potential of resveratrol in diabetic nephropathy according to molecular signaling

(2021) Marziyeh Salami et al.   Current Molecular Pharmacology

Nonalcoholic Steatohepatitis

(2020) Adam C. Sheka et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Canagliflozin ameliorates obesity by improving mitochondrial function and fatty acid oxidation via PPARα in vivo and in vitro

(2020) Dan Wei et al.   LIFE SCIENCES

Estrogen regulates sex-specific localization of regulatory T cells in adipose tissue of obese female mice

(2020) Akari Ishikawa et al.   PLoS One

Sodium–glucose cotransporter 2 inhibition suppresses HIF-1α-mediated metabolic switch from lipid oxidation to glycolysis in kidney tubule cells of diabetic mice

(2020) Ting Cai et al.   Cell Death & Disease

APOL1 Nephropathy: From Genetics to Clinical Applications

(2020) David J. Friedman et al.   Clinical Journal of the American Society of Nephrology

Carbohydrate response element‐binding protein regulates lipid metabolism via mTOR complex1 in diabetic nephropathy

(2020) Nan Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Sterol-O-acyltransferase-1 has a role in kidney disease associated with diabetes and Alport Syndrome.

(2020) Xiaochen Liu et al.   KIDNEY INTERNATIONAL

Liraglutide attenuates renal tubular ectopic lipid deposition in rats with diabetic nephropathy by inhibiting lipid synthesis and promoting lipolysis

(2020) Ke Su et al.   PHARMACOLOGICAL RESEARCH

Antagonistic Effect of Truncated Fragments of Bacillus thuringiensis Vip3Aa on the Larvicidal Activity of its Full-length Protein

(2020) Patcharaporn Boonyos et al.   PROTEIN AND PEPTIDE LETTERS

Comprehensive Lipidome Profiling of the Kidney in Early-Stage Diabetic Nephropathy

(2020) Biyu Hou et al.   Frontiers in Endocrinology

Fatty acid transport protein-2 regulates glycemic control and diabetic kidney disease progression

(2020) Shenaz Khan et al.   JCI Insight

Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism

(2020) Yi Fu et al.   Cell Metabolism

A Meta-Analysis of the Impact of Resveratrol Supplementation on Markers of Renal Function and Blood Pressure in Type 2 Diabetic Patients on Hypoglycemic Therapy

(2020) Tawanda M. Nyambuya et al.   MOLECULES

ATF6α downregulation of PPARα promotes lipotoxicity-induced tubulointerstitial fibrosis

(2019) Tzu-Ming Jao et al.   KIDNEY INTERNATIONAL

Recruitment of APOL1 kidney disease risk variants to lipid droplets attenuates cell toxicity

(2019) Justin Chun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy

(2019) Vlado Perkovic et al.   NEW ENGLAND JOURNAL OF MEDICINE

Kidney Injury Molecule-1 Is Upregulated in Renal Lipotoxicity and Mediates Palmitate-Induced Tubular Cell Injury and Inflammatory Response

(2019) Xueying Zhao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ATP-binding cassette A1 deficiency causes cardiolipin-driven mitochondrial dysfunction in podocytes

(2019) G. Michelle Ducasa et al.   JOURNAL OF CLINICAL INVESTIGATION

SMPDL3b modulates insulin receptor signaling in diabetic kidney disease

(2019) A. Mitrofanova et al.   Nature Communications

Dapagliflozin rescues endoplasmic reticulum stress-mediated cell death

(2019) Ryo Shibusawa et al.   Scientific Reports

The single-cell transcriptomic landscape of early human diabetic nephropathy

(2019) Parker C. Wilson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ipragliflozin Ameliorates Endoplasmic Reticulum Stress and Apoptosis through Preventing Ectopic Lipid Deposition in Renal Tubules

(2019) Kohshiro Hosokawa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Newly Discovered Antifibrotic Pathway Regulated by Two Fatty Acid Receptors

(2018) Lyne Gagnon et al.   AMERICAN JOURNAL OF PATHOLOGY

Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion

(2018) Ilan Y. Benador et al.   Cell Metabolism

The Sodium-Glucose Cotransporter 2 Inhibitor Dapagliflozin Prevents Renal and Liver Disease in Western Diet Induced Obesity Mice

(2018) Dong Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Adiponectin Receptor Agonist AdipoRon Ameliorates Diabetic Nephropathy in a Model of Type 2 Diabetes

(2018) Yaeni Kim et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Markers of early progressive renal decline in type 2 diabetes suggest different implications for etiological studies and prognostic tests development

(2018) Natalia Nowak et al.   KIDNEY INTERNATIONAL

Ipragliflozin improves mitochondrial abnormalities in renal tubules induced by a high-fat diet

(2018) Susumu Takagi et al.   Journal of Diabetes Investigation

Dynamics and functions of lipid droplets

(2018) James A. Olzmann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Proximal Tubular Cannabinoid-1 Receptor Regulates Obesity-Induced CKD

(2017) Shiran Udi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Impaired β -Oxidation and Altered Complex Lipid Fatty Acid Partitioning with Advancing CKD

(2017) Farsad Afshinnia et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Kidney Proximal Tubule Lipoapoptosis Is Regulated by Fatty Acid Transporter-2 (FATP2)

(2017) Shenaz Khan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

FXR/TGR5 Dual Agonist Prevents Progression of Nephropathy in Diabetes and Obesity

(2017) Xiaoxin X. Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Applying systems-level spectral imaging and analysis to reveal the organelle interactome

(2017) Alex M. Valm et al.   NATURE

Cytosolic lipolysis and lipophagy: two sides of the same coin

(2017) Rudolf Zechner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Local TNF causes NFATc1-dependent cholesterol-mediated podocyte injury

(2016) Christopher E. Pedigo et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of ER stress in lipid metabolism and lipotoxicity

(2016) Jaeseok Han et al.   JOURNAL OF LIPID RESEARCH

Mitochondrial Pathology and Glycolytic Shift during Proximal Tubule Atrophy after Ischemic AKI

(2016) R. Lan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Efficacy of statins in patients with diabetic nephropathy: a meta-analysis of randomized controlled trials

(2016) Xue Shen et al.   Lipids in Health and Disease

Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes

(2016) Christoph Wanner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Activation of Kupffer Cells Is Associated with a Specific Dysbiosis Induced by Fructose or High Fat Diet in Mice

(2016) Gladys Ferrere et al.   PLoS One

Impact of renal function on the effects of LDL cholesterol lowering with statin-based regimens: a meta-analysis of individual participant data from 28 randomised trials

(2016)   Lancet Diabetes & Endocrinology

Chemical inhibition of fatty acid absorption and cellular uptake limits lipotoxic cell death

(2015) Constance Ahowesso et al.   BIOCHEMICAL PHARMACOLOGY

Albumin-associated free fatty acids induce macropinocytosis in podocytes

(2015) Jun-Jae Chung et al.   JOURNAL OF CLINICAL INVESTIGATION

Chronic administration of AM251 improves albuminuria and renal tubular structure in obese rats

(2015) K. A. Jenkin et al.   JOURNAL OF ENDOCRINOLOGY

G Protein-Coupled Bile Acid Receptor TGR5 Activation Inhibits Kidney Disease in Obesity and Diabetes

(2015) X. X. Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Normal 25-Hydroxyvitamin D Levels Are Associated with Less Proteinuria and Attenuate Renal Failure Progression in Children with CKD

(2015) R. Shroff et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Tubular atrophy in the pathogenesis of chronic kidney disease progression

(2015) Jeffrey R. Schelling   PEDIATRIC NEPHROLOGY

Non-Proteinuric Diabetic Nephropathy

(2015) Nicolas Robles et al.   Journal of Clinical Medicine

CD36 Mediated Fatty Acid-Induced Podocyte Apoptosis via Oxidative Stress

(2015) Wei Hua et al.   PLoS One

Evaluation of Molecular Profiles in Calcineurin Inhibitor Toxicity Post-Kidney Transplant: Input to Chronic Allograft Dysfunction

(2014) D. G. Maluf et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Lipotoxic disruption of NHE1 interaction with PI(4,5)P2 expedites proximal tubule apoptosis

(2014) Shenaz Khan et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular mechanisms of diabetic kidney disease

(2014) Kimberly Reidy et al.   JOURNAL OF CLINICAL INVESTIGATION

Renal Cortical Pyruvate Depletion during AKI

(2014) R. A. Zager et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Sphingomyelinase-Like Phosphodiesterase 3b Expression Levels Determine Podocyte Injury Phenotypes in Glomerular Disease

(2014) T.-H. Yoo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Blood Kidney Injury Molecule-1 Is a Biomarker of Acute and Chronic Kidney Injury and Predicts Progression to ESRD in Type I Diabetes

(2014) V. S. Sabbisetti et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Deficiency of cannabinoid receptor of type 2 worsens renal functional and structural abnormalities in streptozotocin-induced diabetic mice

(2014) Federica Barutta et al.   KIDNEY INTERNATIONAL

Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development

(2014) Hyun Mi Kang et al.   NATURE MEDICINE

Fenofibrate Improves Renal Lipotoxicity through Activation of AMPK-PGC-1α in db/db Mice

(2014) Yu Ah Hong et al.   PLoS One

Overactive cannabinoid 1 receptor in podocytes drives type 2 diabetic nephropathy

(2014) Tony Jourdan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of Non-alcoholic Fatty Liver Disease with Chronic Kidney Disease: A Systematic Review and Meta-analysis

(2014) Giovanni Musso et al.   PLOS MEDICINE

Susceptibility of Podocytes to Palmitic Acid Is Regulated by Stearoyl-CoA Desaturases 1 and 2

(2013) Jonas Sieber et al.   AMERICAN JOURNAL OF PATHOLOGY

Cyclodextrin Protects Podocytes in Diabetic Kidney Disease

(2013) S. Merscher-Gomez et al.   DIABETES

Fenofibrate and the kidney: an overview

(2013) Michael S. Kostapanos et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis

(2013) Benjamin D. Humphreys et al.   JOURNAL OF CLINICAL INVESTIGATION

Altered renal lipid metabolism and renal lipid accumulation in human diabetic nephropathy

(2013) Michal Herman-Edelstein et al.   JOURNAL OF LIPID RESEARCH

A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity

(2013) Miki Okada-Iwabu et al.   NATURE

Circulating angiopoietin-like 4 links proteinuria with hypertriglyceridemia in nephrotic syndrome

(2013) Lionel C Clement et al.   NATURE MEDICINE

Oxidation of Fatty Acids Is the Source of Increased Mitochondrial Reactive Oxygen Species Production in Kidney Cortical Tubules in Early Diabetes

(2012) M. G. Rosca et al.   DIABETES

Reversibility of Fenofibrate Therapy-Induced Renal Function Impairment in ACCORD Type 2 Diabetic Participants

(2012) J. C. Mychaleckyj et al.   DIABETES CARE

Blockade of Cannabinoid Receptor 1 Improves Insulin Resistance, Lipid Metabolism, and Diabetic Nephropathy in db/db Mice

(2012) D. H. Nam et al.   ENDOCRINOLOGY

The FATP1–DGAT2 complex facilitates lipid droplet expansion at the ER–lipid droplet interface

(2012) Ningyi Xu et al.   JOURNAL OF CELL BIOLOGY

Activation of the unfolded protein response pathway causes ceramide accumulation in yeast and INS-1E insulinoma cells

(2012) Sharon Epstein et al.   JOURNAL OF LIPID RESEARCH

Albuminuria and Estimated Glomerular Filtration Rate as Predictors of Diabetic End-Stage Renal Disease and Death

(2011) A. M. Berhane et al.   Clinical Journal of the American Society of Nephrology

Protective Role of Cannabinoid Receptor Type 2 in a Mouse Model of Diabetic Nephropathy

(2011) F. Barutta et al.   DIABETES

Phosphoinositide Binding Differentially Regulates NHE1 Na+/H+Exchanger-dependent Proximal Tubule Cell Survival

(2011) Bassam G. Abu Jawdeh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Triacylglycerol Accumulation Activates the Mitochondrial Apoptosis Pathway in Macrophages

(2011) Elma Aflaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of lipid droplets in metabolic disease in rodents and humans

(2011) Andrew S. Greenberg et al.   JOURNAL OF CLINICAL INVESTIGATION

Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria

(2011) Hong Wang et al.   JOURNAL OF LIPID RESEARCH

The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial

(2011) Colin Baigent et al.   LANCET

Diabetic Nephropathy Is Accelerated by Farnesoid X Receptor Deficiency and Inhibited by Farnesoid X Receptor Activation in a Type 1 Diabetes Model

(2010) X. X. Wang et al.   DIABETES

Cannabinoid Receptor 1 Blockade Ameliorates Albuminuria in Experimental Diabetic Nephropathy

(2010) F. Barutta et al.   DIABETES

Cannabinoid receptor 1 mediates palmitic acid-induced apoptosis via endoplasmic reticulum stress in human renal proximal tubular cells

(2010) J.C. Lim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Presence and significance of microvesicular steatosis in nonalcoholic fatty liver disease

(2010) Sweta Tandra et al.   JOURNAL OF HEPATOLOGY

BTBR Ob/Ob Mutant Mice Model Progressive Diabetic Nephropathy

(2010) K. L. Hudkins et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Effects of Combination Lipid Therapy in Type 2 Diabetes Mellitus

(2010)   NEW ENGLAND JOURNAL OF MEDICINE

Functional and structural properties of mammalian acyl-coenzyme A thioesterases

(2010) Brenda Kirkby et al.   PROGRESS IN LIPID RESEARCH

Acyl-CoA synthesis, lipid metabolism and lipotoxicity

(2009) Lei O. Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lipid Droplets Finally Get a Little R-E-S-P-E-C-T

(2009) Robert V. Farese et al.   CELL

Saturated with fat: new perspectives on lipotoxicity

(2009) Jeanne Garbarino et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Effects of Long-Term Fenofibrate Treatment on Markers of Renal Function in Type 2 Diabetes: The FIELD Helsinki substudy

(2009) C. Forsblom et al.   DIABETES CARE

Sterol and Diacylglycerol Acyltransferase Deficiency Triggers Fatty Acid-mediated Cell Death

(2009) Jeanne Garbarino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mouse Models of Diabetic Nephropathy

(2009) F. C. Brosius et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

An update on the lipid nephrotoxicity hypothesis

(2009) Xiong Z. Ruan et al.   Nature Reviews Nephrology

Lipid Droplet-Associated Proteins Protect Renal Tubular Cells from Fatty Acid-Induced Apoptosis

(2008) Yoshimichi Urahama et al.   AMERICAN JOURNAL OF PATHOLOGY

Kidney injury molecule–1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells

(2008) Takaharu Ichimura et al.   JOURNAL OF CLINICAL INVESTIGATION

Oleic acid loading does not add to the nephrotoxic effect of albumin in an amphibian and chronic rat model of kidney injury

(2008) M. M. van Timmeren et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION