APOL1 Nephropathy: From Genetics to Clinical Applications

Acute Kidney Injury Due to Collapsing Glomerulopathy Following COVID-19 Infection

(2020) Yonatan Peleg et al.   Kidney International Reports

Collapsing Glomerulopathy in a Patient With COVID-19

(2020) Christopher P. Larsen et al.   Kidney International Reports

APOL1 Kidney Risk Variants Induce Cell Death via Mitochondrial Translocation and Opening of the Mitochondrial Permeability Transition Pore

(2019) Shrijal S. Shah et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Apolipoprotein L1 (APOL1) risk variant toxicity depends on the haplotype background

(2019) Herbert Lannon et al.   KIDNEY INTERNATIONAL

Hypertensive APOL1 risk allele carriers demonstrate greater blood pressure reduction with angiotensin receptor blockade compared to low risk carriers

(2019) Patrick N. Cunningham et al.   PLoS One

Practical considerations for APOL1 genotyping in the living kidney donor evaluation

(2019) Alejandra M. Mena-Gutierrez et al.   TRANSPLANTATION

APOL1 and Kidney Disease: From Genetics to Biology

(2019) David J. Friedman et al.   Annual Review of Physiology

Apolipoprotein L1 and Chronic Kidney Disease Risk in Young Potential Living Kidney Donors

(2018) Jayme E. Locke et al.   ANNALS OF SURGERY

The APOL1 Long-Term Kidney Transplantation Outcomes Network—APOLLO

(2018) Barry I. Freedman et al.   Clinical Journal of the American Society of Nephrology

Genetic risk of APOL1 and kidney disease in children and young adults of African ancestry

(2018) Kimberly J. Reidy et al.   CURRENT OPINION IN PEDIATRICS

APOL1Genotype and Renal Function of Black Living Donors

(2018) Mona D. Doshi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Plasma biomarkers are associated with renal outcomes in individuals with APOL1 risk variants

(2018) Girish N. Nadkarni et al.   KIDNEY INTERNATIONAL

Genome-wide association studies suggest that APOL1 -environment interactions more likely trigger kidney disease in African Americans with nondiabetic nephropathy than strong APOL1 –second gene interactions

(2018) Carl D. Langefeld et al.   KIDNEY INTERNATIONAL

UBDmodifiesAPOL1-induced kidney disease risk

(2018) Jia-Yue Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Donor’s APOL1 Risk Genotype and “Second Hits” Associated With De Novo Collapsing Glomerulopathy in Deceased Donor Kidney Transplant Recipients: A Report of 5 Cases

(2018) Jae-Hyung Chang et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

APOL1-Associated Nephropathy: A Key Contributor to Racial Disparities in CKD

(2018) Barry I. Freedman et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Protective association between JC polyoma viruria and kidney disease

(2018) Jasmin Divers et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Worldwide Frequencies of APOL1 Renal Risk Variants

(2018) Girish N. Nadkarni et al.   NEW ENGLAND JOURNAL OF MEDICINE

Apolipoprotein L1 confers pH-switchable ion permeability to phospholipid vesicles

(2017) Jonathan Bruno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apolipoprotein L1 Variants and Blood Pressure Traits in African Americans

(2017) Girish N. Nadkarni et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Intracellular APOL1 Risk Variants Cause Cytotoxicity Accompanied by Energy Depletion

(2017) Daniel Granado et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice

(2017) Pazit Beckerman et al.   NATURE MEDICINE

A null variant in the apolipoprotein L3 gene is associated with non-diabetic nephropathy

(2017) Karl L Skorecki et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

APOL1 Nephropathy: A Population Genetics and Evolutionary Medicine Detective Story

(2017) Etty Kruzel-Davila et al.   SEMINARS IN NEPHROLOGY

A Brief History of APOL1 : A Gene Evolving

(2017) David J. Friedman   SEMINARS IN NEPHROLOGY

Plasma Levels of Risk-Variant APOL1 Do Not Associate with Renal Disease in a Population-Based Cohort

(2016) J. Kozlitina et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

APOL1 Renal-Risk Variants Induce Mitochondrial Dysfunction

(2016) Lijun Ma et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Most ApoL1 Is Secreted by the Liver

(2016) Khuloud Shukha et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

African Ancestry–Specific Alleles and Kidney Disease Risk in Hispanics/Latinos

(2016) Holly J. Kramer et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

APOL1 Genotype and Kidney Transplantation Outcomes From Deceased African American Donors

(2016) Barry I. Freedman et al.   TRANSPLANTATION

Apolipoprotein L1 and Kidney Disease in African Americans

(2016) David J. Friedman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Collapsing glomerulopathy in a young woman with APOL1 risk alleles following acute parvovirus B19 infection: a case report investigation

(2016) Whitney Besse et al.   BMC Nephrology

BH3 domain-independent apolipoprotein L1 toxicity rescued by BCL2 prosurvival proteins

(2015) J. F. Heneghan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Apolipoprotein L1 Gene Variants in Deceased Organ Donors Are Associated With Renal Allograft Failure

(2015) B. I. Freedman et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Characterization of circulating APOL1 protein complexes in African Americans

(2015) Allison Weckerle et al.   JOURNAL OF LIPID RESEARCH

Clinical Features and Histology of Apolipoprotein L1-Associated Nephropathy in the FSGS Clinical Trial

(2015) J. B. Kopp et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

APOL1 Genotype and Race Differences in Incident Albuminuria and Renal Function Decline

(2015) C. A. Peralta et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

APOL1 Risk Variants Are Strongly Associated with HIV-Associated Nephropathy in Black South Africans

(2015) A. N. Kasembeli et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Innate immunity pathways regulate the nephropathy gene Apolipoprotein L1

(2015) Brendan Nichols et al.   KIDNEY INTERNATIONAL

APOL1nephropathy: from gene to mechanisms of kidney injury

(2015) Etty Kruzel-Davila et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Viral-associated glomerulopathies in children

(2015) Scott E. Wenderfer   PEDIATRIC NEPHROLOGY

Human trypanolytic factor APOL1 forms pH-gated cation-selective channels in planar lipid bilayers: Relevance to trypanosome lysis

(2015) Russell Thomson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases

(2015) Opeyemi A. Olabisi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coupling of lysosomal and mitochondrial membrane permeabilization in trypanolysis by APOL1

(2015) Gilles Vanwalleghem et al.   Nature Communications

Histopathologic Effect of APOL1 Risk Alleles in PLA2R-Associated Membranous Glomerulopathy

(2014) Christopher P. Larsen et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Effect of Genetic African Ancestry on eGFR and Kidney Disease

(2014) M. S. Udler et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Evolution of the primate trypanolytic factor APOL1

(2014) R. Thomson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasma Apolipoprotein L1 Levels Do Not Correlate with CKD

(2013) L. A. Bruggeman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Apolipoprotein L1 Risk Variants Associate with Systemic Lupus Erythematosus-Associated Collapsing Glomerulopathy

(2013) C. P. Larsen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

APOL1 Variants Associate with Increased Risk of CKD among African Americans

(2013) M. C. Foster et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Innate Immune Factor Apolipoprotein L1 Restricts HIV-1 Infection

(2013) H. E. Taylor et al.   JOURNAL OF VIROLOGY

High Population Frequencies of APOL1 Risk Variants Are Associated with Increased Prevalence of Non-Diabetic Chronic Kidney Disease in the Igbo People from South-Eastern Nigeria

(2013) Ifeoma I. Ulasi et al.   NEPHRON CLINICAL PRACTICE

APOL1 Risk Variants, Race, and Progression of Chronic Kidney Disease

(2013) Afshin Parsa et al.   NEW ENGLAND JOURNAL OF MEDICINE

End-Stage Renal Disease in African Americans With Lupus Nephritis Is Associated WithAPOL1

(2013) Barry I. Freedman et al.   Arthritis & Rheumatology

The APOL1 Genotype of African American Kidney Transplant Recipients Does Not Impact 5-Year Allograft Survival

(2012) B. T Lee et al.   AMERICAN JOURNAL OF TRANSPLANTATION

APOL1 Null Alleles from a Rural Village in India Do Not Correlate with Glomerulosclerosis

(2012) Duncan B. Johnstone et al.   PLoS One

The APOL1 Gene and Allograft Survival after Kidney Transplantation

(2011) A. M. Reeves-Daniel et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Genetics of kidney failure and the evolving story of APOL1

(2011) David J. Friedman et al.   JOURNAL OF CLINICAL INVESTIGATION

APOL1 Genetic Variants in Focal Segmental Glomerulosclerosis and HIV-Associated Nephropathy

(2011) J. B. Kopp et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Population-Based Risk Assessment of APOL1 on Renal Disease

(2011) D. J. Friedman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Treatment with IFN- , - , or -  Is Associated with Collapsing Focal Segmental Glomerulosclerosis

(2010) G. S. Markowitz et al.   Clinical Journal of the American Society of Nephrology

Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene

(2010) Shay Tzur et al.   HUMAN GENETICS

Association of Trypanolytic ApoL1 Variants with Kidney Disease in African Americans

(2010) G. Genovese et al.   SCIENCE

Human innate immunity against African trypanosomes

(2009) Etienne Pays et al.   CURRENT OPINION IN IMMUNOLOGY

Activity of trypanosome lytic factor: a novel component of innate immunity

(2009) Russell Thomson et al.   Future Microbiology

The apolipoprotein L family of programmed cell death and immunity genes rapidly evolved in primates at discrete sites of host-pathogen interactions

(2009) E. E. Smith et al.   GENOME RESEARCH

Trypanosome Lytic Factor, an Antimicrobial High-Density Lipoprotein, Ameliorates Leishmania Infection

(2009) Marie Samanovic et al.   PLoS Pathogens

Distinct roles of apolipoprotein components within the trypanosome lytic factor complex revealed in a novel transgenic mouse model

(2008) Maria Pilar Molina-Portela et al.   JOURNAL OF EXPERIMENTAL MEDICINE