Lipid droplet-mitochondria coupling via perilipin 5 augments respiratory capacity but is dispensable for FA oxidation

Mitochondrial compartmentalization: emerging themes in structure and function

(2021) Joseph C. Iovine et al.   TRENDS IN BIOCHEMICAL SCIENCES

Perilipin 5 links mitochondrial uncoupled respiration in brown fat to healthy white fat remodeling and systemic glucose tolerance

(2021) Violeta I. Gallardo-Montejano et al.   Nature Communications

Hepatic PLIN5 signals via SIRT1 to promote autophagy and prevent inflammation during fasting

(2020) Enxiang Zhang et al.   JOURNAL OF LIPID RESEARCH

Perilipin 5 Deletion in Hepatocytes Remodels Lipid Metabolism and Causes Hepatic Insulin Resistance in Mice

(2019) Stacey N. Keenan et al.   DIABETES

Perilipin5 protects against lipotoxicity and alleviates endoplasmic reticulum stress in pancreatic β-cells

(2019) Yunxia Zhu et al.   Nutrition & Metabolism

Plin5 deficiency exacerbates pressure overload-induced cardiac hypertrophy and heart failure by enhancing myocardial fatty acid oxidation and oxidative stress

(2019) Chao Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Perilipin 5 Protects against Cellular Oxidative Stress by Enhancing Mitochondrial Function in HepG2 Cells

(2019) Tan et al.   Cells

Lipid Droplet-Derived Monounsaturated Fatty Acids Traffic via PLIN5 to Allosterically Activate SIRT1

(2019) Charles P. Najt et al.   MOLECULAR CELL

Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion

(2018) Ilan Y. Benador et al.   Cell Metabolism

Perilipin 5 Deletion Unmasks an Endoplasmic Reticulum Stress–Fibroblast Growth Factor 21 Axis in Skeletal Muscle

(2018) Magdalene K. Montgomery et al.   DIABETES

Extended-resolution imaging of the interaction of lipid droplets and mitochondria

(2018) Maria Pribasnig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Super-resolution microscopy localizes perilipin 5 at lipid droplet-mitochondria interaction sites and at lipid droplets juxtaposing to perilipin 2

(2018) Anne Gemmink et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Dynamics and functions of lipid droplets

(2018) James A. Olzmann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Deficiency in perilipin 5 reduces mitochondrial function and membrane depolarization in mouse hearts

(2017) Linda Andersson et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry

(2017) Devin K. Schweppe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plin5 alleviates myocardial ischaemia/reperfusion injury by reducing oxidative stress through inhibiting the lipolysis of lipid droplets

(2017) Pengfei Zheng et al.   Scientific Reports

Decoration of intramyocellular lipid droplets with PLIN5 modulates fasting-induced insulin resistance and lipotoxicity in humans

(2016) Anne Gemmink et al.   DIABETOLOGIA

Perilipin 5 is protective in the ischemic heart

(2016) Christina Drevinge et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1α/SIRT1-dependent transcriptional regulation of mitochondrial function

(2016) Violeta I. Gallardo-Montejano et al.   Nature Communications

Perilipin 5 fine-tunes lipid oxidation to metabolic demand and protects against lipotoxicity in skeletal muscle

(2016) Claire Laurens et al.   Scientific Reports

Perilipin 5 improves hepatic lipotoxicity by inhibiting lipolysis

(2015) Chao Wang et al.   HEPATOLOGY

The Interplay of Protein Kinase A and Perilipin 5 Regulates Cardiac Lipolysis

(2014) Nina M. Pollak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PLIN5 deletion remodels intracellular lipid composition and causes insulin resistance in muscle

(2014) Rachael R. Mason et al.   Molecular Metabolism

Overexpression of PLIN5 in skeletal muscle promotes oxidative gene expression and intramyocellular lipid content without compromising insulin sensitivity

(2013) M. Bosma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Cardiac-specific overexpression of perilipin 5 provokes severe cardiac steatosis via the formation of a lipolytic barrier

(2013) Nina M. Pollak et al.   JOURNAL OF LIPID RESEARCH

Palmitic acid follows a different metabolic pathway than oleic acid in human skeletal muscle cells; lower lipolysis rate despite an increased level of adipose triglyceride lipase

(2012) Siril S. Bakke et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Perilipin 5, a Lipid Droplet-binding Protein, Protects Heart from Oxidative Burden by Sequestering Fatty Acid from Excessive Oxidation

(2012) Kenta Kuramoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria

(2011) Madeleen Bosma et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria

(2011) Hong Wang et al.   JOURNAL OF LIPID RESEARCH

Interactions of Perilipin-5 (Plin5) with Adipose Triglyceride Lipase

(2010) James G. Granneman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid droplets interact with mitochondria using SNAP23

(2009) Sara Jägerström et al.   CELL BIOLOGY INTERNATIONAL

Activation of Hormone-sensitive Lipase Requires Two Steps, Protein Phosphorylation and Binding to the PAT-1 Domain of Lipid Droplet Coat Proteins

(2009) Hong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Interactions between Mldp (LSDP5) and Abhd5 in the Control of Intracellular Lipid Accumulation

(2008) James G. Granneman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY