Recruitment of APOL1 kidney disease risk variants to lipid droplets attenuates cell toxicity

APOL1 Risk Variants Cause Podocytes Injury through Enhancing Endoplasmic Reticulum Stress

(2018) Hongxiu Wen et al.   BIOSCIENCE REPORTS

VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites

(2018) Nikit Kumar et al.   JOURNAL OF CELL BIOLOGY

Identification and characterization of a novelDGAT1missense mutation associated with congenital diarrhea

(2017) Nina L. Gluchowski et al.   JOURNAL OF LIPID RESEARCH

Intracellular APOL1 Risk Variants Cause Cytotoxicity Accompanied by Energy Depletion

(2017) Daniel Granado et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Applying systems-level spectral imaging and analysis to reveal the organelle interactome

(2017) Alex M. Valm et al.   NATURE

Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice

(2017) Pazit Beckerman et al.   NATURE MEDICINE

Therapeutics for APOL1 nephropathies: putting out the fire in the podocyte

(2017) Jurgen Heymann et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Seipin regulates ER–lipid droplet contacts and cargo delivery

(2016) Veijo T Salo et al.   EMBO JOURNAL

Mice with mutant Inf2 show impaired podocyte and slit diaphragm integrity in response to protamine-induced kidney injury

(2016) Balajikarthick Subramanian et al.   KIDNEY INTERNATIONAL

APOL1 Genotype and Kidney Transplantation Outcomes From Deceased African American Donors

(2016) Barry I. Freedman et al.   TRANSPLANTATION

Apolipoprotein L1 and Kidney Disease in African Americans

(2016) David J. Friedman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

APOL1 Risk Variants Are Strongly Associated with HIV-Associated Nephropathy in Black South Africans

(2015) A. N. Kasembeli et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases

(2015) Opeyemi A. Olabisi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

APOL1 Kidney Disease Risk Variants: An Evolving Landscape

(2015) Patrick D. Dummer et al.   SEMINARS IN NEPHROLOGY

The brown adipocyte protein CIDEA promotes lipid droplet fusion via a phosphatidic acid-binding amphipathic helix

(2015) David Barneda et al.   eLife

ApoL1, a BH3-only lipid-binding protein, induces autophagic cell death

(2014) Siqin Zhaorigetu et al.   Autophagy

ER Contact Sites Define the Position and Timing of Endosome Fission

(2014) Ashley A. Rowland et al.   CELL

Lipid biology of the podocyte—new perspectives offer new opportunities

(2014) Alessia Fornoni et al.   Nature Reviews Nephrology

Evolution of the primate trypanolytic factor APOL1

(2014) R. Thomson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasma Apolipoprotein L1 Levels Do Not Correlate with CKD

(2013) L. A. Bruggeman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Endoplasmic reticulum–endosome contact increases as endosomes traffic and mature

(2013) Jonathan R. Friedman et al.   MOLECULAR BIOLOGY OF THE CELL

Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis

(2011) Shreeram Akilesh et al.   JOURNAL OF CLINICAL INVESTIGATION

APOL1 Genetic Variants in Focal Segmental Glomerulosclerosis and HIV-Associated Nephropathy

(2011) J. B. Kopp et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Population-Based Risk Assessment of APOL1 on Renal Disease

(2011) D. J. Friedman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

ER Tubules Mark Sites of Mitochondrial Division

(2011) J. R. Friedman et al.   SCIENCE

A Role for Phosphatidic Acid in the Formation of “Supersized” Lipid Droplets

(2011) Weihua Fei et al.   PLoS Genetics

Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene

(2010) Shay Tzur et al.   HUMAN GENETICS

Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice

(2010) Björn Hartleben et al.   JOURNAL OF CLINICAL INVESTIGATION

Association of Trypanolytic ApoL1 Variants with Kidney Disease in African Americans

(2010) G. Genovese et al.   SCIENCE

The apolipoprotein L family of programmed cell death and immunity genes rapidly evolved in primates at discrete sites of host-pathogen interactions

(2009) E. E. Smith et al.   GENOME RESEARCH

Apolipoprotein L1, a Novel Bcl-2 Homology Domain 3-only Lipid-binding Protein, Induces Autophagic Cell Death

(2008) Guanghua Wan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid droplets are arrested in the ER membrane by tight binding of lipidated apolipoprotein B-100

(2008) Y. Ohsaki et al.   JOURNAL OF CELL SCIENCE

Intracellular lipid droplet targeting by apolipoprotein A-V requires the carboxyl-terminal segment

(2008) Xiao Shu et al.   JOURNAL OF LIPID RESEARCH