Overactive cannabinoid 1 receptor in podocytes drives type 2 diabetic nephropathy

Cardinal Role of the Intrarenal Renin-Angiotensin System in the Pathogenesis of Diabetic Nephropathy

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Nox as a target for diabetic complications

(2013) Yves Gorin et al.   CLINICAL SCIENCE

Renin inhibition in the treatment of diabetic kidney disease: Figure 1

(2013) Radko Komers   CLINICAL SCIENCE

Modulating the endocannabinoid system in human health and disease - successes and failures

(2013) Pál Pacher et al.   FEBS Journal

Common polymorphism in the cannabinoid type 1 receptor gene (CNR1) is associated with microvascular complications in type 2 diabetes

(2013) Monika Buraczynska et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Estimating Podocyte Number and Density Using a Single Histologic Section

(2013) M. Venkatareddy et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Podocyte injury enhances filtration of liver-derived angiotensinogen and renal angiotensin II generation

(2013) Taiji Matsusaka et al.   KIDNEY INTERNATIONAL

Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes

(2013) Tony Jourdan et al.   NATURE MEDICINE

Bardoxolone Methyl in Type 2 Diabetes and Stage 4 Chronic Kidney Disease

(2013) Dick de Zeeuw et al.   NEW ENGLAND JOURNAL OF MEDICINE

Uric acid best predicts metabolically unhealthy obesity with increased cardiovascular risk in youth and adults

(2013) Harald Mangge et al.   Obesity

Angiotensin II Reduces Cardiac AdipoR1 Expression through AT1 Receptor/ROS/ERK1/2/c-Myc Pathway

(2013) Li Li et al.   PLoS One

Podocyte Biology and Pathogenesis of Kidney Disease

(2012) Jochen Reiser et al.   Annual Review of Medicine

JD-5006 and JD-5037: Peripherally restricted (PR) cannabinoid-1 receptor blockers related to SLV-319 (Ibipinabant) as metabolic disorder therapeutics devoid of CNS liabilities

(2012) Robert J. Chorvat et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Peripheral Cannabinoid-1 Receptor Inverse Agonism Reduces Obesity by Reversing Leptin Resistance

(2012) Joseph Tam et al.   Cell Metabolism

Ibipinabant attenuates β-cell loss in male Zucker diabetic fatty rats independently of its effects on body weight

(2012) K. Rohrbach et al.   DIABETES OBESITY & METABOLISM

Blockade of Cannabinoid Receptor 1 Improves Insulin Resistance, Lipid Metabolism, and Diabetic Nephropathy in db/db Mice

(2012) D. H. Nam et al.   ENDOCRINOLOGY

Angiotensin II induces tumor necrosis factor-α expression and release from cultured human podocytes

(2012) Arianna Carolina Rosa et al.   INFLAMMATION RESEARCH

Angiotensin II Induces Vascular Endocannabinoid Release, Which Attenuates Its Vasoconstrictor Effect via CB1Cannabinoid Receptors

(2012) Mária Szekeres et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The high glucose-induced stimulation of B1R and B2R expression via CB1R activation is involved in rat podocyte apoptosis

(2012) Seul Ki Lim et al.   LIFE SCIENCES

The Endocannabinoid System and Plant-Derived Cannabinoids in Diabetes and Diabetic Complications

(2011) Béla Horváth et al.   AMERICAN JOURNAL OF PATHOLOGY

AT1R-CB1R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II

(2011) Raphael Rozenfeld et al.   EMBO JOURNAL

Interleukin 6 Underlies Angiotensin II–Induced Hypertension and Chronic Renal Damage

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Hyperglycemia induces apoptosis via CB1 activation through the decrease of FAAH 1 in retianl pigment epithelial cells

(2011) Seul Ki Lim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hyperactivation of anandamide synthesis and regulation of cell-cycle progression via cannabinoid type 1 (CB1) receptors in the regenerating liver

(2011) B. Mukhopadhyay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CB1 receptor inhibition leads to decreased vascular AT1 receptor expression, inhibition of oxidative stress and improved endothelial function

(2010) Vedat Tiyerili et al.   BASIC RESEARCH IN CARDIOLOGY

Cannabinoid Receptor 1 Blockade Ameliorates Albuminuria in Experimental Diabetic Nephropathy

(2010) F. Barutta et al.   DIABETES

CB1 Antagonism Exerts Specific Molecular Effects on Visceral and Subcutaneous Fat and Reverses Liver Steatosis in Diet-Induced Obese Mice

(2010) T. Jourdan et al.   DIABETES

Transcriptional Regulation of Cannabinoid Receptor-1 Expression in the Liver by Retinoic Acid Acting via Retinoic Acid Receptor-γ

(2010) Bani Mukhopadhyay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity

(2010) Joseph Tam et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of nitrosative stress in the pathogenesis of diabetic vascular dysfunction

(2009) Csaba Szabo   BRITISH JOURNAL OF PHARMACOLOGY

Paracrine Transactivation of the CB1Cannabinoid Receptor by AT1Angiotensin and Other Gq/11Protein-coupled Receptors

(2009) Gábor Turu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The future of endocannabinoid-oriented clinical research after CB1 antagonists

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Analysis of the Relationship of Leptin, High-Sensitivity C-Reactive Protein, Adiponectin, Insulin, and Uric Acid to Metabolic Syndrome in Lean, Overweight, and Obese Young Females

(2008) Abdul Ridha Abdullah et al.   Metabolic Syndrome and Related Disorders

Angiotensin II receptor blocker inhibits tumour necrosis factor-alpha-induced cell damage in human renal proximal tubular epithelial cells

(2008) TORU KAGAWA et al.   NEPHROLOGY